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Effect of elements Ni and Co on morphology and type of IMC at Sn-3Ag-0.5Cu solder joint interface

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Journal of Harbin Institute of Technology(New Series) 2009年第5期16卷 648-651页

作者：孟工戈 TAKEMOTO Tadashi NISHIKAWA hiroshi School of Material Science & Engineering Harbin University of Science and Technology Joining and Welding Research Institute Osaka University

The intermetallic compound (IMC) is hard and brittle,and its forming and growth at soldering joint interface is an important issue in joint *** data obtained by digital optical electronic microscope indicate that the addition of element Co changes the IMC morphology from ball-like and bar-like to distinct and sharp in crest lines and *** addition of elements Ni and Co in Sn-3Ag-0.5Cu solder promotes the nucleation and makes the IMC size *** electron probe microanalysis (EPMA) determines the chemical compositions and confirms that the IMC is changed into the (Cu,Co,Ni)6Sn5+(Cu,Co,Ni)3Sn4 mixed type from the type of Cu6Sn5 with the elements Ni and Co in the solder.

关键词： Sn-3Ag-0. 5Cu solder IMC Ni/Co morphology type

AN EXPERIMENTAL METHOD OF MEASURING THE CRYSTALLIZATION FRONT TEMPERATURE

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Chinese Physics Letters 1984年第2期1卷 53-56页

作者： JIN Wei-qing hiroshi KOMATSU Shanghai Institute of Ceramics Academia Sinica The Research Institute for Iron Steel and Other MetalsTohoku UniversityJapan

By measuring the temperature of the crystallization front of salol by means of in situ observations on a thermally regulating stage, we have obtained the linear form of (TS/L-TM.B),i.e., the difference between the tem... 详细信息

关键词： crystallization interface solidified

Role of autophagy in the pathogenesis of inflammatory bowel disease

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World Journal of Gastroenterology 2017年第11期23卷 1944-1953页

作者： Tomoya Iida Kei Onodera hiroshi Nakase Department of Gastroenterology and Hepatology Sapporo Medical University School of MedicineHokkaido 060-8556Japan

Inflammatory bowel disease(IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune ***, some studies provided strong evidence that the process of autophagy affects several aspects of mucosal immune responses. Autophagy is a cellular stress response that plays key roles in physiological processes, such as innate and adaptive immunity, adaptation to starvation, degradation of aberrant proteins or organelles, antimicrobial defense, and protein secretion. Dysfunctional autophagy is recognized as a contributing factor in many chronic inflammatory diseases, including IBD. Autophagy plays multiple roles in IBD pathogenesis by altering processes that include intracellular bacterial killing, antimicrobial peptide secretion by Paneth cells, goblet cell function, proinflammatory cytokine production by macrophages, antigen presentation by dendritic cells, and the endoplasmic reticulum stress response in enterocytes. Recent studies have identified susceptibility genes involved in autophagy, such as NOD2, ATG16L1, and IRGM, and active research is ongoing all over the world. The aim of this review is a systematic appraisal of the current literature to provide a better understanding of the role of autophagy in the pathogenesis of IBD. Understanding these mechanisms will bring about new strategies for the treatment and prevention of IBD.

关键词： Autophagy Inflammatory bowel disease Genome-wide association study Ulcerative colitis Crohn’s disease

Mucosal-associated invariant T cells from induced pluripotent stem cells:A novel approach for modeling human diseases

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World Journal of Stem Cells 2016年第4期8卷 158-169页

作者： Chie Sugimoto Hiroyoshi Fujita hiroshi Wakao Department of Hygiene and Cellular Preventive Medicine Graduate School of MedicineHokkaido University

Mice have frequently been used to model human diseases involving immune dysregulation such as autoimmune and inflammatory *** models help elucidatethe mechanisms underlying the disease and in the development of novel ***,if mice are deficient in certain cells and/or effectors associated with human diseases,how can their functions be investigated in this species?Mucosal-associated invariant T(MAIT)cells,a novel innate-like T cell family member,are a good *** cells are abundant in humans but scarce in laboratory *** cells harbor an invariant T cell receptor and recognize nonpeptidic antigens vitamin B2metabolites from bacteria and *** studies have shown that MAIT cells play a pivotal role in human diseases such as bacterial infections and autoimmune and inflammatory *** cells possess granulysin,a human-specific effector molecule,but granulysin and its homologue are absent in ***,MAIT cells show poor proliferation in *** overcome these problems and further our knowledge of MAIT cells,we have established a method to expand MAIT cells via induced pluripotent stem cells(iP SCs).In this review,we describe recent advances in the field of MAIT cell research and our approach for human disease modeling with iP SCderived MAIT cells.

关键词： Mucosal-associated invariant T cells Induced pluripotent stem cells Differentiation Adoptive transfer Inflammatory diseases Autoimmune diseases Disease modeling Infectious diseases Immunocompromised mouse

Propofol sedation during endoscopic treatment for early gastric cancer compared to midazolam

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World Journal of Gastroenterology 2014年第34期20卷 11985-11990页

作者： Shinsuke Kiriyama hiroshi Naitoh Hiroyuki Kuwano Department of Surgery Gunma Chuo General HospitalMaebashiGunma 371-0025Japan Department of General Surgical Science Graduate School of MedicineGunma UniversityGunma 371-0025Japan

Endoscopic submucosal dissection(ESD)has been proposed as the gold standard in the treatment of early gastric cancer because it facilitates a more accurate histological assessment and reduces the risk of tumor ***,the time course of ESD for large gastric tumors is frequently prolonged because of the tumor size and technical difficulties and typically requires higher doses of sedative and pain-controlling *** or anesthetic drugs such as midazolam or propofol are used during the *** endoscopy of early gastric cancers can often be performed with only moderate *** with midazolam,propofol has a very fast onset of action,short plasma half-life and time to achieve sedation,faster time to recovery and discharge,and results in higher patient *** overall success,maintaining safety and stability not only during the procedure but also subsequently in the recovery room and ward is *** obese patients,it is recommended that the injected dose be based on a calculated standard *** between gastroenterologists,surgeons,and anesthesiologists is imperative for a successful ESD procedure.

关键词： Sedation Gastric cancer Endoscopic submucosal dissection Endoscopic resection Propofol

Computational Modeling of Optical Response from Excitons in a Nano OpticalMedium

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Communications in Computational Physics 2008年第10期4卷 1051-1068页

作者： Yuanchang Sun hiroshi Ajiki Gang Bao Department of Mathematics Michigan State UniversityEast LansingMI 48824USA Graduate School of Engineering Science Osaka University1-3 MachikaneyamaToyonaka 560-8531Japan

Consider a time-harmonic electromagnetic plane wave incident on a microscopic *** the medium,at any given frequencyω,more than one polariton mode can arise with the same frequency but different wavenumbers due to the presence of *** Maxwell’s boundary conditions,additional boundary conditions are required to handle the multi-mode *** order to model the confinement effect of excitons in the microscopic semiconductor,Maxwell’s equations and the Schr¨odinger equation are coupled to characterize the polarization in terms of the quantum *** the weak confinement regime,we derive a perturbed dispersive dielectric constant by taking the exciton effect into *** also analyze and compute the optical linear response of the exciton in both one-dimensional and two-dimensional *** the one-dimensional case,the existence and uniqueness of the analytical solution are established in the resonance region.A finite difference method is developed to compute the two dimensional confinement.

关键词： Nano optics exciton modeling

Specific targeting of lung ILC2s via NRP1 in pulmonary fibrosis

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Cellular & Molecular Immunology 2022年第8期19卷 869-871页

作者： Takuro Nii Kiyoharu Fukushima hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical Center5-1-1 ToneyamaOsakaJapan Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsakaJapan Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center(WPI-IFReC)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Host Defense Research Institute for Microbial Diseases(RIMD)Osaka UniversityOsaka565-0871Japan Global Center for Medical Engineering and Informatics 2-2 YamadaokaSuitaOsakaJapan

Innate lymphoid cells are predominantly tissue-resident immune cells that have diverse functions similar to T-cell subsets and regulate tissue homeostasis and innate immunity without specific antigen recognition. Prev... 详细信息

关键词： ILC2s immunity homeostasis

TEMPO-substituted polyacrylamide for an aqueous electrolyte-typed and organic-based rechargeable device

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Science China Chemistry 2012年第5期55卷 822-829页

作者： CHIKUSHI Natsuru YAMADA hiroshi OYAIZU Kenichi NISHIDE Hiroyuki Department of Applied Chemistry Waseda University Tokyo 169-8555 Japan

A hydrophilic radical polymer, poly（2,2,6,6-teteramethylpiperidinyloxyl-4-yl acrylamide）（PTAm）, was synthesized via oxidation of the corresponding precursor polymer, poly（2,2,6,6-teteramethylpiperidine-4-yl acrylamide）. Electrochemical properties of the PTAm layer were characterized in three aqueous electrolytes of sodium chloride （NaCl）, sodium tetrafluoroborate （NaBF4）, and sodium hexafluorophosphate （NaPF6） to optimize its activity as an organic cathode. The counter anion species significantly affected the capacity and the cycle performance of the PTAm layer. The PTAm layer in the presence of BF4？ displayed quantitative redox capacity beyond 1 μm layer thickness and maintained the discharging capacity of 110 mAh g-1 （97% vs. the calculated capacity） even after 1000 cycle charging/discharging, which could be ascribed to its appropriate affinity to the aqueous electrolyte without any dissolution into the electrolyte. A totally organic-based rechargeable cell was fabricated using PTAm and poly（N-4,4＇-bipyridinium-N-decamethylene dibromide） as the cathode and the anode, respectively, and the aqueous electrolyte of NaBF4. The cell gave a plateau voltage at 1.2 V both on charging and discharging and an excellent charging/discharging cyclability of ＆gt;2000 with high coulombic efficiency of ＆gt;95%.

关键词： polyacrylamide organic radical molecule redox polymer aqueous electrolyte rechargeable battery

Autonomic and cardiovascular effects of pentobarbital anesthesia during trigeminal stimulation in cats

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International Journal of Oral Science 2012年第1期4卷 24-29页

作者： hiroshi Hanamoto Hitoshi Niwa Mitsutaka Sugimura Yoshinari Morimoto Department of Dental Anesthesiology Osaka University Graduate School of DentistryOsakaJapan

Stimulation of the trigeminal nerve can elicit various cardiovascular and autonomic responses;however,the effects of anesthesia with pentobarbital sodium on these responses are *** sodium was infused intravenously at a nominal rate and the lingual nerve was electrically stimulated at each infusion *** in systolic blood pressure（SBP） and heart rate（HR） were evoked by lingual nerve stimulation at an infusion rate between 5 and 7 mg？kg 21 ？h *** response was associated with an increase in the low-frequency band of SBP variability（SBP-LF）.As the infusion rate increased to 10 mg？kg 21 ？h 21 or more,decreases in SBP and HR were *** response was associated with the reduction of *** conclusion,lingual nerve stimulation has both sympathomimetic and sympathoinhibitory effects,depending on the depth of pentobarbital *** reaction pattern seems to be closely related to the autonomic balance produced by pentobarbital anesthesia.

关键词： autonomic nervous system blood pressure and heart rate variability hemodynamics trigeminal depressor response