检索结果-南通市图书馆

Multidimensional coupled structure-activity relationship models for replacement of SF_(6)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Voltage 2024年第2期9卷 484-494页

作者： Mi Zhang Hua hou Baoshan Wang College of Chemistry and Molecular Sciences Wuhan UniversityWuhanChina

Computational screening of single gases to replace SF_(6)for electrical insulation has been challenged by the difficulty in combining various mutually exclusive properties especially for dielectric performance with liquefaction and environmental *** reveal the inherent correlations between dielectric strength(Er),boiling point(Tb),and global warming potential(GWP)of dielectric materials,a coupled structure-activity relationship(CSAR)model has been proposed for the first *** means of the generic descriptors,as deduced from the electrostatic potentials,and the specific descriptors,as introduced from the respective microscopic mechanisms,the complex interdependence between Er,Tb,and GWP of the insulation gases is quantitatively characterised by the 3-D coupling *** coupling mechanism for the right balance of properties is uncovered in terms of the first-principle *** CSAR model outperforms the previous SAR models in predicting Er,Tb,and GWP simultaneously in a self-consistent *** importantly,the concept of CSAR could be extended readily to any multidimensional macroscopic *** replacement compounds have been identified tentatively to be the promising candidates to replace SF_(6)using the CSAR model.

关键词： properties. dielectric insulation

Multi-functional Hollow Structures for Intelligent Drug Delivery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第3期40卷 394-412页

作者： hou Ping YANG Nailiang WANG Dan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100049P.R.China

Multi-fountional hollow structures have emerged as promising platforms for intelligent drug delivery due to their unique properties,such as high loading capacities and programmed drug *** particular,hollow multishell structures(HoMSs)with multilevel shell and space can regulate the molecular-level interaction between drugs and materials,so as to achieve the temporal-spatial order and sequential release of *** anisotropic hollow structures can control the drug diffusion process by inducing the macroscopic interface flow through autonomous movement,realizing the targeted drug transport and *** this paper,a key focus will be HoMSs with their temporal-ordered architectures and anisotropic hollow carriers with directional *** synthesis mechanisms,structure-property relationships,smartly programmed drug delivery and biomedical applications will be discussed,providing insights into designing next-generation intelligent drug carriers.

关键词： Hollow multishell structure Anisotropic hollow structure Intelligent drug carrier Temporal-spatial order Directional movement

Hierarchical vectorization for facial images

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computational Visual Media 2024年第1期10卷 97-118页

作者： Qian Fu Linlin Liu Fei hou Ying He School of Computer Science and Engineering Nanyang Technological University639798SingaporeSingapore Data61 Commonwealth Scientific and Industrial Research OrganisationSydney2015Australia Interdisciplinary Graduate School Nanyang Technological University and Alibaba Group639798SingaporeSingapore State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

The explosive growth of social media means portrait editing and retouching are in high *** portraits are commonly captured and stored as raster images,editing raster images is non-trivial and requires the user to be highly *** at developing intuitive and easy-to-use portrait editing tools,we propose a novel vectorization method that can automatically convert raster images into a 3-tier hierarchical *** base layer consists of a set of sparse diffusion curves(DCs)which characterize salient geometric features and low-frequency colors,providing a means for semantic color transfer and facial expression *** middle level encodes specular highlights and shadows as large,editable Poisson regions(PRs)and allows the user to directly adjust illumination by tuning the strength and changing the shapes of *** top level contains two types of pixel-sized PRs for high-frequency residuals and fine details such as pimples and *** train a deep generative model that can produce high-frequency residuals *** to the inherent meaning in vector primitives,editing portraits becomes easy and *** particular,our method supports color transfer,facial expression editing,highlight and shadow editing,and automatic *** quantitatively evaluate the results,we extend the commonly used FLIP metric(which measures color and feature differences between two images)to consider *** new metric,illumination-sensitive FLIP,can effectively capture salient changes in color transfer results,and is more consistent with human perception than FLIP and other quality measures for portrait *** evaluate our method on the FFHQR dataset and show it to be effective for common portrait editing tasks,such as retouching,light editing,color transfer,and expression editing.

关键词： face editing vectorization Poisson editing color transfer illumination editing expression editing

A molecular insight into coke formation process of vacuum residue in thermal cracking reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第3期21卷 2130-2138页

作者： Ji-Guang Li Xin Guo Huan-Di hou Heavy Oil Processing Department Sinopec Research Institute of Petroleum Processing Co.LtdBeijing100083China

Understanding the coking behaviors has been considered to be really essential for developing better vacuum residue processing technologies.A battery of thermal cracking tests of typical vacuum residue at 410℃ with various reaction time were performed to evaluate the coke formation *** total yields of ideal components including naphtha,atmospheric gas oil(AGO)and vacuum gas oil(VGO)of thermal cracking reactions increased from 10.89%to 40.81%,and the conversion ratios increased from8.05%to 43.33%with increasing the reaction time from 10 to 70 *** asphaltene content increased from 12.14%to a maximum of 22.39%and then decreased,and this maximum of asphaltene content occurred at the end of the coking induction *** asphaltenes during the coking induction period,at the end and after coking induction period of those tested thermal cracking reactions were characterized to disclose the structure changing rules for coke formation process,and the coke formation pathways were discussed to reveal the coke formation process at molecular level.

关键词： Vacuum residue Thermal cracking Asphaltene Coking induction period Sulfur Nitrogen

Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2018–2021

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第4期37卷 399-405页

作者： hou Yu Shan JIN Yi Chen CAI Chang TANG hou Lin QIN Qian Qian LYU Fan National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to *** also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly *** Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the *** tests and spatial analyses were also *** Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in *** main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in *** proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for *** spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern *** In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual *** primary modes of infection were CHC and *** were variations in the sex ratio among different age groups,infected through various sexual ***/AIDS cases exhibited spatial *** on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

关键词： HIV/AIDS Aged≥50 years China

Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2024年第7期48卷 1055-1069页

作者： YAN-NAN LI YUN-HONG XIU YAN-JUN TANG JING-LONG CAO WEN-SHUANG hou AN-QI WANG TIAN-ZHU LI cheng-HAO JIN Department of Biochemistry and Molecular Biology Heilongjiang Bayi Agricultural UniversityDaqingChina Hemodialysis Center Daqing Oilfield General HospitalDaqingChina Department of Food Science and Engineering Heilongjiang Bayi Agricultural UniversityDaqingChina Department of Molecular Biology Chifeng UniversityChifengChina National Coarse Cereals Engineering Research Center DaqingChina

Objectives:Sciadopitysin(SP)is aﬂavonoid in Ginkgo biloba that exhibits various pharmacological *** study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma(HCC)***:Network pharmacology was used for target prediction *** Counting Kit-8(CCK-8)assay was used to test the cell *** cytometry was used to test the cell cycle distribution,apoptosis status,and reactive oxygen species(ROS)*** and wound-healing assay was used to test the migration effect of SP on HepG2 *** Blot assay was used to test the expression levels of ***:Network pharmacology analysis results showed that the mitogen-activated protein kinase(MAPK)and other signaling pathways are involved in the SP anti-HCC biological ***-8 assay results demonstrated that SP showed an obvious killing effect on three types of HCC cells and low cytotoxic effect on normal *** Blot andﬂow cytometry results showed that SP regulated MAPK/signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa-B(NF-κB)signaling pathway to induce mitochondrion-dependent apoptosis in HepG2 ***,SP can arrest the G0/G1 phase cell cycle via the protein kinase B(AKT)/p21/p27/cyclin-dependent kinase(CDK)/Cyclin signaling *** healing and transwell assays showed that SP inhibited cell motility and invasion through the AKT/glycogen synthase kinase3β(GSK-3β)/vimentin/β-catenin signaling ***:Theseﬁndings demonstrated that SP induced mitochondrion-dependent apoptosis,arrested cell cycle in the G0/G1 phase,and inhibited cell migration by regulating the ROS-mediated signaling pathway in HepG2 ***,SP could serve as a therapeutic agent for the treatment of human HCC.

关键词： Sciadopitysin Hepatocellular carcinoma Apoptosis Cell cycle Cell migration

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu chengpeng Tao Weiming Chen Wen hou Kui cheng Huichang Bi Wanyi Pan Jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

Spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice in multiple dimensions during 1979 to 2020

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2024年第3期43卷 102-114页

作者： Yu Guo Xiaoli Wang He Xu Xiyong hou CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China University of Chinese Academy of Sciences Beijing 100049China

Arctic sea ice is broadly regarded as an indicator and amplifier of global climate *** rapid changes in Arctic sea ice have been widely ***,the spatiotemporal changes in the horizontal and vertical dimensions of Arctic sea ice and its asymmetry during the melt and freeze seasons are rarely quantified simultaneously based on multiple sources of the same long time *** this study,the spatiotemporal variation and freeze-thaw asymmetry of Arctic sea ice were investigated from both the horizontal and vertical dimensions during 1979–2020 based on remote sensing and assimilation *** results indicated that Arctic sea ice was declining at a remarkably high rate of–5.4×10^(4) km^(2)/a in sea ice area(SIA)and–2.2 cm/a in sea ice thickness(SIT)during 1979 to 2020,and the reduction of SIA and SIT was the largest in summer and the smallest in ***,compared with other sub-regions,SIA showed a sharper declining trend in the Barents Sea,Kara Sea,and East Siberian Sea,while SIT presented a larger downward trend in the northern Canadian Archipelago,northern Greenland,and the East Siberian *** to the seasonal trend of sea ice on sub-region scale,the reduction rate of SIA exhibited an apparent spatial heterogeneity among seasons,especially in summer and winter,i.e.,the sub-regions linked to the open ocean exhibited a higher decline rate in winter;however,the other sub-regions blocked by the coastlines presented a greater decline rate in *** SIT,the sub-regions such as the Beaufort Sea,East Siberian Sea,Chukchi Sea,Central Arctic,and Canadian Archipelago always showed a higher downward rate in all ***,a striking freeze-thaw asymmetry of Arctic sea ice was also *** sea ice changes in different dimensions,sea ice over most regions in the Arctic showed an early retreat and rapid advance in the horizontal dimension but late melting and gradual freezing in the vertical *** amount of sea ice me

关键词： Arctic sea ice sea ice area sea ice thickness spatiotemporal variation freeze-thaw asymmetry

Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 427-437页

作者： Yukun Mao Xueying hou Su Fu Jie Luan Breast Plastic and Reconstructive Surgery Center Plastic Surgery HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100144China

Capsular contracture is a prevalent and severe complication that affects the post-operative outcomes of patients who receive silicone breast *** present,prosthesis replacement is the major treatment for capsular contracture after both breast augmentation procedures and breast reconstruction following breast cancer ***,the mecha-nism(s)underlying breast capsular contracture remains *** study aimed to identify the biological features of breast capsular contracture and reveal the potential underlying mechanism using RNA *** tissues from 12 female patients(15 breast capsules)were divided into low capsular contracture(LCC)and high capsular contracture(HCC)groups based on the Baker ***,41 lipid metabolism-related genes were identified through enrichment analysis,and three of these genes were identified as candidate genes by SVM-RFE and LASSO *** then compared the proportions of the 22 types of im-mune cells between the LCC and HCC groups using a CIBERSORT analysis and explored the Cor-relation between the candidate hub features and immune ***,PRKAR2B was positively correlated with the differentially clustered immune cells,which were M1 macro-phages and follicular helper T cells(area under the ROC=0.786).In addition,the expression of PRKAR2B at the mRNA or protein level was lower in the HCC group than in the LCC *** molecular mechanisms were identified based on the expression levels in the high and low PRKAR2B *** findings indicate that PRKAR2B is a novel diagnostic biomarker for breast capsular contracture and might also influence the grade and progression of capsularcontracture.

关键词： Biomarker Breastcapsular contracture Immune infiltration Machinelearning algorithms PRKAR2B