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Impact of stage-specific limb function exercises guided by a selfmanagement education model on arteriovenous fistula maturation status

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World Journal of Clinical Cases 2024年第14期12卷 2316-2323页

作者： Yi Li Li-Jun huang Jian-Wen Hou dan-dan hu Department of Nursing The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Nephrology The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Head and Neck Surgery Zhejiang Cancer HospitalHangzhou 310000Zhejiang ProvinceChina School of Nursing Shangqiu Institute of TechnologyShangqiu 476005Henan ProvinceChina

BACKGROUND The exercise of limb function is the most economical and safe method to promote the maturation of arteriovenous fistula(AVF).However,due to the lack of a uni-fied exercise standard in China,many patients have insufficient awareness of the importance of AVF,leading to poor effectiveness of limb function exercise.The self-management education model can effectively promote patients to take pro-active health-related actions.This study focuses on the characteristics of patients during the peri-AVF period and conducts a phased limb function exercise under the guidance of the self-management education model to observe changes in fac-tors such as the maturity of AVF.AIM To assess the impact of stage-specific limb function exercises,directed by a self-management education model,on the maturation status of AVFs.METHODS This study is a randomized controlled trial involving 74 patients with forearm AVFs from the Nephrology Department of a tertiary hospital in Sichuan Province,China.Patients were randomly divided into an observation group and a control group using a random number table method.The observation group underwent tailored stage-specific limb func-tion exercises,informed by a self-management education model which took into account the unique features of AVF at various stages,in conjunction with routine care.Conversely,the control group was given standard limb function exercises along with routine care.The assessment involves the maturity of AVFs post-intervention,post-operative complications,and the self-management level of the fistula in both groups patients.Analyses were conducted using SPSS version 23.0.Count data were represented by frequency and percentage and subjected to chi-square test comparisons.Measurement data adhering to a normal distribution were presented as mean±SD.The independent samples t-test was utilized for inter-group comparisons,while the paired t-test was used for intra-group comparisons.For measurement data not fitting a normal distribution,the median and interquartile range were

关键词： Self-management Education model Stage-specific Limb function exercises Arteriovenous fistula Maturation status

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Comment on:Clinical Characteristics,Diagnosis,and Treatments for COVID-19

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Current Medical Science 2024年第3期44卷 667-668页

作者： Wen, Ying hu, Xin-dan Department of Infectious Diseases The First Affiliated Hospital of China Medical University Shenyang China

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Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.

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Chinese Journal of Natural Medicines 2023年第11期21卷 868-880页

作者： TANG Pan huANG dan ZHENG Kai-Xuan hu dan DAI Ping LI Chuan-hui QIN Sheng-Ying CHEN Guo-Dong YAO Xin-Sheng GAO Hao Institute of Traditional Chinese Medicine&Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of ChinaJinan UniversityGuangzhou 510632China Clinical Experimental Center First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

From the fungus Trichoderma sp., we isolated seven novel 18-residue peptaibols, neoatroviridins E-K ( 1−7 ), and six new 14-residue peptaibols, harzianins NPDG J-O ( 8−13 ). Additionally, four previously characterized 18-residue peptaibols neoatroviridins A-D ( 14−17 ) were also identified. The structural configurations of the newly identified peptaibols ( 1−13 ) were determined by comprehensive nuclear magnetic resonance (NMR) and high-resolution electrospray ionization tandem mass spectrometry (HR-ESI-MS/MS) data. Their absolute configurations were further determined using Marfey’s method. Notably, compounds 12 and 13 represent the first 14-residue peptaibols containing an acidic amino acid residue. In antimicrobial assessments, all 18-residue peptaibols ( 1 − 7 , 14 − 17 ) exhibited moderate inhibitory activities against Staphylococcus aureus 209P, with minimum inhibitory concentration (MIC) values ranging from 8−32 μg·mL^(−1). Moreover, compound 9 exhibited moderate inhibitory effect on Candida albicans FIM709, with a MIC value of 16 μg·mL^(−1).

关键词： Peptaibols Neoatroviridin Harzianin Trichoderma sp. Antibacterial activity

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Mutation in a non-force-bearing region of protein L influences force-dependent unfolding behavior

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Chinese Physics B 2024年第7期33卷 624-629页

作者：蒋环杰王艳伟陈家媛胡丹潘海郭子龙陈虎 Department of Physics Wenzhou UniversityWenzhou 325035China Center of Biomedical Physics Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Laboratory for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen 361005China

Single-molecule magnetic tweezers(MTs) have revealed multiple transition barriers along the unfolding pathway of several two-state proteins, such as GB1 and Csp. In this study, we utilized MTs to measure the force-dependent folding and unfolding rates of both protein L(PLWT) and its Y47W mutant(PLY47W) where the mutation point is not at the force-bearing β-strands. The measurements were conducted within a force range of 3–120 pN. Notably, the unfolding rates of both PLWT and PWY47W exhibit distinct force sensitivities below 50 pN and above 60 pN, implying a two-barrier free energy landscape. Both PLWT and PLY47W share the same force-dependent folding rate and the same transition barriers,but the unfolding rate of PLY47W is faster than that of PLWT. Our finding demonstrates that the residue outside of the force-bearing region will also affect the force-induced unfolding dynamics.

关键词： protein folding magnetic tweezers protein L

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Fatal multiple acyl-CoA dehydrogenase deficiency caused by ETFDH gene mutation:A case report

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World Journal of Clinical Cases 2024年第23期12卷 5422-5430页

作者： Xue-Xia Li Xiao-Nan Yang hu-dan Pan Liang Liu State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China State Key Laboratory of Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Multiple acyl-CoA dehydrogenase deficiency(MADD)is a disease of rare autosomal recessive disorder.There are three types of MADD.Type I is a neonatalonset form with congenital anomalies.Type II is a neonatal-onset form without congenital anomalies.Type III is considered to a milder form and usually responds to riboflavin.However,late-onset form could also be fatal and not responsive to treatments.CASE SUMMARY We report a severe case of a young man with onset type III MADD induced by drugs and strenuous exercise characterized by rhabdomyolysis and liver dysfunction.Urine analysis indicated 12 out of 70 kinds of organic acids like glutaric acid-2 were detected.Serum analysis in genetic metabolic diseases revealed 24 out of 43 tested items were abnormal,revealing the elevation of several acylcarnitines and the reduction of carnitine in the patient.By next generation sequencing technology for gene sequencing related to fatty acid oxidation and carnitine cycle defects,a rare ETFDH gene variant was identified:NM_004453:4:C.1448C>T(p.Pro483 Leu).The patient was diagnosed with lateonset GAII.He was not responsive to riboflavin and progressively worsened into multiple organ failure that finally led to death.CONCLUSION Type III MADD can also be fatal and not responsive to treatments.

关键词： Electron transfer flavoprotein dehydrogenase mutation Multiple acyl-CoA dehydrogenase deficiency Multiple organ failure Case report

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Downregulation of the circadian clock gene period 2 aggravates prognosis in breast cancer patients with obesity

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Oncology and Translational Medicine 2024年第2期10卷 73-78页

作者： Ru-Xing Wu dan hu Han-Wang Zhang Xiao-Yuan huang Liang Zhuang Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Cancer Biology Research Centre Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Cancer Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Background:Obese individuals diagnosed with breast cancer often experience a less favorable prognosis;however,the underlying mechanisms linking obesity to breast cancer outcomes remain elusive.This study aimed to identify and validate novel prognostic markers associated with breast cancer in patients with obesity.Methods:We conducted a reanalysis of gene expression profiles from normal-weight,overweight,and obese breast cancer patients to identify candidate genes.Subsequently,we validated the protein levels of these candidates using immunohistochemistry.Finally,we investigated the association between candidate genes and breast cancer prognosis at Tongji Hospital,utilizing data from an 8-year follow-up through the Kaplan-Meier method and univariate and multivariate Cox regression models.Results:The fold change of the circadian clock gene period 2(PER2),which exhibited a declining trend with increasing body mass index,was 0.76 in obese patients compared with normal-weight patients.The expression rates of PER2 protein were 44.7%,51.5%,and 61.3%in normal-weight,overweight,and obese patients,respectively.The 8-year recurrence-free survival rates were 75.9%,69.6%,and 64.1%,whereas the 8-year overall survival rates were 86.8%,83.0%,and 76.1%in normal-weight,overweight,and obese patients,respectively(P<0.05).Furthermore,the 8-year recurrence-free survival rates were 66.2%and 76.4%,and the 8-year overall survival rates were 79.9%and 86.3%in the low and high PER2 expression groups,respectively(P<0.05).The unadjusted hazard ratio for PER2 was 1.550(95%confidence interval,1.029–2.335),and the adjusted hazard ratio was 3.003(95%confidence interval,1.838–4.907).Conclusions:Our findings indicate that low PER2 expression serves as an independent risk factor for breast cancer prognosis and may contribute to the unfavorable outcomes observed in obese patients.

关键词： Breast cancer Obesity PER2 Prognosis

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混合所有制改革、跨国技术授权与社会福利——基于混合寡头模型的研究

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运筹与管理 2024年第4期33卷 226-232页

作者：李攀艺胡丹重庆理工大学经济金融学院重庆400054

为探究混合所有制改革过程中公有企业民营化对技术创新传播及本国社会福利产生的影响,将跨国技术授权与混合所有制改革相结合,构建一个存在成本差异的本国公有企业与私有企业进行古诺竞争的混合寡占模型,通过比较混合寡头和私有寡头两... 详细信息

为探究混合所有制改革过程中公有企业民营化对技术创新传播及本国社会福利产生的影响,将跨国技术授权与混合所有制改革相结合,构建一个存在成本差异的本国公有企业与私有企业进行古诺竞争的混合寡占模型,通过比较混合寡头和私有寡头两种市场下外国非生产型技术持有者的最优授权范围,探讨了跨国技术授权时公有企业民营化对社会福利产生的影响。研究表明,无论哪种市场结构下技术持有者最优授权范围都取决于两类企业间的成本差距和技术创新程度;跨国技术授权时公有企业民营化能否提高本国社会福利水平具有不确定性,只有当成本差距或技术创新程度较大时,民营化才有利于提高跨国技术授权带来的社会福利。研究结论对于微观层面的企业选择跨国授权策略,以及宏观层面上国家完善技术进口政策与推动混合所有制改革具有重要实践启示。

关键词：跨国技术授权混合寡头民营化社会福利

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Dual Extended Kalman Filter for Combined Estimation of Vehicle State and Road Friction

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Chinese Journal of Mechanical Engineering 2013年第2期26卷 313-324页

作者： ZONG Changfu hu dan ZHENG Hongyu State Key Laboratory of Automotive Simulation and Control Jilin University

Vehicle state and tire-road adhesion are of great use and importance to vehicle active safety control systems. However, it is always not easy to obtain the information with high accuracy and low expense. Recently, many estimation methods have been put forward to solve such problems, in which Kalman filter becomes one of the most popular techniques. Nevertheless, the use of complicated model always leads to poor real-time estimation while the role of road friction coefficient is often ignored. For the purpose of enhancing the real time performance of the algorithm and pursuing precise estimation of vehicle states, a model-based estimator is proposed to conduct combined estimation of vehicle states and road friction coefficients. The estimator is designed based on a three-DOF vehicle model coupled with the Highway Safety Research Institute（HSRI） tire model; the dual extended Kalman filter （DEKF） technique is employed, which can be regarded as two extended Kalman filters operating and communicating simultaneously. Effectiveness of the estimation is firstly examined by comparing the outputs of the estimator with the responses of the vehicle model in CarSim under three typical road adhesion conditions（high-friction, low-friction, and joint-friction）. On this basis, driving simulator experiments are carried out to further investigate the practical application of the estimator. Numerical results from CarSim and driving simulator both demonstrate that the estimator designed is capable of estimating the vehicle states and road friction coefficient with reasonable accuracy. The DEKF-based estimator proposed provides the essential information for the vehicle active control system with low expense and decent precision, and offers the possibility of real car application in future.

关键词： vehicle state road friction coefficient estimation dual extended Kalman filter （DEKF）

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Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui Chen LI Yan ZHANG Jun Feng LIU Sheng hui hu dan He XU Chong Xiao YIN Jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong NIE Kai LIANG Guo Dong TAO Yong XU Song Tao MA Chao Feng WANG huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human health.It is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other viruses.The laboratory diagnosis of viral encephalitis is a worldwide challenge.Recently,high-throughput sequencing technology has provided new tools for diagnosing central nervous system infections.Thus,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon sequencing.Methods We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant literature.The detection ability of the primers was verified by software simulation and the detection of known positive samples.Amplicon sequencing was used to validate the samples,and consistency was compared with Sanger sequencing.Results The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted amplicons.The sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger sequencing.Conclusion Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral encephalitis.It is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

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智能户外冲锋衣的设计与研发

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北京服装学院学报（自然科学版） 2024年第1期44卷 87-94页

作者：胡丹赵蒙蒙上海工程技术大学纺织与服装学院上海201620

为监测户外运动中的安全风险,设计了一款可实时监测人体皮肤温湿度的智能户外冲锋衣。使用Arduino和MIT App Inventor 2平台,从硬件到软件进行了设计与研发。使用DHT11和iButton温湿度传感器分别在胸部、腋下对衣下空间温湿度进行数据... 详细信息

为监测户外运动中的安全风险,设计了一款可实时监测人体皮肤温湿度的智能户外冲锋衣。使用Arduino和MIT App Inventor 2平台,从硬件到软件进行了设计与研发。使用DHT11和iButton温湿度传感器分别在胸部、腋下对衣下空间温湿度进行数据收集、分析与对比。实验结果表明:DHT11所测得的温湿度数据吻合度较高,能够表征实际衣下空间温湿度;在智能户外冲锋衣的测量点位中,在表征实际衣下空间温湿度时胸部比腋下具有更好的稳定性;DHT11温湿度传感器的温度需补偿校正0.36℃,湿度需要补偿校正5.02%。

关键词：智能户外冲锋衣 Arduino MIT App Inventor 2 DHT11 iButton

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