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Moxifloxacin:cardiovascular effects in conscious,jacketed cynomolgus monkeys following oral (nasogastric intubation) administration

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中国药理学与毒理学杂志 2013年第3期 595-596页

作者： hu miao-miao XING Guo-zhen Matthew SKINNER YU Hong WANG Shao-dong ZHAO Li ZHENG Wei-jun REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park MacclesfieldUK

OBJECTIVE Moxifloxacin is a fluoroquinolone with a broad spectrum of antibacterial *** aim of this study was to investigate the cardiovascular effects of moxifloxacin,administered to conscious,jacketed cynomolgus monkeys as single oral *** was a validation study performed to assess the new DSI Jacketed External Telemetry(JET) system recently installed at *** There were 6 animals(3 males and 3 females) in two *** of the same gender were group-housed in the same *** received 4 doses of vehicle control(3 fe-males) or vehicle control followed by moxifloxacin(3 males) with single ascending doses at 15,45 and 135 mg·*** animals had at least 3 to 4 dose-free days between each dose *** JET system(Data Science International,US),including two receivers and 6 devices,was used for continuous ECG data and body temperature(surface) collection for approximately 1 h before,until 24 h after each *** Administration of moxifloxacin to group-housed conscious male primates was associated with a dose-dependent prolongation of QTc interval(increase of 9 and 16% vs timematched vehicle data after 45 and 135 mg·kg-1,respectively).In female monkeys,administered multiple doses of vehicle,QTc was comparable across consecutive dosing *** results demonstrate the usefulness of the JET system in conscious monkeys for evaluating the cardiovascular effects of drugs under normal physiological conditions.

关键词： moxifloxacin cardiovascular effects

单细胞转录组技术及其在人类细胞图谱构建中的应用

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生物化学与生物物理进展 2019年第8期46卷 751-759页

作者：倪健胡苗苗危莹陈蕊郭妍上海交通大学生物医学工程学院上海200240 上海交通大学医学院附属仁济医院整形外科上海200240

单细胞转录组技术在单细胞水平上进行转录组测序,提供了单个细胞的基因表达差异信息,使在单细胞尺度下研究个体细胞、相关环境细胞及其相互作用的机理成为可能.近年来,单细胞转录组技术在c DNA扩增原理上经历了从末端加尾、体外逆转录... 详细信息

单细胞转录组技术在单细胞水平上进行转录组测序,提供了单个细胞的基因表达差异信息,使在单细胞尺度下研究个体细胞、相关环境细胞及其相互作用的机理成为可能.近年来,单细胞转录组技术在c DNA扩增原理上经历了从末端加尾、体外逆转录到模板置换的方法发展,大大提高了基因检测的数量、基因表达的准确性等.同时,在单细胞选取方式上进行了从96/384孔板到油包水液滴以及纳米微孔的创新,在提高通量和重复性的同时降低了整体实验成本.单细胞转录组技术广泛应用于细胞群体分类和异质性研究,推动了从发育生物学到正常、病态组织细胞图谱的构建.本文对单细胞转录组技术近年的技术进展以及在人类细胞图谱构建中的应用进行了综述.

关键词：单细胞转录组异质性细胞图谱

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急性胰腺炎并脾密度一过性减低1例

中国临床医学影像杂志 2009年第1期20卷 73-74页

作者：胡淼淼张芳北京海淀医院放射科北京100080

病例女，20岁。主因“突发腹痛、恶心、纳差1天”来院就诊，既往有胰腺炎病史。查体：呼气有烂苹果味；皮肤、黏膜未见明显黄染；右上腹及脐周压痛，肝区叩击痛。移动性浊音（-）；心肺未见异常。实验室检查：重度乳糜血，葡萄糖17．9m... 详细信息

病例女，20岁。主因“突发腹痛、恶心、纳差1天”来院就诊，既往有胰腺炎病史。查体：呼气有烂苹果味；皮肤、黏膜未见明显黄染；右上腹及脐周压痛，肝区叩击痛。移动性浊音（-）；心肺未见异常。实验室检查：重度乳糜血，葡萄糖17．9mmol／L，胆固醇30．17mmol／L；甘油三酯64．92mmol／L；白细胞计数12．4×10^9／L，中性粒细胞70．9％；血气分析pH7．29；尿淀粉酶正常，

关键词：胰腺炎,急性坏死性体层摄影术,X线计算机

基于T分布变分贝叶斯滤波的SINS/GPS组合导航

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浙江大学学报（工学版） 2018年第8期52卷 1482-1488页

作者：胡淼淼敬忠良董鹏周贵荣郑智明上海交通大学航空航天学院上海200240 上海飞机设计研究院上海200436

为了解决组合导航中由于野值存在而导致传统滤波算法性能下降的问题,针对SINS/GPS组合导航系统模型提出基于T分布的变分贝叶斯高斯滤波算法,充分考虑野值所导致的噪声厚尾特性,将观测噪声建模为T分布.对系统状态和自举变量进行估计,并... 详细信息

为了解决组合导航中由于野值存在而导致传统滤波算法性能下降的问题,针对SINS/GPS组合导航系统模型提出基于T分布的变分贝叶斯高斯滤波算法,充分考虑野值所导致的噪声厚尾特性,将观测噪声建模为T分布.对系统状态和自举变量进行估计,并且在每个滤波时刻借助变分贝叶斯学习对状态估计进行迭代,以逼近真实后验分布.针对噪声存在野值的场景进行仿真验证,结果表明,在SINS/GPS组合导航系统中,当噪声存在野值时,基于T分布的变分贝叶斯组合导航滤波方法具有一定的鲁棒性,并且精度优于传统组合导航滤波方法.

关键词： SINS/GPS 组合导航系统 T分布变分贝叶斯噪声野值高斯滤波

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空间转录组技术研究进展

生物化学与生物物理进展 2022年第3期49卷 561-571页

作者：危莹张小丹胡苗苗吴忠琴程酩郭妍上海交通大学生物医学工程学院上海200240

空间转录组技术旨在对细胞的基因表达进行定量测量,同时提供细胞在组织空间的具体位置信息。与传统的转录组技术相比,空间转录组技术能获得细胞在组织生理环境下真实的基因表达特征,以及与微环境的关系,进一步推进对正常和病理状态下细... 详细信息

空间转录组技术旨在对细胞的基因表达进行定量测量,同时提供细胞在组织空间的具体位置信息。与传统的转录组技术相比,空间转录组技术能获得细胞在组织生理环境下真实的基因表达特征,以及与微环境的关系,进一步推进对正常和病理状态下细胞特性的理解。近年来,空间转录组技术的发展取得了重要的进展,检测的细胞通量、转录本数量和质量不断提高,空间定位信息更加准确全面。本文总结了四大类不同空间转录组技术的特点和应用,并比较了目前不同空间转录组技术的优缺点。

关键词：空间转录组组学技术空间位置单细胞

Validation and implementation of Provantis Computer System in GLP facility

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Validation and implementation of Provantis Computer System...

2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

作者： hu miao-miao YU Hong Elaine GORDON QIN Qiu-ping QIAO Jun-wen JING Yi LU Jing REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica

CDSER(Centre for Drug Safety Evaluation and Research) perform GLP Toxicology studies according to SFDA,FDA,Japan and OECD *** help achieve this,the Provantis Computerised System for Toxicology Data Management,Collection and Reporting has been implemented to manage the data electronically since 2011 at CDSER. There are some experiences from us:①A hosted environment is used and provided by the vendor,Instem,including Oracle databases(Production,Training and Validation),Citrix Windows Terminal Servers and Fileshare which are accessed via virtual private network from *** IS Team qualified the required infrastructure at CDSER prior to use with Provantis,with support from AstraZeneca IS.②The implementation of Provantis was done as a combined effort between CDSER and AstraZeneca as part of the Alliance between the 2 *** Users from each area were identified(Protocol & Reporting,In-Life,Clinical Pathology and Pathology),and worked closely with Instem and IS representatives from CDSER and *** Expert Users identified business user requirements and working practices for their areas.③Documentation from AstraZeneca was used as templates and amended to match CDSER needs,including whole validation package and maintenance.④Creating dual language for Clinical Observations and Pathology findings so that the data could be collected and also reported in either Chinese or English,depending on where the study reports are to be submitted.⑤CDSER Expert Users performed user acceptance testing covering all areas in the Validation environment and then Operational Qualification testing before the system was used live in the Production environment.⑥There are four steps to start using Provantis in a GLP study:a) Standard training process and controlled procedure for new user to get access into the system,b) Training program was used with CDSER Expert Users training the other CDSER users, and a modified training package was then established and it is used r

关键词： GLP toxicology

Validation and implementation of Provantis ~Computer System in GLP facility

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Validation and implementation of Provantis ~Computer Syste...

作者： hu miao-miao YU Hong Elaine GORDON QIN Qiu-ping QIAO Jun-wen JING Yi LU Jing REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park

CDSER(Centre for Drug Safety Evaluation and Research) perform GLP Toxicology studies according to SFDA,FDA,Japan and OECD *** help achieve this,the Provantis Computerised System for Toxicology Data Management,Collection and Reporting has been implemented to manage the data electronically since 2011 at CDSER. There are some experiences from us:①A hosted environment is used and provided by the vendor,Instem,including Oracle databases(Production,Training and Validation),Citrix Windows Terminal Servers and Fileshare which are accessed via virtual private network from *** IS Team qualified the required infrastructure at CDSER prior to use with Provantis,with support from AstraZeneca IS.②The implementation of Provantis was done as a combined effort between CDSER and AstraZeneca as part of the Alliance between the 2 *** Users from each area were identified(Protocol & Reporting,In-Life,Clinical Pathology and Pathology),and worked closely with Instem and IS representatives from CDSER and *** Expert Users identified business user requirements and working practices for their areas.③Documentation from AstraZeneca was used as templates and amended to match CDSER needs,including whole validation package and maintenance.④Creating dual language for Clinical Observations and Pathology findings so that the data could be collected and also reported in either Chinese or English,depending on where the study reports are to be submitted.⑤CDSER Expert Users performed user acceptance testing covering all areas in the Validation environment and then Operational Qualification testing before the system was used live in the Production environment.? There are four steps to start using Provantis in a GLP study:a) Standard training process and controlled procedure for new user to get access into the system,b) Training program was used with CDSER Expert Users training the other CDSER users, and a modified training package was then established and it is used

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Moxifloxacin:cardiovascular effects in conscious,jacketed cynomolgus monkeys following oral(nasogastric intubation) administration

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Moxifloxacin:cardiovascular effects in conscious,jacketed cy...

OBJECTIVE Moxifloxacin is a fluoroquinolone with a broad spectrum of antibacterial *** aim of this study was to investigate the cardiovascular effects of moxifloxacin,administered to conscious,jacketed cynomolgus monkeys as single oral *** was a validation study performed to assess the new DSI Jacketed External Telemetry (JET) system recently installed at *** There were 6 animals(3 males and 3 females) in two groups. Animals of the same gender were group-housed in the same *** received 4 doses of vehicle control(3 fe- males) or vehicle control followed by moxifloxacin(3 males) with single ascending doses at 15,45 and 135 mg·kg~(-1).All animals had at least 3 to 4 dose-free days between each dose *** JET system(Data Science International,US), including two receivers and 6 devices,was used for continuous ECG data and body temperature(surface) collection for approximately 1 h before,until 24 h after each *** Administration of moxifloxacin to group-housed conscious male primates was associated with a dose-dependent prolongation of QTc interval(increase of 9 and 16%vs timematched vehicle data after 45 and 135 mg·kg~(-1),respectively).In female monkeys,administered multiple doses of vehicle, QTc was comparable across consecutive dosing *** results demonstrate the usefulness of the JET system in conscious monkeys for evaluating the cardiovascular effects of drugs under normal physiological conditions.

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Moxifloxacin:cardiovascular effects in conscious,jacketed cynomolgus monkeys following oral(nasogastric intubation) administration

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Moxifloxacin:cardiovascular effects in conscious,jacketed cy...

2013年（第三届）中国药物毒理学年会暨药物非临床安全...

作者： hu miao-miao XlNG Guo-zhen Matthew SKINNER YU Hong WANG Shao-dong ZHAO Li ZHENG Wei-jun REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica

OBJECTIVE Moxifioxacin is a fluoroquinolone with a broad spectrum of antibacterial *** aim of this study was to investigate the cardiovascular effects of moxifioxacin,administered to conscious,jacketed cynomolgus monkeys as single oral *** was a validation study performed to assess the new DSI Jacketed External Telemetry (JET) system recently installed at *** There were 6 animals(3 males and 3 females) in two groups. Animals of the same gender were group-housed in the same *** received 4 doses of vehicle control(3 fe- males) or vehicle control followed by moxifloxacin(3 males) with single ascending doses at 15,45 and 135 mg·*** animals had at least 3 to 4 dose-free days between each dose *** JET system(Data Science International,US), including two receivers and 6 devices,was used for continuous ECG data and body temperature(surface) collection for approximately 1 h before,until 24 h after each *** Administration of moxifloxacin to group-housed conscious male primates was associated with a dose-dependent prolongation of QTc interval(increase of 9 and 16%vs timematched vehicle data after 45 and 135 mg·kg,respectively).In female monkeys,administered multiple doses of vehicle, QTc was comparable across consecutive dosing *** results demonstrate the usefulness of the JET system in conscious monkeys for evaluating the cardiovascular effects of drugs under normal physiological conditions.

关键词： moxifloxacin cardiovascular effects