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Xenobiotic receptors in mediating the effect of sepsis on drug metabolism

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Acta Pharmaceutica Sinica B 2020年第1期10卷 33-41页

作者： Chuanzhu Lv ling huang Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikou 570300China Emergency and Trauma College Hainan Medical UniversityHaikou 571101China Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical UniversityHaikou 571101China Research Center for Drug Safety Evaluation of Hainan Province Hainan Medical UniversityHaikou 571101China Hainan Province Key Laboratory for Drug Preclinical Study of Pharmacology and Toxicology Research Hainan Medical UniversityHaikou 571101China Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikou 571101China

Sepsis is an infection-induced systemic inflammatory *** immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory *** sepsis occurs,the expression and activity of many inflammatory cytokines are markedly *** receptors are chemical-sensing transcription factors that play essential roles in the transcriptional regulation of drug-metabolizing enzymes(DMEs).Xenobiotic receptors mediate the functional crosstalk between sepsis and drug metabolism because the inflammatory cytokines released during sepsis can affect the expression and activity of xenobiotic receptors and thus impact the expression and activity of *** receptors in turn may affect the clinical outcomes of *** focuses on the sepsis-induced inflammatory response and xenobiotic receptors such as pregnane X receptor(PXR),aryl hydrocarbon receptor(AHR),glucocorticoid receptor(GR),and constitutive androstane receptor(CAR),DMEs such as CYP1A,CYP2B6,CYP2C9,and CYP3A4,and drug transporters such as p-glycoprotein(P-gp),and multidrug resistance-associated protein(MRPs)that are affected by *** the xenobiotic receptor-mediated effect of sepsis on drug metabolism will help to improve the safe use of drugs in sepsis patients and the development of new xenobiotic receptor-based therapeutic strategies for sepsis.

关键词： Sepsis Inflammatory cytokines Xenobiotic receptors Drug metabolism Drug-metabolizing enzymes Drug transporters

Research on the Trajectory Tracking Control of a 6-DOF Manipulator Based on Fully-Actuated System Models

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Journal of Systems Science & Complexity 2022年第2期35卷 641-659页

作者： SUN Hao huang ling HE Liang School of Automation Harbin University of Science and TechnologyHarbin 150080China School of Software Northwestern Polytechnical UniversityXi’an 710072China

The multi-degree of freedom(muti-DOF)manipulator system is a complex control system with the strong coupling feature and high *** this paper,trajectory tracking control of a six-degree of freedom(6-DOF)manipulator based on fully-actuated system models and a direct parametric method is *** fully-actuated system model of the 6-DOF manipulator is established by using the Denavit Hartenberg(DH)notation and Euler-Lagrange dynamics.A disturbance observer is constructed to solve the nonlinear uncertainties such as unmodeled dynamics and external ***,a controller is designed using the direct parametric method to make the 6-DOF manipulator reach the desired position with high *** that,a switching control strategy is developed to suppress the peak value belonging to the *** results reveal the effect of the proposed control approach.

关键词： Direct parametric approach fully-actuated system manipulator nonlinear disturbance observer trajectory tracking

Sensitivity Analysis of Ensemble Simulations on a Torrential Rainfall Case over South China Using Multiple PBL and SL Parameterizations

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Journal of Tropical Meteorology 2020年第2期26卷 208-222页

作者： huang ling Guangzhou Institute of Tropical and Marine Meteorology CMAGuangzhou 510641 China

A good representation of the interaction between the planetary boundary layer(PBL)and the surface layer(SL)in numerical models is of great importance for the prediction of the initiation and development of *** study examined an ensemble that consists of the available suites of PBL and SL parameterizations based on a torrential rainfall event over south *** sensitivity of the simulations was investigated against objective measurements using multiple PBL and SL parameterization *** main causes of the bias from different parameterization schemes were further analysed by comparing the good and bad ensemble *** results showed that good members tended to underestimate the rainfall amount but presented a decent evolution of mesoscale convective systems that were responsible for the torrential *** the total energy mass flux(TEMF)scheme,the bad members overestimated the amount and spatial coverage of *** failure of the bad member was due to a spurious convection initiation(CI)resulting from the overestimated high-θe elevated *** spurious CI developed and expanded rapidly,causing intensive and extensive rainfall over south *** with previous studies,the TEMF scheme tends to produce a warmer and moister PBL *** detailed sensitivity analysis of this case may provide reference for the operational forecast of rainfall over south China using multiple PBL and SL parameterizations.

关键词： PBL SL parameterization torrential rain

Zero-forcing beamforming with receiver antenna selection in downlink multi-antenna multi-user system

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Journal of Systems Engineering and Electronics 2008年第6期19卷 1258-1263页

作者： huang Senhua Qiu ling Shi Lin PCN & SS Lab Univ. of Science and Technology of China Hefei 230027 P. R. China

A study on the zero-forcing beamforming （ZFBF） scheme with antenna selection at user terminals in downlink multi-antenna multi-user systems is presented. Simulation results show that the proposed ZFBF scheme with receiver antenna selection （ZFBF-AS） achieves considerable throughput improvement over the ZFBF scheme with single receiver antenna. The results also show that, with multi-user diversity, the ZFBF-AS scheme approaches the throughput performance of the ZFBF scheme using all receiver antennas （ZFBF-WO-AS） when the base station adopts semi-orthogonal user selection （SUS） algorithm, and achieves larger throughput when the base station adopts the Round-robin scheduling algorithm. Compared with ZFBF-WO-AS, the proposed ZFBF-AS scheme can reduce the cost of user equipments and the channel state information requirement at the transmitter （CSIT） as well as the multiuser scheduling complexity at the transmitter.

关键词： downlink multi-antenna multi-user system zero-forcing beamforming antenna selection throughput performance

Ensemble Based Diagnosis of the Track Errors of Super Typhoon Mangkhut(2018)

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Journal of Meteorological Research 2020年第2期34卷 353-367页

作者： ling huang Qilin WAN Chunxia LIU Huijun huang Institute of Tropical and Marine Meteorology of China Meteorological Administration Guangzhou 510000

Super Typhoon Mangkhut(2018)was the most high-impact typhoon in 2018 because of its long lifespan and significant *** operational track forecasts in the short-to-medium range(deterministic and probabilistic forecast)showed a great uncertainty and the forecast landing points varied with different lead *** study applied ensembles of high-resolution ECMWF forecasts to investigate the major factors and mechanisms of the bias production of the Mangkhut forecast *** ensembles with the largest track bias were analyzed to examine the possible bias associated *** results suggested that environmental steering flows were the main cause for the erroneous southward track error with a variance contribution of 72%.The tropical cyclone(TC)size difference and the interaction of the TC with the subtropical high(SH)were other two key factors that contributed to the track ***,larger TCs may have led to a stronger erosion of the southern part of the SH,and thus induced significant changes in the large-scale environment and eventually resulted in an additional northward movement of TC.

关键词： Super Typhoon Mangkhut ECMWF ensemble tropical cyclone track

NUMERICAL BOUNDARY CONDITIONS FOR THE FAST SWEEPING HIGH ORDER WENO METHODS FOR SOLVING THE EIKONAL EQUATION

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Journal of Computational Mathematics 2008年第3期26卷 336-346页

作者： ling huang Chi-Wang Shu Mengping Zhang Department of Mathematics University of Science and Technology of China Hefei Anhui 230026 China Division of Applied Mathematics Brown University Providence RI 02912 USA Department of Mathematics University of Science and Technology of China Hefei 230026 China

High order fast sweeping methods have been developed recently in the literature to solve static Hamilton-Jacobi equations efficiently. Comparing with the first order fast sweeping methods, the high order fast sweeping methods are more accurate, but they often require additional numerical boundary treatment for several grid points near the boundary because of the wider numerical stencil. It is particularly important to treat the points near the inflow boundary accurately, as the information would flow into the computational domain and would affect global accuracy. In the literature, the numerical solution at these boundary points are either fixed with the exact solution, which is not always feasible, or computed with a first order discretization, which could reduce the global accuracy. In this paper, we discuss two strategies to handle the inflow boundary conditions. One is based on the numerical solutions of a first order fast sweeping method with several different mesh sizes near the boundary and a Richardson extrapolation, the other is based on a Lax-Wendroff type procedure to repeatedly utilizing the PDE to write the normal spatial derivatives to the inflow boundary in terms of the tangential derivatives, thereby obtaining high order solution values at the grid points near the inflow boundary. We explore these two approaches using the fast sweeping high order WENO scheme in [18] for solving the static Eikonal equation as a representative example. Numerical examples are given to demonstrate the performance of these two approaches.

关键词： Fast sweeping method WENO scheme Boundary condition

Colour modulation and enhancement of upconversion emissions in K_(2)NaScF_(6):Yb/Ln(Ln=Er,Ho,Tm) nanocrystals

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Journal of Rare Earths 2021年第12期39卷 1477-1483,I0001页

作者： Yangbo Wang Huaiyong Li Hui Ma ling huang School of Materials Science and Engineering Liaocheng UniversityLiaocheng 252059China Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816China

Effective colour modulation of upconversion emissions in lanthanide-doped nanomaterials becomes even more important for fundamental and applied ***,on the one hand,by raising the content of doped Yb^(3+)from 10 mol%to 50 mol%,a significant increase of the red/green emission ratio from 4.0 to 68.2 is observed in K_(2)NaScF_(6):Yb/Er *** yellow to red colour change is attributed to the increased cross relaxation between Er^(3+)and Yb^(3+)caused by the increased Yb^(3+)amount,^(4) S_(3/2)(Er^(3+))^(+2) F7/2(Yb^(3+))→4 I13/2(Er^(3+))^(+2) F5/2(Yb^(3+)).On the other hand,the upconversion green and red emission of K_(2)NaScF_(6):Yb/Er(20/2 mol%)nanocrystals are intensified 10.6 and 8.8 folds,respectively,after an active shell(K_(2)NaScF_(6):Yb)is epitaxially grown,which are more effective than the7.4-and 6.4-fold enhancement from an inert shell(K_(2)NaScF_(6))***,the shell thickness from2.85 to 9.5 nm through controlling the molar ratio of shell-precursor to core from 1:2 to 3:1 can be easily *** study will provide more opportunities for the application of K_(2)NaScF_(6):Yb/Ln nanoparticles in varied fields such as theranostics,photovoltaics,and photocatalysis.

关键词： Upconversion Emission modulation Core-shell K_(2)NaScF_(6) Rare earths

A Remark on Strong Law of Large Numbers for Weighted U-Statistics

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Acta Mathematica Sinica,English Series 2014年第9期30卷 1595-1605页

作者： Hyung-Tae HA Mei ling huang Department of Applied Statistics Gachon University Department of Mathematics and Statistics Brock University

Let （X, Xn; n≥ 1} be a sequence of i.i.d, random variables with values in a measurable space （S,8） such that E｜h（X1, X2,..., Xm）｜〈 ∞, where h is a measurable symmetric function from Sm into R = （-∞, ∞）. Let {wn,i1,i2 im ; 1 ≤ i1 〈 i2 〈 …… 〈im 〈 n, n ≥ m} be a matrix array of real numbers. Motivated by a result of Choi and Sung （1987）, in this note we are concerned with establishing a strong law of large numbers for weighted U-statistics with kernel h of degree m. We show that whenever SUP n≥m max1〈i1〈i2〈…〈im≤｜wn i1,i2 i,im｜〈∞, where 0 = Eh（X1, X2,..., Xm）. The proof of this result is based on a new general result on complete convergence, which is a fundamental tool, for array of real-valued random variables under some mild conditions.

关键词： Strong law of large numbers weighted U-statistics complete convergence

Asymmetric Polymerization of N-Vinylcarbazole with Optically Active Anionic Initiators

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Chinese Journal of Polymer Science 2015年第11期33卷 1618-1624页

作者： Wei Hu 曹靖 Yi-ling huang Sai Liang Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education College of ChemistryXiangtan University

The anionic polymerization of N-vinylcarbazole（NVC） by using optically active anionic initiators such as the lithium salts of（S）-1-（9H-fluoren-2-yl）-4-isopropyl-4,5-dihydrooxazole（（S）-1-FIDH） and（S）-2-（9H-fluoren-2-yl）-4-isopropyl-4,5-dihydrooxazole（（S）-2-FIDH） and complexes of（-）-Sparteine with n-butylithium（n-Bu Li-（-）-Sp） or fluorenyl lithium（FILi-（-）-Sp） was achieved. The yield and specific rotation of poly（N-vinylcarbazole）s（poly（NVC）s） were considerably affected by the molar ratio of（S）-FIDH to NVC. The highest yield and specific rotation were obtained with Li-（S）-1-FIDH as an initiator, with a molar ratio of monomer and initiator [M]/[I] = 10/1. The effects of the chiral initiators, type of solvent and the polymerization temperature were investigated. The obtained optical activity of polymers was attributed to asymmetric induction of the chiral initiators.

关键词： Helical polymer Anionic polymerization Chiral carbon anionic initiator N-vinylcarbazole