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Combination of Total Astragalus Extract and Total Panax Notoginseng Saponins Strengthened the Protective Effects on Brain Damage through Improving Energy Metabolism and Inhibiting Apoptosis after Cerebral Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2017年第6期23卷 445-452页

作者： huang xiao-ping TAN Hua CHEN Bei-yang DENG Chang-qing Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-Cerebral DiseasesHunan University of Chinese MedicineChangsha 410007China Department of Histology and Embryology Hunan University of Chinese MedicineChangsha 410208China

Objective： To explore the effects and molecular mechanisms of the combination between total Astragalus extract （TAE） and total Panax notoginseng saponins （TPNS） against cerebral ischemia- reperfusion injury. Methods： C57BL/6 mice were randomly divided into sham-operated group, model group, TAE （110 mg/kg） group, TPNS （115 mg/kg） group, TAE-TPNS combination group and Edaravone （4 mg/kg） group, treated for 4 days, then, cerebral ischemia-repeffusion injury was established by bilateral common carotid artery （CCA） ligation for 20 min followed by reperfusion for 1 and 24 h. Results： TPNS could increase adenosine triphosphate （ATP） level, TAE and TAE-TPNS combination increased ATP, adenosine diphosphate （ADP） contents and Na＋-K＋-ATPase activity, and the effects of TAE-TPNS combination were stronger than those of TAE or TPNS alone after reperfusion for 1 h. After reperfusion for 24 h, TAE, TPNS and TAE-TPNS combination significantly increased neurocyte survival rate and decreased the apoptosis rate as well as down-regulated the expression of phosphorylated c-June N-terminal kinasel/2 （p-JNK1/2）, cytochrome C （Cyt C）, cysteine aspartic acid-specific protease （Caspase）-9 and Caspase-3. Furthermore, the effects in TAE-TPNS combination were better than those in TAE or TPNS alone. Conclusion： The combination of TAE 110 mg/kg and TPNS 115 mg/kg could strengthen protective effects on cerebral ischemia injury, the mechanism underlying might be related to improving jointly the early energy metabolism, and relieving the delayed apoptosis via inhibiting the mitochondrial apoptosis pathway of JNK signal transduction.

关键词： total Astragalus extract total Panax notoginseng saponins combination cerebral ischemia- reperfusion energy metabolism C-Jun N-terminal kinase signal transduction mitochondrial apoptosis pathway Chinese medicine

血清SOX6、VCAN表达对胃癌诊断及病情评估的价值分析

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局解手术学杂志 2024年第2期33卷 149-152页

作者：黄小平李轶李萍西安市第九医院消化内科陕西西安710054 西安市第九医院血管介入科陕西西安710054

目的探讨胃癌患者血清中性别决定区Y框蛋白6(SOX6)、多功能蛋白聚糖(VCAN)的表达情况,并分析其对胃癌患者诊断及病情评估的价值。方法选取2019年1月至2021年10月本院收治的胃癌患者105例为胃癌组,依据病理分期将患者分为Ⅰ、Ⅱ期组(37例... 详细信息

目的探讨胃癌患者血清中性别决定区Y框蛋白6(SOX6)、多功能蛋白聚糖(VCAN)的表达情况,并分析其对胃癌患者诊断及病情评估的价值。方法选取2019年1月至2021年10月本院收治的胃癌患者105例为胃癌组,依据病理分期将患者分为Ⅰ、Ⅱ期组(37例)和Ⅲ、Ⅳ期组(68例);另选取本院收治的胃良性病变患者85例为良性组;同时选取85例健康体检者为对照组。采用实时qRT-PCR法对血清中SOX6、VCAN mRNA表达水平进行检测,采用Spearman法分析SOX6、VCAN表达与病理分期的相关性;受试者工作特征(ROC)曲线评价血清SOX6、VCAN表达对胃癌的诊断价值。结果胃癌组患者血清中SOX6表达水平低于对照组和良性组,VCAN表达水平高于对照组和良性组,差异均有统计学意义(P<0.05)。胃癌Ⅲ、Ⅳ期组患者血清中VCAN表达水平高于Ⅰ、Ⅱ期组患者,SOX6表达水平低于Ⅰ、Ⅱ期组患者,差异均有统计学意义(P<0.05)。相关性分析结果显示,胃癌患者血清中SOX6表达与病理分期呈负相关(r=-0.485,P<0.05),VCAN表达与病理分期呈正相关(r=0.518,P<0.05)。ROC曲线结果显示,SOX6、VCAN预测胃癌患者的曲线下面积(AUC)分别为0.921(95%CI:0.873~0.955)、0.915(95%CI:0.865~0.950),敏感度分别为92.38%、79.05%,特异度分别为83.53%、95.29%;二者联合诊断胃癌患者的AUC为0.969(95%CI:0.934~0.989),敏感度为94.29%,特异度为90.59%。结论胃癌患者血清中SOX6表达水平降低,VCAN表达水平升高,二者联合检测可作为胃癌诊断的血清标志物,同时可间接预测胃癌病情程度。

关键词：胃癌性别决定区Y框蛋白6 多功能蛋白聚糖相关性

基于LPWAN和AQI指数预测的空气质量监测系统

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科学技术与工程 2024年第15期24卷 6558-6566页

作者：张天娇海涛王钧黄孝平招兴业广西大学电气工程学院南宁530004 华蓝设计(集团)有限公司南宁530011 南宁学院电气工程学院南宁530200

针对传统空气质量监测系统耗电量大、抗干扰能力差、稳定性不高以及空气质量指数(air quality index,AQI)预测精度不足等问题,设计了一种集低功耗广域物联网LPWAN、One-NET云平台和循环神经网络(gated recurrent unit,GRU)于一体的空气... 详细信息

针对传统空气质量监测系统耗电量大、抗干扰能力差、稳定性不高以及空气质量指数(air quality index,AQI)预测精度不足等问题,设计了一种集低功耗广域物联网LPWAN、One-NET云平台和循环神经网络(gated recurrent unit,GRU)于一体的空气质量监测系统。系统采用光伏为主、市电为辅的混合模式供电;利用远距离无线电LoRa技术采集环境参数,集合云平台技术、麻雀搜索算法-变分模态分解-循环神经网络(sparrow search algorithm-variational mode decomposition-GRU,SSA-VMD-GRU)耦合模型实现远程监控和预测AQI指数。通过通信测试,结果表明通信距离1000 m内,通信率在96%以上,丢包率不超过4%。将采集到的特征参数用传统的GRU模型、VMD-GRU模型和本文提出的SSA-VMD-GRU模型进行训练、测试仿真和对比,结果表明SSA-VMD-GRU模型相较于传统的GRU模型和VMD-GRU模型对AQI指数有更好的预测效果,均方根误差分别减小了22.434、0.833,平均绝对误差分别减小了16.849、0.623,预测误差率在3%以内。该系统能够实现对空气质量的实时监控和AQI指数的精准预测,为准确发布空气质量预警提供借鉴。

关键词：低功耗广域物联网 AQI指数预测 SSA-VMD-GRU模型监测系统光伏供电

Climate change and anthropogenic impacts on marine ecosystems and countermeasures in China

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Advances in Climate Change Research 2015年第2期6卷 118-125页

作者： JIAO Nian-Zhi CHEN Da-Ke LUO Yong-Ming huang xiao-ping ZHANG Rui ZHANG Hai-Bo JIANG Zhi-Jian ZHANG Fei State Key Laboratory of Marine Environmental Science Institute of Marine Microbes and EcospheresXiamen University State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of Oceanography Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of Sciences Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of Sciences

The ecosystems of China seas and coasts are undergoing rapid changes under the strong influences of both global climate change and anthropogenic activities.To understand the scope of these changes and the mechanisms behind them is of paramount importance for the sustainable development of China,and for the establishment of national policies on environment protection and climate change mitigation.Here we provide a brief review of the impacts of global climate change and human activities on the oceans in general,and on the ecosystems of China seas and coasts in particular.More importantly,we discuss the challenges we are facing and propose several research foci for China seas/coasts ecosystem studies,including long-term time series observations on multiple scales,facilities for simulation study,blue carbon,coastal ecological security,prediction of ecosystem evolution and ecosystem-based management.We also establish a link to the Future Earth program from the perspectives of two newly formed national alliances,the China Future Ocean Alliance and the Pan-China Ocean Carbon Alliance.

关键词： Global climate change Anthropogenic activities Blu

Feature Matching via Topology-Aware Graph Interaction Model

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 113-130页

作者： Yifan Lu Jiayi Ma xiaoguang Mei Jun huang xiao-ping Zhang the Electronic Information School Wuhan UniversityWuhan 430072China IEEE Tsinghua Berkeley Shenzhen Institute Shenzhen 518071China the Department of Electrical Computer and Biomedical EngineeringToronto Metropolitan UniversityToronto ON M5B 2K3Canada

Feature matching plays a key role in computer vision. However, due to the limitations of the descriptors, the putative matches are inevitably contaminated by massive outliers.This paper attempts to tackle the outlier filtering problem from two aspects. First, a robust and efficient graph interaction model,is proposed, with the assumption that matches are correlated with each other rather than independently distributed. To this end, we construct a graph based on the local relationships of matches and formulate the outlier filtering task as a binary labeling energy minimization problem, where the pairwise term encodes the interaction between matches. We further show that this formulation can be solved globally by graph cut algorithm. Our new formulation always improves the performance of previous localitybased method without noticeable deterioration in processing time,adding a few milliseconds. Second, to construct a better graph structure, a robust and geometrically meaningful topology-aware relationship is developed to capture the topology relationship between matches. The two components in sum lead to topology interaction matching(TIM), an effective and efficient method for outlier filtering. Extensive experiments on several large and diverse datasets for multiple vision tasks including general feature matching, as well as relative pose estimation, homography and fundamental matrix estimation, loop-closure detection, and multi-modal image matching, demonstrate that our TIM is more competitive than current state-of-the-art methods, in terms of generality, efficiency, and effectiveness. The source code is publicly available at http://***/YifanLu2000/TIM.

关键词： Feature matching graph cut outlier filtering topology preserving

Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi huang xiao-xiao Liu Lan-Wei Li Guang-Ming huang Zhao-Xia huang Jin-ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM resonances.Herein,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors simultaneously.The structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene composites.Then,the result showed that CPP-SS can significantly improve theσof samples.Ultimately,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be surpassed.This work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

Single-cell profiling of the pig cecum at various developmental stages

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Zoological Research 2024年第1期45卷 55-68页

作者： Yan-Yuan xiao Qing Zhang Fei huang Lin Rao Tian-Xiong Yao Si-Yu Yang Lei Xie xiao-xiao Zou Li-ping Cai Jia-Wen Yang Bin Yang Lu-Sheng huang National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangJiangxi 330045China

The gastrointestinal tract is essential for food digestion,nutrient absorption,waste elimination,and microbial defense.Single-cell transcriptome profiling of the intestinal tract has greatly enriched our understanding of cellular diversity,functional heterogeneity,and their importance in intestinal tract development and disease.Although such profiling has been extensively conducted in humans and mice,the single-cell gene expression landscape of the pig cecum remains unexplored.Here,single-cell RNA sequencing was performed on 45572 cells obtained from seven cecal samples in pigs at four different developmental stages(days(D)30,42,150,and 730).Analysis revealed 12 major cell types and 38 subtypes,as well as their distinctive genes,transcription factors,and regulons,many of which were conserved in humans.An increase in the relative proportions of CD8^(+)T and Granzyme A(low expression)natural killer T cells(GZMA^(low)NKT)cells and a decrease in the relative proportions of epithelial stem cells,Tregs,RHEX^(+)T cells,and plasmacytoid dendritic cells(pDCs)were noted across the developmental stages.Moreover,the post-weaning period exhibited an up-regulation in mitochondrial genes,COX2 and ND2,as well as genes involved in immune activation in multiple cell types.Cell-cell crosstalk analysis indicated that IBP6^(+)fibroblasts were the main signal senders at D30,whereas IBP6^(−)fibroblasts assumed this role at the other stages.NKT cells established interactions with epithelial cells and IBP6^(+)fibroblasts in the D730 cecum through mediation of GZMA-F2RL1/F2RL2 pairs.This study provides valuable insights into cellular heterogeneity and function in the pig cecum at different development stages.

关键词： Single-cell RNA-seq Cecum Bama Xiang pigs Various developmental stages Cellular heterogeneity

Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1395-1406页

作者： Qiu-xiao Yu ping-Ying Fu Chi Zhang Li Li Wen-Ting huang Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and the second most common cause of cancer-related mortality worldwide.Mesenchymal-epithelial transition factor(MET)gene participates in multiple tumor biology and shows clinical potential for pharmacological manipulation in tumor treatment.MET amplification has been reported in CRC,but data are very limited.Investigating pathological values of MET in CRC may provide new therapeutic and genetic screening options in future clinical practice.AIM To determine the pathological significance of MET amplification in CRC and to propose a feasible screening strategy.METHODS A number of 205 newly diagnosed CRC patients undergoing surgical resection without any preoperative therapy at Shenzhen Cancer Hospital of Chinese Academy of Medical Sciences were recruited.All patients were without RAS/RAF mutation or microsatellite instability-high.MET amplification and c-MET protein expression were analyzed using fluorescence in situ hybridization(FISH)and immunohistochemistry(IHC),respectively.Correlations between MET aberration and pathological features were detected using the chi-squared test.Progression free survival(PFS)during the two-year follow-up was detected using the Kaplan-Meier method and log rank test.The results of MET FISH and IHC were com pared using one-way ANOVA.RESULTS Polysomy-induced MET amplification was observed in 14.4%of cases,and focal MET amplification was not detected.Polysomy-induced MET amplification was associated with a higher frequency of lymph node metastasis(LNM)(P<0.001)and higher tumor budding grade(P=0.02).In the survival analysis,significant difference was detected between patients with amplified-and non-amplified MET in a two-year follow-up after the first diagnosis(P=0.001).C-MET scores of 0,1+,2+,and 3+were observed in 1.4%,24.9%,54.7%,and 19.0%of tumors,respectively.C-MET overexpression correlated with higher frequency of LNM(P=0.002),but no significant difference of PFS was detected between patients with different protein lev

关键词： Colorectal cancer MET Amplification Pathological features Prognosis Fluorescence in situ hybridization

Superiority of a Convolutional Neural Network Model over Dynamical Models in Predicting Central Pacific ENSO

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Advances in Atmospheric Sciences 2024年第1期41卷 141-154页

作者： Tingyu WANG ping huang Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science&TechnologyNanjing 210044China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The application of deep learning is fast developing in climate prediction,in which El Ni?o–Southern Oscillation(ENSO),as the most dominant disaster-causing climate event,is a key target.Previous studies have shown that deep learning methods possess a certain level of superiority in predicting ENSO indices.The present study develops a deep learning model for predicting the spatial pattern of sea surface temperature anomalies(SSTAs)in the equatorial Pacific by training a convolutional neural network(CNN)model with historical simulations from CMIP6 models.Compared with dynamical models,the CNN model has higher skill in predicting the SSTAs in the equatorial western-central Pacific,but not in the eastern Pacific.The CNN model can successfully capture the small-scale precursors in the initial SSTAs for the development of central Pacific ENSO to distinguish the spatial mode up to a lead time of seven months.A fusion model combining the predictions of the CNN model and the dynamical models achieves higher skill than each of them for both central and eastern Pacific ENSO.

关键词： ENSO diversity deep learning ENSO prediction dynamical forecast system