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Chinese herbal medicine combined with Western medicine for Mycoplasma pneumoniae pneumonia in children:An overview of systematic reviews

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 131-139页

作者： si Zhang Xuan Zhang Yuehua Cui Juan huang Fei Fan simeng Wang Fei Han Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China

Objective:To summarize the characteristics and evaluate the quality of the methodology and evidence within systematic reviews(SRs)of Chinese herbal medicine(CHM)for Mycoplasma pneumoniae pneumonia(MPP)***:SRs of randomized controlled trials were searched using PubMed,the Cochrane Library,Embase,the Chinese National Knowledge Infrastructure Databases(CNKI),the Chinese Scientific Journals Database(VIP),Wanfang,and the sinoMed *** on the use of CHM alone or in combination with Western medications for MPP in children were *** study compared the effects of Western medicine alone with those of *** evidence quality using the A Measurement Tool to Assess Systematic Reviews(AMSTAR)2,the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)2020,and the Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)*** primary indicators were the total effective rate,fever subsidence time,and cough disappearance *** secondary outcomes were pulmonary rale disappearance time,average hospitalization time,lung X-ray infiltrate disappearance time,immunological indices,and inflammatory cytokine ***:Twelve relevant SRs were included;75%(9/12)were assessed as very low quality,and 25%(3/12)Were rated as low quality using the AMSTAR 2 *** to the PRISMA 2020 checklist,the average SR score was 20.3 out of a 27 point *** all SRs,CHM demonstrated improvement in symptoms and signs among children with *** evidence quality using the GRADE criteria ranged from"very low"(>50%)to"moderate"(sion,followed by publication bias and ***:This overview highlights the limited quality of the methodology and evidence of the included *** the included studies showed the beneficial effects of CHM on MPP in children,it was difficult to draw firm conclusions owing to methodological flaws.

关键词： Chinese herbal medicine Mycoplasma pneumoniae pneumonia Children Overview Systematic review

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Multi-lump Kinetic Parameter Estimation and simulation of Trickle-bed Reactor for Ultra-deep Hydrodesulfurization of Diesel

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China Petroleum Processing & Petrochemical Technology 2024年第3期26卷 147-157页

作者： huang Zhen Zhang xun Qiao Aijun Xue Nan Liu Kaixiang Xu Song Wang He siNOPEC Engineering Incorporation Co. Ltd.Beijing 100101China

A three-lumping Langmuir-Hinshelwood kinetic model was established based on the structures and reactivities of sulfur *** model described the ultra-deep hydrodesulfurization(UDHDS)performance of diesel,reducing sulfur content from 10000μg/g to less than 10μg/g,with experimental and predicted data showing a discrepancy of less than 10%.The diesel UDHDS reaction was simulated by combining the mass transfer,reaction kinetics model,and physical properties of *** results showed how the concentrations of H2S,hydrogen,and sulfur in the gas,liquid,and solid phases varied along the reactor ***,the study discussed the effects of each process parameter and impurity concentrations(H2S,basic nitrogen and,non-basic nitrogen)on diesel UDHDS.

关键词： diesel TBR ultra-deep HDS kinetic model simulation

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云的立体观测研究进展

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热带气象学报 2008年第6期24卷 743-747页

作者：李艳兵黄思训翟景秋解放军66199部队解放军理工大学气象学院解放军61741部队

对云的立体观测的研究历史做了回顾,按照具有代表性的观测平台的变化划分了4个发展阶段,分别予以介绍,内容包括典型平台、技术途径和特点、同步精度、云高指定精度等。重点介绍了双星联合观测的云高指定技术,分析了关键技术和可能存在... 详细信息

对云的立体观测的研究历史做了回顾,按照具有代表性的观测平台的变化划分了4个发展阶段,分别予以介绍,内容包括典型平台、技术途径和特点、同步精度、云高指定精度等。重点介绍了双星联合观测的云高指定技术,分析了关键技术和可能存在的问题,为技术实现做了较好的准备。

关键词：立体观测双星联合观测多角度观测云高指定

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Predicting fatigue life of automotive adhesive bonded joints:a data-driven approach using combined experimental and numerical datasets

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Advances in Manufacturing 2024年第3期12卷 522-537页

作者： Chen-Di Wei Qiu-Ren Chen Min Chen Li huang Zhong-Jie Yue si-Geng Li Jian Wang Li Chen Chao Tong Qing Liu School of Advanced Technology Xi’an Jiaotong-Liverpool UniversitySuzhou215123People’s Republic of China Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing210009People’s Republic of China Material Academy JITRISuzhou215100People’s Republic of China Nanjing University of Science and Technology Nanjing210094People’s Republic of China

The majority of vehicle structural failures originate from joint *** loading is one of the primary factors in joint failures,making the fatigue performance of joints a critical consideration in vehicle structure *** use of traditional fatigue analysis methods is constrained by the absence of adhesive life data and the wide variety of joint ***,there is a pressing need for an accurate fatigue life estimation method for the joints in the automotive *** this work,we proposed a data-driven approach embedding physical knowledge-guided parameters based on experimental data and finite element analysis(FEA)*** machine learning(ML)algorithms are adopted to investigate the fatigue life of three typical adhesive joints,namely lap shear,coach peel and KsiI *** the feature engineering and tuned process of the ML models,the preferable model using the Gaussian process regression algorithm is established,fed with eight input parameters,namely thicknesses of the substrates,line forces and bending moments of the adhesive bonded joints obtained from *** proposed method is validated with the test data set and part-level physical tests with complex loading states for an unbiased *** demonstrates that for life prediction of adhesive joints,the data-driven solutions can constitute an improvement over conventional solutions.

关键词： Fatigue life Adhesive bonded joints Finite element analysis(FEA) Machine learning(ML)

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中国东南部地区及近海的气溶胶光学厚度分布特征

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环境科学研究 2010年第5期23卷 634-641页

作者：王毅石汉青何明元黄思训解放军理工大学气象学院江苏南京211101

利用MODIS资料,对中国东南部地区及近海海域实现多通道大气气溶胶光学厚度(AOD)反演;利用地面连续波段的太阳辐射计数据对MODIS资料的反演结果进行校验,结果表明,反演结果的置信度较高;利用经过校验的结果对该地区的AOD分布特征进行了研... 详细信息

利用MODIS资料,对中国东南部地区及近海海域实现多通道大气气溶胶光学厚度(AOD)反演;利用地面连续波段的太阳辐射计数据对MODIS资料的反演结果进行校验,结果表明,反演结果的置信度较高;利用经过校验的结果对该地区的AOD分布特征进行了研究.结果表明:AOD大值区主要集中在海拔低的东南沿海及经济发达地区,而地形比较复杂的山地丘陵地区的值较小;海洋上空的AOD反演由于受到了近海混浊水体和离水辐射的影响,反演结果偏高,但还没有发现能准确反映研究地区特征的输入参量和合适的算法,以提高近海海域AOD的反演精度.

关键词：气溶胶光学厚度(AOD) MODIS 太阳辐射计校验

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single-cell profiling of the pig cecum at various developmental stages

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Zoological Research 2024年第1期45卷 55-68页

作者： Yan-Yuan Xiao Qing Zhang Fei huang Lin Rao Tian-Xiong Yao si-Yu Yang Lei Xie Xiao-Xiao Zou Li-Ping Cai Jia-Wen Yang Bin Yang Lu-Sheng huang National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangJiangxi 330045China

The gastrointestinal tract is essential for food digestion,nutrient absorption,waste elimination,and microbial ***-cell transcriptome profiling of the intestinal tract has greatly enriched our understanding of cellular diversity,functional heterogeneity,and their importance in intestinal tract development and *** such profiling has been extensively conducted in humans and mice,the single-cell gene expression landscape of the pig cecum remains ***,single-cell RNA sequencing was performed on 45572 cells obtained from seven cecal samples in pigs at four different developmental stages(days(D)30,42,150,and 730).Analysis revealed 12 major cell types and 38 subtypes,as well as their distinctive genes,transcription factors,and regulons,many of which were conserved in *** increase in the relative proportions of CD8^(+)T and Granzyme A(low expression)natural killer T cells(GZMA^(low)NKT)cells and a decrease in the relative proportions of epithelial stem cells,Tregs,RHEX^(+)T cells,and plasmacytoid dendritic cells(pDCs)were noted across the developmental ***,the post-weaning period exhibited an up-regulation in mitochondrial genes,COX2 and ND2,as well as genes involved in immune activation in multiple cell ***-cell crosstalk analysis indicated that IBP6^(+)fibroblasts were the main signal senders at D30,whereas IBP6^(−)fibroblasts assumed this role at the other *** cells established interactions with epithelial cells and IBP6^(+)fibroblasts in the D730 cecum through mediation of GZMA-F2RL1/F2RL2 *** study provides valuable insights into cellular heterogeneity and function in the pig cecum at different development stages.

关键词： single-cell RNA-seq Cecum Bama Xiang pigs Various developmental stages Cellular heterogeneity

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Efficacy of Juanbi capsule on ameliorating knee osteoarthritis:a network pharmacology and experimental verification-based study

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Traditional Medicine Research 2024年第6期9卷 19-30页

作者： Wen-Bo huang Shu-Ya Qin Jun-Bo Zou xun Li Wu-Lin Kang Pu-Wei Yuan The First Clinical Medical College of Shaanxi University of Chinese Medicine Xianyang 712046China College of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Department of Orthopedic Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712099China

Background:The purpose of the study was to investigate the active ingredients and potential biochemical mechanisms of Juanbi capsule in knee osteoarthritis based on network pharmacology,molecular docking and animal ***:Chemical components for each drug in the Juanbi capsule were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,while the target proteins for knee osteoarthritis were retrieved from the Drugbank,GeneCards,and OMIM *** study compared information on knee osteoarthritis and the targets of drugs to identify common *** data was imported into the STRING platform to generate a protein-protein interaction network ***,a“component-target”network diagram was created using the screened drug components and target information with Cytoscape *** targets were imported into Metascape for GO function and KEGG pathway enrichment *** was utilized to predict the molecular docking of the primary chemical components and core ***,the key targets were validated through animal ***:Juanbi capsule ameliorated Knee osteoarthritis mainly by affecting tumor necrosis factor,interleukin1β,MMP9,PTGS2,VEGFA,TP53,and other cytokines through quercetin,kaempferol,andβ-*** drug also influenced the AGE-RAGE,interleukin-17,tumor necrosis factor,Relaxin,and NF-κB signaling *** network pharmacology analysis results were further validated in animal *** results indicated that Juanbi capsule could decrease the levels of tumor necrosis factor-αand interleukin-1βin the serum and synovial fluid of knee osteoarthritis rats and also down-regulate the expression levels of MMP9 and PTGS2 proteins in the articular ***:Juanbi capsule may improve the knee bone microstructure and reduce the expression of inflammatory factors of knee osteoarthritis via multiple targets and multiple signaling pathways.

关键词： osteoarthritis inflammation MMP9/PTGS2 network pharmacology Juanbi capsule experimental verification

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Polar-coordinate line-projection light-curing continuous 3D printing for tubular structures

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International Journal of Extreme Manufacturing 2024年第4期6卷 247-260页

作者： Huiyuan Wang siqin Liu Xincheng Yin Mingming huang Yanzhe Fu xun Chen Chao Wang Jingyong Sun Xin Yan Jianmin Han Jiping Yang Zhijian Wang Lizhen Wang Yubo Fan Jiebo Li Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationInstitute of Medical PhotonicsBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191People's Republic of China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191People's Republic of China Peking University School and Hospital of Stomatology Beijing 100081People's Republic of China School of Materials Science and Engineering Beihang UniversityBeijing 100191People's Republic of China

3D printing techniques offer an effective method in fabricating complex radially multi-material ***,it is challenging for complex and delicate radially multi-material model geometries without supporting structures,such as tissue vessels and tubular graft,among *** this work,we tackle these challenges by developing a polar digital light processing technique which uses a rod as the printing *** 3D model fabrication is accomplished through line *** rotation and translation of the rod are synchronized to project and illuminate the photosensitive material *** controlling the distance between the rod and the printing window,we achieved the printing of tubular structures with a minimum wall thickness as thin as 50 *** controlling the width of fine slits at the printing window,we achieved the printing of structures with a minimum feature size of 10 *** process accomplished the fabrication of thin-walled tubular graft structure with a thickness of only 100 micrometers and lengths of several centimeters within a timeframe of just 100 ***,it enables the printing of axial multi-material structures,thereby achieving adjustable mechanical *** method is conducive to rapid customization of tubular grafts and the manufacturing of tubular components in fields such as dentistry,aerospace,and more.

关键词： 3D printing polar coordinate line projection light-curing tubular structure radially multi-material structures

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Endovascular treatment of ruptured lobulated anterior communicating artery aneurysms:A retrospective study of 24 patients

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World Journal of Clinical Cases 2024年第15期12卷 2529-2541页

作者： Sheng-Xuan huang xun-Ping Ai Ze-Hui Kang Zhi-Yong Chen Ren-Man Li Zu-Chao Wu Feng Zhu Department of Neurosurgery Sanming First Hospital Affiliated to Fujian Medical UniversitySanming 365000Fujian ProvinceChina

BACKGROUND Lobulated intracranial aneurysm is a special type of aneurysm with at least one additional cyst in the neck or body of the *** intracranial aneurysm is a complex aneurysm with complex morphology and structure and weak tumor wall,which is an independent risk factor for rupture and *** aneurysms located in the anterior communicating artery complex account for 36.9%of all intracranial lobular *** to its special anatomical structure,both craniotomy and endovascular treatment are more *** with single-capsule aneurysms,craniotomy for lobular intracranial aneurysms has a higher risk and complication *** To investigate the efficacy and safety of endovascular treatment for ruptured lobulated anterior communicating artery aneurysm(ACoAA).METHODS Patients with ruptured lobulated ACoAA received endovascular treatment in Sanming First Hospital Affiliated to Fujian Medical University from June 2020 to June 2022 were retrospectively *** demographic,clinical and imaging characteristics,endovascular treatment methods and follow-up results were *** A total of 24 patients with ruptured lobulated ACoAA were included,including 9 males(37.5%)and 15 females(62.5%).Their age was 56.2±8.9 years old(range 39-74).The time from rupture to endovascular treatment was 10.9±12.5 *** maximum diameter of the aneurysms was 5.1±1.0 mm and neck width were 3.0±0.7 *** patients(79.2%)were double-lobed and 5(20.8%)were ***'s grade:Grade 2 in 16 cases(66.7%),grade 3 in 6 cases(25%),and grade 4 in 2 cases(8.3%).Hunt-Hess grade:Grade 0-2 in 5 cases(20.8%),grade 3-5 in 19 cases(79.2%).Glasgow Coma Scale score:9-12 in 14 cases(58.3%),13-15 in 10 cases(41.7%).Immediately postprocedural Raymond-Roy grade:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).Raymond-Roy grade in imaging follow-up for 2 wk to 3 months:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).Followup for 2 to 12 months sho

关键词： Intracranial aneurysm Anterior cerebral artery Endovascular surgery Embolism Treatment outcome

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In-situ study of the hydrogen peroxide photoproduction in seawater on carbon dot-based metal-free catalyst under operation condition

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Nano Research 2024年第7期17卷 5956-5964页

作者： Jiaxuan Wang Jiacheng Li Zenan Li Jie Wu Honglin si Yangbo Wu Zhiyong Guo Xuepeng Wang Fan Liao Hui huang Mingwang Shao Yang Liu Zhenhui Kang Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products School of Material Science and Chemical EngineeringNingbo UniversityNingbo 315211China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipa 999078MacaoChina

Hydrogen peroxide(H_(2)O_(2))photoproduction in seawater with metal-free photocatalysts derived from biomass materials is a green,sustainable,and ultra environmentally friendly ***,most photocatalysts are always corroded or poisoned in seawater,resulting in a significantly reduced catalytic ***,we report the metal-free photocatalysts(RUT-1 to RUT-5)with in-situ generated carbon dots(CDs)from biomass materials(Rutin)by a simple microwave-assisted pyrolysis *** visible light(λ≥420 nm,81.6 mW/cm^(2)),the optimized catalyst of RUT-4 is stable and can achieve a high H_(2)O_(2)yield of 330.36μmol/L in seawater,1.78 times higher than that in normal *** transient potential scanning(TPS)tests are developed and operated to in-situ study the H_(2)O_(2)photoproduction of RUT-4 under operation ***-4 has strong oxygen(O_(2))absorption capacity,and the O_(2)reduction rate in seawater is higher than that in *** cations in seawater further promote the photo-charge separation and facilitate the photo-reduction *** RUT-4,the conduction band level under operating conditions only satisfies the requirement of O_(2)reduction but not for hydrogen(H2)*** work provides new insights for the in-situ study of photocatalyst under operation condition,and gives a green and sustainable path for the H_(2)O_(2)photoproduction with metal-free catalysts in seawater.

关键词： carbon dots hydrogen peroxide photocatalysis transient potential scanning in-situ study operation condition

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