Manganese-Fluorouracil Metallodrug Nanotheranostic for MRI-Correlated Drug Release and Enhanced Chemoradiotherapy

作     者：Chan Yang Guosheng Song Haifeng Yuan Yue Yang Yuqi Wang Deju Ye Hongmin Meng Shuangyan Huan Xiao-Bing Zhang 

作者机构：State Key Laboratory for Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082 State Key Laboratory of Analytical Chemistry for Life ScienceSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 College of ChemistryZhengzhou UniversityZhengzhou 450001 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2021年第3卷第4期

页      面：1116-1128页

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：This work was supported by National Key R&D Program of China(no.2019YFA0210103) National Natural Science Foundation of China(grant nos.51872088,21804039,21977027,and 21890744) the Fundamental Research Funds for the Central Universities 

主　　题：coordination-driven self-assembly metallodrug nanotheranostics magnetic resonance imaging synergetic chemoradiotherapy 

摘      要：For cancer therapy,drug delivery systems are often limited by insufficient drug loading capacity,which usually results in systemic toxicity and heavy metabolic burden to excrete the ***,we reported a“one-potmethod for constructing metal(Mn^(2+))–fluorouracil(FU)-coordinated nanotheranostics(Mn-FU)by self-assembly of FU(as bridging ligands)and Mn^(2+)(as metal nodes)through Mn–N/O coordination ***,owing to the effective coordination between Mn and FU,Mn-FU exhibits high drug loading efficacy(47.7 wt%),encapsulation efficacy(82.6%),and relatively large yield(1 g/pot).In acidic tumor microenvironments,efficient release of FU and Mn^(2+)is realized because of nitrogen *** released FU and Mn^(2+)from Mn-FU are used for chemotherapy and turn on magnetic resonance imaging(MRI),respectively,achieving MRI-correlated drug *** PEG modification,Mn-FU displays high tumor homing ability via enhanced permeability and retention effects and quick renal clearance owing to the disassembly in acidic biological *** a result,Mn-FU substantially enhances the synergistic effects of ***,the systemic toxic side effects of free FU-based chemoradiotherapy were greatly reduced through this *** strategy offers a facile way to construct metallodrug nanotheranostics for efficient cancer theranostics.