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Plasma Homocysteine and Gene Polymorphisms Associated with the Risk of Hyperlipidemia in Northern Chinese Subjects

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Biomedical and Environmental Sciences 2008年第6期21卷 514-520页

作者： LEI huang xiao-ming SONG WEN-LI ZHU YONG LI Department of Nutrition and Food Hygiene School of Public Health Peking University Beijing 100083 China

Objective To examine the relationship between occurrence of hyperlipidemia, plasma homocysteine and polymorphisms of methylenetetra hydrofolate reductase （MTHFR） gene and methionine synthase （MS） gene. Methods A total of 192 hyperlipidemia patients were selected and divided into hypercholesterolemia group, hypertriglyceridemia group, and combined hyperlipidemia group. Another 208 normal individuals were selected as control. Total plasma homocysteine （tHcy） concentration was measured by high-performance liquid chromatography （HPLC）. Lipid profiles were measured for all subjects The polymorphisms of MTHFR gene C677T and MS gene A2756G were analyzed by PCR-RFLP. Results The tHcy concentration in the combined hyperlipidemia patients was significantly higher than that in the control （15.95μmol/L vs 13.43 μmol/L, P〈0.05）. The prevalence of hyperhomocysteinemia （HHcy） in the combined hyperlipidemia group was significantly higher than that in the control （42.2% vs 23.0%, P=0.015）, with the odds ratio （OR） of 3.339 （95%CI： 1.260-8.849）. The hyperlipidemia patients with HHcy had a higher concentration of total cholesterol （TC） than that in the normal tHcy patients （5.67±0.95 mmol/L vs 5.47±0.92 retool/L, P=0.034）. There was no significant difference in genotype or allele frequencies of MTHFR C677T between the hyperlipidemic and control groups. The hyperlipidemia patients with MTHFR CT/TT genotype had a higher concentration of triglyceride （TG） than those with CC genotype （2.24±1.75 mmol/L vs 1.87±0.95 mmol/L, P〈0.05）. Individuals with CT/TT genotype had a higher concentration of tHcy than those with 677CC genotype both in the hyperlipidemia group （12.61±1.24μmol/L vs 11.20±1.37 μmol/L, P〈0.05） and in the control group （14.04±1.48 μmol/L vs 12.61±1.24 μmol/L, P〈0.05）. The percentage of MS 2756 GG/AG genotype in the combined hyperlipidemia group was significantly higher than that in the control （26.7% vs 13.0%, P=0.012）, with the OR of 3.121 （95%C1： 1.288-7.65/）. The hyperlipid

关键词： Methylenetetra hydrofolate reductase Methionine synthase Gene polymorphism Homocysteine Hyperlipidemia

SYNERGETIC MITIGATION OF THE RAYLEIGH-TAYLORINSTABILITY BY SHEAR AXIAL FLOWS ANDFINITE LARMOR RADIUS

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核聚变与等离子体物理 2003年第2期23卷 77-83页

作者： huang Lin, QIU xiaoming, JIAN Guangde(Southwestern Institute of Physics, Chengdu 610041) Southwestern Institute of Physics Chengdu 610041

A hybrid model of MHD and kinetic theory is proposed to investigate the synergetic stabilizing effects of sheared axial flow and finite Larmor radius on the RayleighTaylor instability in Zpinch *** our model the MHD plasma is considered to respond to a perturbation with exp at frequency ω+ik2⊥ρ2iΩi instead of frequency ω,where k2⊥ρ2i is the finite Larmor radius effects given from the general kinetic theory of magnetized *** linearized continuity and momentum equations include automatically the finite Larmor radius *** relation is derived,which includes the effects of a density discontinuity and the finite Larmor radius as well as a sheared flow that produces the KelvinHelmholtz *** dispersion equation is examined in three *** results indicate that the synergetic effect of sheared axial flow and the finite Larmor radius can mitigate both the RayleighTaylor instability and the hybrid RayleighTaylor/KelvinHelmholtz ***,the synergetic mitigation effect is stronger than either of them acting separately.

关键词：等离子体物理不稳定性协同缓和效应有限拉莫尔辐射散射方程 Z-箍缩剪切层流动

基于振动成型的沥青稳定碎石基层路用性能研究

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公路 2024年第3期69卷 21-29页

作者：钟昆志刘礼辉张秋菊孙玉蛟黄晓明江西省交通科学研究院有限公司南昌市330200 江西省交通投资集团有限责任公司南昌市330025 东南大学交通学院南京市211189 云南宾鹤高速公路投资开发有限公司大理市671500 中建科技集团有限公司四川分公司成都市610000

为研究振动成型对沥青稳定碎石基层(ATB)路用性能的影响,首先采用主骨料空隙填充法(CAVF法)对ATB的级配进行设计,比较干涉系数和松装间隙率对ATB性能的影响,优选ATB级配并确定最佳沥青用量;然后采用低温小梁弯曲试验、单轴压缩试验、贯... 详细信息

为研究振动成型对沥青稳定碎石基层(ATB)路用性能的影响,首先采用主骨料空隙填充法(CAVF法)对ATB的级配进行设计,比较干涉系数和松装间隙率对ATB性能的影响,优选ATB级配并确定最佳沥青用量;然后采用低温小梁弯曲试验、单轴压缩试验、贯入式重复加载试验、水稳定性试验评价振动成型ATB的低温性能、强度、高温性能和抗水损害性能,并与相同级配和沥青用量击实成型ATB的性能进行对比。最后研究级配最大粒径的变化对振动成型ATB性能的影响。研究结果表明:CAVF法设计的ATB结构密实,具备良好的性能;采用振动成型的ATB具有良好的路用性能,且总体性能要优于采用击实成型的ATB;设计ATB级配时,为保证良好的路用性能,最大粒径不宜超过31.5 mm。

关键词：半刚性基层振动成型沥青稳定碎石基层 CAVF法路用性能

Synthesis,structure and photoluminescent property of a novel potassic compound

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Chinese Chemical Letters 2007年第12期18卷 1539-1542页

作者： Guang Xiang Liu Liang Fang huang Heng Xu xiao ming Ren College of Chemistry and Chemical Engineering Anqing Normal University Anqing Anhui 246003 PR China

A novel 3D coordination compound of K（H2TDA）（H20）（1）（H3TDA = 1H-1,2,3-triazole-4,5-dicarboxylic acid） has been prepared and characterized by IR spectroscopy, elemental analysis, ICP and single-crystal X-ray ... 详细信息

关键词： Coordination compound Potassic compound Photoluminescent property

Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi huang xiao-xiao Liu Lan-Wei Li Guang-ming huang Zhao-Xia huang Jin-Ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

Assessment of Wet Season Precipitation in the Central United States by the Regional Climate Simulation of the WRFG Member in NARCCAP and Its Relationship with Large-Scale Circulation Biases

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Advances in Atmospheric Sciences 2024年第4期41卷 619-638页

作者： Yating ZHAO ming XUE Jing JIANG xiao-ming HU Anning huang School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Center for Analysis and Prediction of Storms and School of Meteorology The University of OklahomaNorman 73072U.S.A

Assessment of past-climate simulations of regional climate models(RCMs)is important for understanding the reliability of RCMs when used to project future regional ***,we assess the performance and discuss possible causes of biases in a WRF-based RCM with a grid spacing of 50 km,named WRFG,from the North American Regional Climate Change Assessment Program(NARCCAP)in simulating wet season precipitation over the Central United States for a period when observational data are *** RCM reproduces key features of the precipitation distribution characteristics during late spring to early summer,although it tends to underestimate the magnitude of *** dry bias is partially due to the model’s lack of skill in simulating nocturnal precipitation related to the lack of eastward propagating convective systems in the *** in reproducing large-scale circulation and environmental conditions is another contributing *** too weak simulated pressure gradient between the Rocky Mountains and the Gulf of Mexico results in weaker southerly winds in between,leading to a reduction of warm moist air transport from the Gulf to the Central Great *** simulated low-level horizontal convergence fields are less favorable for upward motion than in the NARR and hence,for the development of moist convection as ***,a careful examination of an RCM’s deficiencies and the identification of the source of errors are important when using the RCM to project precipitation changes in future climate scenarios.

关键词： NARCCAP Central United States precipitation low-level jet large-scale environment diurnal variation

Numerical analysis on thermal regime of wide embankment in permafrost regions of Qinghai-Tibet Plateau

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Journal of Central South University 2016年第12期23卷 3346-3355页

作者：马涛汤涛黄晓明汪浩 School of Transportation Southeast University Department of Civil and Environmental Engineering Rutgersthe State University of New Jersey

This study investigated the temperature field and thawing depth of wide embankment for expressway in permafrost regions based on numerical analysis by using finite element method(FEM).According to specific embankment section of Qinghai-Tibet highway,computational region for numerical analysis was *** numerical model was developed through FEM software named as ABAQUS and was verified by field observed *** effects by width and height of embankment on the thermal regime of computational region were analyzed based on FEM *** analysis showed that embankment construction has serious disturbance on the thermal stability of ground permafrost showing as annual average ground temperature and the maximum thawing depth keeps increasing with service time *** larger embankment width leads to poorer thermal stability and more serious uneven temperature field of *** embankment height can improve the thermal stability; however,the improvement is restricted for wide embankment and it cannot change the degradation trend of thermal stability with service life ***,to construct expressway with wide embankment in permafrost regions of Qinghai-Tibet Plateau,effective measures need to be considered to improve the thermal stability of underlying permafrost.

关键词： permafrost region thermal stability expressway embankment

Screening for metabolic dysfunction-associated fatty liver disease:Time to discard the emperor’s clothes of normal liver enzymes?

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World Journal of Gastroenterology 2024年第22期30卷 2839-2842页

作者： Chen-xiao huang xiao-Dong Zhou Calvin Q Pan ming-Hua Zheng Metabolic Dysfunction-Associated Fatty Liver Disease Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Department of MedicineNew York University Langone HealthNew York University Grossman School of MedicineNew YorkNY 11355United States Institute of Hepatology Wenzhou Medical UniversityKey Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang ProvinceWenzhou 325000Zhejiang ProvinceChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)is the most prevalent chronic liver condition *** liver enzyme-based screening methods have limitations that may missed diagnoses and treatment *** Chen et al,the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal ***,there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early *** paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD:Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

关键词： Metabolic dysfunction-associated fatty liver disease Non-alcoholic fatty liver disease Alanine aminotransferase Liver enzymes Screening Noninvasive liver fibrosis scores

Oxygen-assisted zinc recovery from electric arc furnace dust using magnesium chloride

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2300-2311页

作者： Jingdong huang xiao Yang School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China School of Engineering Westlake UniversityHangzhou 310030China

Electric arc furnace(EAF)dust is an important secondary resource containing metals,such as zinc(Zn)and iron(Fe).Recover-ing Zn from EAF dust can contribute to resource recycling and reduce environmental ***,the high chemical stability of ZnFe_(2)O_(4)in EAF dust poses challenges to Zn *** address this issue,a facile approach that involves oxygen-assisted chlorination using molten MgCl_(2)is *** work focused on elucidating the role of O2 in the reaction between ZnFe_(2)O_(4)and molten MgCl_(2).The results demonstrate that MgCl_(2)effectively broke down the ZnFe_(2)O_(4)structure,and the high O2 atmosphere considerably promoted the sep-aration of Zn from other components in the form of ZnCl_(2).The presence of O2 facilitated the formation of MgFe_(2)O_(4),which stabilized Fe and prevented its ***,the excessive use of MgCl_(2)resulted in increased evaporation loss,and high temperatures pro-moted the rapid separation of *** on these findings,we successfully extracted ZnCl_(2)-enriched volatiles from practical EAF dust through oxygen-assisted *** optimized conditions,this method achieved exceptional Zn chlorination percentage of over 97%within a short period,while Fe chlorination remained below 1%.The resulting volatiles contained 85wt%of ZnCl_(2),which can be further processed to produce metallic *** findings offer guidance for the selective recovery of valuable metals,particularly from solid wastes such as EAF dust.

关键词： electric arc furnace dust zinc oxygen magnesium chloride chlorination