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Solid-phase extraction gold from alkaline cyanide solution with quaternary ammonium surfactant

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Rare Metals 2016年第3期35卷 282-288页

作者： Run-Fang Xie qiu-Fen hu guang-Yu yang Jing Chen Yun-Shan Han yong-He zhao zhen Li School of Forensic Medicine Kunming Medical University School of Chemical Science and technology Yunnan University Inspection and Analysis Center Yunnan Copper Industry Limited by Share Ltd

The solid-phase extraction（SPE） technique applied to the extraction of organic compound was creatively used as the extraction of inorganic gold in the *** types of techniques were proposed and explored,namely the SPE and the liquid–liquid extraction（LLE） of the quaternary ammonium surfactant [cetytrimethyl ammonium bromide（CTMAB）,cetyl pyridine bromide（CPB）,benzyl dimethyl dodecyl ammonium chloride（BDMDAC）,and dodecyl trimethyl ammonium chloride（DTMAC）].The surfactant could react with Au（CN）2^- to form the ionic complex,and the compound could be extracted by SPE column of reversed-phase bonded silica ***,a new method of SPE was proposed to extract gold with these features of the high selectivity,the reliability,and the *** experimental result shows that the recovery rate of gold is more than 98 %,and the solid-phase extraction column is not easily damaged and it can be repeatedly *** new method can be used as the extraction process of gold from alkaline cyanide solution as ***,the paper also puts forward a new process of gold extraction.

关键词： Solid-phase extraction Surfactant Alkaline cyanide solution Gold Mechanism

Combustion characteristics of Daqing oil shale and oil shale semi-cokes

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mining Science and technology 2009年第3期19卷 380-384页

作者： MIAO zhen-yong WU Ouo-guang LI Ping zhao Na WANG Pan-cheng MENG Xian-liang School of Chemical Engineering and technology China University of Mining ＆ Technology Xuzhou Jiangsu 221116 China

Thermo-gravimetric-analysis(TGA) was used to analyze the combustion characteristics of an oil shale and semi-cokes prepared from *** effect of prior pyrolysis and TGA heating rate on the combustion process was *** pyrolysis affects the initial temperature of mass loss and the ignition *** ignition temperature increases as the volatile content of the sample ***/DTG curves obtained at different heating rates show that heating rate has little effect on ignition *** the peak of combustion shifts to higher temperatures as the heating rate is *** Coats-Redfern integration method was employed to find the combustion-reaction kinetic parameters for the burning of oil shale and oil shale semi-coke.

关键词： oil shale semi-coke combustion characteristics pyrolysis degree h-eating rate

OsPPR9 encodes a DYW-type PPR protein that affects editing efficiency of multiple RNA editing sites and is essential for chloroplast development

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Journal of Integrative Agriculture 2023年第4期22卷 972-980页

作者： CHEN Chang-zhao WANG Ya-liang HE Meng-xing LI Zhi-wen SHEN Lan LI qing REN Deyong hu Jiang Zhu Li ZHANG guang-heng gao zhen-yu ZENG Da-li GUO Long-biao qiAN qian ZHANG qiang State Key Lab of Rice Biology China National Rice Research InstituteHangzhou 310006P.R.China College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004P.R.China College of Life and Environmental Sciences Hangzhou Normal UniversityHangzhou 310006P.R.China

Photosynthesis occurs mainly in chloroplasts,whose development is regulated by proteins encoded by nuclear *** them,pentapeptide repeat(PPR)proteins participate in organelle RNA *** there are more than 450 members of the PPR protein family in rice,only a few affect RNA editing in rice *** editing technology has created new rice germplasm and mutants,which could be used for rice breeding and gene function *** study evaluated the functions of OsPPR9 in chloroplast RNA editing in *** osppr9 mutants were obtained by CRISPR/Cas9,which showed yellowing leaves and a lethal phenotype,with suppressed expression of genes associated with chloroplast development and accumulation of photosynthetic-related *** addition,loss of OsPPR9 protein function reduces the editing efficiency of rps8-C182,rpoC2-C4106,rps14-C80,and ndhB-C611 RNA editing sites,which affects chloroplast growth and development in *** data showed that OsPPR9 is highly expressed in rice leaves and encodes a DYW-PPR protein localized in ***,the OsPPR9 protein was shown to interact with OsMORF2 and ***,our findings provide insights into the role of the PPR protein in regulating chloroplast development in rice.

关键词： rice(Oryza sativa L.) PPR protein chloroplast development RNA editing

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang yong-Hao Chen Jing-Yu Tang Rui-Rui Fan qiang Li Gong Li Dong Liu zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei yang Rong Liu Han Yi yang Li zhen yang qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao qi-Ping Chen zhen Chen Zeng-qi Cui An-Chuan Fan Chang-qing Feng Fan-zhen Feng Ke-qing gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He yong-Cheng He yang Hong Yi-Wei hu Han-Xiong huang Wei-hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu guang-Yuan Luan Chang-Jun Ning Bin-Bin qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan zhao-hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang zhao-hui Wang Zhong-Wei Wen Xiao-guang Wu Xuan Wu Li-Kun Xie yong-Ji Yu Guo-hui Zhang Lin-Hao Zhang Mo-Han Zhang qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-yong Zhang Mao-Yuan zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the china Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-Wei yang yong-Hao Chen Rong Liu Bang-Jiao Ye Jie Wen Hai-Rui Guo Zi-Jie Han qi-Ping Chen Zhong-Wei Wen Wei-Li Sun Han Yi Xing-yan Liu Tao Ye Jiang-Bo Bai qi An Jie Bao Yu Bao Ping Cao Hao-Lei Chen zhen Chen Zeng-qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing gao Xiao-Long gao Min-Hao Gu Chang-Cai Han Guo-Zhu He yong-Cheng He yang Hong Yi-Wei hu Han-Xiong huang Xi-Ru huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing ling Kang Bo Li Chao Li Jia-Wen Li qiang Li Xiao Li yang Li Jie Liu Shu-Bin Liu Ze Long guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin qi Jie Ren Xi-Chao Ruan zhao-hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Jing-Yu Tang Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang zhao-hui Wang Xiao-guang Wu Xuan Wu Li-Kun Xie Xiao-Yun yang Li Yu Tao Yu yong-Ji Yu Guo-hui Zhang Lin-Hao Zhang qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the china Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

Back-n white neutron source at CSNS and its applications

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Nuclear Science and Techniques 2021年第1期32卷 95-104页

作者： Jing-Yu Tang qi An Jiang-Bo Bai Jie Bao Yu Bao Ping Cao Hao-Lei Chen qi-Ping Chen yong-Hao Chen zhen Chen Zeng-qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing gao Xiao-Long gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He yong-Cheng He yang Hong Yi-Wei hu Han-Xiong huang Xi-Ru huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing ling Kang Bo Li Chao Li Jia-Wen Li qiang Li Xiao Li yang Li Jie Liu Rong Liu Shu-Bin Liu Xing-yan Liu Ze Long guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan zhao-hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang zhao-hui Wang Zhong-Wei Wen Xiao-guang Wu Xuan Wu Li-Kun Xie Xiao-Yun yang Yi-Wei yang Han Yi Li Yu Tao Yu yong-Ji Yu Guo-hui Zhang Lin-Hao Zhang qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China Northwest Institute of Nuclear technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China The CSNS Back-n Collaboration

Back-streaming neutrons from the spallation target of the china Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March *** Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the *** addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the *** with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional *** article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn.

关键词： White neutron source Nuclear data measurements Experimental setups Neutron applications

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： qiang Li Li‑Jiao Wang Xiang‑Biao qiu Jing‑Wen Li Wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao qi‑Ping Chen zhen Chen Zeng‑qi Cui An‑Chuan Fan Chang‑qing Feng Fan‑zhen Feng Ke‑qing gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He yong‑Cheng He yang Hong Yi‑Wei hu Han‑Xiong huang Wei‑hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang zheng‑Yao Jin ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li yang Li Jie Liu Rong Liu Shu‑Bin Liu guang‑Yuan Luan Bin‑Bin qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan zhao‑hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang zhao‑hui Wang Zhong‑Wei Wen Xiao‑guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei yang Han Yi yong‑Ji Yu Guo‑hui Zhang Lin‑Hao Zhang Mo‑Han Zhang qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑yong Zhang Mao‑Yuan zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the china Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： qiang Li Li‑Jiao Wang Jing‑Yu Tang Xiang‑Biao qiu zhen Chen Mao‑Yuan zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑qing Feng Rong Zhang Xiao‑yang Sun qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao qi‑Ping Chen yong‑Hao Chen Zeng‑qi Cui An‑Chuan Fan Fan‑zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He yong‑Cheng He yang Hong Yi‑Wei hu Han‑Xiong huang Wei Jiang Zhi‑Jie Jiang zheng‑Yao Jin ling Kang Bo Li Gong Li Xiao Li yang Li Jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan zhao‑hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng Wang Peng‑Cheng Wang zhao‑hui Wang Zhong‑Wei Wen Xiao‑guang Wu Xuan Wu Cong Xia yong‑Ji Yu Guo‑hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang qi‑Wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑yong Zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China china Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China china Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the china Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup

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Chinese Journal of Integrative Medicine 2023年第5期29卷 441-447页

作者： LIU Xiao-qing ZHANG Run-shun ZHOU Xue-zhong ZHOU Hong HE Yu-yao HAN Shu ZHANG Jing Shu Zi-xin ZHANG Xue-bin JI Jing-hui ZHONG Quan ZHANG Li-li MOU Zi-jun HE Li-yun ZHANG Lun-zhong yanG Jie hu yan-jie CHEN zheng-guang LI Xiao-zhen TAN yan yan Zhan-feng CAO Ke-gang MENG Wei zhao He ZHANG Wei ZHONG Li-qun Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China Department of Gastroenterology Guanganmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China School of Computer and Information technology and Beijing Key Lab of Traffic Data Analysis and mining Beijing Jiaotong UniversityBeijing(100044)China Department of Neurology Weifang Hospital of Traditional Chinese MedicineWeifangShandong Province(261041)China Beijing Zhong Teng Bai Mai Medical technology Co.Ltd. Beijing(100027)China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China Department of Radiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China School of Life Sciences Beijing University of Chinese MedicineBeijing(100029)China Department of Otolaryngology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100029)China Department of Psychiatry Massachusetts General HospitalHarvard Medical SchoolBoston(MA 02115)United States

Objective: To derive the Chinese medicine(CM) syndrome classification and subgroup syndrome characteristics of ischemic stroke patients. Methods: By extracting the CM clinical electronic medical records(EMRs) of 7,170 hospitalized patients with ischemic stroke from 2016 to 2018 at Weifang Hospital of Traditional Chinese Medicine, Shandong Province, china, a patient similarity network(PSN) was constructed based on the symptomatic phenotype of the patients. Thereafter the efficient community detection method BGLL was used to identify subgroups of patients. Finally, subgroups with a large number of cases were selected to analyze the specific manifestations of clinical symptoms and CM syndromes in each subgroup. Results: Seven main subgroups of patients with specific symptom characteristics were identified, including M3, M2, M1, M5, M0, M29and M4. M3 and M0 subgroups had prominent posterior circulatory symptoms, while M3 was associated with autonomic disorders, and M4 manifested as anxiety;M2 and M4 had motor and motor coordination disorders;M1 had sensory disorders;M5 had more obvious lung infections;M29 had a disorder of consciousness. The specificity of CM syndromes of each subgroup was as follows. M3, M2, M1, M0, M29 and M4 all had the same syndrome as wind phlegm pattern;M3 and M0 both showed hyperactivity of Gan(Liver) yang pattern;M2 and M29 had similar syndromes, which corresponded to intertwined phlegm and blood stasis pattern and phlegm-stasis obstructing meridians pattern, respectively. The manifestations of CM syndromes often appeared in a combination of 2 or more syndrome elements. The most common combination of these 7 subgroups was wind-phlegm. The 7 subgroups of CM syndrome elements were specifically manifested as pathogenic wind, pathogenic phlegm,and deficiency pathogens. Conclusions: There were 7 main symptom similarity-based subgroups in ischemic stroke patients, and their specific characteristics were obvious. The main syndromes were wind phlegm pat

关键词： ischemic stroke patient similarity network subgroup syndrome Chinese medicine