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Predicting overlapping protein complexes in weighted interactome networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第10期14卷 756-765页

作者： Wen-yin NI hui-jun XIONG Bi-hai ZHAO sai hu Department of Information and Computing Science Changsha University

Protein complexes play important roles in integrating individual gene products to perform useful cellular *** increasing mount of protein–protein interaction(PPI)data has enabled us to predict protein *** spite of the advances in these computational approaches and experimental techniques,it is impossible to construct an absolutely reliable PPI *** into account the reliability of interactions in the PPI network,we have constructed a weighted protein–protein interaction(WPPI)network,in which the reliability of each interaction is represented as a weight using the topology of the PPI *** overlaps are likely to have biological importance,we proposed a novel method named WN-PC(weighted network-based method for predicting protein complexes)to predict overlapping protein complexes on the WPPI *** proposed algorithm predicts neighborhood graphs with an aggregation coefficient over a threshold as candidate complexes,and binds attachment proteins to candidate ***,we have filtered redundant complexes which overlap other complexes to a very high extent in comparison to their density and size.A comprehensive comparison between competitive algorithms and our WN-PC method has been made in terms of the F-measure,coverage rate,and *** have applied WN-PC to two different yeast PPI data sets,one of which is a huge PPI network consisting of over 6000 proteins and 200000 *** results show that WN-PC outperforms the state-of-the-art *** think that our research may be helpful for other applications in PPI networks.

关键词： Protein–protein interaction Weighted network Overlap

Stereoselective Synthesis of cis-2,5-Disubstituted Pyrrolidines via Copper-Catalyzed Cyclization of Alkenes

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Chinese Journal of Chemistry 2016年第11期34卷 1076-1080页

作者： sai-hu Cai Bing-Chao Da Jia-hui Zhou Yun-He Xu Teck-Peng Loh Department of Chemistry University of Science and Technology of China Hefei Anhui 230026 China DiVision of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 637371 Singapore

An efficient methodology for the stereoselective synthesis of cis-2,5-disubstituted pyrrolidines using copper catalyst was developed. The corresponding cis-2,5-disubstituted pyrrolidines could be obtained in reasonable yields and with good stereoselectivities in the presence of 4,4＇-di-tert-butyl-2,2＇-bipyridine as ligand and l-methyl-2-pyrrolidinone as solvent.

关键词： stereoselectivity pyrrolidines copper-catalyzed cyclization

Stylistics and college English test

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Sino-US English Teaching 2008年第10期5卷 39-44页

作者： hu sai-zhu School of lnternational Studies Zhejiang University Hangzhou 310058 China

Language learners can hardly develop their communicative competence and aesthetic appreciation of literary works without the awareness of stylistics. Since CET-4 and CET-6 direct college students in China, as learners of English as a foreign language, what to learn and how to learn English, they naturally reflect the importance of stylistics. This paper gives a stylistic analysis of the listening and reading part in CET-4 and CET-6 to show it is important for non-English majors to have some knowledge of stylistics.

关键词： CET-4 and CET-6 stylistics listening reading

Factors Affecting Patient Satisfaction with Community Health Service under the Gatekeeper System:A Cross-sectional Study in Nanjing,China

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Biomedical and Environmental Sciences 2017年第9期30卷 685-690页

作者： LI Wen Zhen GAN Yong ZHOU Yan Feng CHEN Ya Wen LI Jing KKANDAWIRE Naomiem hu sai QIAO Yan LU Zu Xun Department of Social Medicine and Health Management School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina

The gatekeeper policy has been implemented for approximately ten years on a pilot population in China. It is necessary to assess the satisfaction of patients utilizing community health service（CHS） under the gatekeeper system. Our study showed that the cognition of gatekeeper policy was associated with four dimensions including doctor‐patient relationships, information and support, organization of care, and accessibility（P 〈 0.001）. One or more factors such as gender and self‐perceived health scores also affected their satisfaction. General practitioners must be prepared to focus on these aspects of information and support, organization of care, and accessibility as indicators of potential opportunities for improvement. Additionally, policymakers can improve patients＇ satisfaction with CHS by strengthening their awareness of the gatekeeper policy.

关键词： CHS A Cross-sectional Study in Nanjing China Factors Affecting Patient Satisfaction with Community Health Service under the Gatekeeper System

出口信用保险影响下的出口贸易高质量发展研究——以浙江省为例

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商业经济与管理 2018年第12期 63-76页

作者：胡赛中共浙江省委党校经济学教研部浙江杭州311121

在中美贸易摩擦日渐加剧的背景下,出口信用保险成为出口企业重要的避险工具,在出口企业转嫁出口风险、提高风控水平、补偿企业损失、优化资源配置等多方面发挥重要作用。文章采用2003-2016年浙江省出口贸易数据及保险数据(均不含宁波),... 详细信息

在中美贸易摩擦日渐加剧的背景下,出口信用保险成为出口企业重要的避险工具,在出口企业转嫁出口风险、提高风控水平、补偿企业损失、优化资源配置等多方面发挥重要作用。文章采用2003-2016年浙江省出口贸易数据及保险数据(均不含宁波),通过统计分析、构建理论模型及实证检验,试图进一步明确出口信用保险影响出口贸易的作用机制。研究结果表明:在出口信用保险计划下,国际信用评级的存在、投保概率的增加、对出口企业损失的赔偿均可增加浙江省企业的货款回收概率,从而优化出口资源配置、提高出口水平。实证检验证明了以上结论,并发现在面临金融危机时,浙江省出口信用保险对出口的促进作用尤为显著,随着金融危机影响的逐步减小,其作用依然显著。

关键词：出口信用保险出口传导机制国家风险

出口信用保险与出口贸易增长:基于浙江省数据的实证研究

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商业经济与管理 2017年第2期304卷 60-70页

作者：胡赛浙江大学经济学院浙江杭州310027

出口信用保险是一种由国家财政提供保险准备金的政策性金融工具,以推动本国出口贸易,开拓国际市场为出发点,保障本国企业的出口及投资收汇安全。文章运用2003-2011年浙江省外贸出口额、22个出口行业和230个出口国家(地区)的贸易额,以及... 详细信息

出口信用保险是一种由国家财政提供保险准备金的政策性金融工具,以推动本国出口贸易,开拓国际市场为出发点,保障本国企业的出口及投资收汇安全。文章运用2003-2011年浙江省外贸出口额、22个出口行业和230个出口国家(地区)的贸易额,以及同一时间段内浙江省出口信用保险数据作为样本,实证分析了出口信用保险在促进出口贸易增长中的效果。研究结果表明:出口信用保险对出口的促进作用较为显著,其中,对具有较高风险、较高价值和较强外部融资需求行业的杠杆作用更为明显,且对出口到发展中国家或地区的促进作用更明显。最后根据研究结果提出相应政策建议,政府应该充分发挥出口信用保险在我国构建开放型经济新体制中的重要作用。

关键词：出口信用保险出口贸易政策性作用

企业加成率与全球价值链地位提升——基于企业生产率和产品质量的视角

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治理研究 2021年第5期37卷 104-117页

作者：胡赛中共浙江省委党校(浙江行政学院)经济学教研部

在疫情影响下,为实现对外贸易"稳中提质"的目标,外贸产业链和供应链全球地位和价值提升的重要性日渐凸显。因此,在出口企业加成率模型基础上,通过引入企业生产率和产品质量完善对企业加成率影响进行研究,并在企业层面进行实证验证,结果... 详细信息

在疫情影响下,为实现对外贸易"稳中提质"的目标,外贸产业链和供应链全球地位和价值提升的重要性日渐凸显。因此,在出口企业加成率模型基础上,通过引入企业生产率和产品质量完善对企业加成率影响进行研究,并在企业层面进行实证验证,结果表明:拥有较高生产率、产品质量较高的企业具有更高的加成率,且企业生产率越高集约边际和扩展边际越大;出口企业加成率的提升会促进企业全球价值链地位提升,技术含量较高的行业提高加成率对全球价值链所处地位的影响更大;生产率越高的企业提供更高质量的产品,并出口到更多目的地市场。研究结论为推动企业由出口规模导向到高质量发展,继续进一步提升全球价值链地位,提供有价值的政策参考依据。

关键词：企业加成率全球价值链企业生产率产品质量

The voltage-current relationship and equivalent circuit implementation of parallel flux-controlled memristive circuits

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Chinese Physics B 2013年第6期22卷 621-626页

作者：包伯成冯霏董伟潘赛虎 School of Information Science and Engineering Changzhou University

A flux-controlled memristor characterized by smooth cubic nonlinearity is taken as an example, upon which the voltage-current relationships （VCRs） between two parallel memristive circuits - a parallel memristor and capacitor circuit （the parallel MC circuit）, and a parallel memristor and inductor circuit （the parallel ML circuit） - are investigated. The results indicate that the VCR between these two parallel memristive circuits is closely related to the circuit parameters, and the frequency and amplitude of the sinusoidal voltage stimulus. An equivalent circuit model of the memristor is built, upon which the circuit simulations and exper/mental measurements of both the parallel MC circuit and the parallel ML circuit are performed, and the results verify the theoretical analysis results.

关键词： flux-controlled memristor memristor and capacitor (MC) circuit memristor and inductor (ML)circuit equivalent circuit

Overlap maximum matching ratio （OMMR）： a new measure to evaluate overlaps of essential modules

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Frontiers of Information Technology & Electronic Engineering 2015年第4期16卷 293-300页

作者： Xiao-xia ZHANG Qiang-hua XIAO Bin LI sai hu hui-jun XIONG Bi-hai ZHAO Department of Mathematics and Computer Science Changsha University Changsha 410003 China School of lnformation Science and Engineering Central South University Changsha 410083 China

Protein complexes are the basic units of macro-molecular organizations and help us to understand the cell's *** development of the yeast two-hybrid,tandem affinity purification,and mass spectrometry high-throughput proteomic techniques supplies a large amount of protein-protein interaction data,which make it possible to predict overlapping complexes through computational *** shows that overlapping complexes can contribute to identifying essential proteins,which are necessary for the organism to survive and reproduce,and for life's *** pay more attention to the evaluation of protein ***,few of them focus on predicted *** this paper,an evaluation criterion called overlap maximum matching ratio(OMMR) is proposed to analyze the similarity between the identified overlaps and the benchmark overlap *** of essential proteins and gene ontology(GO) analysis are also used to assess the quality of *** perform a comprehensive comparison of serveral overlapping complexes prediction approaches,using three yeast protein-protein interaction(PPI) *** focus on the analysis of overlaps identified by these *** results indicate the important of overlaps and reveal the relationship between overlaps and identification of essential proteins.

关键词： Protein-protein interaction network Essential protein modules Overlap Overlap maximum matching ratio