Understanding the development and function of T follicular helper cells

作     者：Roza I Nurieva Yeonseok Chung 

作者机构：Department of ImmunologyUniversity of Texas MD Anderson Cancer CenterHoustonTXUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2010年第7卷第3期

页      面：190-197页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Institutes of Health, NIH National Institute of Allergy and Infectious Diseases, NIAID, (R01AI083761) 

主　　题：autoimmunity Bcl6 costimulation IL-21 T follicular helper(Tfh)cells 

摘      要：A fundamental function of T helper(Th)cells is to regulate B-cell proliferation and immunoglobulin class switching,especially in the germinal ***1 and Th2 lineages of CD41 T cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a(IgG2a)and IgG1/IgE,***,it has become clear that a subset CD41 T cells,named T follicular helper(Tfh)cells,is critical to B-cell response *** this review,we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation,the relationship of Tfh cells to other CD41 T-cell lineages,and the role of Tfh cells in health and disease.