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Comparison of three fundus inspection methods during phacoemulsification in diabetic white cataract

International Journal of Ophthalmology(English edition) 2023年第11期16卷 1782-1788页

作者： Shu Su Jian Wu Min Ji Yu guan Yao Shen huai-Jin guan Eye Institute Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

AIM:To investigate whether Wild Field Imaging System(WFIS SW-8000),25G endoilluminator,and intraoperative optical coherence tomography(iOCT)can perform realtime screening and diagnosing in patients with suspicious diabetic retinopathy(DR)during phacoemulsification,especially in cases of white ***:A cross-sectional study was carried out.A total of 204 dense diabetic cataractous eyes of 204 patients with suspected DR treated from April 2020 to March 2021 were *** combined with intraocular lens implantation was *** the removal of the lens opacity,the 25G endoilluminator,fundus photography,and iOCT were performed *** coherence tomography(OCT)and/or fundus fluorescein angiography(FFA)were used to verify the fundus findings *** and postoperative results were compared to verify the accuracy of intraoperative diagnosis in each ***:Intraoperative and postoperative examinations revealed 58 and 62 eyes with DR,respectively(positive rate,28.43%and 30.39%,respectively).During the phacoemulsification,WFIS SW-8000 detected 44 eyes with DR(the detection rate,70.97%);25G endo-illuminator found 56 eyes with DR(the detection rate,90.32%);iOCT found 46 eyes with DR(the detection rate,74.19%);and 58 eyes with DR were found by combining the three methods(the detection rate,93.55%).There were statistically significant differences in the diagnostic sensitivity for DR among the methods(χ^(2)=16.36,P=0.001).CONCLUSION:WFIS SW-8000,25G endo-illuminator,iOCT,and especially their combination can be used to inspect the fundus and detect DR intraoperatively;they are helpful for the timely diagnosis and treatment of DR in patients with dense cataract.

关键词： diabetic white cataract fundus inspection phacoemulsification diabetic retinopathy

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Prevalences and causes of vision impairment in elderly Chinese: a socioeconomic perspective of a comparative report nested in Jiangsu Eye Study

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 1051-1056页

作者： Rong-Rong Zhu Jian Shi Mei Yang huai-Jin guan Eye Institute Affiliated Hospital of Nantong University

AIM：To survey the prevalence and causes of visual impairment/blindness among elderly Chinese from different socioeconomic status in community-based ***：Cluster-sampling randomly selected residents from Binhu and Funing District,two areas representing different socioeconomic levels in China with Binhu in an advanced status and Funing in lessdeveloped *** participants subjected to ophthalmic *** presenting visual acuity（PVA） and best-corrected visual acuity（BCVA） were *** impairment and blindness were defined according to World Health Organization *** causes of visual impairment/blindness were identified by ophthalmic examination and/or *** socioeconomic status included the per capita gross domestic product,numbers of hospital with ophthalmic service and the number of ophthalmologists per 1 million ***：We successfully included 12 867 participants form 2 areas in this *** prevalence of PVA impairment（〈20/63 to ≥20/400） in the better eye was 5.4% in Binhu and 23.6% in Funing,while the prevalence of blindness（〈20/400） was 0.9% in Binhu and 2.3% in *** BCVA,the prevalence of visual impairment was 2.4% in Binhu and 6.4% in Funing,while the prevalence of blindness was 0.8% in Binhu and 1.6% in *** participants with older age and female gender had higher prevalence in visual impairment and *** highest prevalences of vision impairment and blindness evaluated by BCVA at 〉80y age group reached 20.4% and 6.3% *** prevalences of vision impairment and blindness evaluated by BCVA were 3.5% and 1.0% in male and 5.0% and 1.3% in *** above differences were statistically significant（P〈0.05）.The predominant causes of visual impairment and blindness were cataract,retinal disorders and uncorrected refractive error in both *** socioeconomic status was associated with visual impairment and ***：This community-based study build a sufficient sam

关键词： blindness vision impairment prevalence community-based socioeconomic development

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Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity

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Chinese Journal of Natural Medicines 2020年第12期18卷 934-940页

作者： KANG Li-Hua ZHANG Guo-Wei ZHANG Jun-Fang QIN Bai guan huai-Jin Eye Institute Affiliated Hospital of Nantong UniversityNantong 226000China

A contributory role of oxidative stress and protection by antioxidant nutrients have been suspected in cataract *** acid A(GAA),an effective lanostane triterpene,is widely reported as an *** aim of this study is to investigate the potential effects of GAA on cataract *** lens epithelial cells(LECs)were exposed to UVB radiation for different periods,cell viability,apoptosis-related protein levels,malondialdehyde(MDA)and superoxide dismutase(SOD)activities were *** found that cell viability,the Bcl-2/Bax ratio and SOD activity were increased,while Cleaved caspase-3 levels and MDA activity were decreased compared with those in UVB-impaired LECs after GAA ***,GAA activated PI3 K/AKT in UVB-impaired LECs and effectively delayed the occurrence of lens opacity in *** conclusion,these findings demonstrated that GAA exhibited protective functions in SRA01/04 cells and rat lenses against UVB-evoked impairment through elevating cell viability and antioxidant activity,inhibiting cell apoptosis,activating the PI3 K/AKT pathway and delaying lens opacity.

关键词： Ganoderic acid A Cataract Lens epithelial cells Cell vitality Apoptosis

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Incomplete capsulotomy and lens fragmentation during femtosecond laser-assisted cataract surgery associated with emulsified anterior chamber silicone oil: a case report

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 1047-1049页

作者： Wei Chen Yong Wang Jian Wu huai-Jin guan Department of Ophthalmology Affiliated Hospital of Nantong University

Dear Editor,I am Dr. Wei Chen, from Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. I write to present one case report of incomplete capsulotomy and lens fragmentation during femtosecond laser-assisted cataract surgery (FLACS) associated with emulsified anterior chamber silicone oil.

关键词： a case report FLACS Figure IOL

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Maternal and Fetal Exposure to Four Carcinogenic Environmental Metals

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Biomedical and Environmental Sciences 2010年第6期23卷 458-465页

作者： huai guan FENG-YUAN PIAO XIAO-WEI LI QIU-JUAN LI LEI XU KAZUHITO YOKOYAMA Department of Occupational and Environmental Health Dalian Medical University Dalian 116044 Liaoning China Department of Obstetrics and Gynecology No. 210 Hospital of PLA Dalian 116021 Liaoning China Department of Public School of Medicine Mie University Tsu Mie-Prefecture Japan

Objective To examine maternal and fetal exposure levels to four carcinogenic metals, arsenic （As）, cadmium （Cd）, nickel （Ni）, and beryllium （Be）, and to investigate their environmental influences. Methods Metal concentrations in maternal and umbilical cord blood were measured by inductively coupled plasma-mass spectrometry （ICP-MS）. Environmental factors that might play a role in exposure were analyzed using Mann Whitney nonparametric U-tests and multiple linear regression. Results The concentrations of As, Cd, and Ni in umbilical cord blood （5.41, 0.87, and 139.54 gg/L） were significantly lower than those in maternal blood （6.91, 1.93, and 165.93 p.g/L）. There were significant positive correlations between the maternal and cord concentrations of each carcinogen. Our results showed that：（i） exposures to potentially harmful occupational factors during pregnancy were associated with high levels of maternal As, Cd, and Ni; （ii） living close to major transportation routes （〈500 m） or exposure to second-hand smoke during pregnancy increased the maternal Cd levels and （iii） living close to industrial chimneys induced high maternal Ni levels. Multiple linear regression analysis showed that these environmental factors remained significant in models of the influences of these four carcinogens. Conclusion Both mothers and fetuses had been exposed to As, Cd, Ni, and Be. The increased levels of these carcinogens in pregnant women were associated with some detrimental environmental factors, such as occupational exposure, contact with second-hand smoke and living close to major transportation routes or industrial chimneys.

关键词： Carcinogenic metals Exposure in utero Maternal blood Cord blood Environment

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Multi-scale design of silicon/carbon composite anode materials for lithium-ion batteries:A review

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Journal of Energy Chemistry 2024年第10期97卷 30-45,I0002页

作者： Liu Yang Shuaining Li Yuming Zhang Hongbo Feng Jiangpeng Li Xinyu Zhang huai guan Long Kong Zhaohui Chen State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBejing 102249China State Key Laboratoryof Mesoscience and Engineering Institute of Process EngineeringChinese Academy of Sciences Beijing 100190China Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi'an 710129ShaanxiChina

Silicon/carbon composites,which integrate the high lithium storage performance of silicon with the exceptional mechanical strength and conductivity of carbon,will replace the traditional graphite electrodes for high-energy lithium-ion *** strategies have been designed to synthesize silicon/carbon composites for tackling the issues of anode pulverization and poor stability in the anodes,thereby improving the lithium storage *** effect of the regulation method at each scale on the final negative electrode performance remains ***,it has not been fully clarified how the regulation methods at each scale influence the final anode *** review will categorize the materials structure into three scales:molecular scale,nanoscale,and ***,the review will examine modification methods at the molecular scale,focusing on the interfacial bonding force between silicon and ***,it will summarize various nanostructures and special shapes in the nanoscale to explore the construction of silicon/carbon ***,the review will provide an analysis of microscale control approaches,focusing on the formation of composite particle with micron size and the utilization of *** review provides a comprehensive overview of the multi-scale design of silicon/carbon composite anode materials and their optimization strategies to enhance the performance of lithium-ion batteries.

关键词： Lithium-ion batteries Silicon/carbon composites Molecular scale Nanoscale Microscale

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Expression profile analysis to identify potential gene changes induced by dexamethasone in the trabecular meshwork

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1240-1248页

作者： Miao Wei Lu-Ming Chen Ze-Yu Huang Guo-Wei Zhang huai-Jin guan Min Ji Eye Institute Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Dalian Medical University Dalian 116000Liaoning ProvinceChina

AIM:To investigate potential gene changes in trabecular meshwork(TM)induced by dexamethasone(DEX)in steroidinduced glaucoma(SIG).METHODS:The expression data of 24 cases from a public functional genomics data were sorted to identify the mechanisms of action of DEX on the *** relationships of the differentially expressed genes(DEGs)were enriched using Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)*** addition,the hub genes were screened by the Search Tool for the Retrieval of Interacting Genes Database(STRING)and Cytoscape ***,human TM cells(HTMCs)were treated with DEX to preliminarily explore the function of hub ***:Totally 47 DEGs,including 21 downregulated and 26 upregulated genes were *** primary enriched results of the DEGs consisted of inflammatory response,extracellular matrix(ECM),negative regulation of cell proliferation,TNF signalling pathway and the regulation of tr yptophan channels by inflammator y ***,pro-melanin-enriched hormone(PMCH)and Bradykinin B1 receptor(BDKRB1)were screened as hub *** is verified in GSE37474 data *** blot and quantitative real-time polymerase chain reaction(q PCR)results showed that protein and RNA expression levels of BDKRB1 were significantly decreased after DEX treatment,while PMCH was not significantly ***:BDKRB1 may be a key gene involved in SIG onset,providing a suitable therapeutic target for improving the prognosis of SIG patients.

关键词： dexamethasone trabecular meshwork cells steroid-induced glaucoma differentially expressed genes protein-protein interaction

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Effects of steep-axis incision on corneal curvature in onehanded phacoemulsification

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1277-1282页

作者： Pan-Pan Li Ye-Meng Huang Qi Cai Li-Li Huang Yu Song huai-Jin guan Department of Ophthalmology Nantong City No.1People’sHospital and Second Affiliated Hospital of Nantong UniversityNantong226000Jiangsu ProvinceChina Department of Ophthalmology Affiliated Hospital of NantongUniversityNantong226000Jiangsu ProvinceChina

AIM: To examine the effects of one-handed phacoemulsification with steep-axis incision on corneal curvature and analyze surgically induced astigmatism(SIA) on the true net power, anterior and posterior corneal surfaces. METHODS: Patients with cataracts underwent onehanded phacoemulsification with a 2.4-mm steep-axis of clear corneal incision(CCI) based on true net power. CCI was created under the guidance of Verion. Central corneal thickness(CCT), keratometry readings of the true net power and anterior and posterior corneal surface were obtained using Pentacam. Biometry, such as axial length, anterior chamber depth(ACD) and white-to-white(WTW) were performed using Lenstar pre-and 3 mo postoperatively. RESULTS: The study evaluated 68 eyes of 65 patients. The mean age was 65.93±9.40 y;CCT was 529.21±37.40 μm;WTW was 11.59±0.35 mm. Regarding true net power, keratometric value at the flattest corneal meridian for the 3-mm central zone(Ks) was significantly decreased postoperatively(P=0.031). Keratometric value at the steepest corneal meridian for the 3-mm central zone(Kf) was increased postoperatively(P>0.05). Astigmatism of true net power was 1.21±0.56 D preoperatively and significantly decreased to 1.02±0.58 D postoperatively(P=0.021). On the anterior corneal surface, no significant difference in Ks and Kf was noted pre-versus postoperatively. Anterior corneal astigmatism was 1.08±0.51 D preoperativelyand significantly decreased to 0.87±0.46 D postoperatively(P=0.002). On the posterior corneal surface, Ks and Kf were significantly increased postoperatively(all P<0.05), and posterior corneal astigmatism also increased(P=0.008). The SIA values of true net power and the anterior and posterior corneal surfaces at 3 mo postoperatively were 1.26±0.63 D(range: 0.11 to 2.80 D), 1.05±0.54 D(range: 0.23 to 2.40 D), and 0.21±0.17 D(range: 0.01 to 0.07 D), respectively. CONCLUSION: One-handed phacoemulsification with steep-axis incision can effectively decrease astigmatism of tru

关键词： steep-axis one-handed phacoemulsification true net power surgically induced astigmatism

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Pain perception enhancement in consecutive secondeye phacoemulsification cataract surgeries under topical anesthesia

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1510-1518页

作者： Jia-Wei Luo Yan-Hua Chen Jian-Feng Yu Yi-Xun Chen Min Ji huai-Jin guan Eye Institute Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong 226001Jiangsu ProvinceChina Nantong Center for Disease Control and Prevention Nantong 226001Jiangsu ProvinceChina

Cataract is the main cause of visual impairment and blindness worldwide while the only effective cure for cataract is still *** phacoemulsification under topical anesthesia has been the routine procedure for cataract ***,patients often grumbled that they felt more painful during the second-eye surgery compared to the first-eye *** intraoperative pain experience has negative influence on satisfaction and willingness for second-eye cataract surgery of patients with bilateral *** ocular pain is a complicated process induced by the nociceptors activation in the peripheral nervous ***,neuropsychological,and pharmacological factors work together in the enhancement of intraoperative *** published literatures have focused on the pain enhancement during the secondeye phacoemulsification *** this review,we searched PubMed database for articles associated with pain perception differences between consecutive cataract surgeries published up to Feb.1,*** summarized the recent research progress in mechanisms and interventions for pain perception enhancement in consecutive secondeye phacoemulsification cataract *** review aimed to provide novel insights into strategies for improving patients’intraoperative experience in second-eye cataract surgeries.

关键词： ocular pain cataract surgery topical anesthesia intraoperative experience second-eye phacoemulsification

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Renal pelvis sarcomatoid carcinoma with renal vein tumor thrombus:A case report and literature review

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World Journal of Clinical Cases 2023年第31期11卷 7690-7698页

作者： huai-Yong guan Jin Wang Ji-Xue Wang Qi-Hui Chen Ji Lu Liang He Department of Urology Jilin University First HospitalChangchun 130000Jilin ProvinceChina

BACKGROUND Renal pelvis sarcomatoid carcinoma(RPSC)is a rare and aggressive malignancy whose diagnosis is difficult because radiological imaging results can lead to misclassification as a more common type of renal *** addition,clinical management of patients with RPSC is difficult because of the limited efficacy of available *** this study,we present a comprehensive description of a patient who presented with RPSC and a simultaneous renal vein tumor *** SUMMARY During April,2020,a 64-year-old female presented with an isolated episode of hematuria accompanied by abdominal *** tomography(CT)and magnetic resonance imaging(MRI)showed a lesion in the right renal *** therefore performed a radical nephrectomy of the right *** subsequent histopathological and immunological results verified the diagnosis of *** administration of 6 cycles of a gemcitabine-cisplatin regimen,the patient's condition progressively deteriorated,and she died about 15 mo after the *** We performed a comprehensive analysis of a patient with RPSC that included CT,MRI,immunohistochemistry,and genetic *** insights from our detailed analysis of this patient and our concomitant review of the literature may assist clinicians in their diagnosis and treatment of RPSC.

关键词： Sarcomatoid carcinoma Renal pelvis Gene analysis Literature review Case report

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