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片仔癀对情志内热诱导流感病毒易感性的作用研究

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中国药理学通报 2024年第8期40卷 1565-1572页

作者：王容陈新星黄睿婷孙万阳何蓉蓉李怡芳黄丰云南中医药大学中药学院云南昆明650500 暨南大学广东省疾病易感性及中医药研发工程技术研究中心广东广州510632 暨南大学中医药与大健康广东省工程研究中心广东广州510632 暨南大学中药及天然药物研究所广东广州510632 暨南大学广东省中药药效物质基础及创新药物研究重点实验室广东广州510632 暨南大学附属江门中医院中国江门529099

目的本研究在中医情志致病理论指导下,基于课题组前期利用小鼠拘束应激附加H1N1感染构建情志内热诱导流感病毒易感模型,评价了名优清热中成药片仔癀对流感病毒易感性的作用。方法小鼠拘束应激18 h后滴鼻感染H1N1流感病毒,记录小鼠的体... 详细信息

目的本研究在中医情志致病理论指导下,基于课题组前期利用小鼠拘束应激附加H1N1感染构建情志内热诱导流感病毒易感模型,评价了名优清热中成药片仔癀对流感病毒易感性的作用。方法小鼠拘束应激18 h后滴鼻感染H1N1流感病毒,记录小鼠的体征和体质量变化,统计各组小鼠的发病率。在病毒感染后的第4日取肺脏组织采用he染色、免疫组化、Western blot、ELISA等方法检测病理情况和炎症水平;分别通过Western blot和试剂盒检测脂质过氧化终产物水平;利用氧化磷脂组学检测肺组织中各类氧化磷脂的含量。结果片仔癀能够显著降低情志应激小鼠感染流感病毒的发病率,抑制肺组织流感病毒复制与炎症因子释放,改善肺部炎症,缓解脂质过氧化终产物堆积。氧化磷脂组学结果显示,情志应激附加流感感染小鼠肺组织中氧化磷脂酰胆碱和氧化磷脂酰乙醇胺水平均明显增加,片仔癀给药能显著降低磷脂过氧化水平。结论清热中药片仔癀对情志内热诱导的流感病毒易感有良好的改善作用,作用机制可能与调节磷脂过氧化有关。

关键词：情志应激片仔癀清热中药病毒性肺炎氧化应激脂质过氧化

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宋代饮茶空间美学意境初探

茶叶学报 2024年第1期65卷 83-88页

作者：何融融罗睿勍朱海燕湖南农业大学园艺学院湖南长沙410128 中国人民大学茶道哲学研究所北京100872

茶空间作为饮茶活动的场所,是愉悦身心和寓情于物的重要场所。宋代是茶空间发展的重要时期,宋代饮茶空间的美学意境是宋代茶人审美价值的展现和精神的寄托,也是现代人向往之所。本文通过对宋代茶事文献与绘画的整理和分析,总结了自然山... 详细信息

茶空间作为饮茶活动的场所,是愉悦身心和寓情于物的重要场所。宋代是茶空间发展的重要时期,宋代饮茶空间的美学意境是宋代茶人审美价值的展现和精神的寄托,也是现代人向往之所。本文通过对宋代茶事文献与绘画的整理和分析,总结了自然山野、亭台轩榭和楼阁肆坊三类饮茶空间,进而归纳自然质朴、虚实相生和闲适淡然三类美学意境及其相应建筑、山水、陈设等组合特征,从而探寻宋代美学影响下的饮茶空间对当代饮茶空间营造的启示作用,以追寻茶我同一、天人合一的精神境界。

关键词：茶空间宋代美学

基于层次分析法-熵权法的古丈县茶产业发展水平评估

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茶叶学报 2024年第3期65卷 86-93页

作者：李博洋朱海燕何融融李甚颖湖南农业大学园艺学院湖南长沙410128

【目的】茶产业是古丈县的支柱产业,为促进古丈县茶产业提质增效发展,本研究基于2017年至2023年古丈县茶产业数据,构建古丈县茶产业发展水平评价体系,包括涵盖生产能力、产业体系建设能力、经营管理能力、经济效益、可持续发展力5个方面... 详细信息

【目的】茶产业是古丈县的支柱产业,为促进古丈县茶产业提质增效发展,本研究基于2017年至2023年古丈县茶产业数据,构建古丈县茶产业发展水平评价体系,包括涵盖生产能力、产业体系建设能力、经营管理能力、经济效益、可持续发展力5个方面共25个评价指标。【方法】运用层次分析法(AHP)和熵权法相结合的博弈论组合赋权法确定了古丈县茶产业发展评价各指标的权重并展开研究。【结果】2017—2023年评价期内古丈县茶产业发展总体呈现上升趋势,各指标指数排名为生产能力0.2541>产业体系建设能力0.2151>经营管理能力0.1839>可持续发展能力0.1733>经济效益0.1719。【建议】分析各评价维度变化趋势提出发展建议:政府需继续加大对茶产业的投入和扶持,完善其配套的产业体系,促进产业链的延伸,以科技引领茶产业可持续发展。

关键词：茶产业评价 AHP-熵权法博弈论组合赋权法

Optimization of Transformation Efficiency of Suspension Cultured Vitis vinifera *** Embryogenic Cells

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Journal of Integrative Agriculture 2012年第3期11卷 387-396页

作者： WU Jiao ZHANG Ya-li he rong-rong ZHU Lei WANG Chao-xia XU Xia LU Jiang College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 P.R. China Center for Viticulture and Small Fruit Research Florida A&M University Tallahassee 32317 USA

Vitis vinifera *** suspension cultures were established from proembryogenic mass and employed for optimizing Agrobacterium-mediated transformation ***-factor-at-a-time experiment revealed that OD600 of Agrobacterium,time of inoculation,co-cultivation,and cell-drying before inoculation significantly affected the transformation efficiency which reached maximum 21.5% at the following conditions：0.8 of OD600,25 min of inoculation,2 d of co-cultivation,and 10 min of cell *** surface methodology experiments based on a five-level,four-factor central-composite rotatable design were then used to optimize these selected *** optimized conditions for Chardonnay grape transformation were：0.8711 of OD600,28.9 min of inoculation,2.25 d of co-cultivation and 11.76 min of cell *** optimization,transformation efficiency was 26.2% and there were no interactions among different factors.

关键词： transformation Chardonnay suspension cultures response surface methodology

Photoinduced bismuth vanadate-catalyzed C(sp^(2))-H functionalization

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Chinese Chemical Letters 2024年第3期35卷 1-2页

作者： rong-Nan Yi Wei-Min he Key Laboratory of Food&Environment&Drug Monitoring and Testing of Universities in Hunan Province Hunan Police AcademyChangsha 410138China School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China

Visible light-induced organic reactions have gained much attention in recent years due to their mild conditions and high efficiency[1,2].In this context,many efficient photocatalysts including transition metal complex... 详细信息

关键词： bismuth catalyzed gained

SEQUENCE CONSERVATION OF HUMAN CYTOMEGALOVIRUS UL140 OPEN READING FRAME IN CLINICAL STRAINS

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Chinese Medical Sciences Journal 2008年第1期23卷 23-27页

作者： Ying Qi Yan-ping Ma rong he Zheng-rong Sun Yao-hua Ji Yu-jing Huang Qiang Ruan Virus Laboratory Shengjing Hospital China Medical University Shenyang 110004

Objective To investigate the variability of human cytomegalovirus （HCMV） UL140 open reading flame （ORF） in clinical strains, and to explore the relationship between the variability of UL140 ORF and different symptoms of HC-MV infection. Methods HCMV UL140 ORF was amplified by polymerase chain reaction and sequenced selectedly in 30 clinical strains. Results UL140 ORF of all clinical strains was amplified successfully. Compared with that of Toledo strain, the nucleotide and amino acid sequence identities among all strains were 96.5% -100.0% and 95.2% -100. 0%, respectively. All of the nucleotide changes were substitutions. The post-translational modification sites were conserved. The result of phylogenetic tree showed that the strains did not cluster according to different clinical symptoms. Conclusion HCMV UL140 ORF in clinical strains is highly conserved, which may play an important role in HC-MV infection.

关键词： human cytomegalovirus UL140 conservation

Theory of optimal harvesting for a nonlinear size-structured population in periodic environments

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International Journal of Biomathematics 2014年第4期7卷 201-218页

作者： Ze-rong he rong Liu Institute of Operational Research and Cybernetics Hangzhou Dianzi University Hangzhou 310018 P. R. China

This paper investigates the theoretical aspects for an optimal harvesting problem of a nonlinear size-structured population model in a periodic environment. We establish the well-posedness of the state system by means of frozen coefficients and fixed point reasoning. The existence of a unique optimal policy is proved via Ekeland＇s variational principle, and the first-order optimality conditions are derived by a suitable normM cone and a dual system. The results obtained would be beneficial for exploration of renewable

关键词： Body size population model harvesting fixed point normal cone Ekeland'sprinciple.

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九节茶药材质量标准研究

中南药学 2024年第1期22卷 209-213页

作者：苏锐辉于小庆江涛汤迎湛彭红英李怡芳何蓉蓉广州白云山敬修堂药业股份有限公司广州510130 暨南大学药学院广州510632

目的对九节茶药材开展全面的质量标准研究,建立完善的九节茶质量标准。方法收集13批九节茶药材,以异嗪皮啶对照品和九节茶对照药材建立薄层色谱鉴别方法;参考《中国药典》(2020年版)四部通则,对九节茶水分、总灰分、酸不溶性灰分及浸... 详细信息

目的对九节茶药材开展全面的质量标准研究,建立完善的九节茶质量标准。方法收集13批九节茶药材,以异嗪皮啶对照品和九节茶对照药材建立薄层色谱鉴别方法;参考《中国药典》(2020年版)四部通则,对九节茶水分、总灰分、酸不溶性灰分及浸出物进行检查;采用高效液相色谱法测定九节茶中异嗪皮啶和迷迭香酸的含量。结果九节茶薄层鉴别特征斑点清晰,分离度良好;13批九节茶药材水分平均为9.4%,总灰分平均为5.2%,酸不溶性灰分平均为0.5%,浸出物平均为12.6%;异嗪皮啶平均含量为0.026%,迷迭香酸平均含量为0.030%。结论本研究建立的薄层鉴别、检查及含量测定方法专属性强、准确度高、操作简便,可用于九节茶药材质量标准研究。

关键词：九节茶质量标准异嗪皮啶迷迭香酸薄层色谱高效液相色谱

Two-photon polymerization-based 4D printing and its applications

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International Journal of Extreme Manufacturing 2024年第1期6卷 1-25页

作者： Bingcong Jian Honggeng Li Xiangnan he rong Wang Hui Ying Yang Qi Ge Shenzhen Key Laboratory of Soft Mechanics&Smart Manufacturing Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Pillar of Engineering Product Development Singapore University of Technology and Design8 Somapah RoadSingapore 487372Singapore

Two-photon polymerization(TPP)is a cutting-edge micro/nanoscale three-dimensional(3D)printing technology based on the principle of two-photon *** surpasses the diffraction limit in achieving feature sizes and excels in fabricating intricate 3D micro/nanostructures with exceptional *** concept of 4D entails the fabrication of structures utilizing smart materials capable of undergoing shape,property,or functional changes in response to external stimuli over *** integration of TPP and 4D printing introduces the possibility of producing responsive structures with micro/nanoscale accuracy,thereby enhancing the capabilities and potential applications of both *** paper comprehensively reviews TPP-based 4D printing technology and its diverse ***,the working principles of TPP and its recent advancements are ***,the optional4D printing materials suitable for fabrication with TPP are ***,this review paper highlights several noteworthy applications of TPP-based 4D printing,including domains such as biomedical microrobots,bioinspired microactuators,autonomous mobile microrobots,transformable devices and robots,as well as anti-counterfeiting *** conclusion,this paper provides valuable insights into the current status and future prospects of TPP-based4D printing technology,thereby serving as a guide for researchers and practitioners.

关键词： two-photonpolymerization 4D printing nano/micro fabrication microrobot