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Estimation of daily PM2.5 concentration and its relationship with meteorological conditions in Beijing

Journal of Environmental Sciences 2016年第10期28卷 161-168页

作者： Qian Yin Jinfeng Wang maogui hu Hoting Wong LREIS Institute of Geographic Sciences and Nature Resources Research Chinese Academy of Sciences Beijing 100101 China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023 China

When investigating the impact of air pollution on health, particulate matter less than 2.5μm in aerodynamic diameter （PM2.5） is considered more harrnful than particulates of other sizes. Therefore, studies of PM2.5 have attracted more attention. Beijing, the capital of China, is notorious for its serious air pollution problem, an issue which has been of great concern to the residents, government, and related institutes for decades. However, in China, significantly less time has been devoted to observing PM2.5 than for PM10. Especially before 2013, the density of the PM2.5 ground observation network was relatively low, and the distribution of observation stations was uneven. One solution is to estimate PM2.5 concentrations from the existing data on PM10. In the present study, by analyzing the relationship between the concentrations of PM2.5 and PM10, and the meteorological conditions for each season in Beijing from 2008 to 2014, a U-shaped relationship was found between the daily maximum wind speed and the daily PM concentration, including both PM2.5 and PM10. That is, the relationship between wind speed and PM concentration is not a simple positive or negative correlation in these wind directions; their relationship has a complex effect, with higher PM at low and high wind than for moderate winds. Additionally, in contrast to previous studies, we found that the PM2.5/PM10 ratio is proportional to the mean relative humidity （MRH）. According to this relationship, for each season we established a multiple nonlinear regression （MNLR） model to estimate the PM2.5 concentrations of the missing periods.

关键词： PM10 concentrationPM2.5 concentration estimationWind speedWind direction

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Optimization of Shanghai Marine Environmental Monitoring Sites in the Identification of Boundaries of Different Water Quality Grades

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Journal of Ocean University of China 2018年第4期17卷 846-854页

作者： FAN Haimei GAO Bingbo WANG Jinfeng QIN Xiaoguang LIU Pengxia hu maogui XU Peng East China Sea Environmental Monitoring Center State Oceanic AdministrationShanghai 201206China Beijing Research Center for Information Technology in Agricultur Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China State Key Laboratory of Resources&Environmental Information System Institute of Geographic Sciences&Nature Resources ResearchChinese Academy of SciencesBeijing 1O0101China

Water quality is critical to ensure that marine resources and the environment are utilized in a sustainable manner. The objective of this study is therefore to investigate the optimum placement of marine environmental monitoring sites to monitor water quality in Shanghai, China. To improve the mapping or estimation accuracy of the areas with different water quality grades, the monitoring sites were fixed in transition bands between areas of different grades rather than in other positions. Following bidirectional optimization method, first, 18 candidate sites were selected by filtering out specific site categories. Second, three of these were, in turn, eliminated because of the rule defined by the changes in the areas of water quality grades and by the standard deviation of the interpolation errors of dissolved inorganic nitrogen(DIN) and phosphate(PO_4-P). Furthermore, indicator kriging was employed to depict the transition bands between different water quality grades whenever new sampling sites were added. The four optimization projects of the newly added sites reveal that, all optimized sites were distributed in the transition bands of different water grades, and at the same time in the areas where the historical sites were sparsely distributed. New sites were also found in the overlap region of different transition bands. Additional sites were especially required in these regions to discriminate the boundaries of different water quality grades. Using the bidirectional optimization method of the monitoring sites, the boundaries of different water quality grades could be determined with a higher precision. As a result, the interpolation errors of DIN and PO_4-P could theoretically decrease.

关键词： bidirectional optimization method boundaries of water quality grades Changjiang River Estuary and its adjacent areas transition bands indicator kriging

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Expenditure of hospital care on cancer in China, from 2011 to 2015

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Chinese Journal of Cancer Research 2017年第3期29卷 253-262页

作者： Yue Cai Ming Xue Wanqing Chen maogui hu Zhiwen Miao Lan Lan Rongshou Zheng Qun Meng Center for Health Statistics and Information National Health and Family Planning Commission National Central Cancer Registry National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences West China School of Public Health Sichuan University

Objective: A solid understanding of levels and trends of spending on cancer is important to evaluate whether our healthcare resources were wisely spent and to prioritize future resources for cancer treatment and prevention. However, studies on economic burden of cancers in China are scant and the results are inconsistent. Methods: The Chinese hospital information database and nearly 350 million inpatient medical record data were used. As the ratios of cancer inpatient payments to total inpatient payments were mainly influenced by the grades and sites of hospitals, the estimates of payments of cancer inpatients in this study were stratified by hospital grades and provinces. Only the payments of cancer inpatients happened in grade 2, grade 3 and specialized cancer hospitals were included in the analyses. The total medical payments of cancers in China were estimated based on the ratios of outpatient payments to inpatient payments in specialized cancer hospitals. Results: From 2011 to 2015, the payments of cancer inpatients in China have increased by 84.1% and the total inpatient payments reached 177.1 billion RMB in 2015, accounting for 4.3% of the total health expenditure in China. Based on the ratio of outpatient payments to inpatient payments, the total payments on cancer treatments in China were estimated to be 221.4 billion RMB in 2015. Among different cancer types, the highest payments were the treatment of trachea, bronchus and lung cancer. The major cancer inpatient payments (67.1% in 2015) spent in grade 3 general hospitals and this ratio increased continually from 2011 to 2015. The expenditure of cancer treatments also varies by region with the major expenditure in the eastern region of China. Conclusions: This study estimated the total payments of cancer treatments in China and analyzed how the money was spent on cancer treatments in the recent 5 years, which would provide information for decision makings on the allocation of resources to service provisionin

关键词： Cancer payments expenditure economic burden

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程序性死亡受体-1与淋巴细胞活化基因-3在滤泡性淋巴瘤中的表达及临床意义

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中国当代医药 2024年第18期31卷 14-20页

作者：倪金菊王馨辰胡茂贵张瑰红丁凯阳安徽医科大学附属省立医院血液科安徽合肥230001 中国科学技术大学附属第一医院血液科安徽合肥230031 安徽医科大学第一附属医院病理教研室安徽合肥230032

目的探讨程序性死亡受体-1(PD-1)、淋巴细胞活化基因-3(LAG-3)在滤泡性淋巴瘤(FL)肿瘤微环境中的表达情况及临床意义。方法选取2017—2022年中国科学技术大学附属第一医院22例病理明确诊断为FL的患者,采用免疫组化方法检测FL患者标本中P... 详细信息

目的探讨程序性死亡受体-1(PD-1)、淋巴细胞活化基因-3(LAG-3)在滤泡性淋巴瘤(FL)肿瘤微环境中的表达情况及临床意义。方法选取2017—2022年中国科学技术大学附属第一医院22例病理明确诊断为FL的患者,采用免疫组化方法检测FL患者标本中PD-1、LAG-3、细胞程序性死亡-配体1(PD-L1)、细胞表面趋化因子受体4(CCR4)、细胞表面趋化因子受体3B(CXCR3B)、叉头蛋白P3抗体(FOXP3)因子的表达水平,分析PD-1、LAG-3与FL患者临床病理特征及预后的关系,并分析各因子间的相关性。结果PD-1高表达组和LAG-3高表达组β2微球蛋白(β_(2)-MG)水平高于低表达组,差异有统计学意义(P0.05)。PD-1高表达组、LAG-3高表达组和PD-1/LAG-3共同高表达组CD8^(+)T细胞计数少于对应低表达组,差异有统计学意义(P<0.05),进一步相关性分析结果显示PD-1表达、LAG-3表达以及PD-1/LAG-3共同表达与CD8^(+)T细胞计数呈负相关(r=-0.631、-0.425、-0.552,P<0.05)。生存分析结果显示LDH低表达组的无进展生存期(PFS)和总体生存期(OS)优于高表达组;PD-1低表达组、LAG-3低表达组和PD-1/LAG-3双低表达组的PFS和OS优于高表达组,差异有统计学意义(P<0.05)。结论PD-1、LAG-3高表达与FL患者较高的临床检验指标水平及较差的生存预后相关;PD-1、LAG-3等免疫检查点在肿瘤微环境中共同表达,影响T细胞计数。

关键词：程序性死亡受体-1 淋巴细胞活化基因-3 肿瘤微环境滤泡性淋巴瘤

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Chidamide-BEAC plus autologous stem cell transplantation in high-risk non-Hodgkin lymphoma:a phase II clinical trial

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Chinese Medical Journal 2023年第12期136卷 1491-1493页

作者： Yi Xia Li Wang Kaiyang Ding Jiazhu Wu hua Yin maogui hu Haorui Shen Jinhua Liang Ruize Chen Yue Li huayuan Zhu Jianyong Li Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China Department of Hematology The First Affiliated Hospital of USTC Anhui Provincial HospitalHefeiAnhui 230001China National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China

To the Editor:Non-Hodgkin lymphoma(NHL)is a common type of hematological *** the development of targeted therapies has improved the survival of patients with aggressive NHL,autologous hematopoietic stem cell transplan... 详细信息

关键词： autologous lymphoma NHL

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Captive Breeding of the Four-eyed Turtle(Sacalia quadriocellata)

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Asian Herpetological Research 2010年第2期1卷 111-117页

作者： HE Bin LIU Yuxiang SHI Haitao ZHANG Jie hu maogui MA Yonggang FU Lirong HONG Meiling WANG Jichao Fong J.Jonathan Parham F.James College of Life Sciences Hainan Normal University Chengdu Institute of Biology Chinese Academy of Sciences Museum of Vertebrate Zoology Department of Integrative BiologyUniversity of California at Berkeley Alabama Museum of Natural History University of Alabama

In 1998,a study on forty-five four-eyed turtles(Sacalia quadriocellata) was initiated to gather preliminary biological data of this species and to investigate the feasibility of its captive *** the following six years,no courtship behavior was found occurring in males and no oviposition in *** 2004 to 2007,two successful techniques were applied to initiate reproductive behavior:1) injecting exogenous reproductive hormones; and 2) reducing the stress of living in *** a result of the hormone treatments,courtship behavior and copulation were observed during September and October,***,no courtship displays were seen from the CK males,which were not treated with *** occurred between December and March,and the correlation was not significant between behavior of ovulation and food *** laid only one clutch of eggs each year,with 2.47 eggs(n=34,range=1–4) at average,and 84 eggs were totally obtained,of which 13 were damaged,52 were infertile and 19 *** the fertile eggs,nine were hatched with mean incubation period of 105.9 days(n=9,range=89–122 days) at temperature ranging from 24 to 27℃.

关键词： four-eyed turtle Sacalia quadriocellata captive breeding hormone stress conservation

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遥感影像混合像元分解及超分辨率重建研究进展

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地理科学进展 2010年第6期29卷 747-756页

作者：胡茂桂王劲峰中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101

随着遥感应用的深入,传统将遥感影像像元当作纯净像元的方式所带来的问题已经被广泛认识到,混合像元分解的相关理论和技术成为遥感领域的一个热点问题。本文总结了混合像元分解及超分辨率影像重建的主要理论和方法。根据超分辨率影像重... 详细信息

随着遥感应用的深入,传统将遥感影像像元当作纯净像元的方式所带来的问题已经被广泛认识到,混合像元分解的相关理论和技术成为遥感领域的一个热点问题。本文总结了混合像元分解及超分辨率影像重建的主要理论和方法。根据超分辨率影像重建的主要流程,分别回顾了混合像元端元类型选择、端元丰度分解和超分辨率影像的重建,并对相关模型和技术给出了总结和评价。端元类型选择是确定在影像范围包含的纯净地物类型,重点介绍了基于统计学和几何学的两种方法。端元丰度估计是目前该领域研究最多的方向之一,集中了很多新的理论和方法,可变端元分解和盲源分解作为2种效果较好的方法在文中作了详细的回顾和评价。空间自相关性是对丰度估计的结果进行超分辨率重建的主要理论基础,如何在丰度约束条件下最大化空间自相关性是大多数基于混合像元分解超分辨率重建的目标。最后,文章在总结目前混合像元分解及超分辨率遥感影像理论发展的基础上,给出了一些意见和展望,指出考虑混合像元形成机理、综合多种模型及先验信息将有助于基于混合像元分解的超分辨率遥感影像研究。

关键词：端元选择丰度估计盲源分解混合像元分解超分辨率重建

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山区过渡性地理空间人文自然交互性识别与分异解析

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地理学报 2022年第5期77卷 1225-1243页

作者：张少尧邓伟胡茂桂张昊王占韵彭立四川师范大学地理与资源科学学院成都610066 中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101 中国科学院成都山地灾害与环境研究所成都610041 四川师范大学川西高原资源环境与可持续发展研究中心成都610066

山区因其人文自然交互过程具有显著的地域性、时空分异性与不确定性,成为典型的过渡性地理空间,其类型量化识别与分异特征的解析可为山区乡村振兴背景下国土空间高质量发展提供决策依据。本文基于地理不确定性的概念构建时空变率指数,... 详细信息

山区因其人文自然交互过程具有显著的地域性、时空分异性与不确定性,成为典型的过渡性地理空间,其类型量化识别与分异特征的解析可为山区乡村振兴背景下国土空间高质量发展提供决策依据。本文基于地理不确定性的概念构建时空变率指数,识别出中国山区过渡性地理空间分布与分区,并运用地理探测器解析其地理时空变率的驱动力谱。结果发现:中国山区过渡性地理空间总面积为238.32×10^(4) km^(2)(约占中国陆表面积的1/4),其地理时空变率从第一阶梯到第三阶梯呈递减趋势;全国山区过渡性地理空间可分为12个分区,其中昆仑—祁连山分区面积最大;人文驱动因子对人口与土地利用的时空变率解析力最强,基础地形因子对植被覆盖时空变率与地理时空变率指数的解析力最为显著,各因子中海拔与夜间灯光的解析驱动力最强。整体而言,人文要素的时空动态均对东南山区过渡性地理空间具有显著的塑造性,而西北山区过渡性地理空间主要受到自然要素的时间变化和人文要素的空间变化所驱动。本文为山区过渡性地理空间的不确定性、多样性与人地关系地域性的定量研究提供了新的见解与启示。

关键词：人文自然交互山区过渡性地理空间时空变率地理不确定性信息熵

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关于安徽广播电视监测网网络安全的研究

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网络安全技术与应用 2013年第8期 126-127页

作者：胡茂贵安徽广播电视监测台安微230022

安徽省广播电视监测台始建于1992年,其担负着对全省覆盖范围内的广播电视节目从播出到有线传输、无线发射、卫星频谱监测以及流动监测的多环节、全方位的监测任务,还担负着对全省广播电视节目安全播出的调度指挥任务。随着人民群众的精... 详细信息

安徽省广播电视监测台始建于1992年,其担负着对全省覆盖范围内的广播电视节目从播出到有线传输、无线发射、卫星频谱监测以及流动监测的多环节、全方位的监测任务,还担负着对全省广播电视节目安全播出的调度指挥任务。随着人民群众的精神文明生活的需求加大,监测工作的工作量也不断加大,这样也给监测网络的安全带来风险,对广播电视网络的性能提出了更高的要求。本文通过对监测网络的安全性和电视广播监测网的分析,提出了电视广播监测网络系统安全性对策。

关键词：广播电视监测网安全对策

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EB病毒动态变化与淋巴瘤疗效的关系

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白血病．淋巴瘤 2018年第6期27卷 336-339页

作者：杨迎雪丁凯阳胡茂贵安徽医科大学研究生院合肥230032 安徽医科大学附属省立医院血液科合肥230001 安徽省肿瘤医院血液科合肥230031

目的观察淋巴瘤患者血清中EB病毒（EBV）DNA的动态变化与临床疗效的关系.方法对2015年9月至2017年8月安徽省肿瘤医院51例EBV阳性的淋巴瘤患者进行回顾性研究,对比EBV DNA含量的变化并通过乳酸脱氢酶（LDH）与肿大淋巴结的变化观察淋... 详细信息

目的观察淋巴瘤患者血清中EB病毒（EBV）DNA的动态变化与临床疗效的关系.方法对2015年9月至2017年8月安徽省肿瘤医院51例EBV阳性的淋巴瘤患者进行回顾性研究,对比EBV DNA含量的变化并通过乳酸脱氢酶（LDH）与肿大淋巴结的变化观察淋巴瘤的治疗效果.结果51例患者中,随EBV DNA升高,LDH亦升高者18例,随EBV DNA降低而LDH降低者23例,随EBV DNA降低而LDH升高者2例,随EBV DNA升高而LDH降低者8例,EBV DNA含量与LDH水平具有高度一致性（κ=0.609,P=0.000）.51例患者中,随EBV DNA升高淋巴结增大者20例,随EBV DNA降低而淋巴结减小者22例,随EBV DNA降低淋巴结增大者3例,随EBV DNA升高淋巴结减小6例,EBV DNA含量与淋巴结大小变化具有高度一致性（κ=0.648,P=0.000）.治疗过程中EBV DNA呈升高趋势的患者,其LDH平均值亦呈升高趋势;治疗过程中EBV DNA降低的患者,其LDH平均值亦降低.EBV阳性淋巴瘤患者LDH水平与EBV DNA含量呈正相关（r=0.627,P=0.000）.结论EBV DNA及LDH动态检测可作为EBV阳性淋巴瘤患者治疗效果及随访评估指标.

关键词：疱疹病毒4型人淋巴瘤乳酸脱氢酶类淋巴结

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