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Odorant receptor orthologues from moths display conserved responses to cis-jasmone

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Insect Science 2024年第4期31卷 1107-1120页

作者： Xiao-Qing hou Zhongqiang Jia dan-dan Zhang Guirong Wang Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureSynthetic Biology Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong ProvinceChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina Department of Biology Lund UniversityLundSweden

In insects,the odorant receptor(OR)multigene family evolves by the birth-and-death evolutionary model,according to which the OR repertoire of each species has undergone specific gene gains and losses depending on their chemical environment,resulting in taxon-specific OR lineage radiations with different sizes in the phylogenetic *** the general divergence in the gene family across different insect orders,the ORs in moths seem to be genetically conserved across species,clustered into 23 major clades containing multiple orthologous groups with single-copy gene from each *** hypothesized that ORs in these orthologous groups are tuned to ecologically important compounds and functionally ***-Jasmone is one of the compounds that not only primes the plant defense of neighboring receiver plants,but also functions as a behavior regulator to various *** test our hypothesis,using Xenopus oocyte recordings,we functionally assayed the orthologues of BmorOR56,which has been characterized as a specific receptor for *** results showed highly conserved response specificity of the BmorOR56 orthologues,with all receptors within this group exclusively responding to *** is supported by the dN/dS analysis,showing that strong purifying selection is acting on this ***,molecular docking showed that the ligand binding pockets of BmorOR56 orthologues to cis-jasmone are *** together,our results suggest the high conservation of OR for ecologically important compounds across Heterocera.

关键词： cis-jasmone evolutionary conservation functional characterization molec-ular docking moths purifying selection

Application of a microscopic optical potential of chiral effective field theory in (p, d) transfer reactions

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Nuclear Science and Techniques 2024年第1期35卷 134-144页

作者： Yi-ping Xu Si-Lu Chen dan-Yang Pang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China School of Physics Beihang UniversityBeijing 100191China

The microscopic global nucleon–nucleus optical model potential(OMP)proposed by Whitehead,Lim,and Holt,the WLH potential(Whitehead et al.,Phys Rev Lett 127:182502,2021),which was constructed in the framework of many-body per-turbation theory with state-of-the-art nuclear interactions from chiral effective field theory(EFT),was tested with(p,d)transfer reactions calculated using adiabatic wave *** target nuclei included both stable and unstable nuclei,and the incident energies reached 200 *** results were compared with experimental data and predictions using the phenomenological global optical potential of Koning and Delaroche,the KD02 ***,we found that the micro-scopic WLH potential described the(p,d)reaction angular distributions similarly to the phenomenological KD02 potential;however,the former was slightly better than the latter for radioactive *** average,the obtained spectroscopic factors(SFs)using both microscopic and phenomenological potentials were similar when the incident energies were below approxi-mately 120 ***,their difference tended to increase at higher incident energies,which was particularly apparent for the doubly magic target nucleus 40Ca.

关键词： Microscopic optical model potential (p,d)transfer Spectroscopic factors

Editorial:special topic on biomaterials and bioinspired materials

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Science China Materials 2024年第8期67卷 2373-2375页

作者： Mingjie Liu Xu hou dan Wang Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China International Research Institute for Multidisciplinary Science Beihang UniversityBeijing 100191China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Laboratory for Soft Functional Materials ResearchCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China State Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Preparation and DeliveryInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Biomaterials have been persistently focused owing to their intricate design and efficient *** order to satisfy the demands of life and medical sciences,large amounts of biomaterials capable of interacting with living systems have been created,thereby achieving the diagnosis,treatment or replacement of cells,tissues,and *** continuous evolution for billions of years,living organisms have eventually developed sophisticated multi-scale structures with diverse biological functions to adapt to the external environment.

关键词： organs diagnosis biomaterials

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Partition-based Network Equivalent Method for Power System Subsynchronous Oscillation Analysis

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 313-320页

作者： Chenxuan Wang Weimin Zheng Zhen Wang Yangqing dan ping Ju the Department of Electrical Engineering Zhejiang UniversityHangzhou 310027China the Economic Research Institute of State Grid Zhejiang Electric Power Co. Ltd.Hangzhou 310016China the College of Energy and Electrical Engineering Hohai UniverstiyNanjing 211100China

Given large-scale modern power systems with pow er electronic converters,the numerical simulation with subsyn chronous oscillation(SSO)faces great challenges in engineering practice due to sharply enlarged modeling scale and high com putational *** reduce the modeling scale,network parti tion and equivalent becomes a vital technique in numerical sim *** several methods have been developed for net work equivalent,a generally accepted rule for network parti tion is still *** paper proposes that the system can be partitioned into three parts,i.e.,the internal,the middle,and the external subsystems,in which the internal subsystem consists of all power electronic components,the middle subsys tem includes those selected AC dynamic components with de tailed models,and the remaining components and buses consti tute the external *** external subsystem is further represented by an equivalent RLC network determined by the frequency dependent network equivalent(FDNE)*** the proposed method,the observability index and the electrical distance index are used to identify the interface between the middle and the external *** studies based on a modified Hydro-Quebec system are used to verify the effective ness of the proposed method.

关键词： Electrical distance network equivalent subsyn chronous oscillation observability index

Small holes,big impact:Stomata in plant–pathogen–climate epic trifecta

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Molecular Plant 2024年第1期17卷 26-49页

作者： Shuguo hou Olivier Rodrigues Zunyong Liu Libo Shan ping He Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agriculture Sciences in WeifangWeifangShandong 261325China School of Municipal&Environmental Engineering Shandong Jianzhu UniversityJinanShandong 250101China Unitéde Recherche Physiologie Pathologie et Génétique VégétalesUniversitéde Toulouse Midi-PyrénéesINP-PURPAN31076 ToulouseFrance Department of Molecular Cellularand Developmental BiologyUniversity of MichiganAnn ArborMI 48109USA

The regulation of stomatal aperture opening and closure represents an evolutionary battle between plants and pathogens,characterized by adaptive strategies that influence both plant resistance and pathogen *** ongoing climate change introduces further complexity,affecting pathogen invasion and host *** review delves into recent advances on our understanding of the mechanisms governing immunity-related stomatal movement and patterning with an emphasis on the regulation of stomatal opening and closure dynamics by pathogen patterns and host *** addition,the review explores how climate changes impact plant–pathogen interactions by modulating stomatal *** light of the pressing challenges associated with food security and the unpredictable nature of climate changes,future research in this field,which includes the investigation of spatiotemporal regulation and engineering of stomatal immunity,emerges as a promising avenue for enhancing crop resilience and contributing to climate control strategies.

关键词： stomatal movement stomatal patterning plant resistance pathogen virulence apoplastic immunity and climate change

Equilibrium Reinsurance Strategy and Mean Residual Life Function

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 758-777页

作者： dan-ping LI Lv CHEN Lin-yi QIAN Wei WANG School of Statistics Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOEEast China Normal UniversityShanghai 200062China Academy of Statistics and Interdisciplinary Sciences Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOEEast China Normal UniversityShanghai 200062China School of Mathematics and Statistics Ningbo UniversityNingbo 315211China

In this paper,we analyze the relationship between the equilibrium reinsurance strategy and the tail of the distribution of the *** Mean Residual Life(MRL)has a close relationship with the tail of the distribution,we consider two classes of risk distributions,Decreasing Mean Residual Life(DMRL)and Increasing Mean Residual Life(IMRL)distributions,which can be used to classify light-tailed and heavy-tailed distributions,*** assume that the underlying risk process is modelled by the classical CramérLundberg model *** the mean-variance criterion,by solving the extended Hamilton-Jacobi-Bellman equation,we derive the equilibrium reinsurance strategy for the insurer and the reinsurer under DMRL and IMRL,***,we analyze how to choose the reinsurance premium to make the insurer and the reinsurer agree with the same reinsurance *** find that under the case of DMRL,if the distribution and the risk aversions satisfy certain conditions,the insurer and the reinsurer can adopt a reinsurance premium to agree on a reinsurance strategy,and under the case of IMRL,the insurer and the reinsurer can only agree with each other that the insurer do not purchase the reinsurance.

关键词： mean residual life excess-of-loss reinsurance insurer reinsurer stochastic control

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Revealing effect of Al content on oxidation of novel Co-Cr-Nb-W carbide-strengthened superalloy

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Rare Metals 2024年第9期43卷 4521-4534页

作者： Chen Ling Shang-ping Li Jie hou He-Li Luo Central Iron & Steel Research Institute Beijing GAONA Materials&Technology Co. Ltd.

The high-temperature oxidation behavior of novel Co-Cr-Nb-W carbide-strengthened wear-resistance alloys with different Al contents（1wt%, 2wt% and 3wt%）at 950, 1000 and 1050 °C was thoroughly investigated by scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy and field emission electron probe analyzer. The porous property of Nb C in-situ oxidation products（Nb2O5, Co Nb2O6and Co4Nb2O9） induces a multi-layered oxide scale with micropores and ***-Cr-Nb-W alloy with 1 wt% Al undergoes catastrophic oxidation and spalling above 1000 °C. The outward transportation of Cr and Co is effectively restrained by a continuous Al2O3scale formed around Nb C in-situ oxidation region when Al content reaches 3 wt%. The β-Co Al in Co-Cr-Nb-W alloy with 3 wt% Al has an oxidation priority over eutectic carbides and the alloy matrix which are both enriched with Cr, thereby preventing the formation of Cr-depletion area and improving the self-healing ability of the oxide film. A slight change in Al content has a remarkable influence on the cooperative effect of Al and Cr and multiplies the antioxidant capacity of Co-Cr-Nb-W alloy above 1000 °C.

关键词： High-temperature oxidation behavior Microstructure Oxidation kinetics Superalloy Wear-resistant alloy

Impact of stage-specific limb function exercises guided by a selfmanagement education model on arteriovenous fistula maturation status

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World Journal of Clinical Cases 2024年第14期12卷 2316-2323页

作者： Yi Li Li-Jun Huang Jian-Wen hou dan-dan Hu Department of Nursing The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Nephrology The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Head and Neck Surgery Zhejiang Cancer HospitalHangzhou 310000Zhejiang ProvinceChina School of Nursing Shangqiu Institute of TechnologyShangqiu 476005Henan ProvinceChina

BACKGROUND The exercise of limb function is the most economical and safe method to promote the maturation of arteriovenous fistula(AVF).However,due to the lack of a uni-fied exercise standard in China,many patients have insufficient awareness of the importance of AVF,leading to poor effectiveness of limb function *** self-management education model can effectively promote patients to take pro-active health-related *** study focuses on the characteristics of patients during the peri-AVF period and conducts a phased limb function exercise under the guidance of the self-management education model to observe changes in fac-tors such as the maturity of *** To assess the impact of stage-specific limb function exercises,directed by a self-management education model,on the maturation status of *** This study is a randomized controlled trial involving 74 patients with forearm AVFs from the Nephrology Department of a tertiary hospital in Sichuan Province,*** were randomly divided into an observation group and a control group using a random number table *** observation group underwent tailored stage-specific limb func-tion exercises,informed by a self-management education model which took into account the unique features of AVF at various stages,in conjunction with routine ***,the control group was given standard limb function exercises along with routine *** assessment involves the maturity of AVFs post-intervention,post-operative complications,and the self-management level of the fistula in both groups *** were conducted using SPSS version *** data were represented by frequency and percentage and subjected to chi-square test *** data adhering to a normal distribution were presented as mean±*** independent samples t-test was utilized for inter-group comparisons,while the paired t-test was used for intra-group *** measurement data not fitting a normal distr

关键词： Self-management Education model Stage-specific Limb function exercises Arteriovenous fistula Maturation status

Directly targeting BAX for drug discovery:Therapeutic opportunities and challenges

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2378-2401页

作者： Zhenwei Zhang Linghui hou dan Liu Shenglin Luan Min Huang Linxiang Zhao Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518000China

For over two decades,the development of B-cell lymphoma-2(Bcl-2)family therapeutics has primarily focused on anti-apoptotic proteins,resulting in the first-in-class drugs called BH3 mimetics,especially for Bcl-2 inhibitor *** pro-apoptotic protein Bcl-2-associated X protein(BAX)plays a crucial role as the executioner protein of the mitochondrial regulated cell death,contributing to organismal development,tissue homeostasis,and *** dysregulation of BAX is closely associated with the onset and progression of diseases characterized by pathologic cell survival or death,such as cancer,neurodegeneration,and heart *** addition to conducting thorough investigations into the physiological modulation of BAX,research on the regulatory mechanisms of small molecules identified through biochemical screening approaches has prompted the identification of functional and potentially druggable binding sites on BAX,as well as diverse all-molecule BAX *** review presents recent advancements in elucidating the physiological and pharmacological modulation of BAX and in identifying potentially druggable binding sites on ***,it highlights the structural and mechanistic insights into small-molecule modulators targeting diverse binding surfaces or conformations of BAX,offering a promising avenue for developing next-generation apoptosis modulators to treat a wide range of diseases associated with dysregulated cell death by directly targeting BAX.

关键词： Apoptosis Pro-apoptotic protein BAX Dynamic conformational activation Small-molecule apoptosis modulators