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Materials Sciences and Applications 2017年第6期8卷 448-475页

作者： Shinya Inazumi Misato Sekitani kwang-seok Chae Ken-Ichi Shishido Department of Civil Engineering College of Engineering Shibaura Institute of Technology Tokyo Japan Graduate School of Global Environmental Studies Kyoto University Kyoto Japan Infra & Offshore Research Team GS Engineering & Construction Seoul Korea Tomec Corporation Tokyo Japan

Asset management is a strategic decision-making aspect of social infra-structure that ensures safety by predicting long-term conditions and maximizing effectiveness under budgetary constraints. Predicting the deterioration of impervious walls is essential in the asset management of coastal landfill sites, particularly in the design of their maintenance and repair strategy. In this paper, a quantitative evaluation of the leakage of toxic substances in coastal landfill sites where deterioration of side impervious walls has decreased the water interception performance is reported. In addition, risk evaluation based on the asset management of the leakage is applied to determine an appropriate repair method. The strategy of repairing the walls when the concentration of the toxic substances leaking into the sea area exceeds the closure and abandonment of coastal landfill sites is demonstrated to be superior. Moreover, the strategy of repairing only the seaside side impervious wall is shown to be cost-effective.

关键词： Coastal Landfill Site Impervious Wall Maintenance Strategy Risk Assessment

Li-ion battery material under high pressure:amorphization and enhanced conductivity of Li4Ti5O12

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National Science Review 2019年第2期6卷 239-246页

作者： Yanwei Huang Yu He Howard Sheng Xia Lu Haini Dong Sudeshna Samanta hongliang Dong Xifeng Li Duck Young Kim Ho-kwang Mao Yuzi Liu Heping Li hong Li Lin Wang Center for High Pressure Science and Technology Advanced Research College of Materials and Environmental Engineering Hangzhou Dianzi University Key Laboratory of High-temperature and High-pressure Study of the Earth's Interior Institute of Geochemistry Chinese Academy of Sciences Department of Physics and Astronomy George Mason University State Key Laboratory of Organic-Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Energy Beijing University of Chemical Engineering School of Mechatronic Engineering and Automation Shanghai University Geophysical Laboratory Carnegie Institution Center for Nanoscale Materials Argonne National Laboratory Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

Lithium titanium oxide(Li4Ti5O12,LTO),a‘zero-strain’anode material for lithium-ion batteries,exhibits excellent cycling ***,its poor conductivity highly limits its ***,the structural stability and conductivity of LTO were studied using in situ high-pressure measurements and first-principles *** underwent a pressure-induced amorphization(PIA)at 26.9 *** impedance spectroscopy revealed that the conductivity of LTO improved significantly after amorphization and that the conductivity of decompressed amorphous LTO increased by an order of magnitude compared with its starting ***,our calculations demonstrated that the different compressibility of the Li O6and Ti O6octahedra in the structure was crucial for the *** amorphous phase promotes Li+diffusion and enhances its ionic conductivity by providing defects for ion *** results not only provide an insight into the pressure depended structural properties of a spinel-like material,but also facilitate exploration of the interplay between PIA and conductivity.

关键词： high pressure pressure-induced amorphization lithium-ion battery materials ionic conductivity

Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B

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World Journal of Gastroenterology 2012年第47期18卷 6943-6950页

作者： Suk Bae Kim Il Han Song Young Min Kim Ran Noh Ha Yan Kang Hyang Ie Lee Hyeon Yoong Yang An Na Kim Hee Bok Chae Sae Hwan Lee hong Soo Kim Tae Hee Lee Young Woo Kang Eaum seok Lee seok Hyun Kim Byung seok Lee Heon Young Lee Department of Internal Medicine Dankook University College of MedicineCheonan 330-715South Korea Department of Internal Medicine Eulji University College of MedicineDaejeon 302-779South Korea Department of Internal Medicine Chungbuk University College of MedicineCheongju 362-711South Korea Department of Internal Medicine Soonchunhyang University College of MedicineCheonan 330-090South Korea Department of Internal Medicine Konyang University College of MedicineDaejeon 371-718South Korea Department of Internal Medicine Chungnam University College of MedicineDaejeon 301-721South Korea

AIM:To evaluate the treatment outcomes of clevudine compared with entecavir in antiviral-naive patients with chronic hepatitis B(CHB).METHODS:We retrospectively analyzed the clinical data of CHB patients treated with clevudine 30 mg/d and compared their clinical outcomes with patients treated with entecavir 0.5 mg/*** biochemical response,as assessed by serum alanine aminotransferase(ALT) activity,virologic response,as assessed by serum hepatitis B virus DNA(HBV DNA) titer,serologic response,as assessed by hepatitis B e antigen(HBeAg) status,and virologic breakthrough with genotypic mutations were ***:Two-hundred and fifty-four patients [clevudine(n = 118) vs entecavir(n = 136)] were *** clevudine-treated patients,the cumulative rates of serum ALT normalization were 83.9% at week 48 and 91.5% at week 96(80.9% and 91.2% in the entecavir group,respectively),the mean titer changes in serum HBV DNA were-6.03 and-6.55 log 10 copies/mL(-6.35 and-6.86 log 10 copies/mL,respectively,in the entecavir group),and the cumulative non-detection rates of serum HBV DNA were 72.6% and 83.1%(74.4% and 83.8%,respectively,in the entecavir group).These results were similar to those of entecavir-treated *** cumulative rates of HBeAg seroconversion were 21.8% at week 48 and 25.0% at week 96 in patients treated with clevudine,which was similar to patients treated with entecavir(22.8% and 27.7%,respectively).The virologic breakthrough in the clevudine group occurred in 9(7.6%) patients at weeks 48 and 15(12.7%) patients at week 96,which primarily corresponded to genotypic mutations of rtM204I and/or *** was no virologic breakthrough in the entecavir ***:In antiviral-naive CHB patients,longterm treatment outcomes of clevudine were not inferior to those of entecavir,except for virologic breakthrough.

关键词： Chronic hepatitis B Hepatitis B virus Clevudine Entecavir Treatment outcomes

Pancreatic tuberculosis masquerading as pancreatic serous cystadenoma

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World Journal of Gastroenterology 2009年第8期15卷 1010-1013页

作者： Seung Goun hong Jae Seon Kim Moon Kyung Joo kwang Gyun Lee Key Hyeon Kim Cho Rong Oh Jong-Jae Park Young-Tae Bak Department of Internal Medicine Korea University College of Medicine Seoul South Korea

Solitary pancreatic involvement of tuberculosis is rare, especially in an immunocompetent individual, and it may be misdiagnosed as pancreatic cystic neoplasms. Pancreatic cystic neoplasms are being identified in increasing numbers, probably because of the frequent use of radiology and advances in endoscopic techniques. However, they are composed of a variety of neoplasms with a wide range of malignant potential, and it is often difficult to differentiate pancreatic tuberculosis mimicking cystic neoplasms from benign or malignant pancreatic cystic neoplasms. Non-surgical diagnosis of pancreatic tuberculosis is inconclusive and continues to be a challenge in many cases. If so, then laparotomy should be employed to establish the diagnosis. Therefore, pancreatic tuberculosis should be kept in mind during the differential diagnosis of solitary cystic masses in the pancreas. We report a patient who had solitary pancreatic tuberculosis masquerading as pancreatic serous cystadenoma.

关键词： Tuberculosis Pancreas Cystadenoma Serous neoplasm

Predictive factors associated with malignancy of intraductal papillary mucinous pancreatic neoplasms

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World Journal of Gastroenterology 2010年第42期16卷 5353-5358页

作者： Jin Hee Lee Kyu Taek Lee Jongwook Park Sun Youn Bae kwang Hyuck Lee Jong Kyun Lee Kee-Taek Jang Jin seok Heo Seong Ho Choi Dong Wook Choi Jong Chul Rhee Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135710South Korea Department of Pathology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135710South Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135710South Korea

AIM:To identify preoperative predictive factors associated with malignancy of intraductal papillary mucinous neoplasms(IPMNs) of the ***:Between April 1995 and April 2010,129 patients underwent surgical resection for IPMNs at our institute and had confirmed pathologic *** medical records were retrospectively reviewed and immunohistochemical staining for mucin(MUC) in pancreatic tissues was ***:Univariate analysis showed that the following five variables were closely associated with malignant IPMNs preoperatively:absence of extrapancreatic malignancy;symptoms;tumor size > 4 cm;main pancreaticduct(MPD) size > 7 mm;and lymph node enlargement on preoperative computed tomography(CT).Multivariate analysis revealed that the following two factors were significantly associated with malignant IPMNs preoperatively:MPD size > 7 mm [odds ratio(OR) = 2.50];and lymph node enlargement on preoperative CT(OR = 3.57).No significant differences in the expression of MUC1,MUC2 and MUC5AC were observed between benign and malignant ***:MPD size > 7 mm and preoperative lymph node enlargement on CT are useful predictive factors associated with malignancy of IPMNs.

关键词： Intraductal papillary mucinous neoplasms Malignancy Predictive factors Pancreatic neoplasms

Identification of TRPM7 channels in human intestinal interstitial cells of Cajal

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World Journal of Gastroenterology 2009年第46期15卷 5799-5804页

作者： Byung Joo Kim Kyu Joo Park Hyung Woo Kim seok Choi Jae Yeoul Jun In Youb Chang Ju-hong Jeon Insuk So Seon Jeong Kim School of Korean Medicine Pusan National University Department of Surgery College of MedicineSeoul National University Department of Physiology College of MedicineChosun University Department of Anatomy College of MedicineChosun University Center for Bio-Artif icial Muscle and Department of Physiology College of MedicineSeoul National University Center for Bio-Artifi cial Muscle and Depart-ment of Biomedical Engineering Hanyang University

AIM： To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 （TRPM7） in the human gastrointestinal （GI） tract. METHODS： Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajat （ICCs）. RESULTS： The human GI tract generated slow electrical waves and had ICCs which functioned as pacemak er cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB （2-aminoethoxydiphenyl borate） and La3＋, TRPM7 channel blockers, inhibited the slowwaves. Also, TRPM7 channels were expressed in ICCs in human tissue. CONCLUSION： These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the gen- eration of the slow waves.

关键词： Electrophysiology Interstitial cells of Cajal TRPM cation channels Transient receptor potential melastatin-type 7 protein Human Gastrointestinal tract

Comparison of cytological and histological preparations in the diagnosis of pancreatic malignancies using endoscopic ultrasoundguided fine needle aspiration

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 418-423页

作者： Dong Kee Jang Sang Hyub Lee Jun Kyu Lee Woo Hyun Paik kwang Hyun Chung Ban seok Lee Jun Hyuk Son Jae Woo Lee Ji Kon Ryu Yong-Tae Kim Kyoung-Bun Lee Department of Internal Medicine Dongguk University Ilsan Medical CenterGoyang-siGyeonggi-doKorea Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Inje University Ilsan Paik HospitalGoyang-siGyeonggi-doKorea Department of Pathology Seoul National University College of MedicineSeoulKorea

BACKGROUND:Endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) has become a crucial diagnostic technique for pancreatic *** specimen obtained by EUS-FNA can be prepared for either cytological or histological *** study was to compare diagnostic performance of cytological and histological preparations using EUSFNA in the same lesions when pancreatic malignancies were ***:One hundred and eighteen patients who underwent EUS-FNA for suspected pancreatic malignancies were consecutively *** procedures were conducted by a single echoendoscopist under the same *** adequate preparations were obtained by 22-gauge needles with 20 to-and-fro movements for each *** 4 preparations included 2 cytological and 2 histological *** pathologic reviews of all specimens were conducted independently by a single experienced ***,specificity,and accuracy of the 2 preparations were ***:The enrolled patients consisted of 62 males(52.5%),with the mean age of 64.6±10.5 *** was performed in 23(19.5%) *** hundred and sixteen(98.3%) lesions were classified as malignant,while 2(1.7%) were *** of cytology and histology were 87.9% and 81.9%,respectively,with no significant difference(P=0.190).Accuracy was also not significantly *** preparation was more sensitive when the size of lesion was <3 cm(86.7% vs 68.9%,P=0.033).CONCLUSIONS:Our results suggested that the diagnostic performances of cytological and histological preparations are not significantly different for the diagnosis of pancreatic ***,cytological preparation might be more sensitive for pancreatic lesions <3 cm.

关键词： endoscopic ultrasound-guided fine needle aspiration pancreatic neoplasms cytology pathology histology

Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

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World Journal of Gastroenterology 2007年第30期13卷 4072-4079页

作者： Yeon seok Seo Ji Hoon Kim Jong Eun Yeon Jong-Jae Park Jae Seon Kim Kwan Soo Byun Young-Tae Bak Chang hong Lee Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University College of Medicine Seoul Korea Division of Gastroenterology and Hepatology Department of Internal Medicine Konkuk University College of Medicine Seoul Korea

AIM： To compare the antiviral efficacy of adefovir （ADV） in lamivudine （LMV）-resistant patients with LMV treatment in nucleoside-naive patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV.METHODS： Forty-four patients with chronic hepatitis B （CHB） were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following： reduction in serum HBV DNA from baseline, HBV DNA negative conversion （defined as HBV DNA being undectable by the hybridization assay）, and HBV DNA response （either HBV DNA level ≤ 10^s copies/mL or a ≥ 2 log10 reduction from baseline HBV DNA level）.RESULTS： After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment （P = 0.021）. HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively （P = 0.001）. Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively （P = 0.026）. The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV.CONCLUSION： The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naive patients during the early course of treatment.

关键词： Chronic hepatitis B Lamivudine Adefovir Treatment efficacy

Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years:comparisons between cohorts aged over 70 and less than 70 years

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Asian Journal of Andrology 2020年第3期22卷 280-286页

作者： Young Ju Lee Jin-Woo Jung Sangchul Lee Sang Wook Lee Jeong Hyun Kim Sung Kyu hong seok-Soo Byun Sang Eun Lee Seong Jin Jeong Departme nt of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Catholic Kwan dong Univerisity International St.Mary's HospitalIncheon 22711Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea.

We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and70 years[n=610]vs70 years gradually increased up to 30.0%,and the rate of robot-assisted RP and neurovascular bundle(NVB)saving increased continually to 80.0%and 67.4%of older patients,*** the rate of recovery of UC within 12 months(3 months)in patients aged>70 years was lower than that in those aged S70 years(81.5%[52.6%]vs 88.6%[60.9%],respectively;both P70 ***,unlike younger patients,only variables(age and MUL),possibly associated with the inhere nt fun ction of the urinary sphi ncter,were predictors of recovery of UC in patients aged>70 years.

关键词： elderly predictor prostate cancer radical prostatectomy urinary incontinence

Dissecting microRNA-mediated regulation of stemness,reprogramming,and pluripotency

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Cell Regeneration 2016年第1期5卷 12-21页

作者： Young Jin Lee Suresh Ramakrishna Himanshu Chauhan Won Sun Park seok-Ho hong Kye-Seong Kim iDream Research Center MizMedi Women’s HospitalSeoul 07639South Korea Department of Biomedical Science Graduate School of Biomedical Science and EngineeringHanyang University222 Wangsimni-roSeongdong-guSeoul 04763South Korea College of Medicine Hanyang UniversitySeoulSouth Korea Uppsala University 75236 UppsalaSweden Department of Physiology School of MedicineKangwon National UniversityChuncheon 24341South Korea Department of Internal Medicine School of MedicineKangwon National University1 Kangwondaehak-gilChuncheon-siGangwon-do 24341South Korea Stem Cell Institute Kangwon National UniversityChuncheon 24341South Korea

Increasing evidence indicates that microRNAs(miRNAs),endogenous short non-coding RNAs 19–24 nucleotides in length,play key regulatory roles in various biological events at the post-transcriptional *** stem cells(ESCs)represent a valuable tool for disease modeling,drug discovery,developmental studies,and potential cell-based therapies in regenerative medicine due to their unlimited self-renewal and ***,remarkable progress has been made in recent decades toward understanding the expression and functions of specific miRNAs in the establishment and maintenance of ***,we summarize the recent knowledge regarding the regulatory roles of miRNAs in self-renewal of pluripotent ESCs and during cellular reprogramming,as well as the potential role of miRNAs in two distinct pluripotent states(naïve and primed).

关键词： miRNAs Embryonic stem cells Pluripotency Reprogramming Self-renewal