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An algorithm for computing the factor ring of an ideal in a Dedekind domain with finite rank

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Science China Mathematics 2018年第5期61卷 783-796页

作者： dandan huang Yingpu Deng Department of Cyber Space Security School of Software EngineeringJinling Institute of Technology Key Laboratory of Mathematics Mechanization National Center for Mathematics and Interdisciplinary SciencesAcademy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences

We give an algorithm for computing the factor ring of a given ideal in a Dedekind domain with finite rank, which runs in deterministic and polynomial time. We provide two applications of the algorithm:judging whether a given ideal is prime or prime power. The main algorithm is based on basis representation of finite rings which is computed via Hermite and Smith normal forms.

关键词： deterministic polynomial-time test Dedekind domains basis representation Hermite and Smith normal forms

Complications and comorbidities associated with antineoplastic chemotherapy:Rethinking drug design and delivery for anticancer therapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2901-2926页

作者： Xiaoman Mao Shuang Wu dandan huang Chong Li College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China Medical Research Institute Southwest UniversityChongqing 400715China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China

Despite the considerable advancements in chemotherapy as a cornerstone modality in cancer treatment,the prevalence of complications and pre-existing diseases is on the rise among cancer patients along with prolonged survival and aging *** relationships between these disorders and cancer are intricate,bearing significant influence on the survival and quality of life of individuals with cancer and presenting challenges for the prognosis and outcomes of ***,we review the prevailing complications and comorbidities that often accompany chemotherapy and summarize the lessons to learn from inadequate research and management of this scenario,with an emphasis on possible strategies for reducing potential complications and alleviating comorbidities,as well as an overview of current preclinical cancer models and practical advice for establishing bio-faithful preclinical models in such complex context.

关键词： Complications Comorbidities Chemotherapy Preclinical cancer models Drug design Drug delivery

High-throughput development and applications of the compositional mechanical property map of the β titanium alloys

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Journal of Materials Science & Technology 2021年第12期71卷 201-210页

作者： Jinfeng Ling dandan huang Kewu Bai Wei Li Zhentao Yu Weimin Chen Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhouGuangdong510632China Guangxi Key Laboratory of Processing for Non-ferrous Metal and Featured Materials Guangxi UniversityNanningGuangxi530004China Institute of High Performance Computing Agency for ScienceTechnology and ResearchSingapore138632Singapore

By a combination of the nanoindentation and electron probe microanalysis(EPMA)techniques,the traditional diffusion couple technique is extended to map the mechanical property of β-type Ti alloys over a wide composition range,which can be utilized to develop very versatile novel bio-Ti alloys for hard tissue re placements in arti ficial bones,joints,and dental *** create complete single-phase composition ranges of Ti-based bcc solid solution,12 types of bcc Ti-Nb-Zr-Mo/Ti-Nb-Zr-Ta quaternary diffusion couples were fabricated and annealed at 1273 K for 25 *** this way,the composition-mechanical property relationships in the vast composition space of Ti-based alloys were established using EPMA and nanoindentation ***,the measured composition-dependent Young’s moduli,hardness,and elastic recovery as well as the derived ratio of hardness to Young’s modulus,and the ratio of the cube of hardness to the square of Young’s modulus,in the developed compositional mechanical property database,were visualized in a five-dimensional scatter *** enables an effective tool to screen the Ti-Nb-Zr-based alloys fororthopedic and dental applications according to different clinical requirements,and to rationalize the fundamental mechanical relationships in the rapid development of β-Ti alloys.

关键词： Mechanical properties Ti–Nb–Zr–Mo and Ti–Nb–Zr–Ta alloys Diffusion couple Nanoindentation

Molecularly imprinted nanoparticles and their releasing properties, bio-distribution as drug carriers

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 172-178页

作者： Yongyan Zhu Ling Yang dandan huang Quanhong Zhu School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Pharmacy Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China

Molecular imprinted nanoparticles(MINPs) can memorize the shape and functional group positions complementary to template, which account for the large drug loading capacity and slow drug release behavior as drug carriers. We synthesized MINPs via precipitation polymerization with vinblastine(VBL) as a model drug, and investigated the drug loading,releasing property in vitro and bio-distribution in vivo. The obtained MINPs, from 300 to 450 nm,had smooth surface and favorable dispersibility. The entrapment efficacy and drug loading capacity of VBL loaded MINPs(MINPs-VBL) were 83.25% and 8.72% respectively. In PBS(pH 7.4),MINPs-VBL showed sustained release behavior. The cumulative release percentage reached about 70% during 216 h and no burst release was observed. The releasing behavior of MINPsVBL in vitro conformed to the first-order kinetics model. MINPs-VBL and commercially available vinblastine sulfate injection(VBL injection) were injected via tail vein of SD rats respectively to investigate the bio-distribution. MINPs-VBL group showed higher concentration of VBL in tissues and serum than VBL injection group after 60 min, and the drug level in liver was the highest. MINPs-VBL exhibited liver targeting trend to some extent, which was based on the evaluation of drug targeting index(DTI) and drug selecting index(DSI).

关键词： Molecular imprinted nanoparticles Vinblastine Drug carrier Sustained release Liver targeting

The influencing mechanism of O_(2),H_(2)O,and CO_(2)on the H_(2)S removal of food waste digestate-derived biochar with abundant minerals

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Biochar 2022年第1期4卷 7-24页

作者： dandan huang Ning Wang Xinyue Bai Yuke Chen Qiyong Xu Shenzhen Campus of Sun Yat-Sen University No.66Gongchang RoadGuangming DistrictShenzhen 518107China. Shenzhen Engineering Laboratory for Eco-Efficient Recycled Materials School of Environment and EnergyPeking University Shenzhen Graduate SchoolUniversity TownXiliNanshan DistrictShenzhen 518055China. Ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life and SciencesHainan Normal UniversityHaikou 571158China

Hydrogen sulfide(H_(2)S)removal has been a significant concern in various *** this study,food waste diges-tate-derived biochar(DFW-BC),a by-product of food waste treatment with abundant minerals,was assessed for removing H_(2)S from different simulated biogas containing oxygen(O_(2))and carbon dioxide(CO_(2))and under differ-ent moisture(H_(2)O)contents(0%and 20%)of *** influencing mechanisms of the gas conditions combined with the moisture contents were also *** results showed an H_(2)S removal of 1.75 mg g^(−1)for dry bio-char under pure H_(2)S,4.29 mg g^(−1)for dry biochar under H_(2)S+O_(2),5.29 mg g^(−1)for humid biochar under H_(2)S,and 12.50 mg g^(−1)for humid biochar under H_(2)S+O_(2).For dry DFW-BC,the high Fe content was responsible for the O_(2)*** contrast,O_(2)+H_(2)O activated the catalytic H_(2)S oxidation of the less reactive minerals(mainly Ca).The inhibition of CO_(2)on H_(2)S adsorption was not obvious for dry DFW-BC;the specific pore structure may have provided a buffer against the physisorption competition of CO_(2).However,when H_(2)O was present on DFW-BC,the changes in critical biochar properties and sulfur speciation as opposed to that without H_(2)O implied an evident occurrence of CO_(2)*** CO_(2)chemisorption partially hindered O_(2)+H_(2)O enhancement,decreasing the H_(2)S removal capacity from 12.50 to 8.88 mg g^(−1).The negative effect was ascribed to mineral carbonation of CO_(2),neutralizing the alkaline surface and immobilizing metal oxides,which thus reduced the acceleration in H_(2)S dissociation and activa-tion in catalytic H_(2)S oxidation by O_(2)+H_(2)O.

关键词： Hydrogen sulfide Carbon Digestate Adsorption Desulfuration Deodorization

Ellagic Acid Enhances Antioxidant System Activity and Maintains the Quality of Strawberry Fruit during Storage

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Phyton-International Journal of Experimental Botany 2024年第1期93卷 15-28页

作者： Jian Chen Jing Zhang Gang Pan dandan huang Shuhua Zhu College of Chemistry and Material Science Shandong Agricultural UniversityTaian271018China Agriculture and Rural Bureau of Penglai District Yantai265699China Laiyang Inspection and Testing Center Yantai265299China

Ellagic acid(EA)is a natural antioxidant,widely present in a lot of forms’soft fruits,nuts,and other plant tissues,and helpful for promoting human health;however,its protective effect on postharvest fruit and improving the quality index of postharvest fruit have rarely been *** this experiment,the strawberries were soaked in 0,100,200,300,400,and 500 mg L^(−1) EA,respectively,and the influential EA on fruit quality and the antioxidant system of strawberries were *** with the control,EA treatment can reduce the browning degree and rotting rate of strawberry fruit during storage and augment the soluble solid content(SSC).EA treatment can also increase the content of related stuff and enzyme activity in antioxidant systems;the gene expression level of polyphenol oxidase(PPO)in strawberries treated with EA was always down-regulated,correspondingly,the expression of other antioxidant enzyme genes was *** the strawberry fruits treated with EA of different concentrations,300 mg L^(−1) EA had the best effect in the process of strawberry *** results suggested that the proper concentration of exogenous EA at 300 mg L−1 could maintain strawberries’quality and enhance the antioxidant system by improving the activities of antioxidative enzymes and the ascorbateglutathione(AsA-GSH)cycle during storage.

关键词： Strawberry ellagic acid antioxidative enzyme AsA-GSH cycle storage

Assembling of a novel 3D Ag(Ⅰ)-MOFs with mixed ligands tactics：Syntheses, crystal structure and catalytic degradation of nitrophenol

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Chinese Chemical Letters 2018年第6期29卷 845-848页

作者： dandan huang Xueqian Wua Junwu Tian Xiaokun Wang Zhihang Zhou Dongsheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials Hubei Provincial Collaborative Innovation Center for New Energy Microgrid China Three Gorges University Yichang 443002 China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 China

A silver-based metal-organic framework（Ag-MOFs）, [Ag2（H3 ddcba）（dpp）2]（1）（H5 ddcba = 3,5-（di（2’,5’-dicarboxylphenyl）benozoic acid, dpp = 1,3-di（4-pyridyl）propane）, was successfully constructed via hydrothermal assembly of a pentacaboxylate ligand, a N-donor ligand and Ag（I） ions, which possesses a pcu topology and exhibits excellent catalytic properties in aqueous solution for the degradation of onitrophenol（2-NP）, m-nitrophenol（3-NP） and p-nitrophenol（4-NP）. Related kinetics of such catalytic reactions, photoluminescent and thermal stability of compound 1 were also investigated.

关键词： Ag(Ⅰ) metal organic framework Mixed ligands tactics Crystal structure Nitrophenol Catalytic properties

Nitric Oxide Regulates Mitochondrial Fatty Acids and Promotes CBF Expression of Peach Fruit during Cold Storage

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Phyton-International Journal of Experimental Botany 2022年第2期91卷 409-427页

作者： Xiaoshan Guo dandan huang Siyu Wen Yang Bai Shuhua Zhu Jianrong Feng Department of Horticulture College of AgricultureShihezi UniversityShihezi832000China College of Chemistry and Material Science Shandong Agricultural UniversityTaian271018China

Low-temperature storage is convenient for postharvest preservation of peach fruit,but peach fruit is sensitive to cold damage,which lowers its *** oxide(NO)has the potential to improve the bitter resistance of peach *** this work,peach fruit was treated with 15μmol L^(−1)NO and 5μmol L^(−1)c-PTIO[2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxo-3-oxide],to study changes in mitochondrial fatty acids and expression of the C-repeat binding factor(CBF).The results showed that 15μmol L^(−1)exogenous NO significantly maintained fruit quality,reduced peroxidation of mitochondrial fatty acids,increased the activities of the antioxidants superoxide dismutase(SOD),peroxidase(POD),catalase(CAT),ascorbic acid peroxidase(APX),and reduced the content of hydrogen peroxide(H_(2)O_(2)).Meanwhile,NO treatment suppressed the increase in browning index and ion leakage rate,increased the activity of S-nitrosoglutathione reductase(GSNOR),the contents of S-nitrosothiols(SNOs),and the ratios of mitochondrial NAD^(+)/NADH and NADP^(+)/NADPH,increased the expression levels of PpCBF1/5/***,the expression levels of PpCBF2/3/4 were not significantly regulated by exogenous *** treated with c-PTIO showed opposite effects to those treated with exogenous *** results suggest that exogenous NO can improve antioxidant capacity,preserve mitochondrial fatty acids,and upregulate the expression of PpCBF1/5/6 to alleviate cold tolerance and maintain the peach quality during storage.

关键词： Peach cold storage nitric oxide mitochondrial fatty acid CBF

Cloning of a microphthalmia-associated transcription factor gene and its functional analysis in nacre formation and melanin synthesis in Hyriopsis cumingii

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Aquaculture and Fisheries 2018年第6期3卷 217-224页

作者： Jiexuan Shen dandan huang Chaohu Sun Jiale Li Zhiyi Bai Key Laboratory of Genetic Resources for Freshwater Aquaculture and Fisheries Ministry of AgricultureShanghai Ocean UniversityShanghai 201306China Shanghai Engineering Research Center of Aquaculture Shanghai Ocean UniversityShanghai 201306China Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding Shanghai 201306China

Microphthalmia-associated transcription factor(MITF)is an essential transactivator in melanin *** characterize the role of MITF in the pearl mussel Hyriopsis cumingii,the MITF homolog of *** was *** full-length HcMitf cDNA consisted of a 1332-bp with an open reading frame that encode for a 443 amino acid protein that contain a conserved basic helix-loop-helix zipper *** HcMitf was found to widespread tissue distribution but expression was higher in purple mussels than in white mussels,mostly in mantle,liver,kidney,gill,and foot with the exception of the adductor *** and its downstream gene tyrosinase(HcTyr)were highly expressed at the nacre deposition stage after implantation of mantle tissue to produce *** RNA interference,the expression of HcMitf was reduced by 78%(P<0.01)and expression of HcTyr was also significantly suppressed and consequently total melanin content was decreased(P<0.05).The results suggest that HcMitf plays an important role in melanin synthesis,nacre formation and shell pigmentation in the ***.

关键词： Microphthalmia-associated transcription factor Freshwater pearl mussel Melanin Nacre formation Shell pigmentation