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Does ergogenic effect of caffeine supplementation depend on CYP1A2 genotypes? A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第4期13卷 499-508页

作者： Jieping Wang Luthfia Dewi Yundong Peng chien-wen Hou Yanmin Song Giancarlo Condello Laboratory of Exercise Biochemistry University of TaipeiTianmu CampusTaipei 11153China Department of Emergency Medicine National Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangsha 410008China Department of Nutrition Universitas Muhammadiyah SemarangSemarang 50273Indonesia School of Sports Medicine and Rehabilitation Beijing Sport UniversityBeijing 10084China Department of Medicine and Surgery University of ParmaParma 43126Italy

Background:The ergogenic effects of caffeine intake on exercise performance are well-established,even if differences exist among individuals in response to caffeine *** genetic variation of a specific gene,human cytochrome P450 enzyme 1A2(CYP1A2)(rs762551),may be one reason for this *** systematic review and meta-analysis aimed to comprehensively evaluate the influence of CYP1A2 gene types on athletes’exercise performance after caffeine ***:A literature search through 4 databases(Web of Science,PubMed,Scopus,and China National Knowledge Infrastructure)was conducted until March *** effect size was expressed as the weighted mean difference(WMD)by calculating fixed effects meta-analysis if heterogeneity was not significant(I^(2)≤50%and p≥0.1).Subgroup analyses were performed based on AA and AC/CC genotype of ***:The final number of studies meeting the inclusion criteria was 12(n=666 participants).The overall analysis showed that the cycling time trial significantly improved after caffeine intake(WMD=-0.48,95%confidence interval(95%CI):-0.83 to-0.13,p=0.007).In subgroup analyses,acute caffeine intake improved cycling time trial only in individuals with the A allele(WMD=-0.90,95%CI:-1.48 to-0.33,p=0.002),but not the C allele(WMD=-0.08,95%CI:-0.32 to 0.17,p=0.53).Caffeine supplementation did not influence the Wingate(WMD=8.07,95%CI:-22.04 to 38.18,p=0.60)or countermovement jump test(CMJ)performance(WMD=1.17,95%CI:-0.02 to 2.36,p=0.05),and these outcomes were not influenced by CYP1A2 ***:Participants with the CYP1A2 genotype with A allele improved their cycling time trials after caffeine ***,compared to placebo,acute caffeine supplementation failed to increase the Wingate or CMJ performance,regardless of CYP1A2 genotype.

关键词： Countermovement jump test Endurance Ergogenic aid Gene polymorphism Wingate

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Retinal vein occlusion coinciding with paracentral acute middle maculopathy in patient with menorrhagia causing life-threatening anemia

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1760-1762页

作者： wen-Yun Lin Jin-Jhe Wang chien-hsiung Lai School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Department of Ophthalmology Chang Gung Memorial HospitalChiayi 61363TaiwanChina Department of Nursing Chang Gung University of Science and TechnologyChiayi 61363TaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

Dear Editor,We present two cases of retinal vein occlusion,one central retinal vein occlusion(CRVO)and one branch retinal vein occlusion(BRVO)respectively,coinciding with paracentral acute middle maculopathy(PAMM)on optical coherence tomography(OCT)in patients with menorrhagia causing life-threatening *** is considered a manifestation of acute ischemia affecting the deep macular capillary plexus.

关键词： anemia occlusion acute

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质子重离子肿瘤放疗的临床注册试验初步报告

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中华肿瘤杂志 2018年第1期40卷 52-56页

作者：陆嘉德叶明郭小毛傅深 Moyers F. Michael 章青茅静芳孔琳 hsi wen chien Shahnazi Kambiz 赵静芳章真马秀梅来松涛张晓萌麻宁一高云生蔡昕管西寅张军华吴斌程竞仪盛尹祥子任炜赵俊孙力宁蒋国梁上海市质子重离子医院放疗科 201315 上海市质子重离子医院物理科 201315 上海市质子重离子医院放射诊断科 201315 上海市质子重离子医院核医学科 201315 上海交通大学医学院仁济医院放疗科 200127 复旦大学附属肿瘤医院放疗科上海200032 复旦大学附属肿瘤医院放射诊断科上海200032 复旦大学附属肿瘤医院核医学科上海200032 上海交通大学医学院瑞金医院放疗科 200025

目的探讨IONTRIS粒子放疗设备临床应用的安全性和有效性。方法2014年6月至2014年8月间共有35例肿瘤患者入组，其中男性31例，女性4例：年龄36～80岁，中位年龄69岁。头颈肿瘤10例（均为手术后复发），胸部肿瘤4例，原发性肝癌1例，腹膜... 详细信息

目的探讨IONTRIS粒子放疗设备临床应用的安全性和有效性。方法2014年6月至2014年8月间共有35例肿瘤患者入组，其中男性31例，女性4例：年龄36～80岁，中位年龄69岁。头颈肿瘤10例（均为手术后复发），胸部肿瘤4例，原发性肝癌1例，腹膜后肉瘤术后复发1例．前列腺癌19例。碳离子照射剂量为2．74—10GyE／次，质子照射剂量为2—5．5GyE／次，5次／周。放疗前对每个放射野进行水箱剂量验证。结果碳离子照射22例，质子照射13例。放疗后1年，35例患者全部生存。在16例头颈部、胸部和腹盆腔肿瘤患者中，完全缓解2例，部分缓解1例，疾病稳定12例，疾病进展1例，1年无进展生存率为93．8％（15／16）。19例前列腺癌患者的1年无生化复发生存率为100％。35例患者对粒子放疗的耐受性良好，放疗期间的美国东部肿瘤协作组评分和体重无明显改变。25例（71．4％）患者发生了与粒子放疗相关的急性不良事件（AE）33例次，均为1级．在放疗1年时急性AE全部消失。有6例（17．1％）患者在放疗后1年发生后期AE6例次，全部为1级。结论采用IONTRIS设备治疗肿瘤患者安全、有效。

关键词：肿瘤质子重离子放射治疗临床试验

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Spilled gallstone mimicking intra-abdominal seeding of gallbladder adenocarcinoma: A case report

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 622-627页

作者： Cheng-Ken Huang Ruey-Hwa Lu chien-Cheng Chen Po-Chun Chen wen-Chang Hsu Meng-Jui Tsai Chin-Tsung Ting Division of Gastrointestinal Surgery Department of SurgeryRen-Ai BranchTaipei City HospitalTaipei 106TaiwanChina Division of General Surgery Department of SurgeryZhongxing BranchTaipei City HospitalTaipei 103TaiwanChina School of Medicine Institute of Traditional MedicineNational Yang-Ming UniversityTaipei 112TaiwanChina Department of Health and Welfare University of TaipeTaipe 104TaiwanChina

BACKGROUND Gallbladder rupture is common in laparoscopic cholecystectomy because the gallbladder is usually in acute or chronic inflammation *** gallstones may sometime be spilled into the peritoneal cavity,resulting in intra-abdominal ab-scess if the gallstones were not *** diagnosis of intra-abdominal ab-scess caused by unretrieved gallstone can usually be correctly identified in the routine imaging studies,such as abdominal ultrasonography or computed tomo-graphy(CT).Here we present a case of abscess formation from unretrieved gall-stone following laparoscopic cholecystectomy,which mimics the imaging findings of metastatic gallbladder *** SUMMARY This case described a 78-year-old man who received laparoscopic cholecystectomy and gallbladder adenocarcinoma was diagnosed after *** adjuvant chemotherapy,the following up abdominal CT showed several small nodules at right upper abdomen and peritoneal carcinomatosis is *** laparoscopic surgery for the excision of seeding tumor was conducted and the pathological diagnosis of the nodules and mass was inflammatory tissues and gallbladder *** Spilled gallstones are a common complication during laparoscopic cholecystectomy and some gallstones fail to be retrieved due to the size or the restricted view of laparoscopic *** spilled gall bladder stones,surgeons may consider regular computerized tomography follow-up,and if necessary,laparoscopic examination can be used as a means of confirming the diagnostic and treatment.

关键词： Laparoscopic cholecystectomy Gallstone spillage Gallbladder cancer Mimicked cancerous Case report

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Structure,bioavailability and physicochemical properties of icariin-soymilk nanoparticle

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Food Science and Human Wellness 2024年第2期13卷 972-981页

作者： Jinping Wang Lingrong wen Yueming Jiang Hong Zhu Weizheng Sun Guangyi Dai Bao Yang Guangdong Provincial Key Laboratory of Applied Botany Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic ImprovementSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China South China National Botanical Garden Guangzhou 510650China College of Food Science and Engineering Jilin Agricultural UniversityChangchun 130118China University of Chinese Academy of Sciences Beijing 100049China School of Food Sciences and Engineering South China University of TechnologyGuangzhou 510640China

Soymilk is a natural ***,the performance of flavonoid-soymilk nano-complex remains *** this work,icariin-soymilk nano-complexes(ISNCs)were successfully fabricated and *** effects of high-pressure homogenization(HPH)treatment on structure and physicochemical properties of soymilk and nano-complexes were *** treatment could significantly improve the surface hydrophobicity and interfacial activity of *** soymilk with HPH treatment could significantly improve the water solubility(20 folds),thermal stability and bioavailability of *** highest encapsulation efficiency(93.28%),loading capacity(39.09μg/mg),ζ-potentia(absolute value,31.20 mV)and bioavailability(72.14%)were observed in hsi-200(200 bar of homogenization pressure).While hsi-500(500 bar of homogenization pressure)showed the smallest particle size(183.73 nm).ISNCs showed a rougher surface and an irregular lamellar structure with large amount of fine particles by using Cryo-SEM,suggesting that icariin was encapsulated in *** data supplied a novel strategy to improve the performance of icariin in functional foods.

关键词： Encapsulation efficiency Flavonoid High pressure homogenization Loading capacity Nano-complex

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Prognostic factors of early recurrence after complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Clinical Cases 2024年第27期12卷 6057-6069页

作者： Chao-Yu Chen Tzu-Hao Huang Li-wen Lee Jrhau Lung Yu-Che Ou chien-Hui Hung Huei-Chieh Chuang Min-Chi Chen Ting-Yao Wang Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayi 613Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Research and Development Chang Gung Memorial HospitalChiayi 613Taiwan Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalChiayi 613Taiwan Department of Public Health Chang Gung UniversityTaoyuan 333Taiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayi 613Taiwan

BACKGROUND Although cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)offer the potential for long-term survival in peritoneal carcinomatosis,outcomes following CRS/HIPEC vary *** To identify the clinical factors associated with progression-free survival(PFS)after complete CRS/HIPEC in patients with colorectal/high-grade appendiceal,ovarian,and gastric *** We retrospectively evaluated the risk of recurrence within 1 year after CRS/HIPEC and its impact on overall survival(OS)in patients recruited between 2015 and *** regression models were used to assess the prognostic factors for the risk of recurrence within 1 ***–Meier survival curves and Cox proportional hazards models were used to evaluate the association between recurrence and *** Of the 80 enrolled patients,39 had an unfavorable PFS(12 was associated with a lower rate of achieving CC-0(P=0.027).The favorable PFS group had a significantly longer OS(median 81.7 mo vs 17.0 mo,P<0.001).CONCLUSION Achieving CC-0 was associated with a lower early recurrence rate and improved long-term *** study underscores the importance of selecting appropriate candidates for CRS/HIPEC to manage peritoneal carcinomatosis.

关键词： Peritoneal metastasis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Predictor Recurrence

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基层全科医生岗位胜任力评价指标体系的构建研究

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中国全科医学 2024年第13期27卷 1568-1572,1615页

作者：王星又苏巧俐李双庆钱庆文清华大学医院管理研究院广东省深圳市518055 成都高新区芳草社区卫生服务中心四川省成都市610094 四川大学华西医院全科医学科四川省成都市610041

背景分级诊疗制度是深化医药卫生体制改革、建立中国特色基本医疗卫生制度的重要内容。基层医疗卫生机构是分级诊疗服务体系的必要组成部分,承担居民健康“守门人”的职责。全科医生作为基层医疗卫生机构的核心人才要素,其岗位胜任力直... 详细信息

背景分级诊疗制度是深化医药卫生体制改革、建立中国特色基本医疗卫生制度的重要内容。基层医疗卫生机构是分级诊疗服务体系的必要组成部分,承担居民健康“守门人”的职责。全科医生作为基层医疗卫生机构的核心人才要素,其岗位胜任力直接影响医疗机构的服务能力。目的构建基层全科医生岗位胜任力评价指标体系,为基层医疗卫生机构开展全科医生岗位胜任力评价提供依据。方法于2022年9—12月,通过德尔菲专家咨询法对13位行业专家进行咨询;运用层次分析法与熵值法确认指标权重。结果本研究通过两轮德尔菲专家咨询对指标体系进行优化筛排,最终构建了由5个一级指标、27个二级指标组成的基层全科医生岗位胜任力评价指标体系。通过层次分析法结合熵值法明确各级指标权重,其中基本公共卫生服务能力指标权重最高,为核心指标。指标体系通过小样本信效度检测,均处于可接受水平。结论初步构建了基层全科医生岗位胜任力评价指标体系,有助于基层医疗卫生机构选贤任能,为评价基层全科医生岗位胜任力评价提供参考依据。

关键词：基层全科医生岗位胜任力评价指标指标体系德尔菲专家咨询法层次分析法

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The designing strategies of graphene-based peroxidase mimetic materials

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Science China Chemistry 2018年第3期61卷 266-275页

作者： Yanjie wen Linyin Yan Yong-chien Ling Taiwan Tsing Hua University Hsinchu 30013 Taiwan China Beijing National Laboratory for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Natural enzymes have been praised highly as ideal catalysts, presumably owing to their remarkable advantages of high efficiency,high selectivity, and mild reaction conditions. The reports of chemical simulation and systematic synthesis of natural enzymes such as peroxidase(POD) are rare because of their complex biological structures. POD represents a large family of oxidoreductases and offers a wide range of applications in many fields of science. Recent advance in the fusion of nanomaterial, catalysis, and biochemistry has inspired the development of artificial enzymes implemented with desired catalytic features of natural ***, we review the redox chemistry of POD and compare its catalytic performance to graphene-based nanomaterials(G-NMs)as POD mimetic nanoenzymes bases on catalytic center, binding site, and carrier function. Based on the viewpoints of stereo chemistry and molecular kinetic and dynamics in heterogeneous system, we evaluate and compare the suitability of different NMs as artificial enzyme constituent. We propose that reevaluates design strategies of graphene-based peroxidase(G-POD) mimetic materials and emphasizes on their selectivity(role as catalytic center, binding site, or carrier) is of uttermost.

关键词： graphene graphene oxide graphene-based composites artificial enzymes biomimetic chemistry nanozymes functionalnanomaterials

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VISCOPLASTIC COLLAPSE OF SHARP-NOTCHED CIRCULAR TUBES UNDER CYCLIC BENDING

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Acta Mechanica Solida Sinica 2013年第6期26卷 629-641页

作者： Kuo-Long Lee chien-Min Hsu wen-Fung Pan Department of Computer Application Engineering Far East University Department of Interior Design Tung Fang Design University Department of Engineering Science National Cheng Kung University

This study discusses the experimental result of the viscoplastic response and col- lapse of sharp-notched 316L stainless steel tubes with different notched depths subjected to cyclic bending. The tube bending machine and curvature-ovalization measurement apparatus were used for conducting the symmetric curvature-controlled cyclic bending. To highlight the viscoplastic behavior, three different curvature-rates, 0.0035, 0.035 and 0.35 m-1s-1, were controlled. Ob- servations of a certain curvature-rate reveal that five almost parallel lines corresponding to five different notch-depth （0.2, 0.4, 0.6, 0.8 and 1.0 mm） tubes were presented in the experimental relationship between the cyclic controlled curvature and the number of cycles needed to pro- duce buckling on a log-log scale. However, the slopes for the three different curvature-rates are different. An empirical formulation was proposed to simulate the aforementioned relationship. When comparing with the experimental findings, the simulation was in good agreement with the experimental data.

关键词： viscoplastic collapse sharp-notched circular tube cyclic bending curvature-rate ovalization

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Using a biological aerated filter to treat mixed water-borne volatile organic compounds and assessing its emissions

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Journal of Environmental Sciences 2009年第11期21卷 1497-1502页

作者： CHENG wen-hsi Department of Occupational Safety and Hygiene, Fooyin University, Kaohsiung County 83102, Taiwan, China Department of Occupational Safety and Hygiene Fooyin University Kaohsiung County 83102 Taiwan China

A biological aerated filter （BAF） was evaluated as a fixed-biofilm process to remove water-borne volatile organic compounds （VOCs） from a multiple layer ceramic capacitor （MLCC） manufacturing plant in southern Taiwan. The components of VOC were identified to be toluene, 1,2,4-trimethylbenzene, 1,3,5-trimethylbenzene, bromodichloromethane and isopropanol （IPA）. The full-scale BAF was constructed of two separate reactors in series, respectively, using 10- and 15-cm diameter polypropylene balls as the packing materials and a successful preliminary bench-scale experiment was performed to feasibility. Experimental results show that the BAF removed over 90% chemical oxygen demand （COD） from the influent with （1188 ± 605） mg/L of COD. A total organic loading of 2.76 kg biochemical oxygen demand （BOD）/（m3 packing·d） was determined for the packed bed, in which the flow pattern approached that of a mixed flow. A limited VOC concentration of （0.97 ± 0.29） ppmv （as methane） was emitted from the BAF system. Moreover, the emission rate of VOC was calculated using the proposed formula, based on an air-water mass equilibrium relationship, and compared to the simulated results obtained using the Water 9 model. Both estimation approaches of calculation and model simulation revealed that 0.1% IPA （0.0031-0.0037 kg/d） were aerated into a gaseous phase, and 30% to 40% （0.006-0.008 kg/d） of the toluene were aerated.

关键词： volatile organic compounds biological aerated filter total organic loading emission

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