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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Self‑Powered Airflow Sensor Based on Energy Harvesting of Ventilation Air in Buildings

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Advanced Fiber Materials 2023年第5期5卷 1788-1798页

作者： moon hyun Chung Seunghwan Yoo Woo‑Nam Jung Hakgeun Jeong kyung‑Hwa Yoo Department of Physics Yonsei University50 Yonsei‑RoSeodaemun‑GuSeoul 03722Republic of Korea Energy ICT Convergence Research Department Energy Efficiency Research DivisionKorea Institute of Energy Research152 Gajeong‑RoYuseong‑GuDaejeon 34129Republic of Korea Advanced Combustion Power Lab Energy Efficiency Research DivisionKorea Institute of Energy Research152Gajeong‑RoYuseong‑GuDaejeon 34129Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑RoYuseongDaejeon 34141Republic of Korea

Heating,ventilation,and air conditioning(HVAC)systems account for one-third of the total energy consumption in office *** use of airflow measurements to control the operation of HVAC systems can reduce energy consumption;thus,a sensor capable of monitoring airflow in a duct system is *** nanogenerators(TENGs)can be utilized as self-powered sensors in airflow-driven TENGs(ATENGs)as self-powered *** employing ferroelectric materials and surface modifications,the surface charges of TENGs can be *** this study,fibrous-mat TENGs were prepared using ferroelectric materials consisting of poly(vinylidene fluoride-co-trifluoroethylene)(PVDF-TrFE)and polyamide 11(nylon-11).And these materials were subsequently ***(3,4-ethylenedioxythiophene):poly(styrenesulfonate)was added to PVDF-TrFE to enhance the ferroelectric crystalline phase.X-ray diffraction analysis revealed that this incorporation affects theβ*** addition,the surface of nylon-11 was modified using the electrospray technique for post-treatment,thereby improving the interfacial adhesion between the *** materials were then utilized in fibrous-mat ATENGs(FM-ATENGs)to demonstrate their practical *** FM-ATENGs can be effectively used in an Arduino airflowcheck sensor,showcasing their potential for application in HVAC systems,to enhance airflow control and energy efficiency.

关键词： HVAC Airflow-driven triboelectric nanogenerator Building energy harvesting Fibrous mat Airflow sensor

Prediction of nephrotoxicity induced by cisplatin combination chemotherapy in gastric cancer patients

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World Journal of Gastroenterology 2011年第30期17卷 3510-3517页

作者： hyung Hwan moon kyung Won Seo Ki Young Yoon Yeon Myung Shin kyung hyun Choi Sang Ho Lee Department of Surgery Kosin University College of Medicine602-703 BusanSouth Korea

AIM:To evaluate the treatment options for nephrotoxicity due to cisplatin combination ***:We retrospectively reviewed patients who had received cisplatin combination chemotherapy for gastric cancer between January 2002 and December *** investigated patients who had shown acute renal failure(ARF),and examined their clinical characteristics,laboratory data,use of preventive measures,treatment cycles,the amount of cisplatin administered,recovery period,subsequent treatments,and renal status between the recovered and unrecovered ***:Forty-one of the 552 patients had serum creatinine(SCR)levels greater than 1.5 mg/*** found that pre-ARF SCR,ARF SCR,and ARF glomerular filtration rates were significantly associated with renal status postARF between the two groups(P=0.008,0.026,0.026,respectively).On the receiver operating characteristic curve of these values,a 1.75 mg/dL ARF SCR value had 87.5%sensitivity and 84.8%specificity(P=0.011).CONCLUSION:Cessation or reduction of chemotherapy should be considered for patients who have an elevation of SCR levels during cisplatin combination chemotherapy.

关键词： Acute renal failure Cisplatin Drug toxicities Nephrotoxicity

FET-based nanobiosensors for the detection of smell and taste

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Science China(Life Sciences) 2020年第8期63卷 1159-1167页

作者： Dongseok moon Yeon kyung Cha So-ong Kim Seongyeon Cho Hwi Jin Ko Tai hyun Park School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea

Various nanobiosensors composed of biomaterials and nanomaterials have been developed,due to their demonstrated advantage of showing high *** various biomaterials for biological recognition elements of the nanobiosensor,sensory receptors,such as olfactory and taste receptors,are promising biomaterials for developing nanobiosensors,because of their high selectivity to target ***-effect transistors(FET)with nanomaterials such as carbon nanotube(CNT),graphene,and conducting polymer nanotube(CPNT),can be combined with the biomaterials to enhance the sensitivity of ***,many efforts have been made to develop nanobiosensors using biomaterials,such as olfactory receptors and taste receptors for detecting various smells and *** review focuses on the biomaterials and nanomaterials used in nanobiosensor systems and studies of various types of nanobiosensor platforms that utilize olfactory receptors and taste receptors which could be applied to a wide range of industrial fields,including the food and beverage industry,environmental monitoring,the biomedical field,and anti-terrorism.

关键词： nanobiosensor olfactory receptor taste receptor field-effect transistor(FET)

Fish bone migration to the urinary bladder after rectosigmoid colon perforation

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World Journal of Gastroenterology 2014年第22期20卷 7075-7078页

作者： Min-kyung Cho moon-Soo Lee hyun-Young Han Seung Hyo Woo Department of Surgery Eulji University HospitalDaejeon 302-799South Korea Department of Radiology Eulji University HospitalDaejeon 302-799South Korea Department of Urology Eulji University HospitalDaejeon 302-799South Korea

Fish bones are the most common foreign objects leading to bowel *** cases are confined to the extraluminal space without penetration of an adjacent ***,abscess formation due to the perforation of the rectosigmoid colon by a fish bone can lead to the penetration of the urinary bladder and may subsequently cause the fish bone to migrate into the urinary *** the presented case,a 42-yearold female was admitted for lower abdominal *** computed tomography(CT)demonstrated a 5cm pelvic abscess containing a thin and curvilinear foreign *** conservative management,the patient was *** 1 mo,the subject developed a mechanical *** had to be delayed due to her *** of the foreign body to the urinary bladder was shown on additional CT.A Yellowish fish bone 3.5 cm in size was removed through intraoperative *** patient was discharged 8 d after the operation without any unexpected event.

关键词： Fish bone Rectosigmoid colon perforation Urinary bladder Foreign body ingestion Foreign body induced bowel perforation

Association between Tropical Convection and Boreal Wintertime Extratropical Circulation in 1982/83 and 1988/89

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Advances in Atmospheric Sciences 2003年第4期20卷 593-603页

作者： Ja-Yeon moon kyung-Ja HA Climate Research Laboratory Meteorological Research InstituteSeoul156-720KoreaDepartment of Atmospheric SciencesPusan National UniversityPusan609-735Korea

Boreal wintertime extratropical circulation is studied in relation to the tropical convection during the 1982/83 El Niño and 1988/89 La Niña. The anomaly structure of 1982/83 and 1988/89 over the extratropics reveals remarkably different features as the longitudinal tropical forcing region changes. The Rossby wave source (Positive) shows the largest maximum over East Asia in both years due to the persistent heating from the western Pacific warm pool area. However, the sink term shows contrasting features over the subtropics and extratropics between the two years. In the El Niño year, enhanced tropical convection over the eastern Pacific produces the Rossby wave sink at 10°N and shifted eastward over the North Pacific, while in the La Niña year, the sink area is shifted westward over the North Pacific. The contrasting features between the two events in mean-eddy interaction appears especially over the downstream area of the East Asian Jet. The extension (retraction) of the meanflow eastward (westward) to the east (west) of the dateline is related with the effect of the westward (eastward) E-vector and the strengthening (weakening) of the negative anomalies of the barotropic growth of kinetic energy. Hence, almost opposite characteristics between the two events can explain the close relationship of tropical convection and the extratropical internal variability.

关键词： tropical convection extratropical circulation rossby wave source mean-eddy interaction

Suggestion of advanced regression model on friction angle of fault gouge in South Korea

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第6期13卷 1368-1379页

作者： Seong-Woo moon hyun-Seok Yun Yong-Seok Seo Department of Earth and Environmental Sciences Chungbuk National University1 Chungdae-roCheongju-siChungcheongbuk-do28644South Korea

Although friction characteristics of fault gouge are important to understand reactivation of fault,behavior of earthquake,and mechanism of slope failure,analysis results of fault gouge have low accuracy mostly than those of soils or rocks due to its high heterogeneity and low ***,to improve the accuracy of analysis results,we conducted simple regression analysis and structural equation model analysis and selected major influential factors of friction characteristics among many factors,and then we deduced advanced regression model with the highest coefficient of determination(R^(2)) via multiple regression *** most coefficients of determination in simple regression analysis are below0.3-0.4,coefficient of determination in multiple regression analysis is remarkably large as 0.657.

关键词： Fault gouge Friction angle Simple regression analysis Structural equation model analysis Multiple regression analysis

Recent updates of precision therapy for gastric cancer: Towards optimal tailored management

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World Journal of Gastroenterology 2016年第19期22卷 4638-4650页

作者： moon kyung Joo Jong-Jae Park Hoon Jai Chun Division of Gastroenterology Department of Internal Medicine Korea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Digestive Disease and Nutrition Korea University College of Medicine

Signaling pathways of gastric carcinogenesis and gastric cancer progression are being avidly studied to seek optimal treatment of gastric cancer. Among them, hepatocyte growth factor (HGF)/c-MET, phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathways have been widely investigated. Their aberrant expression or mutation has been significantly associated with advanced stage or poor prognosis of gastric cancer. Recently, aberrations of immune checkpoints including programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) have been suggested as an important step in the formation of a microenvironment favorable for gastric cancer. Accomplishments in basic research have led to the development of novel agents targeting these signaling pathways. However, phase III studies of selective anti-HGF/c-MET antibodies and mTOR inhibitor failed to show significant benefits in terms of overall survival and progression-free survival. Few agents directly targeting STAT3 have been developed. However, this target is still critical issue in terms of chemoresistance, and SH2-containing protein tyrosine phosphatase 1 might be a significant link to effectively inhibit STAT3 activity. Inhibition of PD-1/PD-L1 showed durable efficacy in phase I studies, and phase III evaluation is warranted. Therapeutic strategy to concurrently inhibit multiple tyrosine kinases is a reasonable option, however, lapatinib needs to be further evaluated to identify good responders. Regorafenib has shown promising effectiveness in prolonging progression-free survival in a phase II study. In this topic highlight, we review the biologic roles and outcomes of clinical studies targeting these signaling pathways.

关键词： Gastric cancer Hepatocyte growth factor Mammalian target of rapamycin Signal transducer and activator of transcription 3 Programmed cell death ligand-1

Proton pump inhibitor: The dual role in gastric cancer

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World Journal of Gastroenterology 2019年第17期25卷 2058-2070页

作者： moon kyung Joo Jong-Jae Park Hoon Jai Chun Division of Gastroenterology Department of Internal MedicineKorea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of Medicine

Proton pump inhibitors(PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicobacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile,several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer stemness and signal transducer and activator of transcription 3(STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may"play dual role" in gastric carcinogenesis and treatment of gastric cancer.

关键词： Proton pump inhibitor Gastric cancer Drug resistance Signal transducer and activator of transcription 3