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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 106-111页

作者： Yuhang Zhang Cong Liu Xiyu Zhu hai-hu Wen Center for Superconducting Physics and Materials National Laboratory of Solid State Microstructures and Department of PhysicsNational Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Recent claim of discovering above-room-temperature superconductivity(Tc≈400 K)at ambient pressure in copper doped apatite Pb10(PO_(4))_(6)O has stimulated world-wide enthusiasm and impulse of motion.A lot of follow-up works have been carried out with controversial conclusions.To check whether superconductivity is really present or absent in the material,we need samples which should have a rather pure phase of Pb_(10-x)Cux(PO_(4))_(6)O.Here we report the characterization results from the Pb_(10-x)Cux(PO_(4))_(6)O with a fraction of about 97 wt.%inferred from the fitting to the X-ray diffraction pattern,if assuming Cu2S as the only impurity.The resistivity measurements show that it is a semiconductor characterized roughly by a ln(1/T)temperature dependence in wide temperature region without trace of superconductivity.Magnetization measurements show that it has a general ferromagnetic signal with a weak superparamagnetic background.Many grains of the sample show clear interactions with a Nb Fe B magnet.The detected Cu concentration is much lower than the expected nominal one.Our results show the absence of metallicity and superconductivity in Pb_(10-x)Cux(PO_(4))_(6)O at ambient pressure,and suggest the presence of strong correlation effect.

关键词： superconductivity Pb10(PO4)6O ferromagnetic correlation effect

Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats

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Current Medical Science 2024年第2期44卷 355-368页

作者： Shao-ze JING Shu-han YANG Yun-kun QU hai-hu HAO hua WU Department of Orthopedics Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Osteoarthritis(OA)is a degenerative joint disorder characterized by the gradual degradation of joint cartilage and local inflammation.This study aimed to investigate the anti-OA effect of scutellarein(SCU),a single-unit flavonoid compound obtained from Scutellaria barbata D.Don,in rats.Methods:The extracted rat chondrocytes were treated with SCU and IL-1β.The chondrocytes were divided into control group,IL-1βgroup,IL-1β+SCU 50µmol/L group,and IL-1β+SCU 100µmol/L group.Morphology of rat chondrocytes was observed by toluidine blue and safranin O staining.CCK-8 method was used to detect the cytotoxicity of SCU.ELISA,qRT-PCR,Western blotting,immunofluorescence,SAβ-gal staining,flow cytometry,and bioinformatics analysis were applied to evaluate the effect of SCU on rat chondrocytes under IL-1βintervention.Additionally,anterior cruciate ligament transection(ACL-T)was used to establish a rat OA model.Histological changes were detected by safranin O/fast green,hematoxylin-eosin(HE)staining,and immunohistochemistry.Results:SCU protected cartilage and exhibited anti-inflammatory effects via multiple mechanisms.Specifically,it could enhance the synthesis of extracellular matrix in cartilage cells and inhibit its degradation.In addition,SCU partially inhibited the nuclear factor kappa-B/mitogen-activated protein kinase(NF-κB/MAPK)pathway,thereby reducing inflammatory cytokine production in the joint cartilage.Furthermore,SCU significantly reduced IL-1β-induced apoptosis and senescence in rat chondrocytes,further highlighting its potential role in OA treatment.In vivo experiments revealed that SCU(at a dose of 50 mg/kg)administered for 2 months could significantly delay the progression of cartilage damage,which was reflected in a lower Osteoarthritis Research Society International(OARSI)score,and reduced expression of matrix metalloproteinase 13(MMP13)in cartilage.Conclusion:SCU is effective in the therapeutic management of OA and could serve as a potential candidate for future clinical drug therapy for OA.

关键词： scutellarein osteoarthritis apoptosis mitogen-activated protein kinase(MAPK) nuclear factor kappa-B(NF-κB)

Pressure-induced color change arising from transformation between intra-and inter-band transitions in LuH_(2±x)N_(y)

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 161-166页

作者： Zhe Liu Yingjie Zhang Shenyang huang Xue Ming Qing Li Chenghao Pan Yaomin Dai Xiaoxiang Zhou Xiyu Zhu hugen Yan hai-hu Wen Center for Superconducting Physics and Materials National Laboratory of Solid State Microstructures and Department of PhysicsNational Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China State Key Laboratory of Surface Physics Key Laboratory of Micro and Nano-Photonic Structures of the Ministry of EducationDepartment of PhysicsFudan UniversityShanghai 200433China

The pressure-induced color change in the nitrogen-doped lutetium hydride has triggered extensive discussions about the underlying physics and potential applications.Here,we study the optical response of LuH_(2±x)N_(y)in a broad frequency range at ambient pressure and its evolution with pressure in the visible spectral range.The broad-band optical spectra at ambient pressure reveal a Drude component associated with intra-band electronic transitions and two Lorentz components(L1 and L2)arising from inter-band electronic transitions.The application of pressure causes a spectral weight transfer from L1 to the Drude component,leading to a blue shift of the plasma edge in the reflectivity spectrum alongside a reduction of the high-frequency reflectivity.Our results suggest that the pressure-induced color change in LuH_(2±x)N_(y)is closely related to the transformation between intra-and inter-band electronic transitions,providing new insights into the mechanism of the pressure-induced color change in LuH_(2±x)N_(y).

关键词： nitrogen-doped lutetium hydride optical spectroscopy high-pressure technique color change

High-efficiency gene editing in Anopheles sinensis using ReMOT control

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Insect Science 2024年第1期31卷 307-312页

作者： Xiao-lin Yang Xia Ling Quan Sun Pin-pin Qiu Kai Xiang Jun-feng Hong Shu-lin He Jie Chen Xin Ding hai hu Zheng-bo He Cao Zhou Bin Chen Liang Qiao Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyCollege of Life SciencesChongqing Normal UniversityChongqingChina Xunjian Life Science&Technology Co.Ltd. ChongqingChina State Key Laboratory of Resource Insects Southwest UniversityChongqingChina

Dear editor,Functional genomics studies of mosquito vectors are crucial for understanding their physiological behavior,pathogen transmission,and evolution,and for providing essential molecular targets for genetic control(Severson&Behura,201l;Alphey,2014;Ruzzante et al.,2019;Hong et al.,2022).The main methods involve clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing via embryo microinjection(Criscione et al.,2015;Kistler et al.,2015).

关键词： editor editing injection

现代化产业体系构建与农民农村共同富裕:影响机理与实证检验

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云南民族大学学报（哲学社会科学版） 2024年第1期41卷 139-151页

作者：胡海庄天慧四川农业大学马克思主义学院四川成都611130 四川农业大学西部乡村振兴研究中心四川成都611130

基于2008—2021年中国31个省、市、自治区(不包含港澳台)面板数据,运用主成分分析法与优序图分析相结合的方法测算现代化产业体系构建水平,并研判现代化产业体系构建对农民农村共同富裕的影响。实证分析结果显示:现代化产业体系构建可... 详细信息

基于2008—2021年中国31个省、市、自治区(不包含港澳台)面板数据,运用主成分分析法与优序图分析相结合的方法测算现代化产业体系构建水平,并研判现代化产业体系构建对农民农村共同富裕的影响。实证分析结果显示:现代化产业体系构建可有效赋能农民农村共同富裕。传导机制分析显示,现代化产业体系构建能够通过扩大财税规模、增加创业活动、缩小城乡数字鸿沟,赋能农民农村共同富裕。异质性检验证实,现代化产业体系构建对农民农村共同富裕的赋能作用在东部地区更为显著。空间效应分析显示,现代化产业体系构建对农民农村共同富裕具有正向空间溢出效应。针对于此,未来应构建现代乡村产业体系、激发农村创业创新活力、推动区域产业协调发展,加速推进农民农村共同富裕。

关键词：现代化产业体系财税规模创业活动农民农村共同富裕城乡数字鸿沟

中国式农业农村现代化水平测度与影响因素分析

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科学管理研究 2024年第1期42卷 126-134页

作者：胡海庄天慧四川农业大学马克思主义学院四川成都611130 四川农业大学西部乡村振兴研究中心四川成都611130

立足2013-2021年全国31个省份面板数据,在构建中国式农业农村现代化水平评价指标体系基础上,利用熵权法测算各省份中国式农业农村现代化水平。进一步采用Dagum基尼系数实证分析不同地区中国式农业农村现代化水平的差异及时空演化规律,... 详细信息

立足2013-2021年全国31个省份面板数据,在构建中国式农业农村现代化水平评价指标体系基础上,利用熵权法测算各省份中国式农业农村现代化水平。进一步采用Dagum基尼系数实证分析不同地区中国式农业农村现代化水平的差异及时空演化规律,并通过地理探测器细致考察经济、生产、人力等因素对中国式农业农村现代化水平影响的时空分异。结果表明:中国式农业农村现代化总体发展水平呈逐年缓慢递增趋势且存在区域异质性,其中东部地区中国式农业农村现代化水平最高,中部地区次之,西部地区最低。中国式农业农村现代化水平在不同地区发展不平衡主要由区域间差异引起。从区域内差异来看,东部地区区域内各省份中国式农业农村现代化水平差异最大,中部地区差异最小;从区域间差异来看,西部-东部中国式农业农村现代化水平的区域间基尼系数最大,中部-西部区域间基尼系数最小。农村人均GDP、政府扶持力度和农村产业现代化是导致中国式农业农村现代化产生分异现象的决定性因素。据此,提出有效完善农业农村现代化系统、多维打造农村新型服务模式和统筹整合农业农村资源建议,以全面驱动中国式农业农村现代化水平持续提升。

关键词：农业农村现代化 Dagum基尼系数时空分异影响因素

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无限与一体:重构魏晋思想的一种可能

中山大学学报（社会科学版） 2024年第1期64卷 133-142页

作者：胡海忠中国社会科学院哲学研究所北京100871

基于整体性—个体性、无限性—有限性这一解释框架,可对魏晋思想进行重新刻画。以风俗、制度为表征的整体性秩序的扭曲和破裂,导致汉末魏晋时期个体性被突出强调。为避免对个体性的深刻理解走向个人主义、虚无主义,玄学家提出两种理性方... 详细信息

基于整体性—个体性、无限性—有限性这一解释框架,可对魏晋思想进行重新刻画。以风俗、制度为表征的整体性秩序的扭曲和破裂,导致汉末魏晋时期个体性被突出强调。为避免对个体性的深刻理解走向个人主义、虚无主义,玄学家提出两种理性方案:将个体视域从政治社会扩大到天地万物的整体,以至大无外的“一体”化解有限性焦虑;以“无限”作为克服有限的支点,寻求在有限的立场上通向无限的可能性。形神、礼乐、生死、公私、自然与名教、独化与玄同、有无、儒道等都是在“无限”“一体”逻辑中展开的分议题。这一奠定魏晋思想走向的深层逻辑在郭象那里充分展开:变化的绝对性意味着个体无法外在于变化,所以个体必然与变化为一体;变化的绝对性还意味着变化是无限的,所以与变化为一体的个体也应该是无限的。在“以天下为一体”的整体感与自生独化的主体自觉中实现的“自得”,可能是魏晋玄学为宋明理学留下的一个宝贵启示。

关键词：魏晋玄学《世说新语》郭象嵇康自得

中华民族现代文明的“哲学自我”——马克思主义哲学与中国哲学会通的思维方式与思想追求

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东北师大学报（哲学社会科学版） 2024年第3期 1-8页

作者：胡海波东北师范大学马克思主义学部吉林长春130024

中华民族现代文明理念表征的是中国人对其生命体验的自我理解,塑造中华民族现代文明的“哲学自我”有赖于马克思主义哲学与中国哲学的会通。塑造“哲学自我”与实现“马中会通”,二者是一致的:一方面,当代中华民族在思想与实践上创造性... 详细信息

中华民族现代文明理念表征的是中国人对其生命体验的自我理解,塑造中华民族现代文明的“哲学自我”有赖于马克思主义哲学与中国哲学的会通。塑造“哲学自我”与实现“马中会通”,二者是一致的:一方面,当代中华民族在思想与实践上创造性地理解、运用与实现自己的文明理念,需要在现实性、实践性、哲学性以及历史时代性等方面探索马克思主义哲学与中国哲学的会通;另一方面,理解和把握中华民族现代文明的“哲学自我”,需要超越用西方哲学的模式解释中国哲学的哲学观,消解直观性、外在性、机械性的思维方式,以各自保有其个性特质的马克思主义哲学与中国哲学为基础,实现二者的真正会通。实现“马中会通”,需要真实地把握其思想实质、现实基础与哲学使命,阐明相关哲学观及其变革,揭示二者的内在契合性,澄明会通的连续性与时代超越性。只有在“马中会通”的基础上,才能憧憬当代中华民族走向未来的文明境界与塑造新的“哲学自我”。

关键词：中华民族现代文明哲学自我马克思主义哲学中国哲学会通

Clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride on mild-to-moderate depression

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World Journal of Psychiatry 2024年第6期14卷 848-856页

作者： Yi Wang Qun Lu Ittipalanukul Penpat Juan Wu Dilinuer Abulikemu Fei-Cui Zeng Jia-Ying huang Zhi-hai hu Department of Acupuncture and Moxibustion Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Laboratory Medicine Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of Postgraduate Student Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Radiology Shanghai Hospital of Integrated Traditional Chinese and Western MedicineThe Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200082China Department of General Practice Shanghai University of Traditional Chinese Medicine Affiliated Shuguang HospitalShanghai 200120China General Practice of Traditional Chinese Medicine North Bund Street Community Health Service CenterShanghai 200080China General Practice of Traditional Chinese Medicine Shanghai Hongkou District Jiaxing Road Community Health Service CenterShanghai 200082China

BACKGROUND Depression is a common,chronic,and recurrent mood disorder that has become a worldwide health hazard.Fluoxetine hydrochloride,a common treatment method,can inhibit 5-hydroxytryptamine(5-HT)recycling in the presynaptic membrane;however,the efficacy of a single drug is inadequate.At present,mildto-moderate depression can be treated with acupuncture of ghost caves,but the clinical curative effect of combined therapy with fluoxetine hydrochloride has not been sufficiently reported.AIM To evaluate the clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride in the treatment of mild-to-moderate depression.METHODS This retrospective study included 160 patients with mild-to-moderate depression who were admitted to Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Affiliated to Shanghai University of Traditional Chinese Medicine,between January 2022 and June 2023.Patients were separated into a single-agent group(fluoxetine hydrochloride treatment,n=80)and a coalition group(fluoxetine hydrochloride treatment combined with acupuncture at ghost points,n=80).Pre-treatment symptoms were recorded,and the clinical curative effect and adverse reactions[Asberg Antidepressant Side Effects Scale(SERS)]were assessed.Depression before and after treatment[Hamilton Depression Scale(HAMD)-24],neurotransmitter levels[5-HT,norepinephrine(NE),dopamine(DA)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)],and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were compared.RESULTS The total efficacy rate was 97.50%in the coalition group and 86.25%in the single-agent group(P<0.05).After 2,4,6,and 8 wk of treatment,the HAMD,self-rating depression scale,and SERS scores of the coalition and single-agent groups decreased compared with pre-treatment,and the decrease was more significant in the coalition group(P<0.05).After 8 wk of treatment,the levels of NE,DA,5-HT,and SOD in the coalition and single-agent groups increased,while the levels of MDA decreased;th

关键词： Depression Prick Fluoxetine hydrochloride Curative effect Depressive symptoms Oxidative stress index

消费盲从、生活附魅与精神虚空——数字资本主义社会的三重“异化”

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东北师大学报（哲学社会科学版） 2024年第1期 18-24页

作者：夏巍胡运海复旦大学马克思主义学院上海200433

依托于人工智能、大数据、5G、云等新型数字科技之翼,西方资本主义社会迈向了一个以数字化为特征的数字资本主义社会。在这一社会中,异化现象仍然存在。具体表现为,数字资本主义社会对消费观念进行了新塑造,算法指令的生成引发消费内容... 详细信息

依托于人工智能、大数据、5G、云等新型数字科技之翼,西方资本主义社会迈向了一个以数字化为特征的数字资本主义社会。在这一社会中,异化现象仍然存在。具体表现为,数字资本主义社会对消费观念进行了新塑造,算法指令的生成引发消费内容的私人定制化,数据平台的产生促成消费生态的重新架构,数字技术的普及致使消费主义的大肆泛滥,消费趋于盲从;对日常生活进行了全覆盖,其连续性与稳定性逐渐被数字信息的狂轰滥炸打破,呈现碎片化样态;日常生活的惬意与宁静逐渐被数据与算法的推送与订阅打破,显现出平庸化样态;对精神世界进行了新渗透,个体思想日趋浅薄空疏、大众审美日趋媚俗粗鄙、精神世界日趋虚无。厘清西方数字资本主义社会在消费、生活与精神层面产生的异化现象,对于我国今后在发展人工智能技术和数字技术避免异化现象的产生具有重要的警醒作用。

关键词：数字资本主义社会异化消费日常生活精神世界