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Journal of Integrative Medicine 2024年第5期22卷 614-620页

作者： Yong-guang Fang Shi-lin huang Nan-nan Chen Department of Hematology PLA 967th HospitalDalian 116021Liaoning ProvinceChina

Introduction There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the successful treatment of patients with relapsed and ATO-resistant *** presentation Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission(HCR)when reinduced by ATO;the other five patients progressed to relapse during ATO-based regimens for post-remission *** eight patients received RIF in three doses per day totaling 130 mg/kg(≤30 pills)as induction therapy and achieved HCR at a median time of 46.5 *** received 5 years of post-remission therapy,which consisted of combined chemotherapy followed by *** this period,the patients did not experience renal dysfunction or QT interval *** the last follow-up,three patients survived without relapse,two patients survived with a second or third relapse and third or fourth remission,and the other three patients relapsed for a third or fourth time and *** 5-year overall survival and event-free survival rates were 75.0%(95%confidence interval[CI]:31.5–93.1)and 37.5%(95%CI:5.6–71.7),*** RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.

关键词： Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide Resistant Case report

Quantifying the strength of magnetic fields using baryon electric charge correlation

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Nuclear Science and Techniques 2024年第8期35卷 5-8页

作者： Xu‑guang huang Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics National Natural Science Foundation of China and Fudan UniversityShanghai 200438China

Although heavy-ion collisions generate strong magnetic fields,their direct measurement is a challenging task.A new observable,the baryon electric charge correlation,was recently found to be sensitive to the magnetic field strength and thus could be used as a magnetometer for heavy-ion ***,this observable may shed light on the equation of state and phase structure of quantum chromodynamics(QCD)under magnetic *** and understanding the phase structure of quantum chromodynamics(QCD)is important in contemporary physics[1].

关键词： charge observable magnetic

Counterion-Mediated Hydrogen Bonding Making Strong Polyelectrolytes pH-Responsive:Current Understanding and Perspectives

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Chinese Journal of Polymer Science 2024年第9期42卷 1270-1277,I0005页

作者： Yue huang guang-Tao Mei Zan Hua guang-Ming Liu Hefei National Research Center for Physical Sciences at the Microscale Department of Chemical PhysicsKey Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei230026China The Key Laboratory of Functional Molecular Solids Ministry of Educationand Department of Materials ChemistrySchool of Chemistry and Materials ScienceAnhui Normal UniversityWuhu214002China

The counterion-mediated hydrogen bonding(CMHB)is related to the hydrogen bonding between bound counterions and polyelectrolyte chains in polyelectrolyte systems,where the counterions can both electrostatically bind to the charged groups of polyelectrolyte chains and act as hydrogen bond donors or acceptors to form hydrogen bonds with the hydrogen bond sites associated with polyelectrolyte chains simultaneously.A large number of literatures illustrate that strong polyelectrolytes(SPs)are insensitive to pH,which severely limmits the applications of SPs as smart ***,our studies have demonstrated that the CMHB makes SPs *** perspective discusses the mechanism of pH responsiveness of SPs and the pH-tunable properties of SPs,based on the pH-controlled CMHB *** future research directions on the pH responsiveness of SPs are also discussed *** is anticipated that the study of the pH responsiveness of SPs not only will provide a new understanding of the fundamental properties of SPs,but also will greatly expand the applications of SPs in the field of smart materials.

关键词： Counterion binding Hydrogen bond Polyelectrolyte brush Polyelectrolyte complexation

Predict the evolution of mechanical property of Al-Li alloys in a marine environment

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Defence Technology（防务技术） 2024年第1期31卷 557-566页

作者： Wei Li lin Xiang guang Wu Hongli Si Jinyan Chen Yiming Jin Yan Su Jianquan Tao Chunyang huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100036China Chongqing Innovation Center Beijing Institute of TechnologyChongqing400044China First Research Institute of the Ministry of Public Security for PR China Beijing100036China Southwest Technology and Engineering Research Institute Chongqing400039China

The ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and *** study it is to develop a Machine learning(ML)-based prediction method to study the evolution of the mechanical properties of Al-Li alloys in the marine *** obtained the mechanical properties of Al-Li alloy samples under uniaxial tensile deformation at different exposure times through Marine exposure *** obtained the strain evolution by digital image correlation(DIC).The strain field images are voxelized using 2D-Convolutional Neural Networks(CNN)autoencoders as input data for Long Short-Term Memory(LSTM)neural ***,the output data of LSTM neural networks combined with corrosion features were input into the Back Propagation(BP)neural network to predict the mechanical properties of Al-Li *** main conclusions are as follows:*** variation law of mechanical properties of2297-T8 in the Marine atmosphere is *** the increase in outdoor exposure test time,the tensile elastic model of 2297-T8 changes slowly,within 10%,and the tensile yield stress changes significantly,with a maximum attenuation of 23.6%.*** prediction model can predict the strain evolution and mechanical response simultaneously with an error of less than 5%.*** study shows that a CNN/LSTM system based on machine learning can be built to capture the corrosion characteristics of Marine exposure *** results show that the relationship between corrosion characteristics and mechanical response can be predicted without considering the microstructure evolution of metal materials.

关键词： Marine environment Al-Li alloy Machine learning Corrosion

Time-of-flight resolved stimulated Raman scattering microscopy using counter-propagating ultraslow Bessel light bullets generation

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Light(Science & Applications) 2024年第7期13卷 1427-1440页

作者： Shulang lin Li Gong Zhiwei huang Optical Bioimaging Laboratory Department of Biomedical EngineeringCollege of Design and EngineeringNational University of SingaporeSingapore 117576Singapore

We present a novel time-of-flight resolved Bessel light bullet-enabled stimulated Raman scattering(B2-SRS)microscopy for deeper tissue 3D chemical imaging with high resolution without a need for mechanical *** accomplish the tasks,we conceive a unique method to enable optical sectioning by generating the counterpropagating pump and Stokes Bessel light bullets in the sample,in which the group velocities of the Bessel light bullets are made ultraslow(e.g.,vg≈0.1c)and tunable by introducing programmable angular dispersions with a spatial light *** theoretically analyze the working principle of the collinear multicolor Bessel light bullet generations and velocity controls with the relative time-of-flight resolved detection for SRS 3D deep tissue *** have also built the B2-SRS imaging system and present the first demonstration of B2-SRS microscopy with Bessel light bullets for 3D chemical imaging in a variety of samples(e.g.,polymer bead phantoms,biological samples such as spring onion tissue and porcine brain)with high *** B2-SRS technique provides a>2-fold improvement in imaging depth in porcine brain tissue compared to conventional SRS *** method of optical sectioning in tissue using counter-propagating ultraslow Bessel light bullets developed in B2-SRS is generic and easy to perform and can be readily extended to other nonlinear optical imaging modalities to advance 3D microscopic imaging in biological and biomedical systems and beyond.

关键词： Bessel resolved propagating

Friction moment calculation method for tapered roller bearings under combined loads

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Science China(Technological Sciences) 2024年第8期67卷 2565-2578页

作者： LI XinBin LIU Jing huang SuHe PAN guang School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory for Unmanned Underwater Vehicle Northwestern Polytechnical UniversityXi’an 710072China System Engineering Research Institute Beijing 100094China

Tapered roller bearings(TRBs) can withstand axial loads, radial loads, and overturning moments. The performance, safety, and efficiency of rotating machinery are directly influenced by the friction moments within the TRBs. However, most current research has relied on empirical formulas that focus on axial loads. Additionally, the friction coefficient between the rollers and the inner ring rib has been defined using simple empirical methods. In actual applications, the loads on TRBs are not purely axial or radial, and simple empirical friction coefficients do not adequately account for the varying lubrication conditions. To address this challenge, this study proposes an improved method for calculating the friction moments of TRB under combined axial and radial loads. This study employs a calculation method for sliding friction coefficients that can model dry, boundary, elastohydrodynamic, and mixed lubrication conditions. To demonstrate the advantages of the proposed method, the friction moments obtained using the existing and proposed methods are compared. Additionally, the influence of TRB structural parameters on the friction moment is discussed. An experimental study is conducted to validate the effectiveness of the proposed method. The findings provide valuable insights for designing TRB structural parameters to minimize friction moments.

关键词： tapered roller bearing friction moment structural parameters combined loads

Work Capacity of the Bladder During Voiding： A Novel Method to Evaluate Bladder Contractile Function and Bladder Outlet Obstruction

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Chinese Medical Journal 2015年第24期128卷 3329-3334页

作者： Ning Liu Li-Bo Man Feng He guang-lin huang Ning Zhou Xiao-Fei Zhu Department of Urology Beijing Jishuitan Hospital Beijing 100035 China

Background： Work in voiding （WIV） of the bladder may be used to evaluate bladder status throughout urination rather than at a single time point. Few studies, however, have assessed WIV owing to the complexity of its calculations. We have developed a method of calculating work capacity of the bladder while voiding and analyzed the associations of bladder work parameters with bladder contractile function and bladder outlet obstruction （BOO）. Methods： The study retrospectively evaluated 160 men and 23 women, aged 〉40 years and with a detrusor pressure at maximal flow rate （PdetQmax） of ≥40 cmH2O in men, who underwent urodynamic testing. The bladder power integration method was used to calculate WIV; WIV per second （WIV/t） and WIV per liter of urine voided （WIV/v） were also calculated. In men, the relationships between these work capacity parameters and PdetQmax and Abrams-Griffiths （AG） number were determined using linear-by-linear association tests, and relationships between work capacity parameters and BOO grade were investigated using Spearman＇s association test. Results： The mean WIV was 1.15 ± 0.78 J and 1.30 ± 0.88 J, mean WIV/t was 22.95 ± 14,45 mW and 23.78 ± 17.02 mW, and mean WIV/v was 5.59 ± 2.32 J/L and 2.83 ± 1.87 J/L in men and women, respectively. In men, WIV/v showed significant positive associations with PdetQmax （r = 0.845, P = 0.000）, AG number （r = 0.814, P = 0.000）, and Schafer class （r = 0.726, P = 0.000）. Conversely, WIV and WIV/t showed no associations with PdetQmax or AG number. In patients with BOO （Schafer class 〉 II）, WIV/v correlated positively with increasing BOO grade. Conclusions： WIV can be calculated from simple urodynamic parameters using the bladder power integration method. WIV/v may be a marker of BOO grade, and the bladder contractile function can be evaluated by WIV and WIV/t.

关键词： Bladder Function Bladder Outlet Obstruction Urodynamics Work in Voiding

Effect of MgO-Cr_(2)O_(3) and Mg0-MgAl_(2)0_(4)-based refractories on refractory-steel interface reaction and cleanliness of pipeline steel

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Journal of Iron and Steel Research International 2024年第4期31卷 849-860页

作者： guang-mei Yang Cheng Yuan Chang Liu Qiang Wang guang-qiang Li Yong-shun Zou Ao huang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The interaction of MgO-MgAl_(2)O_(4)-based and MgO-Cr_(2)O_(3)-based refractories with X70 molten steel was studied by immersion experiments at 1560℃.The effects of immersion time(30 and 60 min)on the contents of total oxygen(TO),Al,Nb,Si,Mn,and Cr as well as the composition,number density,and size distribution of inclusions in the molten steel were *** influence of the penetration and erosion degree of the molten steel to the refractory on the steel-refractory interface layer was *** results show that,at 1560℃,the MgO-MgAl_(2)O_(4)-based refractory can better control the contents of TO and the composition of molten steel compared with the MgO-Cr_(2)O_(3)-based *** TO content is only 16×10^(-4) wt.%in the molten steel after reacted with the Mg0-MgAl_(2)O_(4)-based refractory at the end point of refining,4 accounting for 11.5%of that reacted with the MgO-Cr_(2)O_(3)-based refractory(139×10^(-4) wt.%).The number density of inclusions is only 14 mm^(-2),and the average size ofinclusions is only 1.31μm,with thelargest proportion of inclusions in 1-2μm(70%).The Al_(2)O_(3)-MnS-CaO complex inclusions in the original steel changed to complex inclusions dominated by Cr-Nb-Mn-S-O and ***_(2)O_(3),corresponding to the MgO-Cr_(2)O_(3)-based and MgO-MgAl_(2)O_(4)-based refractories,*** ***_(2)O_(3) layer was formed at the reaction interface between MgO-MgAl_(2)O_(4)-based refractory and molten steel,which is helpful to restrict the erosion of refractories and the pollution of molten *** damage mechanism of the MgO-Cr_(2)O_(3)-based refractory is mainly permeation and chemical reaction,while the damage of the MgO-MgAl_(2)O_(4)-based refractory is mainlyscouring erosion.

关键词： MgO-Cr_(2)O_(3)-based refractory MgO-MgAl O_(4)-based refractory Nonmetallic inclusion Erosion interface layer Steel penetration

Applying deep learning technique to chiral magnetic wave search

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Chinese Physics C 2024年第8期48卷 170-176页

作者： Yuan-Sheng Zhao Xu-guang huang Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics National Natural Science Foundation of China and Fudan UniversityShanghai 200438China

The chiral magnetic wave(CMW)is a collective mode in quark-gluon plasma originated from the chiral magnetic effect(CME)and chiral separation *** detection in heavy-ion collisions is challenging owing to significant background ***[*** et al.,***.C 106,L051901(2022)],we constructed a neural network that accurately identifies the CME-related signal from the final-state pion *** this study,we have generalized this neural network to the case of CMW *** show that,after an updated training,the neural network effectively recognizes the CMW-related ***,we have assessed the performance of the neural network in comparison with other known methods for CMW search.

关键词： deep learning chiral magnetic wave relativistic heavy-ion collisions

Electromagnetic fields in ultra-peripheral relativistic heavy-ion collisions

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Nuclear Science and Techniques 2024年第2期35卷 103-109页

作者： Jie Zhao Jin-Hui Chen Xu-guang huang Yu-Gang Ma Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200438China

Ultra-peripheral heavy-ion collisions(UPCs)offer unique opportunities to study processes under strong electromagnetic *** these collisions,highly charged fast-moving ions carry strong electromagnetic fields that can be effectively treated as photon *** exchange of photons can induce photonuclear and two-photon interactions and excite *** excitation of the ions results in Coulomb dissociation with the emission of photons,neutrons,and other ***,the electromagnetic fields generated by the ions can be sufficiently strong to enforce mutual interactions between the two colliding ***,the two colliding ions experience an electromagnetic force that pushes them in opposite directions,causing a back-to-back correlation in the emitted *** a Monte Carlo simulation,we qualitatively demonstrate that the above electromagnetic effect is large enough to be observed in UPCs,which would provide a clear means to study strong electromagnetic fields and their effects.

关键词： Electromagnetic fields Neutrons Ultra-peripheral relativistic heavy-ion collisions(UPC)