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Risk factor for ischemic-type biliary lesion after ABO-incompatible living donor liver transplantation

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World Journal of Gastroenterology 2016年第30期22卷 6925-6935页

作者： Jun Bae Bang Bong-Wan Kim Young Bae Kim Hee-Jung Wang Hyun Yeong Lee Joohyun Sim Taegyu Kim Kyeong Lok Lee Xu-guang hu Wei Mao Department of Liver Transplantation and Hepatobiliary Surgery Ajou University School of Medicine Department of Pathology Ajou University School of Medicine Department of Biostatistics Ajou University School of Medicine

AIM: To evaluate the risk factors for ischemic-type biliary lesion(ITBL) after ABO-incompatible(ABO-I) adult living donor liver transplantation(ALDLT).METHODS: Among 141 ALDLTs performed in our hospital between 2008 and 2014, 27(19%) were ABO-I ALDLT and 114 were ABO-identical/compatible ALDLT. In this study, we extensively analyzed the clinico-pathological data of the 27 ABO-I recipients to determine the risk factors for ITBL after ABO-I ALDLT. All ABO-I ALDLT recipients underwent an identical B-cell depletion protocol with preoperative rituximab, plasma exchange(PE), and operative splenectomy. The median follow-up period after transplantation was 26 mo. The clinical outcomes of the 27 ABO-I ALDLT recipients were compared with those of 114 ABO-identical/compatible ALDLT ***: ITBL occurred in four recipients(14.8%) between 45 and 112 d after ABO-I ALDLT. The overall survival rates were not different between ABO-I ALDLT and ABO-identical/compatible ALDLT(P = 0.303). Among the ABO-I ALDLT recipients, there was no difference between patients with ITBL and those without ITBL in terms of B-cell and T-cell count, serum isoagglutinin titers, number of PEs, operative time and transfusion, use of graft infusion therapy, or number of remnant B-cell follicles and plasma cells in the spleen. However, the perioperative NK cell counts in the blood of patients with ITBL were significantly higher than those in the patients without ITBL(P 150/μL and postoperative NK cell count > 120/μL were associated with greater relative risks(RR) for development of ITBL(RR = 20 and 14.3, respectively, P < 0.05). CONCLUSION: High NK cell counts in a transplant recipient's blood are associated with ITBL after ABO-I ALDLT. Further research is needed to elucidate the molecular mechanism of NK cell involvement in the development of ITBL.

关键词： Liver transplantation ABO-incompatibility Ischemic-type biliary lesion Natural killer cell

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塔河油田TK305井井筒沥青质沉积防治

油田化学 2006年第1期23卷 12-14,26页

作者：胡广杰中国石化西北分公司塔河采油一厂新疆轮台841600

塔河油田奥陶系油藏（地温126℃）多口采油井井筒出现沥青质沉积，其中TK305井多次处理无效而停产，连续注入掺沥青分散稳定剂SLAD-02（主要成分为大分子含氟表面活性剂）的原油，使该井恢复生产。TK305井沥青质沉积物含沥青质60．19％... 详细信息

塔河油田奥陶系油藏（地温126℃）多口采油井井筒出现沥青质沉积，其中TK305井多次处理无效而停产，连续注入掺沥青分散稳定剂SLAD-02（主要成分为大分子含氟表面活性剂）的原油，使该井恢复生产。TK305井沥青质沉积物含沥青质60．19％，含胶质7．64％，85℃时不流动，95℃时较易流动，在120℃不溶于性质与TK305井原油相近的S86井原油（稀油），在塔一联原油（稠油）中溶解率为4.8％，在加入0．4％SLAD-02的塔一联原油中溶解率达30．13％，混入高达50％的模拟地层水基本上不影响加剂塔一联原油对沥青质沉积物的溶解率。溶解了沥青质沉积物的加剂塔一联原油与S86井原油的等量混合油，30~60℃黏度在50～350mPa·s之间，在井筒内可正常举升。TK305井井筒沉积沥青质沉积物4800m，用SLAD-02处理解堵后，2005年8月13日～10月6日期间通过环空注入加剂塔一联原油，根据产出油黏度调整加剂原油注入量和地层产油量，10月1日～6日期间进行评价．累计注入加剂原油550．2m^3，累计地层产油399．9m^3，注采比1：0．73，该并恢复了生产。图4表4参5。

关键词：沥青质沉积井简采油井沥青质分散稳定剂井下处理有机沉积防治塔河油田 TK305井

多径衰落环境下采用参考信道的自适应混合捕获

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上海交通大学学报 2005年第4期39卷 623-625页

作者：宋阳胡光锐许光辉上海交通大学电子工程系上海200030

引入参考信道方法实现直序扩频系统PN码的自适应混合捕获,判决门限由参考信道采用单元平均恒虚警方法自适应设置.由于2个信道的本地PN码相位差远大于多径信号的最大时延,参考信道不会出现多径信号,因此能有效消除多径干扰对捕获系统的影... 详细信息

引入参考信道方法实现直序扩频系统PN码的自适应混合捕获,判决门限由参考信道采用单元平均恒虚警方法自适应设置.由于2个信道的本地PN码相位差远大于多径信号的最大时延,参考信道不会出现多径信号,因此能有效消除多径干扰对捕获系统的影响.对提出的参考信道捕获方法性能进行分析.仿真结果表明,提出的方法在良性环境下具有接近传统单元平均方法的性能,而多径衰落下性能明显优于传统的单元平均方法.

关键词：伪随机码恒虚警率多径干扰

Blast resistance evaluation of urban utility tunnel reinforced with BFRP bars

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Defence Technology（防务技术） 2021年第2期17卷 512-530页

作者： Qiang Zhou hu-guang He San-feng Liu Xiao-shuo Chen Ze-xun Tang Yang Liu Zhen-yu Qiu Sen-sen Li He Wang Yin-zhi Zhou Jian-nan Zhou hua-lin Fan Feng-nian Jin State Key Laboratory for Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China Research Center of Lightweight Structures and Intelligent Manufacturing State Key Laboratory of Mechanics and Control of Mechanical StructuresNanjing University of Aeronautics and AstronauticsNanjing210016China

To improve corrosion-resistance of shallow-buried concrete urban utility tunnels(UUTs),basalt fiber reinforced polymer(BFRP)bars are applied to reinforce *** the UUT must have excellent survival capability under accidental explosions,a shallow-buried BFRP bars reinforced UUT(BBRU)was designed and *** blast experiments were carried out on this *** responses,damage evolutions and failure styles of the BBRU under repetitive explosions were *** tunnel roof is the most vulnerable component and longitudinal cracks develop along the *** the scaled distance is larger than 1.10 m/kg1/3,no cracks are observed in the *** the BBRU is severely damaged,there are five cracks forming and developing along the *** roof is simplified as a clamped-supported one-way slab,proved by the observation that the maximum strain of the transverse bar is much larger than that of the longitudinal *** responses of the roof slab are predicted by dynamic Euler beam theory,which can consistently predict the roof displacement under large-scaleddistance *** with the UUT reinforced with steel bars,the BBRU has advantages in blast resistance with smaller deflections and more evenly-distributed cracks when the scaled distance is smaller than 1.260 m/kg1/3 and the steel bars enter plastic *** elastic defamation of the BFRP bars endows the UUT more excellent blast resistance under small-scaled-distance explosions.

关键词： Utility tunnel BFRP bars Explosion Dynamic response Crack Dynamic theory

Identification of Low-Frequency Zonal Flow in a Linear Magnetic Plasma Device

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Chinese Physics Letters 2011年第2期28卷 156-159页

作者： CHEN Ran XIE Jin-Lin YU Chang-Xuan LIU A-Di LAN Tao ZHANG Shou-Biao hu guang-Hai LI Hong LIU Wan-Dong CAS Key Laboratory of Plasma Physics Department of Modern PhysicsUniversity of Science and Technology of ChinaHefei 230026

A low-frequency(f<2 kHz)potential structure(LFPS)is observed in a linear magnetic plasma device using Langmuir probe *** center frequency of this structure is near *** structure has azimuthal and axial symmetries while with a finite radial *** complete 3D spectra features of this structure have been identified to have the characteristics expected for zonal flows.

关键词： number structure radial

VPSA变压吸附制氧技术在制浆过程中的应用

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中国造纸 2011年第3期30卷 49-51页

作者：胡光勇云南云景林纸股份有限公司云南普洱666400

氧漂白是清洁制浆的必需工艺。VPSA变压吸附制氧控制系统操作方便,维护简单,投资少,运行费用低,在国内越来越多的纸浆企业得以广泛应用。

关键词：氧漂白变压吸附制氧控制系统清洁制浆

Investigation on the Metabolism of Salvianolic acid B, Tanshinone Ⅱ A, Ginsenoside Rg1 and Ginsenoside Rb1 from Danshen-Sanqi Herbal Pair in Zebrafish by Liquid Chromatography-Tandem Mass Spectrometry Analysis

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Clinical Complementary Medicine and Pharmacology 2021年第1期1卷 1-8页

作者： Shijun Yin Congpeng Zhao guang hu hua Chen Fengqing Yang School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China

Background:Salvianolic acid B(SAB),tanshinone IIA(TIIA),ginsenoside Rg1(GRg1)and ginsenoside Rb1(GRb1)are the main active components of Danshen-Sanqi herbal pair(DS-SQ),which is widely used in the treatment of cardiovascular diseases in *** compatibility mechanisms of compound Chinese herbal preparation may be clarified to some degree by understanding the interactions of the active components based on their metabolic ***,zebrafish is a convenient and feasible model to study the metabolism of ***:To investigate the metabolism of SAB,TIIA,GRg1 and GRb1 in zebrafish by liquid chromatography-tandem mass spectrometry(LC-MS/MS)***:Zebrafish embryos after 48-hour hatching were divided into nine experimental *** blank group was exposed to 1 mL ultra-pure *** drug-treated groups were exposed to 1 mL solution of SAB,TIIA,GRg1,GRb1,SAB and GRg1,SAB and GRb1,TIIA and GRg1,TIIA and GRb1,*** homogenization,they were analyzed by LC-MS/*** Structures of the metabolites were determined by analyzing their corre-sponding mass spectra information and comparing the data with relevant *** to the change of the amount of metabolites,the metabolic effect between SAB,TIIA,GRg1 and GRb1 were ***:Eighteen metabolites and four parent drugs of SAB,TIIA,GRg1 and GRb1 in zebrafish were identified by LC-MS/MS,including methylation,degradation,reduction,dehydrogenation,hydroxylation,desugarization and glucuronidation ***,after being combined exposed of drugs,GRg1 and GRb1 could promote the metabolism of TIIA,while SAB and TIIA could promote the metabolism of GRg1 and GRb1 to different ***:By using LC-MS/MS analysis,zebrafish was successfully applied to study the metabolism of SAB,TIIA,GRg1 and GRb1,which is significance to explain the possible synergistic effect of components in DS-SQ through modifying the metabolism in *** study can be helpfu

关键词： Zebrafish Danshen-Sanqi herbal pair Metabolite Metabolic pathways Synergistic effect

Specific targeting of angiogenesis in lung cancer with RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a 4.7T magnetic resonance scanner

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Chinese Medical Journal 2013年第12期126卷 2242-2247页

作者： LIU Can LIU Dong-bo LONG Guo-xian WANG Jun-feng MEI Qi hu guang-yuan QIU Hong hu Guo-qing Cancer Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China Department of Oncology Puai Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430035 China

Background Angiogenesis is an essential step for tumor development and *** cell adhesion molecule αvβ3 integrin plays an important role in angiogenesis and is a specific marker of tumor angiogenesis.A novel αvβ3 integrintargeted magnetic resonance （MR） imaging contrast agent utilizing Arg-Gly-Asp （RGD） and ultrasmall superparamagnetic iron oxide particles （USPIO）（referred to as RGD-USPIO） was designed and its uptake by endothelial cells was assessed both in vitro and in vivo to evaluate the angiogenic profile of lung *** USPIO were coated with-NH3＋ and conjugated with RGD *** blue staining was performed to evaluate the specific uptake of RGD-USPIO by human umbilical vein endothelial cells （huVECs）.Targeted uptake and subcellular localization of RGD-USPIO in huVECs were confirmed by transmission electron microscopy （TEM）.The ability of RGD-USPIO to noninvasively assess αvβ3 integrin positive vessels in lung adenocarcinoma A549 tumor xenografts was evaluated with a 4.7T MR *** was used to detect αvβ3 integrin expression and vessel distribution in A549 tumor *** huVECs internalized RGD-USPIO significantly more than plain *** uptake of RGD-USPIO by huVECs could be competitively inhibited by addition of free RGD.A significant decrease in T2 signal intensity （SI） was observed at the periphery of A549 tumor xenografts at 30 minutes （P 〈0.05） and 2 hours （P 〈0.01） after RGD-USPIO was injected via the tail *** blood vessels were mainly distributed in the periphery of tumor xenografts with positive αvβ3 integrin *** RGD-USPIO could specifically label αvβ3 integrin and be taken up by *** molecular MR imaging contrast agent can specifically evaluate the angiogenic profile of lung cancer using a 4.7T MR scanner.

关键词： ultrasmall superparamagnetic iron oxide particles Arg-Gly-Asp avfβ magnetic resonance imaging

Castleman disease in the neck with postoperative hemorrhage in children

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中国口腔颌面外科杂志 2008年第B5期6卷 176-177页

作者： Jing Zhou hu Han guang Zhu Zhi Yuan Zhang Department of Oral and Maxillofacial Surgery College ofStomatology Ninth People's Hospital School of MedicineShanghai JiaoTong University. Shanghai 200011 China