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融媒体场域下地方传统戏剧的文化传承——以粤剧为例

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武夷学院学报 2024年第7期43卷 58-64页

作者：贺雪玲同济大学人文学院上海200092

随着融媒体时代的到来和先进技术的加速发展,地方传统戏剧的文化传承步入新纪元。以粤剧为个案对象,对融媒体场域下地方传统戏剧的文化传承进行研究具有重要意义。当下,各级政府、传承人、社会大众等多方力量都在积极探索粤剧的现代化... 详细信息

随着融媒体时代的到来和先进技术的加速发展,地方传统戏剧的文化传承步入新纪元。以粤剧为个案对象,对融媒体场域下地方传统戏剧的文化传承进行研究具有重要意义。当下,各级政府、传承人、社会大众等多方力量都在积极探索粤剧的现代化传承之路,粤剧与多元媒介的结合也日趋紧密。然而,粤剧的创新传承仍然面临不少困难,如粤剧艺术内容创作专业性与传播力尚显不足,观众参与式审美对粤剧艺术本真构成挑战,粤剧产业化转型引发市场风险等。鉴于此,提出在融媒体场域下构筑“内容—观众—市场”三位一体的粤剧传承路径:一是通过创新作品激发粤剧传承活力;二是提倡扩展观众弥合粤剧传承沟壑;三是强调传播与价值变现赋能粤剧传承现代化。

关键词：粤剧融媒体文化传承地方传统戏剧

一种聚氨酯微孔薄膜医用补片表层材料的制备及其性能研究

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四川大学学报（医学版） 2024年第4期55卷 853-860页

作者：田晨旭罗锋李洁华何学令四川大学高分子科学与工程学院成都610065 四川大学学报(医学版)编辑部成都610041

目的本研究拟制备一种具有微孔结构的聚氨酯(polyurethane, PU)薄膜的医用补片表层材料,并对PU微孔薄膜的材料学特性和生物学性能进行评价,以期提升盆底修复补片材料的临床适用性。方法采用PU预聚体发泡技术制备表面具有微孔结构的PU... 详细信息

目的本研究拟制备一种具有微孔结构的聚氨酯(polyurethane, PU)薄膜的医用补片表层材料,并对PU微孔薄膜的材料学特性和生物学性能进行评价,以期提升盆底修复补片材料的临床适用性。方法采用PU预聚体发泡技术制备表面具有微孔结构的PU薄膜,通过调节最佳PU预聚体异氰酸根指数(R值)和发泡环境相对湿度(relative humidity, RH),制备PU微孔薄膜。采用扫描电子显微镜观察PU微孔薄膜表面形貌,利用红外光谱、拉曼光谱和水接触角分析PU微孔薄膜的化学结构亲水性;体外评价PU微孔薄膜浸提液对L929小鼠成纤维细胞增殖的影响,并观察PU微孔薄膜对L929小鼠成纤维细胞黏附和形态的影响和对RAW264.7小鼠单核巨噬细胞的影响;使用Sprague Dawley(SD)大鼠评价PU微孔薄膜的体内免疫反应和组织再生。结果 PU预聚体R值=1.5,发泡环境RH=70%时PU薄膜形成明显的微孔,且均匀致密;与PU薄膜相比较,PU微孔薄膜的化学结构无明显改变,其水接触角[(55.7±1.5)°]低于PU薄膜[(69.5±1.7)°]和聚丙烯(polypropylene, PP)的水接触角[(104.3±2.2)°](P<0.05),显示出较强的亲水性;PU微孔薄膜浸提液具有良好体外生物相容性,可促进L929小鼠成纤维细胞增殖,同时PU微孔薄膜表面形态有利于L929小鼠成纤维细胞的黏附,细胞呈铺展生长,其表面形貌可以抑制RAW264.7小鼠单核巨噬细胞肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)、白细胞介素(interleukin, IL)-1β分泌,促进IL-10、IL-4分泌,与24 h相比较,培养72 h时PU薄膜组和PU微孔薄膜组TNF-α、IL-1β表达水平降低,且低于PP薄膜组(P<0.05);其中,PU微孔薄膜组TNF-α和IL-10表达水平降低最明显;而IL-10、IL-4表达水平增加,且高于PP薄膜组(P<0.01),其中,PU微孔薄膜组IL-4表达水平增加最显著。PU微孔薄膜植入体内后植入微环境炎症较轻,未见明显的纤维囊形成,植入后60 d, PU微孔薄膜部分降解,膜中央出现大量的胶原纤维生长和肌肉形成。结论 PU微孔薄膜具有良好的亲水性和生物相容性,其表面形貌可调节增加细胞的黏附、调控RAW264.7小鼠单核巨噬细胞的功能以及促进组织修复,为女性盆底修复重建补片材料的设计提供了新思路。

关键词：聚氨酯微孔薄膜表面形貌调控免疫微环境生物相容性

Bailing capsule(百令胶囊) alleviates autoimmune thyroiditis via regulating peroxisome proliferator-activated receptor signaling pathway: a multi-omics analysis

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Journal of Traditional Chinese Medicine 2024年

作者： WANG Qixin XU Liting WU Jiangpeng he xueling TANG Huan CheNG Guangqing LU Tianming DAI Chuanhao GUO Qiuyan WANG Jigang State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di herbs， Artemisinin Research Center， and Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences School of Chinese Materia Medica， and State Key Laboratory of Component-based Chinese Medicine， Tianjin University of Traditional Chinese Medicine

OBJECTIVE: To investigate the efficacy and potential mechanism of Bailing capsule (百令胶囊， BL) anti-autoimmune thyroiditis (AIT). METHODS: Based on the AIT rat model， the effect of BL in alleviating AIT was evaluated by detecting serum thyroid index free triiodothyronine (FT3)， free thyroxine (FT4)， thyroid-stimulating hormone (TSH)， thyroglobulin antibody (TGAb)， thyroid peroxidase antibody (TPOAb)， and inflammatory factors Interferon-gamma (IFN-γ)， Interleukin-4， -10， and -12 (IL-4， IL-10， and IL-12) as well as thyroid tissue hematoxylin-eosin (he) staining and ultrastructure observation. The mechanism of BL was explored by combining transcriptome and proteome analysis， and further verified by Western blot (WB). RESULTS: BL effectively reduced serum FT3， FT4， TGAb， and TPOAb levels in AIT rats， restored TSH balance， inhibited the release of pro-inflammatory cytokines IFN-γ and IL-12， promoted the production of anti-inflammatory cytokines IL-4 and IL-10， and significantly reduced IFN-γ/IL-4 and IL-12/IL-10， improved thyroid follicular structure， and protected thyroid tissue from injury. Kyoto Encyclopedia of Genes and Genomes and protein interaction network analysis showed that BL affected the expression of fatty acid-binding protein 4， acyl-CoA synthetase long-chain family member 1， and acyl-CoA dehydrogenase long chain to regulate the peroxisome proliferator-activated receptor signaling pathway， thereby inhibiting the fatty acid metabolism and the inflammatory state of AIT rats. CONCLUSIONS: BL could effectively reduce thyroid inflammation in AIT model rats. The possible BL mechanism was to regulate the peroxisome proliferator-activated receptor signaling pathway and inhibit fatty acid metabolism. This study suggested that BL has the potential to be used in clinical treatment of AIT.

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创新扩散理论视域下的家用美容仪品牌设计研究

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鞋类工艺与设计 2024年第16期4卷 189-191页

作者：吴卓昕何雪玲华南师范大学广东广州510635

随着当前居民消费能力的显著提升,美容仪器的使用需求呈现出稳步增长的趋势,进而有力地推动了美容仪市场的蓬勃发展。家用美容仪以其小巧便携、操作简便的特性,赢得了广大消费者的青睐。众多中小型企业在这一背景下,纷纷致力于通过创新... 详细信息

随着当前居民消费能力的显著提升,美容仪器的使用需求呈现出稳步增长的趋势,进而有力地推动了美容仪市场的蓬勃发展。家用美容仪以其小巧便携、操作简便的特性,赢得了广大消费者的青睐。众多中小型企业在这一背景下,纷纷致力于通过创新产品的研发,展现其独特的差异化竞争优势,以期吸引消费者的目光,构建良性的销售循环机制,从而实现企业的规模扩张与实力增强。本文从创新扩散理论在新兴的美容仪产品品牌推广营销中的实践应用入手,尝试为经营创新型产品的中小型企业找到一条可行的营销思路,使得论文本身具有理论和实践的双重价值。

关键词：家用美容仪创新扩散理论市场营销产品设计

Cyclic biaxial tensile strain enhances osteogenic differentiation in rat bone marrow-derived mesenchymal stem cells via activating ERα-Wnt3a/β-catenin pathway

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BIOCELL 2022年第6期46卷 1465-1472页

作者： MIN TANG xueling he XINGHONG YAO JIRUI WEN MINGYUE BAO LIANG LI Institute of Biomedical Engineering School of Preclinical and Forensic MedicineSichuan UniversityChengdu610041China Laboratory Animal Center of Sichuan University Chengdu610041China

The present study was designed to investigate the role of estrogen receptorα(ERα)in biaxial tensile strain(BTS)regulated osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells(rBMSCs).rBMSCs were derived fromrats and overexpressed ERα.The rBMSCs were subjected to BTS at 1Hz with a strain of 2%for 4 h per day,3 days,with or without ERαinhibitor ICI 182,780(ICI).Then,bone mineralization was performed by Alizarin Red *** markers of osteogenic differentiation and downstream Wnt3a/β-catenin signaling were detected by western *** showed that BTS enhanced the osteogenic differentiation of rBMSCs,increased protein expression levels of alkaline phosphatase(ALP),runt-related transcription factor 2(Runx2),collagen type I(Col I)and osteocalcin(OCN),and it increased the protein expression levels of estrogen receptor(ER)α(ERα),Wnt3a,andβ-*** The activated Wnt3a/β-catenin signaling pathway induced by BTS was abolished by ICI 182,780(ICI).In addition,overexpressing ERαin rBMSCs promoted the osteogenic differentiation by *** together,BTS induced osteogenic differentiation of rBMSCs via the ERαand downstream canonical Wnt3a/β-catenin pathway.

关键词： BMSCs BTS Osteogenic differentiation ERα Wnt pathway

Single-cell RNA sequencing reveals classical monocytes are the major precursors of rat osteoclasts

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BIOCELL 2022年第3期46卷 655-665页

作者： JIRUI WEN WENCHAO WU MIN TANG MINGYUE BAO xueling he XINGHONG YAO LIANG LI Institute of Biomedical Engineering West China School of Basic Medical Science and Forensic MedicineSichuan UniversityChengdu610041China Laboratory of Cardiovascular Diseases Regenerative Medicine Research CenterWest China HospitalSichuan UniversityChengdu610041China Laboratory Animal Center Sichuan UniversityChengdu610041China

To dissect which subset of bone marrow monocyte is the major precursor of osteoclast,3-month-old rat bone marrow was obtained for single-cell RNA sequencing.A total of 6091 cells were acquired for detailed analysis,with a median number of 1206 genes detected per cell and 17,959 genes detected in total.A total of 19 cell clusters were recognized,with the main lineages identified as B cells,Granulocytes,Monocytes,T cells,Erythrocytes and *** were further divided into classical monocytes and non-classical *** with non-classical monocytes,classical monocytes highly expressed osteoclast differentiation related genes Mitf,Spi1,Fos and ***,biological processes of classical monocytes were related to osteoclast *** revealed differentially expressed genes of classical monocytes played a role in osteoclast *** conclusion,classical monocytes were identified as the main precursors of osteoclasts in rats,and may contribute to osteoclast differentiation by regulating S100a4,S100a6,S100a10,Fn1,Vcan and *** results of this study contribute to the understanding of the origin of osteoclasts and may provide potential biomarkers for early diagnosis of bone metabolic diseases,as well as molecular and cellular targets for clinical intervention in bone metabolic diseases.

关键词： Single-cell RNA sequencing Monocytes Subsets Osteoclast differentiation

Monazite U-Th-Pb and sericite Rb-Sr dating of the Xiajiadian black shale-hosted gold deposit in the Qinling orogen,central China:Implications for regional gold metallogeny

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Science China Earth Sciences 2024年第8期67卷 2478-2494页

作者： xueling YU Jianwei LI Xiaoye JIN Shaorui ZHAO Chongguo he Yunlong ZHU State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China School of Earth Resources China University of GeosciencesWuhan 430074China

The Qinling orogen in central China contains several black shale-hosted gold deposits,but the age of their formation and a possible relation between gold mineralization and regional tectonism remain *** we present results of in situ monazite U-Th-Pb dating and sericite Rb-Sr dating of the Xiajiadian black shale-hosted gold deposit to provide tight constraints on the time of gold deposition and information on the tectonic setting under which the deposit *** Xiajiadian gold deposit is mainly hosted in black shales of the Lower Cambrian Shuigoukou formation,with minor ores contained in sandy conglomerate of the Lower Devonian Xichahe *** ores in the black shales have been intensively oxidized and consist mainly of hematite,goethite,gypsum,quartz,calcite,native gold,and unrecognized iron ***,gold ores in the sandy conglomerate are free of oxidation and thus provide an opportunity to date the formation of the Xiajiadian gold *** ores consist of pyrite,marcasite,sericite,and quartz,which are associated with a variety of accessory minerals,including monazite,apatite,and *** is mainly present as structure-bound ions or nanoparticles in pyrite and marcasite,but minor native gold grains also occur as inclusions in *** is well developed in the ores,and has close textural association with Au-bearing pyrite and *** monazite grains have zoned textures consisting of a core area(Mnz1)and an overgrowth zone(Mnz2).Mnz1 contains 4.8–13 wt.%ThO_(2)and shows large variations in HREE and prominent negative Eu anomalies in the chondrite-normalized REE *** yields common lead-corrected^(208)Pb/^(232)Th dates ranging from 910±10 to416±4 Ma(2σ).These dates are interpreted in terms of a detrital origin for monazite in the core ***2 has much lower ThO_(2)contents of 0.8–1.7 wt.%and shows weak negative Eu anomalies in the chondrite-normalized REE *** yields common lead-corrected^(208)Pb/^(232

关键词： Monazite U-Th-Pb dating Sericite Rb-Sr dating Late Triassic(Norian) Orogenic gold deposit Xiajiadian

A systematic understanding of microbial reductive dechlorination towards an improved “one health” soil bioremediation: A review and perspective

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Science China Technological Sciences 2024年第10期67卷 3009-3031页

作者： he Yan LI ShuYao YUAN Jing CheNG Jie DOU JiBo YANG xueling XU JianMing Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Institute of Soil and Water Resources and Environmental ScienceCollege of Environmental and Resource SciencesZhejiang University Key Laboratory of Environment Remediation and Ecological health Ministry of Education Microbiome Network and Department of Agricultural Biology Colorado State University Departments of Chemistry and Chemical & Biomolecular Engineering Institute for Functional Intelligent Materials (I-FIM)National University of Singapore

Chlorinated organic pollutants(COPs), both emerging and traditional, are typical persistent pollutants that harm soil health worldwide. Dechlorinators mediated reductive dechlorination is the optimal way to completely remove COPs from anaerobic soil through a redox reaction driven by electron transfer during microbial anaerobic respiration. Generally, the dechlorinated depletion of COPs in situ often interacts with multiple element biogeochemical activities, e.g., methanogenesis, sulfate reduction, iron reduction, and denitrification. Elucidating the relevance of biogeochemical cycles between COPs and multiple elements and the coupled mechanisms involved, thus, helps to develop effective pollution control strategies with the balance between pollution degradation and element cycles in heterogeneous soil, ultimately contributing to “one health” goal. In this review, we summarized the microbial-chemical coupling redox processes and the driving factors, elucidated the interspecies metabolites exchange and electron transfer mechanisms within COP-dechlorinating communities, and further proposed a detailed design, construction, and analysis framework of engineering COP-dechlorinating microbiomes via “top-down” selfassembly and “bottom-up” synthesis to pave the way from laboratory to practical field application. Especially, we delve into the major challenges and perspectives surrounding the design of state-of-the-art synthetic microbial communities. Our goal is to improve the understanding of the microbial-mediated coupling between reductive dechlorination and element biogeochemical cycling, with a particular focus on the implications for health-integrated soil bioremediation under the “one health” concept.

关键词： reductive dechlorination biogeochemical redox processes interspecies interaction synthetic microbiomes, anaerobic soils

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Aligned 3D porous polyurethane scaffolds for biological anisotropic tissue regeneration

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Regenerative Biomaterials 2020年第1期7卷 19-27页

作者： Weiwei Lin Wanling Lan Yingke Wu Daiguo Zhao Yanchao Wang xueling he Jiehua Li Zhen Li Feng Luo Hong Tan Qiang Fu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Sichuan Institute for Food and Drug Control Chengdu 611731China Department of Neurosurgery West China Hospital Sichuan UniversityChengdu 610065China Laboratory Animal Center of Sichuan University Chengdu 610041China

A green fabrication process(organic solvent-free)of artificial scaffolds is required in tissue engineering *** this work,a series of aligned three-dimensional(3D)scaffolds are made from biodegradable waterborne polyurethane(PU)emulsion via directional freeze–drying method to ensure no organic *** optimizing the concentration of polymer in the emulsion and investigating different freezing temperatures,an aligned PUs scaffold(PU14)generated from 14wt%polymer content and processed at196C was selected based on the desired oriented porous structure(pore size of 32.569.3 lm,porosity of 92%)and balanced mechanical properties both in the horizontal direction(strength of 41.3 kPa,modulus of 72.3 kPa)and in the vertical direction(strength of 45.5 kPa,modulus of 139.3 kPa).The response of L929 cells and the regeneration of muscle tissue demonstrated that such pure material-based aligned 3D scaffold can facilitate the development of orientated cells and anisotropic tissue regeneration both in vitro and in ***,these pure material-based scaffolds with ordered architecture have great potentials in tissue engineering for biological anisotropic tissue regeneration,such as muscle,nerve,spinal cord and so on.

关键词： polyurethane aligned scaffolds tissue engineering anisotropic regeneration