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Chinese Journal of Natural Medicines 2023年第12期21卷 884-885页

作者： hou xiaoying LIU Yuchen DU Hongzhi Wuhan Institute of Biomedical Sciences School of MedicineJianghan UniversityWuhan 430000China Cancer Institute School of MedicineJianghan UniversityWuhan 430000China School of Pharmacy Hubei University of Chinese MedicineWuhan 430000China Center of Traditional Chinese Medicine Modernization for Liver Diseases Hubei University of Chinese MedicineWuhan 430000China

Emerging epidemiological findings indicate a rising incidence of primary liver cancer,now a foremost contributor to cancer-related mortalities worldwide[1].Several factors play a pivotal role in liver cancer etiology,including infections from the Hepatitis B/C virus,a spectrum of liver diseases like alcoholic and nonalcoholic fatty liver diseases(NAFLD,ASH,and NASH),metabolic aberrations(e.g.,obesity,diabetes),exposure to hepatocarcinogens(e.g.,aflatoxin,aristolochic acid,and iron overload),and disruptions in gut *** liver diseases,encompassing conditions such as NAFLD and NASH,represent hepatic expressions of metabolic syndrome and bear the potential to culminate in liver cancer.

关键词： cancer diseases liver

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腹泻动物模型及治疗药物研究进展

中国比较医学杂志 2024年第9期34卷 94-107页

作者：石玉存董小丽侯效英尹凯高帆吴国泰甘肃中医药大学药学院兰州730000 陇药产业创新研究院兰州730000 西北中藏药省部共建协同创新中心兰州730000 甘肃省中药药理与毒理学重点实验室兰州730000

腹泻是临床常见并且多发的疾病,引发腹泻的因素也比较多,目前有关腹泻动物模型的研究方法也比较多,但在临床上治疗腹泻的药物种类有限,现有的一部分药物也只适用于单一因素的腹泻。因此构建及选择合适的腹泻动物模型不仅是深入研究腹泻... 详细信息

腹泻是临床常见并且多发的疾病,引发腹泻的因素也比较多,目前有关腹泻动物模型的研究方法也比较多,但在临床上治疗腹泻的药物种类有限,现有的一部分药物也只适用于单一因素的腹泻。因此构建及选择合适的腹泻动物模型不仅是深入研究腹泻发病机制的重要基础,也是临床筛选和评价全面防治腹泻药物的有效手段。本文综述功能性、细菌性、病毒性、症状性腹泻动物模型的建立和评价以及治疗药物研究进展,以期为腹泻有关的动物实验研究和药物防治提供参考依据。

关键词：腹泻动物模型药物治疗研究进展

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双酚类化合物促进乳腺癌转移的研究进展

江汉大学学报（自然科学版） 2024年第5期52卷 79-87页

作者：刘金咪王海萍侯晓莹刘钰晨江汉大学医学部湖北武汉430056

双酚类化合物(bisphenols,BPs)是最常见的环境内分泌干扰物,且在环境中的含量不断增加。它们通过消化道、呼吸道和皮肤接触途径进入机体,对多个系统均能产生负面影响。乳腺癌是全球女性最常见的恶性肿瘤,流行病学和临床数据表明激素和... 详细信息

双酚类化合物(bisphenols,BPs)是最常见的环境内分泌干扰物,且在环境中的含量不断增加。它们通过消化道、呼吸道和皮肤接触途径进入机体,对多个系统均能产生负面影响。乳腺癌是全球女性最常见的恶性肿瘤,流行病学和临床数据表明激素和内分泌干扰物在乳腺癌的发生和发展中发挥重要作用。BPs的长期低剂量暴露还促进乳腺癌的发生发展与转移。介绍了BPs促进乳腺癌转移的研究进展及其潜在作用机制,从环境污染物的角度为理解乳腺癌的转移提供新的思路。

关键词：双酚类化合物乳腺癌转移分子机制

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超高强复相钢组织调控及强塑性提升机理

中国冶金 2024年第1期34卷 61-71页

作者：侯晓英刘万春王军丁明凯初林王业勤山东钢铁集团日照有限公司山东日照276805

通过调控微观组织形貌及各相组织配比,进一步优化超高强复相钢的综合力学性能,并采用扫描电镜(SEM)、电子探针(EPMA)、透射电镜(TEM)等表征手段,研究其强塑性提升机理。研究结果表明,在820℃的(γ+α)临界区温度退火工艺条件下,显微组... 详细信息

通过调控微观组织形貌及各相组织配比,进一步优化超高强复相钢的综合力学性能,并采用扫描电镜(SEM)、电子探针(EPMA)、透射电镜(TEM)等表征手段,研究其强塑性提升机理。研究结果表明,在820℃的(γ+α)临界区温度退火工艺条件下,显微组织由约37%铁素体、49%贝氏体以及14%残余奥氏体(体积分数)组成,其中铁素体组织以再结晶铁素体和先共析铁素体两种形态存在;贝氏体呈块状;残余奥氏体呈不规则颗粒状,主要分布在铁素体晶界处或铁素体与贝氏体相界面间,其晶粒大小与其周围“贫碳区”BCC晶粒尺寸大致成正比。在910℃奥氏体单相区退火时,显微组织由约19%先共析铁素体、61%板条束状贝氏体型铁素体以及厚度在60~130 nm范围的20%片层状残余奥氏体组成,其中贝氏体铁素体以再结晶γ晶粒作为相变的块状基准单元且呈不同位向分布;大角度晶界所占比例达85.4%;基体中V(C,N)第二相粒子为相间析出,析出粒子直径为3~9 nm,平均列间距约31 nm,对材料的强度贡献计算值约为281 MPa。超高强复相钢的综合力学性能与其微观形貌特征、晶体结构和晶体取向、第二相析出粒子、高密度位错以及残余奥氏体的TRIP效应贡献均密切关联,单相奥氏体区退火工艺条件下,复相钢的抗拉强度达到1226 MPa,同时伸长率和扩孔率分别提高至19.1%和51%,强塑积达到23.42 GPa·%。研究结果可为高强化材料综合性能的提升提供参考。

关键词：复相钢组织调控强塑性机理相间析出晶体学结构

Study on Microstructure and Mechanical Properties of Hot Rolled Low Silicon Containing Phosphorus TRIP Steel

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稀有金属材料与工程 2011年第S3期40卷 228-233页

作者： hou xiaoying, Xu Yunbo, Wu Di State Key Laboratory of Rolling and Automation, Northeastern University, Shenyang 110819, China Northeastern Univ State Key Lab Rolling & Automat Shenyang 10819 Peoples R China

The effects of final air cooling temperature on the microstructure and mechanical properties of hot rolled 0.2C-1.9Mn-0.5Si-0.08P TRIP steel were studied by utilizing OM, SEM, TEM and tensile tests. Experimental results showed that in the multiphase microstructure of the investigated steel when the finish rolling temperature was about 820 ℃ and the final air cooling temperature was in the range of 630-700 ℃, the grain size of most of ferrite was finer (about 4 μm) and which had higher dislocation density, the bainite packets had chaotic orientations and lath boundaries of bainite were not quite straight, the retained austenite distributed in the ferrite grain boundaries or triradius was fine and dispersive, and their grain size was about 0.4-1.9 μm. With increasing the amount of ferrite, the volume fraction of retained austenite had a slight decrease. When the final air cooling temperature was 630 ℃, the steel had excellent mechanical properties, which was characterized by combination of continuous yielding, high strength (about 796 MPa) and high elongation (22.7%) as well as low yield/strength ratio (0.58); when the final air cooling temperature increased to 700 ℃, the matrix structure was bainite packets and the comprehensive properties were deteriorated.

关键词： hot rolled TRIP steel low silicon containing phosphorus microstructure and mechanical properties final air cooling temperature

Boosting sodium-storage properties of hierarchical Na_(3)V_(2)(PO_(4))_(3)@C micro-flower cathodes by tiny Cr doping:The effect of“four ounces moving a thousand pounds”

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Nano Research 2024年第1期17卷 235-244页

作者： Yongjia Wang Guoshuai Su xiaoying Li Linrui hou Longwei Liang Changzhou Yuan School of Materials Science&Engineering University of JinanJinan 250022China

Na_(3)V_(2)(PO_(4))_(3)(NVP),as a great potential cathode candidate for Na-ion batteries(NIBs),has attracted enormous interest due to its three-dimensional(3D)large open framework for convenient Na+transport,yet its practical application is still limited by its inferior electron conductivity and sluggish Na+diffusion ***,the tiny Cr doped hierarchical NVP micro-flower cathodes(i.e.,Na_(3)V_(2-x)Crx(PO_(4))_(3)@C,x≤0.1),which are self-assembled with single-crystal nanoflake subunits in-situ coated with carbon nano-shell,are designed and fabricated via a scalable *** optimized cathode,i.e.,Na_(3)V_(1.94)Cr_(0.06)(PO_(4))_(3)@C(NVCP-6),was endowed with more electro-active Na(2)sites and higher electronic/ionic conductivity for efficient sodium *** from these competitive merits,the NVCP-6,when evaluated as a cathode towards NIBs,exhibits an ultrahigh-rate capability of 99.8 mAh·g^(-1)at 200 C and superior stability of 82.2%over 7300 cycles at 50 ***,the NVCP-6 based full NIBs display remarkable electrochemical properties in terms of both high-rate capacities and long-duration cycling properties at different temperatures(-20–50°C).The contribution,i.e.,the design of“four ounces can move a thousand pounds”,here will promote the practical industrial application of NVP towards advanced NIBs.

关键词： Na_(3)V_(2)(PO_(4))_(3)cathode tiny Cr doping active Na sites ultrahigh-rate capability Na-ion batteries

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中药牙膏的发展与研究现状

化工管理 2024年第23期 75-80页

作者：石玉存董小丽侯效英尹凯高帆吴国泰甘肃中医药大学药学院甘肃兰州730000 陇药产业创新研究院甘肃兰州730000 西北中藏药省部共建协同创新中心甘肃兰州730000 甘肃省中药药理与毒理学重点实验室甘肃兰州730000

文章对近年来中药牙膏配方的组成药物和中药牙膏的功效研究进展进行概述。根据配方组分及功效总结出目前中药牙膏主要有抗炎镇痛型、抑菌防龋型、止血型、防牙本质过敏型四大类。同时通过专利检索平台中的国内外中药牙膏注册专利进行统... 详细信息

文章对近年来中药牙膏配方的组成药物和中药牙膏的功效研究进展进行概述。根据配方组分及功效总结出目前中药牙膏主要有抗炎镇痛型、抑菌防龋型、止血型、防牙本质过敏型四大类。同时通过专利检索平台中的国内外中药牙膏注册专利进行统计整理,综合分析了已批准的各类型中药牙膏专利的配方组成药材、专利中常用的中药主产区、专利分布地区等情况,探讨了中药牙膏开发的优势与劣势,并提出了相关建议,为中国中药牙膏产业发展提供参考。

关键词：中药牙膏分类配方组成专利分析

Classic mechanisms and experimental models for the anti-inflammatory effect of traditional Chinese medicine

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Animal Models and Experimental Medicine 2022年第2期5卷 108-119页

作者： Du Hongzhi hou xiaoying Guo Yujie Chen Le Miao Yuhuan Liu Dahui Huang Luqi National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijingChina Hubei Provincial Key Laboratory of Traditional Chinese Medicine Resources and Traditional Chinese Medicine Chemistry Hubei University of Chinese MedicineWuhanChina Wuhan Biomedical Research Institute School of MedicineJiang Han UniversityWuhanChina

Inflammation is a common disease involved in the pathogenesis,complications,and sequelae of a large number of related diseases,and therefore considerable research has been directed toward developing anti-inflammatory drugs for the prevention and treatment of these *** Chinese medicine(TCM)has been used to treat inflammatory and related diseases since ancient *** to the re-view of abundant modern scientific researches,it is suggested that TCM exhibit anti-inflammatory effects at different levels,and via multiple pathways with various targets,and recently a series of in vitro and in vivo anti-inflammatory models have been developed for anti-inflammation research in ***,the reported classic mechanisms of TCM and experimental models of its anti-inflammatory effects pro-vide reference points and guidance for further research and development of ***,the research clearly confirms that TCM is now and will continue to be an effective form of treatment for many types of inflammation and inflammation-related diseases.

关键词： anti-inflammatory effect inflammation and related diseases the classical mechanisms the experimental models traditional Chinese medicine

鲜胚移植周期超声参数预测体外受精-胚胎移植患者妊娠结局的临床价值

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临床超声医学杂志 2024年第2期26卷 158-162页

作者：王付敏申向辉尹素芳侯晓英张欢河北省邯郸市中心医院超声医学科 056001

目的探讨鲜胚移植周期超声参数预测体外受精-胚胎移植(IVF-ET)患者妊娠结局的临床价值。方法选取在我院就诊的98例IVF-ET患者,根据患者IVF-ET术后12~14 d是否妊娠将其分为妊娠组59例和非妊娠组39例,比较两组IVF-ET术当天经阴道超声检查... 详细信息

目的探讨鲜胚移植周期超声参数预测体外受精-胚胎移植(IVF-ET)患者妊娠结局的临床价值。方法选取在我院就诊的98例IVF-ET患者,根据患者IVF-ET术后12~14 d是否妊娠将其分为妊娠组59例和非妊娠组39例,比较两组IVF-ET术当天经阴道超声检查所测子宫内膜厚度、容积、血管指数(VI)、血流指数(FI)、血管血流指数(VFI)、子宫内膜形态及子宫内膜下血流参数[动脉收缩期峰值血流速度与舒张末期血流速度比值(S/D)、搏动指数(PI)、阻力指数(RI)]的差异。应用Logistic回归分析预测IVF-ET患者妊娠结局的独立影响因素,并建立联合应用模型;绘制受试者工作特征(ROC)曲线分析各超声参数单独及联合应用预测IVF-ET患者妊娠结局的诊断效能。结果妊娠组患者子宫内膜下S/D、PI、RI均低于非妊娠组,子宫内膜和子宫内膜下FI、VI、VFI均高于非妊娠组,差异均有统计学意义(均P<0.05);两组患者子宫内膜厚度、容积及形态比较差异均无统计学意义。Logistic回归分析显示,子宫内膜下S/D、PI、VI和子宫内膜VI、VFI为预测IVF-ET患者妊娠结局的独立影响因素,基于此建立联合应用模型为:Logit(P)=-6.013+1.025×子宫内膜下S/D+3.428×子宫内膜下PI+0.831×子宫内膜下VI+0.633×子宫内膜VI+5.934×子宫内膜VFI。ROC曲线分析显示,子宫内膜下S/D、PI、VI和子宫内膜VI、VFI单独及联合应用预测IVF-ET患者妊娠结局的曲线下面积分别为0.796、0.736、0.735、0.780、0.725、0.978,其中联合应用模型预测妊娠结局的曲线下面积最高,与各超声参数单独应用预测的曲线下面积比较差异均有统计学意义(均P<0.05)。结论子宫内膜下S/D、PI、VI和子宫内膜VI、VFI均可预测IVF-ET患者妊娠结局,且多参数联合应用的预测价值更高。

关键词：超声检查体外受精-胚胎移植血管指数血流指数子宫内膜容积

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客方言的[u]介音

方言 2017年第1期39卷 88-100页

作者：侯小英嘉应学院文学院

大多数客方言点有带[u]介音韵母。少数无[u]介音的客家方言主要分布于东江流域及其相邻地区;古合口二等[u]介音的有无亦呈现出明显的地域性。[u]介音韵母一般与中古合口韵对应并受主元音影响,古开口韵今读[u]介音的有无则与主元音及韵... 详细信息

大多数客方言点有带[u]介音韵母。少数无[u]介音的客家方言主要分布于东江流域及其相邻地区;古合口二等[u]介音的有无亦呈现出明显的地域性。[u]介音韵母一般与中古合口韵对应并受主元音影响,古开口韵今读[u]介音的有无则与主元音及韵尾的发音特点均相关。与[u]介音相拼的声母多是软腭辅音。客方言[u]介音大多具音位性,它应该是早期汉语唇化软腭音声母的唇化成分发展而来。综合来看,今天梅县等音系中的[u]介音不宜取消。

关键词： [U]介音客方言地理分布语音环境音位性