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Studies on the Voltammetric Behavior of Nicardipine Hydrochloride and its Voltammetric Determination at the Co/GC Modified Electrode

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Chemical Research in Chinese Universities 1999年第2期15卷 36-41页

作者： ZHI Yao HU Jingbo LI Qilong huang qingquan Department of Chemistry Beijing Normal UniversityBeijing100875 National Institute for the Control of Pharmaceutical and Biological Products Beijing100050

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ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅｔｅｃｈｎｉｑｕｅｏｆｉｏｎｉｍｐｌａｎｔａｔｉｏｎｈａｓｂｅｅｎｄｅｖｅｌｏｐｅｄａｓａｍｅａｎｓｏｆｉｎｔｒｏｄｕｃｔｉｎｇｆｏｒｅｉｇｎａｔｏｍｓｉｎｔｏｔｈｅｓｕｒｆａｃｅｌａｙｅｒｓｏｆａｓｏｌｉｄ．Ｔｈｉｓｔ...

关键词： Ion implantation Modified electrode Nicardipine Linearsweep voltammetry

Electrochemical behavior of adriamycin at a cobalt ion implantation modified elec-trode

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Chinese Science Bulletin 2001年第16期46卷 1355-1357页

作者： HU Jinbo huang qingquan LI Qilong Department of Chemistry Beijing Normal UniversityBeijing 100875China National Institute for the Control of Pharmaceutical and Biological Products Beijing 100050China

With Co/GCE in 0.005 mol Tris/L/0.05 mol/L NaCl solution (pH 7.1), a sensitive reductive peak of adriamgcin (ADM) was obtained by the linear scan voltammetry. The peak potential is -0.62 V (vs. SCE). The peak current is proportional to the concentration of ADM. The electrochemical behavior of the system was studied by the linear-sweep and cyclic voltammetry. The experiments showed that the reduction at Co/GCE is a quasi-reversible process with adsorption. According to Laviron抯 theory, the electrode reaction rate constant k0 and the electron transfer coefficient a are determined to be 2.15 s-1 and 0.62, respectively. The composition of the surface, valence state of elements and depth distribution of elements on the surfaces of Co/GCE were determined by the X-ray photoelectron spectroscopy and Auger electron spectroscopy. The experiments showed that Co was surely implanted into the surface of GCE. The implanted Co element in the form of Co-C catalyzed the reduction of ADM.

关键词： adriamycin ion implantation modified electrode electrochemical behavior surface analysis.

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广西特色药材横经席鉴别方法的研究

中国药事 2024年第4期38卷 403-415页

作者：张颖婷罗轶黄清泉梁柳春马双成郑健林雀跃广西壮族自治区食品药品检验所国家中药材质量监测与评价重点实验室南宁530000 中国食品药品检定研究院北京102629

目的:建立横经席专属性鉴别方法。方法:采用性状、显微及薄层色谱相结合的方法对横经席及其同属品种绣毛红厚壳、红厚壳进行对比研究,找到横经席的鉴别特征。结果:横经席性状鉴别特征为叶呈长圆状披针形,两面无毛;锈毛红厚壳叶呈矩圆形... 详细信息

目的:建立横经席专属性鉴别方法。方法:采用性状、显微及薄层色谱相结合的方法对横经席及其同属品种绣毛红厚壳、红厚壳进行对比研究,找到横经席的鉴别特征。结果:横经席性状鉴别特征为叶呈长圆状披针形,两面无毛;锈毛红厚壳叶呈矩圆形至椭圆形,两面主脉及小枝均密被锈红色柔毛;红厚壳叶呈宽椭圆形或倒卵状椭圆形,两面无毛。横经席粉末显微特征可观察到叶表皮细胞、纤维等,无非腺毛;锈毛红厚壳粉末可见较多非腺毛;红厚壳叶下表皮细胞垂周壁波浪状弯曲并呈连珠状增厚。薄层色谱鉴别结果显示,横经席比同属其他品种多1个特征斑点。结论:研究建立的横经席鉴别方法具有专属性,可区别横经席正品及其混伪品。

关键词：横经席锈毛红厚壳红厚壳性状鉴别显微鉴别薄层色谱鉴别

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商贸流通业聚集对城市经济发展韧性的影响

商业经济研究 2023年第9期 18-21页

作者：黄庆泉东莞城市学院广东东莞523419

本文通过构建2013-2021年我国商贸流通业聚集和城市经济发展韧性的指标体系,探究商贸流通业聚集对城市经济发展韧性的影响作用。研究表明:在基准回归下,商贸流通业聚集对城市经济发展韧性呈正向影响;不同城市规模下商贸流通业聚集对城... 详细信息

本文通过构建2013-2021年我国商贸流通业聚集和城市经济发展韧性的指标体系,探究商贸流通业聚集对城市经济发展韧性的影响作用。研究表明:在基准回归下,商贸流通业聚集对城市经济发展韧性呈正向影响;不同城市规模下商贸流通业聚集对城市经济发展韧性存在较大的异质性,其影响程度受城市规模大小呈逐步减弱趋势;商贸流通业聚集与城市经济发展韧性存在显著的空间自相关性,商贸流通业聚集对本地区城市经济发展韧性带来正向促进作用,同时对邻接城市经济发展韧性也带来显著的提升作用。最后,文章提出全面规划商贸流通业发展,增强商贸流通业服务产品技术创新,根据自身情况制定城市经济发展韧性战略,加大商贸流通业人才引进的建议。

关键词：商贸流通业聚集城市经济发展韧性异质性

Effects of 8-OHdG,H-FABP and CRP on the Development of Ischemic Cardiomyopathy

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Medicinal Plant 2024年第4期15卷 69-72页

作者： qingquan WU Yong ZHANG Xiuxian huang Hainan Provincial Geriatric Hospital Haikou 571100China Hainan Provincial People's Hospital Haikou 571100China

[Objectives]To analyze the relationship between serum 8-hydroxydeoxyguanosine(8-OHdG),heart fatty acid-binding protein(H-FABP),C-reactive protein(CRP)levels and clinical efficacy and short-term prognosis in patients with ischemic cardiomyopathy.[Methods]The clinical data of 100 patients with ischemic cardiomyopathy from October 2021 to November 2022 were retrospectively analyzed,and the serum levels of 8-OHdG,H-FABP and CRP were compared before and one week after *** patients were followed up for 12 months after discharge,and the incidence of major adverse cardiovascular events(MACE)was counted during the follow-up *** and multivariate Logistic regression analysis were used to analyze the prognostic factors of patients with ischemic cardiomyopathy in the near future,and the predictive value of serum 8-OHdG,H-FABP and CRP levels for the prognosis of patients was evaluated by ROC curve.[Results]After 1 week of treatment,the serum levels of 8-OHdG,H-FABP and CRP in patients with ischemic cardiomyopathy were significantly lower than those before treatment(P<0.05).During the follow-up period,34 patients developed MACE;the serum levels of 8-OHdG,H-FABP and CRP in the MACE group were higher than those in the non-MACE group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that 8-OHdG,H-FABP and CRP were the risk factors of MACE in patients with ischemic cardiomyopathy(P<0.05).ROC curve analysis showed that the combined prediction of 8-OHdG,H-FABP and CRP for MACE in patients with ischemic cardiomyopathy was higher than that of CRP,H-FABP and 8-OHdG alone(P<0.05).[Conclusions]8-OHdG,H-FABP and CRP are closely related to the clinical efficacy and short-term prognosis of patients with ischemic cardiomyopathy,and the detection of serum 8-OHdG,H-FABP and CRP levels can help to evaluate the clinical efficacy and short-term prognosis of patients with ischemic cardiomyopathy.

关键词： chemic cardiomyopathy 8-hydroxydeoxyguanosine heart type fatty acid binding protein C-reactive protein Clinical efficacy Short-term prognosis

博莱霉素与DNA在镍离子注入修饰电极上的相互作用及其应用

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化学学报 2001年第6期59卷 836-841页

作者：胡劲波黄清泉李启隆北京师范大学化学系中国药品生物制品检定所

博莱霉素(BLM)在0.1 mol/L HOAc-NaOAc缓冲溶液(pH4.62)中,在Ni/GCE离子注入修饰电极上有一灵敏的还原峰,峰电位为-1.16 V(***),峰电流与BLM浓度有关.用线性扫描和循环伏安法研究体系的行为表明,体系为具有加速作用的不可逆过程.是注入... 详细信息

博莱霉素(BLM)在0.1 mol/L HOAc-NaOAc缓冲溶液(pH4.62)中,在Ni/GCE离子注入修饰电极上有一灵敏的还原峰,峰电位为-1.16 V(***),峰电流与BLM浓度有关.用线性扫描和循环伏安法研究体系的行为表明,体系为具有加速作用的不可逆过程.是注入的Ni加速BLM的还原.引入DNA后,BLM的峰电位为-1.15 V(***),与未加入DNA前几乎完全一致;只使峰电流降低,形成一种非电活性的结合物.求得该结合物的结合比为BLM:DNA=3:1,结合常数为β=3.16×1016.用线性扫描和循环伏安法,并辅以紫外可见光谱法等手段研究表明,电极过程仍为不可逆过程,与未加入DNA时一样.加入DNA后,BLM的峰电流降低,据此,可用于DNA的测定,回收率在96.8～103.9%之间.

关键词：镍离子化学修饰电极博莱霉素离子注入伏安行为表面分析抗癌药物相互作用 DNA

A thermodynamic perspective on electrode poisoning in solid oxide fuel cells

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1449-1455页

作者： Kevin huang Department of Mechanical Engineering University of South CarolinaColumbiaUSA

A critical challenge to the commercialization of clean and high-efficiency solid oxide fuel cell(SOFC)technology is the insuf-ficient stack lifespan caused by a variety of degradation mechanisms,which are associated with cell components and chemical *** components related degradation refers to thermal/chemical/electrochemical deterioration of cell materials under operating conditions,whereas the latter regards impurities in feedstocks of oxidant(air)and reductant(fuel).This article provides a thermodynamic perspective on the understanding of the impurities-induced degradation mechanisms in *** discussion focuses on using thermodynamic ana-lysis to elucidate poisoning mechanisms in cathodes by impurity species such as Cr,CO_(2),H_(2)O,and SO_(2) and in the anode by species such as S(or H_(2)S),SiO_(2),and P_(2)(or PH_(3)).The author hopes the presented fundamental insights can provide a theoretical foundation for search-ing for better technical solutions to address the critical degradation challenges.

关键词： impurities air fuel reaction activity

流程导向监管理念下药品检验机构留样的管理与评价

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中国药房 2021年第3期32卷 257-261页

作者：张炜敏黄清泉黄宝斌中国食品药品检定研究院北京102629

目的:结合流程导向监管理念,为完善药品检验机构留样管理与评价的流程和措施提供参考。方法:从组织管理和控制措施方面探讨健全留样管理制度的措施;从入库检查、存储管理和出库判定、库房管理和信息化等方面探讨完善留样管理的流程和措... 详细信息

目的:结合流程导向监管理念,为完善药品检验机构留样管理与评价的流程和措施提供参考。方法:从组织管理和控制措施方面探讨健全留样管理制度的措施;从入库检查、存储管理和出库判定、库房管理和信息化等方面探讨完善留样管理的流程和措施;从评价内容和质控措施方面探讨留样管理的评价与持续改进。结果与结论:在组织管理方面,要完善管理程序与流程、确定留样目标与计划、完善岗位配置与管理、完善安全应急预案;在控制措施方面,要完善留样入库状态检查等业务管理措施、调整库房空间分配等条件、完善留样剩余有效期智能提示等措施。留样入库检查、存储空间和条件控制、留样出库判定是入库、存储、出库三大环节的关键,要从这些方面入手完善相关流程和措施。留样管理评价的内容包括管理制度、管理措施和流程、改进与评价三个方面。药品检验机构可采用计划-执行-检查-处理(PDCA)循环来改善留样管理效率、提升其管理质量。

关键词：流程导向药品检验机构留样流程管理

Fast Blood Oxygenation through Hemocompatible Asymmetric Polymer of Intrinsic Microporosity Membranes

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Research 2024年第1期2023卷 261-270页

作者： Xinxi huang Junping huang Pengcheng Su Wanbin Li Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China

Membrane technology has attracted considerable attention for chemical and medical applications,among *** organs play important roles in medical science.A membrane oxygenator,also known as artificial lung,can replenish O_(2) and remove CO_(2) of blood to maintain the metabolism of patients with cardiopulmonary ***,the membrane,a key component,is subjected to inferior gas transport property,leakage propensity,and insufficient *** this study,we report efficient blood oxygenation by using an asymmetric nanoporous membrane that is fabricated using the classic nonsolvent-induced phase separation method for polymer of intrinsic *** intrinsic superhydrophobic nanopores and asymmetric configuration endow the membrane with water impermeability and gas ultrapermeability,up to 3,500 and 1,100 gas permeation units for CO_(2) and O_(2),***,the rational hydrophobic–hydrophilic nature,electronegativity,and smoothness of the surface enable the substantially restricted protein adsorption,platelet adhesion and activation,hemolysis,and thrombosis for the ***,during blood oxygenation,the asymmetric nanoporous membrane shows no thrombus formation and plasma leakage and exhibits fast O_(2) and CO_(2) transport processes with exchange rates of 20 to 60 and 100 to 350 ml m^(−2) min^(−1),respectively,which are 2 to 6 times higher than those of conventional *** concepts reported here offer an alternative route to fabricate high-performance membranes and expand the possibilities of nanoporous materials for membrane-based artificial organs.

关键词： porosity asymmetric Oxygen