Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2
作者机构：Institute for HepatologyNational Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and Technology518112 ShenzhenGuangdong ProvinceChina Guangzhou LaboratoryGuangzhou Medical UniversityGuangzhouChina Department of MicrobiologySecond Military Medical UniversityShanghai Key Laboratory of Medical Biodefense200433 ShanghaiChina Guangdong Key laboratory for anti-infection Drug Quality Evaluation518112 ShenzhenGuangdong ProvinceChina Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical ScienceShenzhenGuangdong ProvinceChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2022年第7卷第10期
页 面：3898-3910页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported in part by the National key research and development program(2021YFC2300103) the National Natural Science Foundation of China(82101857,82151212) the National Science Fund for Distinguished Young Scholars(82025022) the Guangdong Provincial Department of Science and Technology(2021B1212030010) the Shenzhen Science and Technology Innovation Committee(KQTD20200909113758004) the Central Charity Fund of Chinese Academy of Medical Science(2020-PT310-009) Guangzhou Lab Emerging Funding(EKPG21-03)
摘 要：The Coronavirus Disease 2019(COVID-19)caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a global pandemic that seriously threatens health and socioeconomic development,but the existed antiviral drugs and vaccines still cannot yet halt the spread of the ***,a comprehensive and profound understanding of the pathogenesis of SARS-CoV-2 is urgently needed to explore effective therapeutic ***,we conducted a multiomics study of SARS-CoV-2-infected lung epithelial cells,including transcriptomic,proteomic,and *** analysis showed that SARS-CoV-2-infected lung epithelial cells activated strong innate immune response,including interferon and inflammatory *** further reveals the underlying mechanism of SARS-CoV-2 disrupting the host innate immune *** addition,SARS-CoV-2 proteins were found to be ubiquitinated during infection despite the fact that SARS-CoV-2 itself didn’t code any E3 ligase,and that ubiquitination at three sites on the Spike protein could significantly enhance viral *** screening of the E3 ubiquitin ligases and deubiquitinating enzymes(DUBs)library revealed four E3 ligases influencing SARS-CoV-2 infection,thus providing several new antiviral *** multiomics combined with high-throughput screening study reveals that SARS-CoV-2 not only modulates innate immunity,but also promotes viral infection,by hijacking ubiquitination-specific processes,highlighting potential antiviral and anti-inflammation targets.
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