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Comparing the effects of dual-task training and single-task training on walking,balance and cognitive functions in individuals with Parkinson’s disease:A systematic review

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Chinese Medical Journal 2024年第13期137卷 1535-1543页

作者： Xiaoying Lin Yanming Zhang Xiaowei Zhang Xi Chen Jianhua Liu Lei Yang Marco Yiu chung Pang Department of Rehabilitation Medicine the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Rehabilitation Medicine The Second People’s Hospital of KunmingKunmingYunnan 650051China Department of Rehabilitation Medicine Xuanwu HospitalCapital Medical UniversityBeijing 100000China Department of Physical therapy China Rehabilitation Research CenterBeijing 100000China Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong 999077China

Background:t.is systematic review aimed to examine whether dual-task(Dt)training was superior to single-task(St)training in improving Dt walking,balance and cognitive functions for individuals with Parkinson’s disease(PD).Methods:Literature search was performed in the following electronic databases:PubMed,the Cochrane Library,Web of Science,and Metstr covering inception to May 10,*** in order to facilitate comparison across t.ials,we calculated the effect size(Hedges’g)of gait,balance,cognitive,and other parameters under both St and Dt conditions,using the mean change score and standard deviation(SD)of change score of the experimental and control *** controlled t.ials that examined the effects of Dt motor and cognitive training in individuals with Parkinson’s disease were included for t.is systematic ***:A total of 214 participants recruited from six articles(actually five t.ials)were involved in t.is *** terms of walking ability,only double support time and st.ide time variability showed significant between-group difference(Hedges’g=0.34,0.18,respectively).Compared to St training group,Dt training group had a more improvement effect.in laboratory balance measurement(Hedges’g=0.18,1.25),but no significant.improvement.in clinical balance *** significant between-group differences were observed,thus its training effect on cognitive function was ***:the Dt training failed to achieve promising results better than St training in improving Dt walking and balance functions for individuals with *** firm conclusion cannot be drawn at present,due to the limited number of eligible *** sample size and high-quality studies are needed to investigate the effectiveness of Dt training in individuals with PD.

关键词： Parkinson’s disease Dual-task training Mobility Cognition Systematic review

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Galectin 3-binding prot.in(LGALS3BP)depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1(tGF-β1)availability and inhibits hepatocarcinogenesis

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Cancer Communications 2024年第10期44卷 1106-1129页

作者： Dae-Hwan Kim Minjeong Sung Myong-Suk Park Eun-Gene Sun Sumin Yoon Kyung Hyun Yoo Kamalakannan Radhakrishnan Sung Yun Jung Woo-Kyun Bae Sang-Hee Cho ik-Joo chung Department of internal Medicine Division of Hematology and OncologyChonnam National University Medical SchoolHwasunSouth Korea Department of internal Medicine Division of Hematology and OncologyChonnam National University Hwasun HospitalHwasunSouth Korea Combinatorial tumor immunotherapy MRC Center Chonnam National University Medical SchoolHwasunSouth Korea National immunotherapy innovation Center HwasunSouth Korea BioMedical Sciences Graduate Program Chonnam National UniversityHwasunSouth Korea Department of Biological Science SookmyungWomen’s UniversitySeoulSouth Korea Clinical Vaccine R&D Center Chonnam National UniversityHwasunSouth Korea Department of Biochemistry and Molecular Pharmacology Baylor College of MedicineHoustonTexasUSA

Background:increased Galectin 3-binding prot.in(LGALS3BP)serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma(HCC).Considering the crucial role of transforming growth factor-β1(tGF-β1)in the emergence of these diseases,the present study tested the hypothesis that LGALS3BP regulates the tGF-β1 signaling ***:the expression levels of LGALS3BP and tGFB1 were analyzed in patients with metabolic dysfunction-associated steatohepatitis(MASH)and *** omics techniques,such as RNA-sequencing,transposaseaccessible chromatin-sequencing assay,and liquid chromatography-tandem mass spectrometry proteomics,were used to identify the regulatory mechanisms for the LGALS3BP-tGF-β1 *** effects of altered tGF-β1 signaling by LGALS3BP were investigated in conditional LGALS3BP-knockin and LGALS3BP-knockout ***:in patients with MASH and HCC,the levels of LGALS3BP and tGFB1 exhibited positive *** of LGALS3BP by the inflammatory cytokine interferonαin HCC cells or ectopic overexpression of LGALS3BP in hepatocytes promoted the expression levels of *** fibrosis was observed in the livers of hepatocyte-specific LGALS3BP-knockin mice,with increased tGFB1 ***3BP directly bound to and assembled integrinαV,an integral mediator required for releasing active tGF-β1 from extracellular latent complex with the rearranged F-actin *** released tGF-β1 activated JunB transcription factor,which in turn promoted the tGF-β1 positive feedback ***3BP deletion in the hepatocytes downregulated tGF-β1 signaling and CCl4 induced ***,LGALS3BP depletion hindered hepatocarcinogenesis by limiting the availability of fibrogenic tGF-β***:LGALS3BP plays a crucial role in hepatic fibrosis and carcinogenesis by controlling the tGF-β1 signaling pathway,making it a promising therapeutic target.in tGF-β1-related diseases.

关键词： F-actin FAK hepatic carcinogenesis integrinαV interferonα JunB LGALS3BP metabolic dysfuntion-associated steatohepatitis tensile force tGF-β1

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Heightened prot.in-translation activities in mammalian cells and the disease/treatment.implications

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National Science Review 2020年第12期7卷 1851-1855页

作者： chung-i Wu Haijun Wen State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen University

After cells divide,the new cells have to synthesize all the necessary cellular components in time for the next *** is a lower bound of time required for cells to double their *** mammalian cells,t.is lower bound may b... 详细信息

关键词： MYELOiD-LEUKEMiA OMACEtAXiNE MEPESUCCiNAtE HOMOHARRiNGtONiNE iNHiBitiON CANCER HARRiNGtONiNE HEtEROGENEitY EVOLUtiON

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Elect.ical performance and reliability analysis of vertical gallium nit.ide Schottky barrier diodes with dual-ion implanted edge termination

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Chip 2024年第3期3卷 36-42页

作者： Bo Li Jinpei Lin Linfei Gao Zhengweng Ma Huakai Yang Zhihao Wu Hsien-Chin Chiu Hao-chung Kuo Chunfu Zhang Zhihong Liu Shuangwu Huang Wei He Xinke Liu College of Materials Science and Engineering College of Electronics and Information EngineeringInstitute of Microelectronics(IME)Guangdong Research Center for Interfacial Engineering of Functional MaterialsState Key Laboratory of Radio Frequency Heterogeneous IntegrationShenzhen UniversityShenzhen 518060China Department of Electronic Engineering Chang Gung UniversityTaoyuan 333TaiwanChina Department of Photonics and the institute of Electro-Optical Engineering and with Foxconn Semiconductor Research InstituteNational Chiao Tung UniversityHsinchu 300TaiwanChina Xidian University School of MicroelectronicsXi’an710071China

in t.is study,a galliumnit.ide(GaN)substrate and its 15μmepitaxial layer were entirely grown by adopting the hydride vapor phase epitaxy(HVPE)*** enhance the breakdown voltage(VBR)of vertical GaN-on-GaN Schottky barrier diodes(SBDs),a dual ion coimplantation of carbon and heliumwas employed to create the edge *** resulting devices exhibited a low turn-on voltage of 0.55 V,a high ion/ioff ratio of approximately 109,and a lowspecific onresistance of 1.93 mU cm^(2).When the ion implantation edge was terminated,the maximumVBR of the devices reached 1575 V,with an average improvement of 126%.these devices demonstrated a high figure of merit(FOM)of 1.28 GW cm^(-2) and showed excellent reliability during pulse stress testing.

关键词： Vertical GaN SBD HVPE Dual ion co-implantation Leakage mechanism Device reliability

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Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endomet.iosis

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Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan Hung Massimiliano Gaetani Yiran Li Zhouyurong tan Xu Zheng Ruizhe Zhang Yang Ding Gene Chi Wai Man tao Zhang Yi Song Yao Wang Jacqueline Pui Wah chung tak Hang Chan Roman A.Zubarev Chi Chiu Wang Department of Obstet.ics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry i Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endomet.iosis is a common chronic gynecological disease with endomet.ial cell implantation out.ide the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endomet.iotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** t.is study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome integral Solubility Alteration assay-based chemical proteomics identified metadherin(MtDH)and PX domain cont.ining serine/threonine kinase-like(PXK)as novel binding targets of EGCG and ProEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MtDH-EGCG inhibited prot.in kinase B(Akt)-mediated angiogenesis,while PXK-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HiF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endomet.iosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis treatment Endomet.iosis

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Blockchain for Education:Verification and Management of Lifelong Learning Data

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Computer Systems Science & Engineering 2022年第11期43卷 591-604页

作者： Ba-Lam Do Van-thanh Nguyen hoang-Nam Dinh thanh-chung Dao BinhMinh Nguyen School of information and Communication technology Hanoi University of Science and TechnologyHanoiVietnam

in recent years,blockchain technology has been applied in the educational domain because of its salient advantages,i.e.,transparency,decentralization,and *** systems typically use public blockchain networks such as Ethereum and Bitcoin to store learning ***,the cost of writing data on these networks is significant,making educational institutions limit data sent to the target network,typically cont.ining only hash codes of the issued *** t.is paper,we present a system based on a private blockchain network for lifelong learning data authentication and management named B4E(Blockchain For Education).B4E stores not only certificates but also learners’training data such as transcripts and educational programs in order to create a complete record of the lifelong education of each user and verify certificates that they have *** a result,B4E can address two types of fake certificates,i.e.,certificates printed by unlawful organizations and certificates issued by educational institutions for learners who have not met the training *** addition,B4E is designed to allow all participants to easily deploy software packages to manage,share,and check stored information without depending on a single point of *** such,the system enhances the transparency and reliability of the stored *** experiments show that B4E meets expectations for deployment.in reality.

关键词： training data certificate verification and management private blockchain

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Univector field method-based multi-agent navigation for pursuit problem in obstacle environments

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Journal of Central South University 2017年第4期24卷 1002-1012页

作者： Le Pham tuyen hoang Huu Viet Sang Hyeok An Seung Gwan Lee Dong-Han Kim tae Choong chung Department of Computer Science and Engineering Kyung Hee University Yongin Gyeonggi 446-701 Korea Department of information technology Vinh University 182-Le Duan Vinh City Nghe An 461056 Vietnam Humanitas College Kyung Hee University Yongin Gyeonggi 446-701 Korea Department of Electronics and Radio Engineering Kyung Hee University Yongin Gyeonggi 446-701 Korea

the pursuit problem is a well-known problem in computer science. in t.is problem, a group of predator agents attempt to capture a prey agent.in an environment with various obstacle types, partial observation, and an infinite grid-world. Predator agents are applied algorithms that use the univector field method to reach the prey agent, strategies for avoiding obstacles and strategies for cooperation between predator agents. Obstacle avoidance strategies are generalized and presented through strategies called hit.ing and following boundary(HFB); trapped and following shortest path(tFSP); and predicted and following shortest path(PFSP). in terms of cooperation, cooperation strategies are employed to more quickly reach and capture the prey agent. Experimental results are shown to illustrate the efficiency of the method in the pursuit problem.

关键词： pursuit problem predator agent prey agent univector field method multi-agent systems

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Understanding the development and function of t follicular helper cells

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Cellular & Molecular immunology 2010年第3期7卷 190-197页

作者： Roza i Nurieva Yeonseok chung Department of immunology University of Texas MD Anderson Cancer CenterHoustonTXUSA

A fundamental function of t helper(th)cells is to regulate B-cell proliferation and immunoglobulin class switching,especially in the germinal ***1 and th2 lineages of CD41 t cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a(igG2a)and igG1/igE,***,it has become clear that a subset CD41 t cells,named t follicular helper(tfh)cells,is critical to B-cell response *** t.is review,we summarize the latest advances in our understanding of the regulation of tfh cell differentiation,the relationship of tfh cells to other CD41 t-cell lineages,and the role of tfh cells in health and disease.

关键词： aut.immunity Bcl6 costimulation iL-21 t follicular helper(tfh)cells

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integration of 1H-NMR-Based Metabolomics Approach with traditional Chinese Pulse Diagnosis to Evaluate the Qi-Enhancing Activity of Herbal tea

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Chinese Medicine 2024年第3期15卷 49-74页

作者： Chia-Hsin Lin Po-Jung Huang chung-Hsuan Wang Mo-Rong Xu Sheng-Yang Wang Department of Forestry Chung Hsing University Taichung Fu Kang traditional Chinese Medicine Clinic Nantou Special Crop and Metabolome Discipline Cluster Academy Circle Economy Chung Hsing University Taichung Agricultural Biotechnology Research institute Academia Sinica Taipei City

Human metabolism is int.icately linked to an individual’s health status. Regardless of living habits, it will be reflected in the metabolic characteristics of urine. the utilization of the 1H NMR-based metabolomics method has enabled examine the metabolomic changes in urine under various physiology conditions, providing valuable insights into metabolites. in t.is particular study, volunteers were divided into two groups based on the strength of their spleen pulses, using the pulse diagnosis method employed in traditional Chinese medicine. Subsequently, their urine samples were analyzed, revealing notable variances in urea, creatinine, cit.ic acid, succinic acid, t.imethylamine-N-oxide (tMAO), alanine, hippuric acid, and glycine between the two groups. interestingly, individuals with weak spleen pulses showed significant.improvements after consuming herbal tea. Furthermore, we conducted LC-MS analysis on herbal tea and performed adenosine t.iphosphate (AtP) activity tests on the C2C12 mouse skeletal muscle cell line. the results indicated that wit.in a reasonable concentration range, exposure to herbal tea led to an increase in the mitochondrial AtP production capacity of C2C12 cells. these findings shed light on the relationship between traditional Chinese medicine pulse diagnosis and urine metabolites, highlighting their potential as non-invasive and straightforward health assessment.indicators. they can aid in the preliminary determination of necessary dietary and lifestyle changes to enhance overall bodily health.

关键词： 1H-NMR Metabolomics traditional Chinese Pulse Diagnosis Qi-Enhancing Herbal tea

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Ocular image-based deep learning for predicting refractive error:A systematic review

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Advances in Ophthalmology Practice and Research 2024年第3期4卷 164-172页

作者： Samantha Min Er Yew Yibing Chen Jocelyn Hui Lin Goh David Ziyou Chen Marcus Chun Jin tan Ching-Yu Cheng Victor teck Chang Koh Yih chung tham Department of Ophthalmology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Centre for innovation and Precision Eye Health Yong Loo Lin School of MedicineNational University of SingaporeSingapore School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore Singapore Eye Research institute Singapore National Eye CentreSingapore Department of Ophthalmology National University HospitalSingapore Ophthalmology and Visual Sciences(Eye ACP) Duke-NUS Medical SchoolSingapore

ackground:Uncorrected refractive error is a major cause of vision impairment worldwide and its increasing prevalent necessitates effective screening and management ***,deep learning,a subset of Artificial intelligence,has significantly advanced ophthalmological diagnostics by automating tasks that required extensive clinical *** recent studies have investigated the use of deep learning models for refractive power detection through various imaging techniques,a comprehensive systematic review on t.is topic is has yet be *** review aims to summarise and evaluate the performance of ocular image-based deep learning models in predicting refractive *** text:We search on three databases(PubMed,Scopus,Web of Science)up till June 2023,focusing on deep learning applications in detecting refractive error from ocular *** included studies that had reported refractive error outcomes,regardless of publication *** systematically extracted and evaluated the continuous outcomes(sphere,SE,cylinder)and categorical outcomes(myopia),ground truth measurements,ocular imaging modalities,deep learning models,and performance met.ics,adhering to PRiSMA *** studies were identified and categorised into three groups:retinal photo-based(n=5),OCt-based(n=1),and external ocular photo-based(n=3).For high myopia prediction,retinal photo-based models achieved AUC between 0.91 and 0.98,sensitivity levels between 85.10%and 97.80%,and specificity levels between 76.40%and 94.50%.For continuous prediction,retinal photo-based models reported MAE ranging from 0.31D to 2.19D,and R^(2) between 0.05 and *** OCt-based model achieved an AUC of 0.79–0.81,sensitivity of 82.30%and 87.20%and specificity of 61.70%–68.90%.For external ocular photo-based models,the AUC ranged from 0.91 to 0.99,sensitivity of 81.13%–84.00%and specificity of 74.00%–86.42%,MAE ranges from 0.07D to 0.18D and accuracy ranges from 81.60%to 96.70%.the reported papers colle

关键词： Deep Learning Artificial intelligence Refractive Error Retinal images Optical Coherence tomography Photorefraction Ocular images Prediction

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