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Spatial pattern and drivers of urbanization in China's mid-level developing urban agglomeration:A case study of Chang-Zhu-Tan

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Regional Sustainability 2021年第1期2卷 83-97页

作者： yanhua he Yi Lin Guohua Zhou Yixuan Zhu Kai Tang Key Laboratory of Geospaial Big Data Mining and Appication Department of Resources and Envirornental ScienceHunan Normal UniverstyChangsha410081China Instinute of Real Estate Administration Hunan Normal UniversityChangsha410081China Human Parning Insriate of Land and Resources Changsha410007China

Urban agglomeration has become the main form of regional spatial organization in *** most of the existing studies of urban agglomeration in China have focused on the eastern coastal areas,urban agglomeration with mid-level development in the rest of the country has been *** better understand the urbanization process of the mid-level developing urban agglomeration,this study investigated the clustering pattern and the drivers of both urban population and firm dynamics during 2005-2015 in the Changsha-Zhuzhou-Xiangtan(Chang-Zhu-Tan)urban agglomeration of China using the methods ofkernel density estimation and geographic *** results show that centralization was obvious,although decentralization also occurred in Chang-Zhu-Tan,and that the spatial agglomeration was promoted by several factors,such as administrative resources,location advantage,labor cost,and consumption *** problems hindering the development of this region were also discovered:administrative resources played a critical role in urbanization because small towns and villages did not receive enough attention,and the effect of local policy was not as beneficial as *** findings partly explain the relatively slow development of mid-level developing urban agglomerations and have important implications for promoting healthier urbanization.

关键词： Urbanization Spatial pattern Urban agglomeration Firm clustering Driving mechanism China

Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3898-3910页

作者： Gang Xu Yezi Wu Tongyang Xiao Furong Qi Lujie Fan Shengyuan Zhang Jian Zhou yanhua he Xiang Gao Hongxiang Zeng Yunfei Li Zheng Zhang Institute for hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and Technology518112 ShenzhenGuangdong ProvinceChina Guangzhou Laboratory Guangzhou Medical UniversityGuangzhouChina Department of Microbiology Second Military Medical UniversityShanghai Key Laboratory of Medical Biodefense200433 ShanghaiChina Guangdong Key laboratory for anti-infection Drug Quality Evaluation 518112 ShenzhenGuangdong ProvinceChina Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science ShenzhenGuangdong ProvinceChina

The Coronavirus Disease 2019(COVID-19)caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a global pandemic that seriously threatens health and socioeconomic development,but the existed antiviral drugs and vaccines still cannot yet halt the spread of the ***,a comprehensive and profound understanding of the pathogenesis of SARS-CoV-2 is urgently needed to explore effective therapeutic ***,we conducted a multiomics study of SARS-CoV-2-infected lung epithelial cells,including transcriptomic,proteomic,and *** analysis showed that SARS-CoV-2-infected lung epithelial cells activated strong innate immune response,including interferon and inflammatory *** further reveals the underlying mechanism of SARS-CoV-2 disrupting the host innate immune *** addition,SARS-CoV-2 proteins were found to be ubiquitinated during infection despite the fact that SARS-CoV-2 itself didn’t code any E3 ligase,and that ubiquitination at three sites on the Spike protein could significantly enhance viral *** screening of the E3 ubiquitin ligases and deubiquitinating enzymes(DUBs)library revealed four E3 ligases influencing SARS-CoV-2 infection,thus providing several new antiviral *** multiomics combined with high-throughput screening study reveals that SARS-CoV-2 not only modulates innate immunity,but also promotes viral infection,by hijacking ubiquitination-specific processes,highlighting potential antiviral and anti-inflammation targets.

关键词： ubiquitin immunity drugs

Dynamic mechanism and present situation of rural settlement evolution in China

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Journal of Geographical Sciences 2013年第3期23卷 513-524页

作者： ZHOU Guohua he yanhua TANG Chengli YU Tao XIAO Guozhen ZHONG Ting College of Resources and Environment Science Hunan Normal University Changsha 410081 China Science Press Beijing 100717 China

This paper provides a detailed analysis of the factors influencing the evolution of rural settlements, including natural environmental constraints, infrastructure, regional cultural inheritance and integration, urbanization and rural industrial transformation, land use refor- mation and innovation, rural household behavior conversion, macro-control policy factors, and so on. Based on differences between the ways and degree of effect on rural settlement evolution, these factors are classified into basic factors, new-type factors and mutation factors The drive of basic factors mainly focuses on the traditional inheritance of rural settlements, the new-type factors mainly affect rural settlement transition, and the mutation factors may bring about sudden changes. All these factors constitute a ＂three-wheel＂ driving mechanism for the evolution of rural settlements, and shape three typical driver paths： slow smooth path under the basic factors, new path to rapid development under the new-type factors, and the sudden change path under the mutation factors. The paper also investigates the overall situation of rural settlement evolution in the aspects of settlement system, settlement scale, settlement morphology, settlement function, settlement culture, settlement environment, etc. The general process of rural settlement evolution is divided into four stages： initial, transi- tional, developmental, and mature stages.

关键词： rural settlements evolution evolution stage dynamic mechanism China

Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo

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Science China(Life Sciences) 2022年第6期65卷 1181-1197页

作者： Haoran Peng Cuiling Ding Liangliang Jiang Wanda Tang Yan Liu Lanjuan Zhao Zhigang Yi Hao Ren Chong Li yanhua he Xu Zheng Hailin Tang Zhihui Chen Zhongtian Qi Ping Zhao Department of Microbiology Second Military Medical UniversityShanghai Key Laboratory of Medical BiodefenseShanghai 200433China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China Cancer Institute Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Infectious Disease Changhai HospitalShanghai 200433China

The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a global *** candidates with high efficacy,ready availability,and that do not develop resistance are in urgent *** that screening to repurpose clinically approved drugs has provided a variety of hits shown to be effective against SARS-CoV-2 infection in cell culture,there are few confirmed antiviral candidates in *** this study,94 compounds showing high antiviral activity against SARS-CoV-2 in Vero E6 cells were identified from 2,580 FDA-approved small-molecule *** them,24 compounds with low cytotoxicity were selected,and of these,17 compounds also effectively suppressed SARS-CoV-2 infection in he La cells transduced with human *** compounds disturb multiple processes of the SARSCoV-2 life *** prophylactic efficacies were determined in vivo using Syrian hamsters challenged with *** compounds reduced weight loss and promoted weight regain of hamsters infected not only with the original strain but also the D614G *** for cisatracurium,six compounds reduced hamster pulmonary viral load,and IL-6 and TNF-αm RNAwhen assayed at 4 d *** particular,sertraline,salinomycin,and gilteritinib showed similar protective effects as remdesivir in vivo and did not induce antiviral drug resistance after 10 serial passages of SARS-CoV-2 in vitro,suggesting promising application for COVID-19 treatment.

关键词： SARS-CoV-2 drug repurposing drug screening hamster model D614G variant drug resistance

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老年人健康权理论逻辑及实现

湖南师范大学社会科学学报 2020年第4期49卷 29-38页

作者：何燕华湖南师范大学法学院湖南长沙410081

我国公民健康权近几年受到广泛关注。但老年人健康权在我国健康权规范体系中处于边缘化地位。自由权向社会权转移是老年人健康权源起的理论基础,全球老龄化社会治理使健康成为核心要素,国际人权行动的推动为国家保障老年人健康权的实现... 详细信息

我国公民健康权近几年受到广泛关注。但老年人健康权在我国健康权规范体系中处于边缘化地位。自由权向社会权转移是老年人健康权源起的理论基础,全球老龄化社会治理使健康成为核心要素,国际人权行动的推动为国家保障老年人健康权的实现提供了制度契机。老年人健康权规范内涵应关注国际上业已形成的经验表达,还应了解其强调积极面向的复合权利属性,才能清晰地展现老年人健康权国家义务的复合形态。在基本权利功能体系理论下,老年人健康权义务体系包括基于防御权功能的国家尊重义务、基于受益权功能的国家给付义务、基于客观价值秩序功能的国家保护义务。我国老年人健康权的实现首先应在公民健康权立法中加强老年人专项立法,在特殊群体权益保障立法中强调老年人健康权内涵,同时通过构建"医养结合"的综合性的卫生保健制度保证国家的给付义务,通过完善老年人健康权司法救济保障其效力。

关键词：老年人健康权社会权复合权利给付义务医养结合

“中华古籍保护计划”实施十年来北京大学图书馆古籍保护成果及思考

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大学图书馆学报 2018年第2期36卷 107-111页

作者：何燕华北京大学图书馆北京100871

"中华古籍保护计划"实施十年来,北京大学图书馆在没有专项经费的情况下,探寻出一条符合馆情的古籍保护之路,在海外古文献回归、馆藏古籍再生性保护和馆藏古籍原生性保护等方面取得了很好成绩。这是图书馆古籍部全体业务人员齐心协力勇... 详细信息

"中华古籍保护计划"实施十年来,北京大学图书馆在没有专项经费的情况下,探寻出一条符合馆情的古籍保护之路,在海外古文献回归、馆藏古籍再生性保护和馆藏古籍原生性保护等方面取得了很好成绩。这是图书馆古籍部全体业务人员齐心协力勇于担当的体现;是建立健全各项规章制度,全面推行精细化规范管理的结果。建议在未来的国家古籍保护工作中,国家古籍保护中心应完善顶层设计的同时,还要注意将国家项目与各馆古籍保护业务给予协同支持。

关键词：中华古籍保护计划北京大学图书馆馆藏古籍保护成绩

WTO框架下人民币汇率问题的贸易救济措施探析

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山东社会科学 2011年第5期 135-138页

作者：何艳华浙江理工大学法政学院浙江杭州310018

美国一些学者、政府官员指责人民币汇率被操纵和低估,并认为这是导致世界经济失衡的主要原因,威胁要对人民币汇率低估采取反补贴措施、反倾销措施,甚至建议美国贸易代表对人民币汇率低估问题发动301调查。事实上,即使人民币汇率被低估,... 详细信息

美国一些学者、政府官员指责人民币汇率被操纵和低估,并认为这是导致世界经济失衡的主要原因,威胁要对人民币汇率低估采取反补贴措施、反倾销措施,甚至建议美国贸易代表对人民币汇率低估问题发动301调查。事实上,即使人民币汇率被低估,也只能构成所谓的"汇率补贴"、"汇率倾销",与WTO相关协定所规制的补贴、倾销存在本质上的不同。由于汇率措施是一种与贸易有关的外汇措施,根据GATT1994第15条的规定,WTO对此具有管辖权,如果美国对人民币汇率问题发动301调查,我国可以向WTO申诉其措施违反WTO规定。

关键词： WTO 人民币汇率补贴倾销 301调查

GATS《金融服务附件》第2(a)段适用措施的范围--以“相同标题是否必须相同含义”为视角

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征信 2021年第2期39卷 79-87页

作者：何艳华上海商学院上海200235

GATS《金融服务附件》第2(a)段为WTO成员国出于审慎原因而采取或维持与GATS承诺和义务不符的措施提供了一个政策空间,意图在金融服务自由化和国内规制权之间取得平衡。在阿根廷-金融服务案中,关于第2(a)段的适用范围,巴拿马作为申诉方... 详细信息

GATS《金融服务附件》第2(a)段为WTO成员国出于审慎原因而采取或维持与GATS承诺和义务不符的措施提供了一个政策空间,意图在金融服务自由化和国内规制权之间取得平衡。在阿根廷-金融服务案中,关于第2(a)段的适用范围,巴拿马作为申诉方基于该段与GATS第6条的标题都是“国内规制”这一事实,主张第2(a)段所涉措施必须是GATS第6条范围内的国内规制措施。然而,固守相同标题相同含义的解释方法会导致此种解释与文本含义相矛盾,缩小适用范围,不符合有效解释原则,还会导致严重的系统影响。事实上,市场准入措施与国内规制措施并非泾渭分明,相同标题并不一定在所有方面具有相同含义,我们可以从条款功能的角度理解标题“国内规制”的含义。两个条款性质不同却采用了同一标题,容易导致适用范围的混淆。部分区域贸易协定的做法对此问题的解决具有借鉴意义。

关键词：《金融服务附件》适用范围市场准入国内规制 GATS第6条审慎例外

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长沙城市土地扩张特征及影响因素

地理学报 2006年第11期61卷 1171-1180页

作者：周国华贺艳华湖南师范大学资源与环境科学学院长沙410081

以不同时期长沙市城区土地利用现状图为基础,通过对城市用地结构比例、扩张强度指数、人口弹性指数、经济弹性指数、紧凑度变化指数等指标的具体研究,从时间序列、空间形态、结构演变等方面对长沙市城市土地扩张特征进行了系统分析,并... 详细信息

以不同时期长沙市城区土地利用现状图为基础,通过对城市用地结构比例、扩张强度指数、人口弹性指数、经济弹性指数、紧凑度变化指数等指标的具体研究,从时间序列、空间形态、结构演变等方面对长沙市城市土地扩张特征进行了系统分析,并结合区域社会经济发展情况从自然地理环境、人口与经济发展、交通设施建设、规划与区域发展战略引导、体制与制度创新等方面探讨了城市土地扩张的作用机制。研究表明:从1949年到2004年,长沙市城市土地扩张速度和强度逐步上升,整体上呈现出非理性向理性发展的趋势,扩张形态也经历了一个由单一的外部空间扩展向外部空间扩展与内部填充相结合转变,由以圈层状、轴线状为主的连续扩展形态向以斑块状与组团状为主的非连续扩展形态转变的过程,总体而言,长沙市城市土地扩张是一个具有阶段性、多样性和复杂性的过程。无论是哪个阶段,城市土地的扩张均受到多重力量的影响,某一时期的城市土地扩张是多重速度、多重模式以及多重形态的有机叠合体,由于力与力之间的均衡与偏向性差异而导致了不同时期城市土地扩张主导特征的凸现,最后在各阶段性合力的共同作用下,形成了现有城市土地边界和形态。

关键词：长沙城市土地扩张影响因素动力机制