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Nanotechnology for diagnosis and therapy of theumatoid arthritis:Evolution towards theranostic approaches

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Chinese Chemical Letters 2021年第1期32卷 66-86页

作者： Junkai Zhao Xuan Chen Kwun-hei Ho Chao Cai Cheuk-Wing li Mo yang Changqing yi Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China Department of Biomedical Engineering the Hong Kong Polytechnic UniversityHong KongChina School of Science and Technology Nottingham Trent UniversityClifton LaneNottinghamNG118NSUnited Kingdom

Rheumatoid arthritis(RA),as a chronic autoimmune disease,damages the bone and cartilage of patients,and even leads to ***,the diagnosis and treatment of RA is particularly ***,due to the complexity of RA,it is difficult to make effective early diagnosis of RA,which is detrimental to RA ***,long-term intake of anti-RA drugs can also cause damage to patients' *** emergence of nanotechnology provides the new train of thoughts for the diagnosis and treatment of *** the combination of diagnosis and therapy is an ideal method to solve the problem of disease management of RA *** this review,we summarize the mechanism and microenvironment of RA,discuss the commonly used diagnostic techniques and therapeutic drugs for RA,and review their advantages and *** nanotherapy strategies such as drug-carrying nanoparticles,PTT,PDT are listed,and their applications in RA treatment are also *** addition,multimodal imaging,combined therapy and responsive diagnosis and treatment are also summarized as important *** last,we also review typical nanocarriers that can be used in the integration of diagnosis and therapy,and discussed their potential applications in RA theranostics.

关键词： Rheumatoid arthritis Diagnosis Therapy Theranostics Nanomedicine

Observation and mitigation of image distortion in high-energy electron radiography

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Nuclear Science and Techniques 2023年第6期34卷 69-77页

作者： Hao-Qing li liang Sheng Chang-Qing Zhang ying-Chao Du Zheng Zhou Xiu-Feng Weng Jia-Hao Xiao hong-Qiao yin Bin Sun Kun Wei yang li Bao-Jun Duan Yong-Tang liu Yan-hong Zhang Mei Zhang Yan Song Xiao-Dong Zhang Jun liu Zhu-Ming Fu Qing Xu Xue Du Jian-Peng Gao Xin-yi Wang Xin-Jian Tan Dong-Wei hei Department of Engineering Physics Tsinghua UniversityBeijing100084China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an710024China Institute of Applied Electronics China Academy of Engineering PhysicsMianyang621900China Institute of Intelligent Machines Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China Zhongke Hefei Institutes of Collaborative Research and Innovation for Intelligent Agriculture Hefei231131China

Image distortion caused by the angular misalignment of quadrupole magnets in high-energy electron radiography has been studied *** propose that the distortion originates from the coupling of the electron motions in the transverse directions,based on a theoretical analysis and the transfer-matrix *** relative angular rotation between the second and third magnetic quadrupoles was identified as the main contributor to image *** was verified by both a beam-dynamics simulation and *** strategies to mitigate this image distortion are also explored,including magnets online tuning,higher beam energy and larger magnification *** study provides criteria for designing experiments and paves the way for achieving higher image precision.

关键词： Misalignment Angular rotation Russian quadruplet Transfer matrix

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低复杂度上行多用户MIMO检测算法

通信学报 2010年第8期31卷 114-120页

作者：黑永强李晓辉易克初杨宏西安电子科技大学综合业务国家重点实验室陕西西安710071 中国空间技术研究院总体部北京100094

针对上行多用户MIMO系统,提出了一种新的空时检测算法。算法首先对接收信号进行线性重组,然后采用正交于各用户干扰集的匹配滤波向量来消除多用户间干扰,最后各用户利用等效信道的正交性实现线性译码。给出了非理想信道环境下算法的设... 详细信息

针对上行多用户MIMO系统,提出了一种新的空时检测算法。算法首先对接收信号进行线性重组,然后采用正交于各用户干扰集的匹配滤波向量来消除多用户间干扰,最后各用户利用等效信道的正交性实现线性译码。给出了非理想信道环境下算法的设计。理论分析及仿真结果表明,该算法具有复杂度低和顽健性好的优势,且性能优于其他检测算法。

关键词：多用户空时编码检测等效信道

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一种波束成形的分组空时编码系统检测算法

西安电子科技大学学报 2009年第4期36卷 649-654页

作者：黑永强李晓辉易克初杨宏西安电子科技大学综合业务网理论及关键技术国家重点实验室陕西西安710071 中国空间技术研究院总体部北京100094

根据分组空时编码系统的特性,提出了一种新的基于波束成形的检测算法.发射端采用酉矩阵将数据映射到空间正交的波束方向上,通过接收端波束方向上的匹配滤波,各数据分块所获得的增益为信道矩阵在其波束方向上的投影之和,波束选择通过最... 详细信息

根据分组空时编码系统的特性,提出了一种新的基于波束成形的检测算法.发射端采用酉矩阵将数据映射到空间正交的波束方向上,通过接收端波束方向上的匹配滤波,各数据分块所获得的增益为信道矩阵在其波束方向上的投影之和,波束选择通过最大化所有数据分块最小增益,从而有效地提高了系统的分集增益.进一步提出一种多速率分组空时编码的设计方案.理论分析和仿真结果表明,这种算法可获得更好的容量和误码性能,同时具有较低的译码复杂度.

关键词：波束成形分组空时编码波束选择分集增益

TNF-α,IL-6 and hs CRP in patients with melancholic,atypical and anxious depression:an antibodyyarrayanalysis related to somatic symptoms

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General Psychiatry 2022年第5期35卷 354-365页

作者： hongmei liu xiaohui Wu Yun Wang Xiaohua liu Daihui Peng Yan Wu Jun Chen Yun-Ai Su Jia Xu Xiancang Ma yi li Jianfei Shi Xiaodong yang Han Rong Marta Di Forti yiru Fang Clinical Research Center Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina Peking University Sixth Hospital BeijingChina Harbin First Specific Hospital HarbinChina Department of Psychiatry The First Affiliated Hospital of Xi'an Jiaotong UniversityXianChina Wuhan Mental Health Center WuhanChina Hangzhou Seventh People's Hospital HangzhouChina Shandong Mental Health Center JinanChina Shenzhen Mental Health Center ShenzhenChina Department of Social Genetics and Developmental Psychiatry Institute of Psychiatry Psychology and Neuroscience King's College LondonLondonUK Guangdong-hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence GuangzhouChina State Key Laboratory of Neuroscience Shangha nstitute for Biological SciencesCASShanghaiChina

Background The association between inflammation and major depressive disorder(MDD)remains poorly understood,given the heterogeneity of patients with *** We investigated inflammatory markers,such as interleukin(IL)-6,high-sensitivity C reactive protein(hsCRP)and tumour necrosis factor-α.(TNF-α)in melancholic,atypical and anxious depression and explored whether baseline inflammatory protein levels could indicate *** The sample consisted of participants(aged 18-55 years)from a previously reported multicentre randomised controlled trial with a parallel-group design registered with ***,including melancholic(n=44),atypical(n=37)and anxious(n=44)patients with depression and healthy controls(HCs)(n=33).Subtypes of MDD were classified according to the 30-item Inventory of Depressive Symptomatology,Self-Rated Version and the.17-item Hamilton Depression Rating *** *** TNF-α,IL-6 and hsCRP were assessed using antibody array *** Patients with MDD,classified according to melancholic,atypical and anxious depression subtypes,and HCs did not differ significantly in baseline TNF-α,IL-6 and hsCRP levels after *** patients with anxious depression,hsCRP levels increased significantly if they experienced no pain(adjusted(adj.)p=0.010)or mild to moderate pain(adj.p=0.038)compared with those with severe ***,the patients with anxious depression and severe pain showed a lower trend in hsCRP levels than patients with atypical depression who experienced severe pain(p=0.022;adj.p=0.155).Baseline TNF-α(adj.p=0.038)and IL-6(adj.p=0.006)levels in patients in remission were significantly lower than those in patients with no remission among the participants with the atypical depression subtype at the eighth-week *** This study provides evidence of differences in inflammatory proteins in patients with varied symptoms among melancholic,atypical and anxious depression *** studies on the immuno

关键词： patients atypical Blood

一种低复杂度Householder变换发射天线选择算法

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系统仿真学报 2010年第8期22卷 1997-2000页

作者：黑永强李晓辉易克初杨宏西安电子科技大学综合业务国家重点实验室西安710071 中国空间技术研究院总体部北京100094

提出一种低复杂度Householder变换发射天线选择算法(LGHQR)。以发射天线数目的一半为界,根据所选天线数目确定采用增加或删除的天线选择方式。分别将具有最大和最小范数的天线标记于增加集和删除集,每次只对剩余天线集进行Householder变... 详细信息

提出一种低复杂度Householder变换发射天线选择算法(LGHQR)。以发射天线数目的一半为界,根据所选天线数目确定采用增加或删除的天线选择方式。分别将具有最大和最小范数的天线标记于增加集和删除集,每次只对剩余天线集进行Householder变换,保证性能的同时降低算法的复杂度。所提算法进一步应用于相关信道下VBLAST系统来验证有效性。理论分析和仿真结果表明,与传统算法相比,所提算法具有较好的容量和误码性能。

关键词： Householder变换天线选择相关信道 QR分解

2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents

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Science Bulletin 2018年第23期63卷 1558-1564页

作者： Cheng Wang Yaqi li ying liao hong Tian Min Huang Xiangyu Dong lin Shi Jinghui Sun hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan hongyu Duan Xiangyu Dong lin Feng lijun Fu Fangqi Gong Yonghao Gui ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang hongfang Jin Mei Jin Bo li Fen li Tao li xiaohui li Xiaoyan liu Yan li Haitao Lv Tiewei Lv Zipu li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen lin Shi Kun Sun Jinghui Sun hong Tian Jie Tian Cheng Wang hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu yi Xu Hui Yan Shiwei yang Qijian yi Xia Yu Xianyi Yu Yue Yuan hongyan Zhang Huili Zhang li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu Department of Pediatric Cardiovasoloy Children's Medical CenterThe Second Xiangya HospitalCentral South UniversityChangsha 410071China Department of Pediatrics Peking University First HospitalBeijing 100034China Department of Pediatric Cardiology Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Cardiology Shanghai Children's HospitalShanghai 207102China of Pediatrics the 2nd Hospital of Lanzhou UniversityLanzhou 730020China Department of Pediatric Cardiology Capital Institute of PediatricsBezjing 100020China Department of Pediatrics Jilin University First HospitalChangchun 130021China Chinese Pediatric Cardiology Society Chinese Pediatric Society(CPCS)Chinese Medical Association(CMA)China Committee on Pediatric Syncope Pediatricians BranchChinese Medical Doctor Association(CMDA)China Pediatric Cardiology Society Beijing Pediatric SocietyBeijing Medical Association(BMA)China Committee on Pediatric Cardiology Chinese College of Cardiovascular PhysiciansChinese Medical Doctor Association(CMDA)China

Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department *** syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up.

关键词： CPCS Children Adolescent syncope

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眼眶骨瘤的手术技巧和疗效分析

中华眼科杂志 2008年第5期44卷 427-430页

作者：肖利华杨新吉王毅鲁小中魏红黑砚武警总医院眼眶病研究所北京100039

目的探讨眼眶骨瘤的手术技巧和疗效。方法系列病例研究。回顾性分析19例眼眶骨瘤患者的临床资料，患者的诊断均经手术和病理检查结果证实。结果骨瘤位于眶内侧10例，眶顶4例，眶外侧5例。手术入路为前路开眶8例，外侧开眶7例，内侧开... 详细信息

目的探讨眼眶骨瘤的手术技巧和疗效。方法系列病例研究。回顾性分析19例眼眶骨瘤患者的临床资料，患者的诊断均经手术和病理检查结果证实。结果骨瘤位于眶内侧10例，眶顶4例，眶外侧5例。手术入路为前路开眶8例，外侧开眶7例，内侧开眶2例，鼻侧切开2例。完全切除病变12例，大部分切除7例。结论眼眶骨瘤临床诊断容易，但手术治疗困难，选择合适的手术入路、娴熟的手术技巧，可避免术中和术后合并症的出现。

关键词：眶肿瘤骨瘤眼外科手术治疗结果

工业大数据驱动的核电装备智能设计-制造-服务技术与应用

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中国科学：技术科学 2023年第7期53卷 1043-1061页

作者：冯毅雄赵泽田胡炳涛易树平陈晓慧洪兆溪司恒远王理杨秦秦谭建荣浙江大学流体动力与机电系统国家重点实验室杭州310027 重庆大学机械传动国家重点实验室重庆400030 深圳中广核工程设计有限公司深圳518172 中广核工程有限公司深圳518038

针对核电大数据集成管理缺乏适应性和应用价值有限的问题,提出了一种基于工业大数据分析架构的核电装备智能设计制造服务体系.首先,基于核电大数据的领域特性设计了核电装备全生命周期数据空间,通过业务系统数据与主数据两个层次,实现... 详细信息

针对核电大数据集成管理缺乏适应性和应用价值有限的问题,提出了一种基于工业大数据分析架构的核电装备智能设计制造服务体系.首先,基于核电大数据的领域特性设计了核电装备全生命周期数据空间,通过业务系统数据与主数据两个层次,实现海量多源异构数据分布式存储,并提出模型驱动的核电大数据应用模式.在此基础上,基于数据空间提出了核电装备智能设计制造服务体系框架和关键技术,包括基于模型数据知识联合学习的智能协同设计、多阶段数据融合驱动的质量管控与精准追溯、高维动态边缘数据驱动的运行服务智能诊断预测等技术,为生产决策和运作管理提供依据,促进核电装备安全性、可靠性和经济性指标持续优化.最后通过核电装备典型业务场景来验证所提框架和技术的有效性,并取得了良好的应用效果,为未来核电大数据协同管理和智能应用提供参考.

关键词：工业大数据数据空间数据驱动设计-制造-服务核电装备