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A controllable self-localized imaging strategy capable of synchronous in situ tracking of local changes in intracellular bioactive small-molecules

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Science China Chemistry 2023年第8期66卷 2425-2434页

作者： Ke Li Shuai Xu Benhua Wang shuangyan huan Xiangzhi Song Lin Yuan Xiao-Bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China College of Chemistry&Chemical Engineering Central South UniversityChangsha410083China School of Chemistry and Chemical Engineering University of JinanJinan250022China

In situ tracking and localization of ubiquitous bioactive small molecules(BSMs)within their native habitats is particularly challenging because of their low-molecular weight and widespread distribution *** report the proof of concept of a synchronous in situ imaging strategy,whereby the representative BSM amino-biothiols(ABs)mediate activation of the selflocalizable probe HYPQS,thereby releasing insoluble emissive precipitates to afford holistic distribution information of ***,three organelle-targetable ABs inhibitors were innovatively fabricated for directed clearance of ABs in particular organelles,providing a powerful aid for HYPQS to achieve programmed in situ tracking of ABs in different organelles“on demand”.Biological transmission electron microscopy images confirmed that this probe released insoluble emissive precipitates at the reaction sites,which is of primary importance for achieving synchronous in situ tracking of ***,the probe HYPQS was successfully applied to monitor the dynamic changes in the endogenous ABs pool during diverse cell *** strategy opens a promising avenue for investigating the undiscovered functional mechanism of local BSMs in relevant biological processes.

关键词： bioactive small-molecules in situ imaging fluorescent probes precipitated fluorophore imaging reagents

Imaging Carotid Plaque Burden in Living Mice via Hybrid Semiconducting Polymer Nanoparticles-Based Near-Infrared-II Fluorescence and Magnetic Resonance Imaging

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Research 2024年第3期2023卷 71-81页

作者： Li Xu Zhe Li Yuan Ma Lingling Lei Renye Yue Hui Cao shuangyan huan Wei Sun Guosheng Song State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringEngineeringHunan UniversityChangsha 410082China. Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjingMedical University Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityNanjing 210029JiangsuChina.

The majority of atherothrombotic events (e.g., cerebral or myocardial infarction) often occur as a result of plaque rupture or erosion in the carotid, and thereby it is urgent to assess plaque vulnerability and predict adverse cerebrovascular events. However, the monitoring evolution from stable plaque into life-threatening high-risk plaque in the slender carotid artery is a great challenge, due to not enough spatial resolution for imaging the carotid artery based on most of reported fluorescent probes. Herein, copolymerizing with the small molecules of acceptor-donor-acceptor-donor-acceptor (A-D-A′-D-A) and the electron-donating units (D′), the screened second near-infrared (NIR-II) nanoprobe presents high quantum yield and good stability, so that it enables to image slender carotid vessel with enough spatial resolution. Encouragingly, NIR-II nanoprobe can effectively target to intraplaque macrophage, meanwhile distinguishing vulnerable plaque in carotid atherosclerosis in living mice. Moreover, the NIR-II nanoprobe can dynamically monitor the fresh bleeding spots in carotid plaque, indicating the increased risk of plaque instability. Besides, magnetic resonance imaging is integrated with NIR-II fluorescence imaging to provide contrast for subtle structure (e.g., narrow lumen and lipid pool), via incorporating ultrasmall superparamagnetic iron oxide into the NIR-II nanoprobe. Thus, such hybrid NIR-II/magnetic resonance imaging multimodal nanoprobe provides an effective tool for assessing carotid plaque burden, selecting high-risk plaque, and imaging intraplaque hemorrhage, which is promising for reducing cerebral/ myocardial infarction-associated morbidity and mortality.

关键词： enough conducting Infrared

Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy

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Science China Chemistry 2020年第7期63卷 924-935页

作者： Haifeng Yuan Yan Zhao Chan Yang Cheng Zhang Yue Yang Hongmin Meng shuangyan huan Guosheng Song Xiaobing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Chemistry Zhengzhou UniversityZhengzhou 450001China

For chemotherapy, drug delivery systems often suffer from the inefficient drug loading capability, which usually cause systems toxicity and extra burden to excrete carrier itself. Moreover, the cancer therapeutic efficacy is also greatly limited by the specificity of tumor microenvironment for reactive oxygen species(ROS) based cancer therapeutic strategy(e.g., chemodynamic therapy). Herein, we have developed metal-drug coordination nanoplatform that can not only be responsive to tumor microenvironment but also modulate it, so as to achieve efficient treatment of cancer. Excitingly, by employing small molecule drug(6-thioguanine) as ligand copper ions, we achieve a high drug loading rate(60.1%) and 100% of utilization of metal-drug coordination nanoplatform(Cu-TG). Interestingly, Cu-TG possessed high-efficiently horseradish peroxidase-like, glutathione peroxidase-like and catalase-like activity. Under the tumor microenvironment, Cu-TG exhibited the self-reinforcing circular catalysis that is able to amplify the cellular oxidative stress, inducing notable cancer cellular apoptosis. Moreover, Cu-TG could be activated with glutathione(GSH) and facilitated for GSH triggered 6-TG release, higher selective therapeutic effect toward cancer cells, and GSH activated T1 weight-magnetic resonance imaging. Based on the above properties, Cu-TG exhibited magnetic resonance imaging(MRI) guiding, efficient and synergistic combination of chemodynamic and chemotherapy with self-reinforcing therapeutic outcomes in vivo.

关键词： coordination nanoplatform metallodrug chemodynamic therapy circular catalysis drug delivery

Manganese-Fluorouracil Metallodrug Nanotheranostic for MRI-Correlated Drug Release and Enhanced Chemoradiotherapy

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CCS Chemistry 2021年第4期3卷 1116-1128页

作者： Chan Yang Guosheng Song Haifeng Yuan Yue Yang Yuqi Wang Deju Ye Hongmin Meng shuangyan huan Xiao-Bing Zhang State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082 State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 College of Chemistry Zhengzhou UniversityZhengzhou 450001

For cancer therapy,drug delivery systems are often limited by insufficient drug loading capacity,which usually results in systemic toxicity and heavy metabolic burden to excrete the ***,we reported a“one-pot”method for constructing metal(Mn^(2+))–fluorouracil(FU)-coordinated nanotheranostics(Mn-FU)by self-assembly of FU(as bridging ligands)and Mn^(2+)(as metal nodes)through Mn–N/O coordination ***,owing to the effective coordination between Mn and FU,Mn-FU exhibits high drug loading efficacy(47.7 wt%),encapsulation efficacy(82.6%),and relatively large yield(1 g/pot).In acidic tumor microenvironments,efficient release of FU and Mn^(2+)is realized because of nitrogen *** released FU and Mn^(2+)from Mn-FU are used for chemotherapy and turn on magnetic resonance imaging(MRI),respectively,achieving MRI-correlated drug *** PEG modification,Mn-FU displays high tumor homing ability via enhanced permeability and retention effects and quick renal clearance owing to the disassembly in acidic biological *** a result,Mn-FU substantially enhances the synergistic effects of ***,the systemic toxic side effects of free FU-based chemoradiotherapy were greatly reduced through this *** strategy offers a facile way to construct metallodrug nanotheranostics for efficient cancer theranostics.

关键词： coordination-driven self-assembly metallodrug nanotheranostics magnetic resonance imaging synergetic chemoradiotherapy

Near-Infrared Fluorescent Probe for Carbon Monoxide Detection in Live Cells and Drug-Induced Liver Injury Sample

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Near-Infrared Fluorescent Probe for Carbon Monoxide Detectio...

中国化学会第十三届全国分析化学年会

作者： Shuai Xu Hongwen Liu shuangyan huan Lin Yuan Xiao-Bing Zhang Molecular Science and Biomedicine Laboratory College of Chemistry and Chemical Engineering and College of Biology State KeyLaboratory of Chemo/Biosensing and Chemometrics Collaborative Innovation Center for Chemistry and Molecular MedicineHunan University

Carbon monoxide, a gasotransmitter molecule, is primarily produced from heme degradation by heme oxygenase in the liver. The production of CO is influenced by many physiological factors, including disease. Drug-induced liver injury（DILI） is a potential complication of any prescribed medication due to the important role of liver in drug metabolism and elimination. In this work, we reported a near-infrared fluorescent probe to research the fluctuation of CO in DILI process. This probe exhibited higher selectivity towards CO over other relevant reactive small molecules, accompanying with about 40-fold fluorescence enhancement in buffer solution. This probe was successfully applied in detecting CO in live cells and DILI samples, and the results showed that CO level was increased in DILI process. We believe that this newly developed probe would be a potential method for diagnosis of DILI.

关键词： Carbon monoxide Drug-induced liver injury Near-infrared fluorescent probe

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分析化学(1)思政育人元素的融入途径探索

大学化学 2022年第10期37卷 51-59页

作者：宦双燕王玉枝湖南大学化学化工学院长沙410082

在学情与学科特点分析的基础上,提出分析化学(1)课程思政建设的总体思路,凝炼四大核心育人元素,构建了课程思政案例库。从学生学习能力、社会认知能力和未来职业发展潜力等角度出发,借助案例、事件或问题进行多元融合的创新教学设计,以... 详细信息

在学情与学科特点分析的基础上,提出分析化学(1)课程思政建设的总体思路,凝炼四大核心育人元素,构建了课程思政案例库。从学生学习能力、社会认知能力和未来职业发展潜力等角度出发,借助案例、事件或问题进行多元融合的创新教学设计,以期构筑情感、态度、价值观的链接点,在知识传授的同时实现能力培养和价值引领,探索从教学走向教育的有效途径。

关键词：课程思政分析化学核心育人元素

构建“葡萄糖”立体化教学案例启迪科研创新思维

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大学化学 2018年第4期33卷 11-16页

作者：宦双燕王玉枝湖南大学化学化工学院长沙410082

构建了"葡萄糖"立体化教学案例,将葡萄糖在生命体系中的代谢平衡、消化吸收、分子转运、糖尿病成因、血糖检测、无创诊断技术、分子诊疗等领域的研究串联起来,从微观与宏观、疾病与健康、生活应用与科研前沿的不同角度来展示相关内容。... 详细信息

构建了"葡萄糖"立体化教学案例,将葡萄糖在生命体系中的代谢平衡、消化吸收、分子转运、糖尿病成因、血糖检测、无创诊断技术、分子诊疗等领域的研究串联起来,从微观与宏观、疾病与健康、生活应用与科研前沿的不同角度来展示相关内容。将该案例用于化学与生命相关知识的教学,探索其在本科生科研创新思维训练中的应用。

关键词：立体化教学案例科研创新思维葡萄糖

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高锰酸钾法氧化还原滴定实验的课程思政设计

大学化学 2024年第2期39卷 175-180页

作者：石慧宦双燕王玉枝湖南大学化学化工学院长沙410082

以“高锰酸钾法氧化还原滴定实验”为基础,结合水质化学耗氧量(COD)监测应用,进行实验课程思政创新设计。案例通过引入梯度化COD水样为检测对象,结合工业废水排放监管探索性实践,以及研讨身边水污染治理实例等,引导学生关注水污染防治... 详细信息

以“高锰酸钾法氧化还原滴定实验”为基础,结合水质化学耗氧量(COD)监测应用,进行实验课程思政创新设计。案例通过引入梯度化COD水样为检测对象,结合工业废水排放监管探索性实践,以及研讨身边水污染治理实例等,引导学生关注水污染防治等社会问题,激发其保护生态环境的责任感和国家生态文明建设服务意识。

关键词：分析化学实验高锰酸钾法课程思政 COD测定水环境监测

阳极溶出伏安法测定微量镉实验的课程思政设计

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大学化学 2024年第2期39卷 155-161页

作者：李昆高娜宦双燕王玉枝湖南大学化学化工学院化学生物传感与计量学国家重点实验室基础化学国家级实验教学示范中心(湖南大学)教育部分析化学课程虚拟教研室长沙410082

阳极溶出伏安法测定微量镉是一项经典的仪器分析基础实验。然而,该实验项目的传统教学内容较难使学生体会所学知识对实际生产生活的价值,不能有效落实课程思政建设的要求。本文旨在通过对教学内容的创新设计,更好地实现思政育人目标。... 详细信息

阳极溶出伏安法测定微量镉是一项经典的仪器分析基础实验。然而,该实验项目的传统教学内容较难使学生体会所学知识对实际生产生活的价值,不能有效落实课程思政建设的要求。本文旨在通过对教学内容的创新设计,更好地实现思政育人目标。引导学生对新闻事件、学科发展历史、科学家的故事和行业发展最新动态进行调研与讨论,增加设计性和探索性内容,提高本实验的高阶性。采用实际购得的大米等粮食替代以往预先配制的镉溶液,并采用自己独立制备的汞膜电极替代商业化的极谱仪电极,使学生在巩固实验操作技能的基础上,了解分析仪器的发展及改造方式,并掌握分析化学的基本研究范式。对本实验内容的优化,有助于培养学生的科学精神与科研素养,使学生体会专业知识对解决实际生产生活问题的意义,帮助其树立职业追求目标并养成良好的社会责任意识。

关键词：仪器分析实验阳极溶出伏安法电分析化学镉离子课程思政实验设计