检索结果-南通市图书馆

Rhododendron Molle(Ericaceae):phytochemistry,pharmacology,and toxicology

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2018年第6期16卷 401-410页

作者： CAI Yong-Qing hu jian-hui QIN Jie SUN Tao LI Xiao-Li Department of Pharmacy Institute of Surgery ResearchDaping HospitalThird Military Medical UniversityChongqing 400042China Student Brigade Ten Team Second Military Medical UniversityShanghai 200433China Student Eleven Camp Third Military Medical UniversityChongqing 400038China College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China College of Pharmacy Chongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Drug Metabolism Chongqing 400016China

Rhododendron molle G. Don, belonging to the Ericaceae family, is a traditional Chinese medicinal plant with a wide spectrum of pharmacological effects. This paper aimed to review the phytochemistry, pharmacology and toxicology of R. molle, and to discuss the tendency of future investigations on this plant. A systematic review of literature about R. molle was carried out using resources including classic books about Chinese herbal medicine, and scientific data bases including CNKI, Pubmed, Sci Finder, Scopus, and Web of Science. Over 67 compounds, including diterpenes, triterpenes, flavonoids, and lignans, had been extracted and identified from R. molle. The extracts/monomers isolated from the root, flower and fruits of this plant were used as effective agents for treating pains, inflammatory diseases, hypertension, and pest, etc. In addition, diterpenes, such as rhodojaponin III, were considered as the toxic agents associated with the toxicities of this plant. These findings will be significant for the discovery of new drugs from this plant and full utilization of R. molle.

关键词： Rhododendron molle Phytochemistry Pharmacology Toxicology

Natural forests exhibit higher organic carbon concentrations and recalcitrant carbon proportions in soil than plantations:a global data synthesis

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2024年第5期35卷 131-141页

作者： Xiuqing Nie hui Wang jian Wang Shirong Liu Ecology and Nature Conservation Institute Chinese Academy of ForestryKey Laboratory of Forest Ecology and Environment of National Forestry and Grassland AdministrationNo.2 DongxiaofuHaidian DistrictBeijing 100091People’s Republic of China

Different chemical compositions of soil organic carbon(SOC)affect its persistence and whether it signifi-cantly differs between natural forests and plantations remains *** synthesizing 234 observations of SOC chemical compositions,we evaluated global patterns of concentra-tion,individual chemical composition(alkyl C,O-alkyl C,aromatic C,and carbonyl C),and their distribution *** results indicate a notably higher SOC,a markedly larger proportion of recalcitrant alkyl C,and lower easily decomposed carbonyl C proportion in natural ***-ever,SOC chemical compositions were appreciably more evenly distributed in *** on the assumed con-ceptual index of SOC chemical composition evenness,we deduced that,compared to natural forests,plantations may have higher possible resistance to SOC decomposition under *** tropical regions,SOC levels,recalcitrant SOC chemical composition,and their distributed evenness were significantly higher in natural forests,indicating that SOC has higher chemical stability and possible resistance to *** factors had minor effects on alkyl C in forests globally,while they notably affected SOC chemi-cal composition in tropical *** could contribute to the differences in chemical compositions and their distrib-uted evenness between plantations and natural stands.

关键词： Global data synthesis Natural forest Plantations Soil organic carbon Soil organic carbon chemical composition

Optimizing magnetoelastic properties by machine learning and high-throughput micromagnetic simulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第5期43卷 2251-2262页

作者： jian-hu Gong Zheng-Ming Zhang Cheng-Liang Zhang Peng-Qiang hu Chao Zhou Dun-hui Wang Sen Yang Division of Microelectronic Materials and Devices Hangzhou Dianzi UniversityHangzhou 310018China School of Physics MOEKey Laboratory forNonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an 710049China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

Magnetoelastic couplings in giant magnetostrictive materials(GMMs)attract significant interests due to their extensive applications in the fields of spintronics and energy harvesting *** the role of the selection of materials and the response to external fields is essential for attaining desired functionality of a ***,machine learning(ML)models are conducted to predict saturation magnetostrictions(λ_(s))in RFe_(2)-type(R=rare earth)GMMs with different *** to ML-predicted composition–λsrelations,it is discovered that the values ofλshigher than1100×10^(-6)are almost situated in the composition space surrounded by 0.26≤x≤0.60 and 1.90≤y≤2.00 for the ternary compounds of Tb_(x)Dy_(1-x)Fe_(y).Assisted by ML predictions,the compositions are further narrowed down to the space surrounded by 0.26≤x≤0.32 and 1.92≤y≤1.97 for the excellent piezomagnetic(PM)performance in the Tb_(x)Dy_(1-x)Fe_(y)based PM device through our developed high-throughput(HTP)micromagnetic simulation(MMS)***,high sensitivities up to10.22-13.61 m T·MPa^(-1)are observed in the optimized range within which the available experimental data fall *** work not only provides valuable insights toward understanding the mechanism of magnetoelastic couplings,but also paves the way for designing and optimizing highperformance magnetostrictive materials and PM sensing devices.

关键词： Magnetostriction Piezomagnetic effect Machine learning Micromagnetic simulation

A high-performance electromagnetic energy harvester for scavenging ultra-low frequency vibration energy of human foot movement

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第5期67卷 1391-1400页

作者： hu JiaJun QIAN Shuo WU hui hu DongXu NIU LiXin BI XiaoXue ZHANG Jie HOU XiaoJuan GENG WenPing MU JiLiang HE jian CHOU Xiujian Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan030051China School of Software North University of ChinaTaiyuan030051China

In our daily lives,low-frequency kinetic energy primarily manifests as ***,effective harnessing of lowfrequency kinetic energy remains a formidable *** paper proposes a rope-driven rotor that rotates around an axis and consists of an ultra-high-molecular-weight polyethylene(UHMWPE)wire wrapped around a metal *** rotor can convert ultra-low frequency vibration/linear motion into rapid rotation by pressing the top at low frequencies and driving the rope for a quick *** harvester can generate up to 36.25 m W power using a 0.1-mm-diameter UHMWPE wire as the rotor when periodically pressed down to 20 mm at a frequency of 1 Hz.A simple power generation floor is assembled,generating 28.58-m W power with a matching load at a frequency of 1.5 ***,the harvester can increase the charging voltage of a 0.47-F supercapacitor from 0 to 6.8 V within 10 *** addition,the harvester can harvest energy through a light finger press motion,and the energy obtained can also support the continuous operation of multiple electronic devices *** study introduces an effective method for harvesting ultra-low frequency energy and has great prospects in the field of power generation floor and human movement energy harvesting.

关键词： electromagnetic energy harvester rope-shaft coupling structure human motion ultra-low frequency

Ribonucleotide reductase subunit M1 blocks glucose catabolism via phosphorylation of pyruvate kinase M2 in human esophageal squamous cell cancer

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 69-71页

作者： jian Yang Lingxiao Wang hui Sun Zhenxiang Zhao Yanchuan Ma Zhen hu Liqin Zhai Yonggang Wang Translational Medicine Research Center Shanxi Medical UniversityTaiyuanShanxi030001China Department of Cell Biology and Genetics Shanxi Medical UniversityTaiyuanShanxi 030001China Key Laboratory of Cellular Physiology of the Ministry of Education Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Colorectal Surgery The Fifth Clinical Medical College of Shanxi Medical UniversityTaiyuanShanxi 030012China Science&Technology Information and Strategy Research Center of Shanxi TaiyuanShanxi 030006China Department of Pathology Shanxi Provincial People's HospitalTaiyuanShanxi 030012China Department of Anatomy College of Basic MedicineShanxi Medical UniversityTaiyuanShanxi 030001China

Esophageal squamous cell cancer(EScC)is one of the malignant tumors with high morbidity and mortality all over the world.^(1) In recent years,combined chemotherapy has gradually been the effective treatment method for EscC ***,it is imperative to explore potential therapeutic targets for the treatment of *** previously reported a high-frequency amplification of pyrimidine metabolic pathway-related genes in EsCC tissues.

关键词： squamous esophageal cancer

Neg-Entropy Mechanism as a Target for Natural Medicines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2024年第7期38卷 11-12页

作者： Tian-Le Gao hui-hui Guo jian-Dong jiang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Current strategies for drug discovery research mainly focus on molecular targets,in which structure biology plays a central role,such as the detailed mechanism of a drug-target *** principle of this approach is the presumed molecular mechanism or genetic background of the disease being *** this approach has brought progress in understanding the mode of action for some drugs,most prevalent illnesses-especially chronic diseases-are multifactorial and present with a group of symptoms,as is often the case in cardiovascular diseases,metabolic disorders,cancers,and so *** newly emerging term“multi-morbidity”(i.e.,multiple co-occurring diseases)describes a grand challenge for this strategy,and successful drug intervention for multimorbidity should be multifaceted[1].So,our research team has shifted its attention to a new direction that views the disease as a whole instead of a single-molecule abnormality,and focusing on drugs with multiple targets.

关键词： drugs diseases cardiovascular

Patterns and drivers of avian taxonomic and phylogenetic beta diversity in China vary across geographical backgrounds and dispersal abilities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2024年第1期45卷 125-135页

作者： jian-Chao Liang Zhi-Feng Ding Chun-Lin Li Yi-Ming hu Zhi-Xin Zhou Gan-Wen Lie Xiao-Nan Niu Wen-Bin huang hui-jian hu Xing-Feng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Resources and Environmental Engineering Anhui UniversityHefeiAnhui 230601China Guangdong Eco-Engineering Polytechnic GuangzhouGuangdong 510520China huizhou Institute of Forestry(huizhou Botanical Garden Management Service Center) HuizhouGuangdong 516001China Administration of National Nature Reserve for Marine Ecology of Guangdong Nanpeng Islands ShantouGuangdong 515900China Zhejiang Zhoushan Archipelago Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Geographical background and dispersal ability may strongly influence assemblage dissimilarity;however,these aspects have generally been overlooked in previous large-scale beta diversity ***,we examined whether the patterns and drivers of taxonomic beta diversity(TBD)and phylogenetic beta diversity(PBD)of breeding birds in China vary across(1)regions on both sides of the hu Line,which demarcates China’s topographical,climatic,economic,and social patterns,and(2)species with different dispersal *** and PBD were calculated and partitioned into turnover and nestedness components using a moving window *** representing climate,habitat heterogeneity,and habitat quality were employed to evaluate the effects of environmental *** distance was considered to assess the impact of dispersal *** partitioning analysis was applied to assess the relative roles of these *** general,the values of TBD and PBD were high in mountainous areas and were largely determined by environmental ***,different dominant environmental filters on either side of the hu Line led to divergent beta diversity ***,climate-driven species turnover and habitat heterogeneity-related species nestedness dominated the regions east and west of the line,***,bird species with stronger dispersal ability were more susceptible to environmental filtering,resulting in more homogeneous *** results indicated that regions with distinctive geographical backgrounds may present different ecological factors that lead to divergent assemblage dissimilarity patterns,and dispersal ability determines the response of assemblages to these ecological *** a single universal explanation for the observed pattern without considering these aspects may lead to simplistic or incomplete ***,a comprehensive understanding of large-scale beta diversity patterns and effective pla

关键词： Beta diversity Environmental filtering Dispersal limitation hu Line Species dispersal ability Breeding birds

具有不确定参数永磁同步电动机的自适应反步控制

在线全文

学校读者我要写书评

暂无评论

控制与决策 2006年第11期21卷 1264-1269页

作者：胡建辉邹继斌哈尔滨工业大学电气工程系哈尔滨150001

针对永磁同步电动机系统的非线性耦合特性以及参数的不确定性,采用自适应反步控制实现永磁同步电动机的非线性控制,在补偿参数不确定性影响,提高系统的抗干扰能力的同时,实现了永磁同步电动机的高性能全局渐近稳定速度跟踪控制.采用二... 详细信息

针对永磁同步电动机系统的非线性耦合特性以及参数的不确定性,采用自适应反步控制实现永磁同步电动机的非线性控制,在补偿参数不确定性影响,提高系统的抗干扰能力的同时,实现了永磁同步电动机的高性能全局渐近稳定速度跟踪控制.采用二阶滤波环节平滑速度指令,实现了理想无超调的快速速度跟踪控制.仿真结果证明了所提出方法的有效性.

关键词：永磁同步电动机自适应反步控制非线性控制二阶滤波速度跟踪

Impact of preoperative inflammatory and nutritional markers on the prognosis of patients with peritoneal metastasis of colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3865-3874页

作者： Zhi-Jie Wu Bing Lan jian Luo Ayniyazi Ameti hui Wang Qiong-Yu hu Department of General Surgery(Colorectal Surgery) The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Anesthesiology Kashgar First People’s HospitalKashgar 844000Xinjiang Uygur Autonomous RegionChina Department of Anesthesiology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Identifying patients with peritoneal metastasis(PMs)of colorectal cancer(CRC)who will benefit from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is crucial before *** and nutritional indicators play essential roles in cancer development and *** To investigate the association of preoperative inflammatory and nutritional markers with prognosis in patients with *** We included 133 patients diagnosed with CRC-PM between July 2012 and July ***’demographics,overall survival(OS),and preoperative inflammatory and nutritional markers were *** Kaplan-Meier method and log-rank test were used to estimate *** Of the 133 patients,94(70.6%)had normal hemoglobin(Hb)and 54(40.6%)had a high neutrophil-to-lymphocyte ratio(NLR).The median OS(mOS)was significantly lower for patients with high NLR(7.9 months)than for those with low NLR(25.4 months;P=0.002).Similarly,patients with normal Hb had a longer mOS(18.5 months)than those with low Hb(6.3 months;P<0.001).Multivariate analysis identified age,carbohydrate antigen 199 levels,NLR,Hb,and peritoneal cancer index as independent predictors of *** on these findings,a nomogram was constructed,which demonstrated a good capacity for prediction,with a C-index of 0.715(95%confidence interval:0.684-0.740).Furthermore,the 1-and 2-year survival calibration plots showed good agreement between predicted and actual OS *** areas under the curve for the 1-and 2-year survival predictions of the nomogram were 0.6238 and 0.6234,*** High NLR and low Hb were identified as independent predictive risk factors for poor prognosis in patients with *** established nomogram demonstrated high accuracy in predicting OS for patients with CRC-PM,indicating its potential as a valuable prognostic tool for this patient population.

关键词： Colorectal cancer Peritoneal metastasis Neutrophil-to-lymphocyte ratio Hemoglobin Prognosis Overall survival