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Spatio-temporal Variation of Landscape heterogeneity under Influence of Human Activities in Xiamen City of China in Recent Decade

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Chinese Geographical Science 2013年第2期23卷 227-236页

作者： HUANG Yixiong yin Xiuqin YE Gongfu LIN Jiemin HUANG ru WANG Na WANG Liang SUN Yue College of Urban and Environmental Sciences Northeast Normal University College of Geographical Sciences Fujian Normal University Fujian Academy of Forestry Sciences Quanzhou Land and Resources Bureau

Xiamen is an economically competitive and highly urbanized city along the coastal area of Fujian Province, China. The research on spatio-temporal variation of landscape heterogeneity under the influence of human activities is of great importance to the further study on the relationship of landscape pattern and ecological process. It is also crucial to the discovery of spatial variation and intensity distribution of human activities. The research analyzed the intensity of human impacts and the spatial variation features and dynamics of landscape patterns by introducing statistical theories and approaches. We analyzed spatio-temporal variation of landscape heterogeneity using the geostatistical techniques, such as semivariogram and Kriging *** show that there is a higher correlation between landscape heterogeneity indexes and human impact index. Both the indexes show a moderate spatial autocorrelation as well as an obvious characteristic of anisotropy. From 1998 to 2008, the spatial differentiation of the changes in the intensity of human activities and the changes in landscape heterogeneity shows that the landscape patterns in Xiamen are closely related with the urban land utilization methods, the condition of traffic and geographical location and the physical geographical condition such as the terrain and the ecological environment. The process of urbanization has a significant impact on the urban landscape pattern.

关键词： landscape heterogeneity human impact index human activities Xiamen City

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Synthesis, Characterization and Inhibition Effects of Vanadium Substituted Dawson-type heteropoly Acids(Mo, P)

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Chemical Research in Chinese Universities 2011年第3期27卷 358-360页

作者： yin Yan-bing YANG Yu-lil FAN rui-qing ZHU Yang-qing SUN Ji-ru Department of Applied Chemistry Harbin Institute of Technology Harbin 150001 P. R. China Department of Chemistry and Chemical Engineering Qiqihar University Qiqihar 161006 P. R. China

Four new vanadium substituted Dawson-type heteropoly acids H7[P2Mo17VO62]·39H2O（1）, H8[P2Mo16V2O62]·41H2O（2）, H9[P2Mo15V3O62]·51H2O（3） and H8[P2Mo14V4O62H2]·45H2O（4） were prepared respec-tively. Their structures were determined by IR and ICP. The inhibition effects of vanadium substituted Dawson-type heteropoly acids（Mo, P） on free radical polymerization of methyl methacrylate（MMA） were investigated by dilatometry. The results show that the rate of the polymerization of MMA decreases and the inhibition effects of the four heteropoly acids reach the inhibitor performance of hydroquinone at a certain ratio.

关键词： heteropoly acid Inhibition Dilatometry

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教育生态视角下海外华文教育区域整合发展的路径研究

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齐齐哈尔大学学报（哲学社会科学版） 2024年第2期 168-172页

作者：杨岭纪梦茹刘思洋杨佳茵集美大学陈嘉庚研究院福建厦门361021 集美大学师范学院福建厦门361021

海外华文教育区域整合发展契合华文教育生态系统中生态因子的区域分化,是海外华文教育发展的内在需求,是构建“一带一路”教育共同体的重要基础,同时也是区城社会发展的客观需要。教育生态视角下海外华文教育区域整合发展要夯实科学、... 详细信息

海外华文教育区域整合发展契合华文教育生态系统中生态因子的区域分化,是海外华文教育发展的内在需求,是构建“一带一路”教育共同体的重要基础,同时也是区城社会发展的客观需要。教育生态视角下海外华文教育区域整合发展要夯实科学、全面的宏观统筹与法律保障,打造华文教育生态链;明确区域华文教育的责任与使命,增强华文教育生态系统的协同互动;强化海外华人基本盘,以文化认同为枢纽建立华文教育群落生态;以可持续发展为原则,促进华文教育区域资源的高效整合;基于生态平衡法则,建立华文教育区城化发展评价体系。

关键词：教育生态学华文教育区域整合

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Effect of etanercept on refractory systemic-onset juvenile idiopathic arthritis

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世界儿科杂志:英文版 2016年第1期12卷 96-102页

作者： Xiao Hu Fang Yuan Jian Zhang Lei yin Bi-ru Li Yan-Liang Jin Department of Rheumatology Shanghai Children's Medical CenterShanghai Jiaotong UniversitySchool of MedicineShanghaiChina

Background:Treatment of systemic-onset juvenile idiopathic arthritis(So-JIA)is challenging,and the effi cacy of injectable recombinant human tumor necrosis factor type 1 receptor-antibody fusion protein(etanercept)on So-JIA has been ***:We retrospectively studied 12 patients with refractory systemic juvenile arthritis treated with etanercept at our hospital in the past 5 *** 12 patients were divided into a corticosteroid-dependent group(n=7)and an ineffective group(n=5)on the basis of their responses to treatment before the administration of *** was added to the treatment without substantially changing the original regimens in general,and doses,and signs of efficacy including alleviation or resolution of symptoms such as high fever,infl ammatory arthropathy,eruption rash,hydrohymenitis,as well as changes in the levels of laboratory infl ammatory markers such as the white blood cell count,erythrocyte sedimentation rate,levels of C-reactive protein and serum ferritin were ***:Etanercept was withdrawn after the first dose from one patient in the corticosteroid-dependent group because of a systemic allergic rash,and was also withdrawn from one patient in the ineffective group after 2 months of treatment owing to ineffi cacy;the remaining 10 patients completed the entire treatment protocol,at which point etanercept was *** that time,clinical symptoms and laboratory infl ammatory markers of the remaining patients were within the normal range and the mean dose of prednisone was 0.18 mg/kg per day,an 81%decrease from the mean dose at *** present,the corticosteroid has been discontinued and only methotrexate maintenance treatment is used in 3 patients;the other 7 patients are treated with prednisone and methotrexate maintenance *** of the 10 patients are in a medicated remission with no ***:In the treatment of patients with refractory So-JIA,the principles of individual ther

关键词： etanercept juvenile idiopathic arthritis systemic-onset therapy

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Study on the performance of ceramic composite projectile penetrating into ceramic composite target

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Defence Technology（防务技术） 2017年第4期13卷 295-299页

作者： Rong-cheng Yi Li-kui yin Jian-ru Wang Zhi-gang Chen Di-qi Hu National Defense Key Laboratory of Underground Damage Technology North University of China Taiyuan 030051 China

In order to study the performance of ceramic composite projectile penetrating into ceramic composite target,the contrast test and numerical simulations of the penetration of standard projectile and the ceramic composite projectile into a ceramic composite target were *** results show that the penetration performance of ceramic composite projectile is obvious superior to that of standard projectile for ceramic composite *** ceramic nose of ceramic composite projectile fully destroys the ceramic panels anterior to its following armor-piercing projectile body,thus maintaining the penetration ability of the following armor-piercing projectile body.

关键词： Ceramic Composite projectile Penetration Composite target Test

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Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes

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World Journal of Gastroenterology 2001年第3期7卷 394-398页

作者： ru Tao Cui Gan Cai Zhao Bao yin Yong Cheng Qiu Hong Yang Tao Tian Liver Center Beijing Friendship Hospital Affiliated to CapitalUniversity of Medical Sciences Department of Gastroenterology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai ChinaDepartment of Pathophysiology.Shanghai Medical University.ShanghaiChina Pathological Department Shanghai Medical University

INTRODUCTIONGastric epithelial dysplasia (GED) hypothetically is a straight-forward concept: dysplastic epithelium replacing the normal gastric epithelium of the stomach [1].In the stomach ,like any other segment of the gut ,it is defined as an unequivocal non-invasive epithelial change[2,3].The observation of gastric dysplasia as a cancerous lesion was recognized over a century ago ,but it is only after the advent of gastroscopy that its clinical significance has been stressed[4-7].

关键词： Animals Antigens, CD95 Antineoplastic Agents Apoptosis Caspase 1 Cyclin D1 Gastric Mucosa Gene Expression Immunohistochemistry Male Membrane Glycoproteins Methylnitronitrosoguanidine RNA, Messenger Rats Rats, Wistar Research Support, Non-U.S. Gov't Stomach Diseases Tretinoin

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Air tamponade in retinal detachment surgery followed by ultra-widefield fundus imaging system

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1198-1203页

作者： Qian-yin Chen Yun-Xia Tang Yan-Qiong he Hui-Min Lin ru-Long Gao Meng-Yuan Li Jin-Tong Hou Hong-Jie Ma Jing-Lin Zhang Guangzhou Aier Eye Hospital Guangzhou 510010 Guangdong Province China Aier School of Ophthalmology Central South UniversityChangsha 410015 Hunan Province China

AIM： To report the surgical result of pars plana vitrectomy（PPV） with air tamponade for rhegmatogenous retinal detachment（RRD） by ultra-widefield fundus imaging system. METHODS： Of 25 consecutive patients（25 eyes） with fresh primary RRD and causative retinal break and vitreous traction were presented. All the patients underwent PPV with air tamponade. Visual acuity（VA） was examined postoperatively and images were captured by ultrawidefield scanning laser ophthalmoscope system（Optos）. RESULTS： Initial reattachment was achieved in 25 cases（100%）. The air volume was 〉60% on the postoperative day（POD） 1. The ultra-widefield images showed that the retina was reattached in all air-filled eyes postoperatively. The retinal break and laser burns in the superior were detected in 22 of 25 eyes（88%）. A missed retinal hole was found under intravitreal air bubble in 1 case（4%）. The air volume was range from 40% to 60% on POD 3. A doublelayered image was seen in 25 of 25 eyes with intravitreal gas. Retinal breaks and laser burns around were seen in the intravitreal air. On POD 7, small bubble without effect was seen in 6 cases（24%） and bubble was completely disappeared in 4 cases（16%）. Small oval bubble in the superior area was observed in 15 cases（60%）. There were no missed and new retinal breaks and no retinal detachment in all cases on the POD 14 and 1 mo and last follow-up. Air disappeared completely on a mean of 9.84 d postoperatively. The mean final postoperative bestcorrected visual acuity（BCVA） was 0.35 log MAR. Mean final postoperative BCVA improved significantly relative to mean preoperative（P〈0.05）. Final VA of 0.3 log MAR or better was seen in 13 eyes. CONCLUSION： PPV with air tamponade is an effective management for fresh RRD with superior retinal breaks. The ultra-widefield fundus imaging can detect postoperative retinal breaks in air-filled eyes. It would be a useful facility for follow-up after PPV with air tamponade. Facedown position and acquired visual rehabilit

关键词： rhegmatogenous retinal detachment air tamponade ultra-widefield fundus imaging system

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大口黑鲈弹状病毒Taq Man荧光定量PCR检测方法的建立及初步应用

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中国预防兽医学报 2024年第4期46卷 379-384页

作者：孔明慧梁红茹李宁求林强牛银杰罗霞马宝福付小哲上海海洋大学水产与生命学院上海201306 中国水产科学研究院珠江水产研究所农村农业部渔用药物创制重点实验室/广东省水产动物免疫技术与绿色养殖重点实验室广东广州510380

为建立快速、敏感的大口黑鲈弹状病毒(MSRV)流行株Taq Man荧光定量PCR (qPCR)方法,本研究采用NCBI分析MSRV流行株N基因的保守序列,设计特异性引物和Taq Man探针,以构建的并经PCR和测序鉴定正确的重组质粒标准品p MD18-MSRV-N为模板,通... 详细信息

为建立快速、敏感的大口黑鲈弹状病毒(MSRV)流行株Taq Man荧光定量PCR (qPCR)方法,本研究采用NCBI分析MSRV流行株N基因的保守序列,设计特异性引物和Taq Man探针,以构建的并经PCR和测序鉴定正确的重组质粒标准品p MD18-MSRV-N为模板,通过优化各反应条件初步建立MSRV的Taq Man q PCR检测方法。结果显示,建立的Taq Man q PCR方法标准曲线的R2为0.9906,质粒标准品在6.79×10^(8)拷贝/μL~6.79×10^(2)拷贝/μL范围内与Ct值均存在较好的线性关系。采用该方法检测MSRV及相关病毒,评估该方法的特异性,结果显示,该方法可以特异性检测MSRV,而草鱼出血病病毒、神经坏死病毒、鲤春病毒血症病毒、大口黑鲈双RNA病毒、鳜蛙虹彩病毒、传染性脾肾坏死病毒、石斑鱼虹彩病毒、大口黑鲈蛙虹彩病毒等8种常见鱼类病毒检测结果均为阴性;采用建立的方法检测不同浓度的质粒标准品(6.79×10^(8)拷贝/μL~6.79×10^(1)拷贝/μL),评估该方法的敏感性,结果显示,该方法的检测限为6.79×10^(2)拷贝/μL,比文献中的常规PCR方法敏感1 000倍;以不同批次或同一批次提取的不同浓度的质粒标准品作为模板,分别利用该方法检测,评估该方法的重复性,结果显示,该方法批内和批间重复性试验的变异系数均小于2%。采用该方法和文献中的常规PCR同时检测71份临床发病的大口黑鲈、鳜鱼、鲮鱼组织样品,结果显示阳性率为16.9%(12/71),阴性率为83.1%(59/71),且阳性样品均是从发病大口黑鲈的组织样品中检测到,而发病的鳜鱼、鲮鱼组织样品中均未检测到该病毒;常规PCR方法的阳性率为9.9%(7/71),阴性率为90.1%(64/71),二者的总符合率为93.0%。本研究建立的MSRV Taq Man q PCR方法特异性强、敏感性高、重复性和准确性均较好,可用于大口黑鲈临床样品的检测,为MSRV的快速检测提供了可行的技术手段。

关键词：大口黑鲈弹状病毒 Taq Man荧光定量PCR N基因

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‘红满堂’苹果MbbZIP43基因的克隆与功能研究

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生物技术通报 2024年第2期40卷 146-159页

作者：杨艳胡洋刘霓如殷璐杨锐王鹏飞穆霄鹏张帅程春振张建成山西农业大学园艺学院太谷030801

【目的】为探究碱性亮氨酸拉链(bZIP)转录因子在‘红满堂’苹果花青素代谢中的调控作用。【方法】从‘红满堂’苹果克隆得到一个bZIP基因,分析了其基因及编码蛋白序列特性,利用洋葱表皮细胞瞬时转化确定其编码蛋白亚细胞定位,利用实时... 详细信息

【目的】为探究碱性亮氨酸拉链(bZIP)转录因子在‘红满堂’苹果花青素代谢中的调控作用。【方法】从‘红满堂’苹果克隆得到一个bZIP基因,分析了其基因及编码蛋白序列特性,利用洋葱表皮细胞瞬时转化确定其编码蛋白亚细胞定位,利用实时荧光定量PCR(RT-qPCR)研究了该基因在不同成熟时期‘红满堂’果实中的表达情况,基于烟草叶片、苹果叶片以及苹果果实瞬时转化研究了其对花青素积累和花青素合成相关结构基因表达的调控作用。【结果】该基因不含内含子,与MdbZIP43(XP_008393381.1)相似度最高,故命名为MbbZIP43。其编码序列长为522 bp,可编码由173 aa组成、含有bZIP_plant_GBF1结构域、定位于细胞核的亲水蛋白。RT-qPCR分析结果显示,随着果实成熟,MbbZIP43在‘红满堂’果实中的表达水平呈“先升后降”的变化趋势,在花后11周的果实中表达量最高。相关性分析显示MbbZIP43基因表达量与总黄酮和花青素含量正相关。瞬时过表达该基因的烟草叶片、苹果叶片和果皮中花青素含量分别提高了17.42%、25.66%和48.99%,过表达MbbZIP43的苹果叶片中花青素合成结构基因CHI、F3'H、DFR和UFGT分别提高了2.27倍、1.84倍、2.39倍和2.89倍;过表达MbbZIP43的苹果果皮中CHI、F3'H、DFR和UFGT分别提高了1.79倍、1.70倍、1.35倍和1.51倍,说明MbbZIP43可以通过上调这些结构基因的表达正调控苹果花青素合成。【结论】MbbZIP43可通过激活花青素合成相关结构基因CHI和UFGT等的表达进而促进花青素的积累。

关键词： bZIP转录因子苹果花青素合成调控基因克隆瞬时转化表达分析亚细胞定位

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Oriented Antibody Immobilization and Immunoassay Based on Boronic Acid-containing Polymer Brush

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Chinese Journal of Polymer Science 2018年第4期36卷 472-478页

作者： Jie Zhao ru Mo Li-Mei Tian Ling-Jie Song Shi-Fang Luan Jing-Hua yin Lu-Quan Ren Key Laboratory of Bionic Engineering Ministry ofEdueationJilin UniversityChangchun 130022China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Jilin Province People's Hospital Changchun 130021China

High sensitive immunoassay platforms have gained intense attention due to their vital roles in early-stage disease diagnosis and therapeutic information feedback. Although random covalent-binding of antibody has been widely adopted in immunoassays due to its simplicity and effectiveness, it readily loses its activity and fails to exhibit high antigen-binding capacity. In this work, copolymer of zwitterionic sulfobetaine methacrylate（SBMA） and glycidyl methacrylate（GMA） brushes were immobilized onto inert polypropylene（PP） via surface-initiated atom transfer radical polymerization（ATRP） based on biomimetic dopamine pretreatment. Subsequently, boronic acid（BA） groups were covalently bonded via active GMA units, followed by the introduction of oriented immobilization of antibody. Owing to the oriented immobilization of antibody facilitated by BA groups in polymer brush, the bioactivity of antibody is well preserved, which endows the surface with significantly enhanced antigen-binding capacity. Moreover, the existence of SBMA segments in polymer brushes renders the surface high resistance to nonspecific protein adsorption, significantly alleviating the signal interference of antigen recognition. This strategy could find potential applications in developing high sensitive immunoassay platforms based on the different substrates.

关键词： Biomimetic dopamine Atom transfer radical polymerization (ATRP) Boronic acid (BA) Immunoassay Biomimetic

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