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Journal of Thermal Science 2021年第2期30卷 682-695页

作者： GAO Limin YANG Guanhua GAO Tianyu LI Ruiyu hu xiaoquan School of Power and Energy Northwestern Polytechnical UniversityXi'an 710129China The National Key Laboratory of Aerodynamic Design and Research Xi'an 710129China

Pressure Sensitive Paint(PSP)technique has been increasingly applied to the experimental research of aerodynamics and thermodynamics due to its strengths of non-contact,high resolution results and large coverage area,***,rarely has this technique been successfully used to the study of internal flow such as compressor cascade,since narrow flow passages would heavily restrict the acquisition of PSP *** this paper,PSP technique was used to study the pressure distribution on a linear compressor cascade with large solidity of 2.3,where the view of recording camera can be heavily blocked due to adjacent blade *** help get integrated PSP images of the internal flow passage,dual camera system along with image processing tools like 3D reconstruction and image integration were *** results showed that with the aid of such assistance,image results with good quality and readability could be ***,pressure data given by PSP were compared with data from traditional way of pressure taps and showed good *** results of the entire cascade passage surface were given with different inlet Mach numbers and incidence *** results showed that PSP technique can integrally measure cascade tunnel of large solidity with the help of dual-camera system.

关键词： pressure sensitive paint compressor cascade dual-camera system large solidity full channel measurement

Antibodies elicited by Newcastle disease virus-vectored H7N9 avian influenza vaccine are functional in activating the complement system

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Journal of Integrative Agriculture 2024年第6期23卷 2052-2064页

作者： Zenglei hu Ya huang Jiao hu xiaoquan Wang Shunlin hu Xiufan Liu Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China Yangzhou UniversityYangzhou 225009China Animal Infectious Disease Laboratory School of Veterinary MedicineYangzhou UniversityYangzhou 225009China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou UniversityYangzhou 225009China

H7N9 subtype avian influenza virus poses a great challenge for poultry *** disease virus(NDV)-vectored H7N9 avian influenza vaccines(NDV_(vec)H7N9)are effective in disease control because they are protective and allow mass *** note,these vaccines elicit undetectable H7N9-specific hemagglutination-inhibition(HI)but high IgG antibodies in ***,the molecular basis and protective mechanism underlying this particular antibody immunity remain ***,immunization with an NDV_(vec)H7N9 induced low anti-H7N9 HI and virus neutralization titers but high levels of hemagglutinin(HA)-binding IgG antibodies in *** residues(S150,G151 and S152)in HA of H7N9 virus were identified as the dominant epitopes recognized by the NDV_(vec)H7N9 immune *** transferred NDV_(vec)H7N9 immune serum conferred complete protection against H7N9 virus infection in *** NDV_(vec)H7N9 immune serum can mediate a potent lysis of HA-expressing and H7N9 virus-infected cells and significantly suppress H7N9 virus *** activities of the serum were significantly impaired after heat-inactivation or treatment with complement inhibitor,suggesting the engagement of the complement ***,mutations in the 150-SGS-152 sites in HA resulted in significant reductions in cell lysis and virus neutralization mediated by the NDV_(vec)H7N9 immune serum,indicating the requirement of antibody-antigen binding for complement ***,antibodies induced by the NDV_(vec)H7N9 can activate antibody-dependent complement-mediated lysis of H7N9 virus-infected cells and complement-mediated neutralization of H7N9 *** findings unveiled a novel role of the complement in protection conferred by the NDV_(vec)H7N9,highlighting a potential benefit of engaging the complement system in H7N9 vaccine design.

关键词： H7N9 subtype avian influenza virus NDV vector vaccine antibody immunity complement protection

Phosphorylation of PB2 at serine 181 restricts viral replication and virulence of the highly pathogenic H5N1 avian influenza virus in mice

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Virologica Sinica 2024年第1期39卷 97-112页

作者： Jiao hu Zixiong Zeng Xia Chen Manyu Zhang Zenglei hu Min Gu xiaoquan Wang Ruyi Gao Shunlin hu Yu Chen Xiaowen Liu Daxin Peng Xiufan Liu Animal Infectious Disease Laboratory School of Veterinary MedicineYangzhou UniversityYangzhou225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou University225009China Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis Yangzhou UniversityYangzhou225009China Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agri-food Safety and Quality Ministry of Agriculture of China(26116120)Yangzhou UniversityYangzhou225009China

Influenza A virus(IAV)continues to pose a pandemic threat to public health,resulting a high mortality rate annually and during pandemic *** modification of viral protein plays a substantial role in regulating IAV ***,based on immunoprecipitation(IP)-based mass spectrometry(MS)and purified virus-coupled MS,a total of 89 phosphorylation sites distributed among 10 encoded viral proteins of IAV were identified,including 60 novel phosphorylation ***,for the first time,we provide evidence that PB2 can also be acetylated at site ***,the PB2 S181 phosphorylation site was consistently identified in both IP-based MS and purified virus-based *** S181 and K187 are exposed on the surface of the PB2 protein and are highly conserved in various IAV strains,suggesting their fundamental importance in the IAV life *** analysis results demonstrated that S181E/A and K187Q/R mimic mutations do not significantly alter the PB2 protein *** continuous phosphorylation mimicked by the PB2 S181E mutation substantially decreases viral fitness in mice,PB2 K187Q mimetic acetylation slightly enhances viral virulence in ***,PB2 S181E substantially impairs viral polymerase activity and viral replication,remarkably dampens protein stability and nuclear accumulation of PB2,and significantly weakens IAV-induced inflammatory ***,our study further enriches the database of phosphorylation and acetylation sites of influenza viral proteins,laying a foundation for subsequent mechanistic ***,the unraveled antiviral effect of PB2 S181E mimetic phosphorylation may provide a new target for the subsequent study of antiviral drugs.

关键词： H5N1 influenza virus PB2 Phosphorylation Acetylation Viral fitness Mice

A Half-Proximal Symmetric Splitting Method for Non-convex Separable Optimization

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Acta Mathematica Sinica,English Series 2024年

作者： Pengjie LIU Jinbao JIAN hu SHAO xiaoquan WANG Xiangfeng WANG School of Mathematics China University of Mining and Technology School of Mathematics and Physics Center for Applied Mathematics of GuangxiGuangxi Minzu University School of Mathematics Jiangsu Center for Applied Mathematics China University of Mining and Technology School of Computer Science and Technology East China Normal University

In this paper, we explore the convergence and convergence rate results for a new methodology termed the half-proximal symmetric splitting method (HPSSM). This method is designed to address linearly constrained two-block non-convex separable optimization problem. It integrates a half-proximal term within its first subproblem to cancel out complicated terms in applications where the subproblem is not easy to solve or lacks a simple closed-form solution. To further enhance adaptability in selecting relaxation factor thresholds during the two Lagrange multiplier update steps, we strategically incorporate a relaxation factor as a perturbation parameter within the iterative process of the second subproblem. Building on several foundational assumptions, we establish the subsequential convergence, global convergence, and iteration complexity of HPSSM. Assuming the presence of the Kurdyka-Lojasiewicz inequality of Lojasiewicz-type within the augmented Lagrangian function (ALF),we derive the convergence rates for both the ALF sequence and the iterative sequence. To substantiate the effectiveness of HPSSM, sufficient numerical experiments are conducted. Moreover, expanding upon the two-block iterative scheme, we present the theoretical results for the symmetric splitting method when applied to a three-block case.

关键词：

ESTIMATION OF HMM PARAMETERS BASED ON GRADIENTS

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Journal of Electronics(China) 2001年第3期18卷 277-280页

作者： Mao xiaoquan hu Guangrui(Department of Electronic Engineering, Shanghai Jiaotong University, Shanghai 200030) Department of Electronic Engineering Shanghai Jiaotong University Shanghai 200030

Based on the matrix representation, a new method is proposed to calculate the partial derivatives of the likelihood probability of an HMM with respect to its parameters. Experimental results are presented and a compar... 详细信息

关键词： HMM Gradients

INDUCTION OF DECISION TREES BASED ON A FUZZY NEURAL NETWORK

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Journal of Electronics(China) 2002年第1期19卷 68-70页

作者： Tang Bin hu Guangrui Mao xiaoquan (Department of Electronic Engineering, Shanghai Jiaotong University, Shanghai 200030) Department of Electronic Engineering Shanghai Jiaotong University Shanghai 200030

Based on a fuzzy neural network, the letter presents an approach for the induction of decision trees. The approach makes use of the weights of fuzzy mappings in the fuzzy neural network which has been trained. It can realize the optimization of fuzzy decision trees by branch cutting, and improve the ratio of correctness and efficiency of the induction of decision trees.

关键词： Induction Decision tree Fuzzy neural network

胰岛素泵联合利拉鲁肽强化降糖治疗初诊2型糖尿病1例

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中华糖尿病杂志 2022年第S1期14卷 109-111页

作者：胡晓权高梦娇浙江省慈溪市人民医院内分泌科，慈溪315300

报道1例浙江省慈溪市人民医院内分泌科采用胰岛素泵联合利拉鲁肽强化降糖治疗的初诊2型糖尿病1例。患者为青年男性,因“多饮、多尿、消瘦1个月”就诊。入院完善各项检查,体重指数34.08 kg/m 2,空腹血糖18.4 mmol/L,糖化血红蛋白11.3%,... 详细信息

报道1例浙江省慈溪市人民医院内分泌科采用胰岛素泵联合利拉鲁肽强化降糖治疗的初诊2型糖尿病1例。患者为青年男性,因“多饮、多尿、消瘦1个月”就诊。入院完善各项检查,体重指数34.08 kg/m 2,空腹血糖18.4 mmol/L,糖化血红蛋白11.3%,糖尿病相关三联抗体均无异常,促肾上腺皮质激素-皮质醇系列检查无异常,诊断为2型糖尿病,高脂血症,脂肪肝,肝功能不全,高尿酸血症。入院后予胰岛素泵皮下持续注射,餐前总剂量为20 U,基础总剂量为22 U,同时联合利拉鲁肽0.6 mg(1次/d)皮下注射,经3 d的强化治疗后,患者血糖控制在目标范围,经过1周的强化治疗后,撤掉胰岛素泵,利拉鲁肽剂量调整为1.2 mg(1次/d)皮下注射,同时联用二甲双胍0.5 g(2次/d)治疗,患者血糖稳定,无明显胃肠道不良反应,出院门诊随访。随访3个月,患者空腹血糖为5.0~6.0 mmol/L,餐后2 h血糖为5.0~8.0 mmol/L,体重下降11.5 kg,糖化血红蛋白6.1%。

关键词：糖尿病,2型肥胖胰高糖素样肽-1受体激动剂

浅议建国初期我国向社会主义过渡起点问题上的失误

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党史研究与教学 2000年第5期 8-11页

作者：胡晓泉泉州市委党校福建362000

1940年毛泽东在中创造性地提出了新民主主义社会理论,而在建国前夕,作为新中国的立国理论和政策导向,新民主主义社会理论却显得极为初步和不足.因此,在毛泽东的倡导下,党和国家领导人,把全面系统地探索新民主主义社会理论作为一项重要... 详细信息

1940年毛泽东在中创造性地提出了新民主主义社会理论,而在建国前夕,作为新中国的立国理论和政策导向,新民主主义社会理论却显得极为初步和不足.因此,在毛泽东的倡导下,党和国家领导人,把全面系统地探索新民主主义社会理论作为一项重要而紧迫的课题,特别是对新民主主义社会的历史定位和基本属性问题,展开了积极的探索并达成共识.但是事实上,建国后新民主主义社会的存在极为短暂,'过渡形态'也离开了原始设想的相对稳定的初衷.本文拟对此问题作些肤浅的分析.

关键词：新民主主义社会理论建国初期社会主义毛泽东新中国国家领导人建国后《新民主主义论》立国建国前

R-matrix for the 8-Dimensional Spin Representation of Uq(so7)

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Acta Mathematica Sinica,English Series 2024年第2期40卷 485-497页

作者： Hong Mei hu Nai Hong hu School of Mathematical Sciences Suzhou University of Science and TechnologySuzhou 215009P.R.China School of Mathematical Sciences MOE Key Laboratory of Mathematics and Engineering Applications&Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241P.R.China

The purpose of the paper is to describe the solution to the quantum Yang-Baxter equation associated with the 8-dimensional spin representation Tsp of Uq(so7).The self-duality of Tsp and the symmetry of the corresponding braiding matrix are ***,the minimal polynomial of the braiding R-matrix of Tsp is presented explicitly in an ingenious method by taking advantage of nice features of the spin representation Tsp.

关键词： Braiding R-matrix spin module minimal polynomial

Mapping out the reaction network of humin formation at the initial stage of fructose dehydration in water

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Green Energy & Environment 2024年第6期9卷 1016-1026页

作者： Xing Fu Yexin hu Ping hu hui Li Shuguang Xu Liangfang Zhu Changwei hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengduSichuan610064China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan611137China

The formation of humins hampers the large-scale production of 5-hydroxymethylfurfural(HMF)in ***,a detailed reaction network of humin formation at the initial stage of fructose-to-HMF dehydration in water is delineated by combined experimental,spectroscopic,and theoretical *** bimolecular reaction pathways to build up soluble humins are *** is,the intermolecular etherification of β-furanose at room temperature initiates the C12 path,whereas the C-C cleavage of a-furanose at 130-150℃ leads to C11 path,and that of open-chain fructose at 180℃ to C11' *** successive intramolecular dehydrations and condensations of the as-formed bimolecular intermediates lead to three types of soluble *** show that the C12 path could be restrained by using HCl or AlCl_(3) catalyst,and both the C12 and C110 paths could be effectively inhibited by adding THF as a co-solvent or accelerating heating rate via microwave heating.

关键词： Carbohydrates 5-hydroxymethylfurfural Reaction network Soluble humins Tautomer