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Comparative study on epidemiological and etiological characteristics of patients with acute diarrhea with febrile or non-febrile symptoms in China

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Infectious Diseases of Poverty 2023年第4期12卷 17-28页

作者： Tao Wang Gang Wang chun-xi Shan Yan-Qun Sun xiang Ren Lin-jie yu yi-Fei Wang sheng-Hong Lin xiao-Ai Zhang Hao Li Cui-Hong Zhang Meng-jie Geng wei-Zhong yang Li-Ping Wang wei Liu Li-Qun Fang Department of Epidemiology and Biostatistics School of Public HealthWuhan UniversityWuhanHubeiPeople’s Republic of China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology20 Dong-Da StreetFengtai DistrictBeijing100071People’s Republic of China Nanjing Center for Disease Control and Prevention NanjingPeople’s Republic of China Division of Infectious Disease Key Laboratory of Surveillance and Early-Warning On Infectious DiseaseChinese Center for Disease Control and PreventionNo.155 Changbai RoadChangping DistrictBeijing102206People’s Republic of China Chinese Center for Disease Control and Prevention BeijingPeople’s Republic of China

Background Acute diarrhea with fever can potentially represent a more severe form of the disease compared to non-febrile diarrhea. This study was to investigate the epidemiological characteristics and enteric pathogen composition of febrile-diarrheal patients, and to explore factors including pathogens associated with fever by age *** A nationwide surveillance study of acute diarrheal patients of all ages was conducted in 217 sentinel hospitals from 31 provinces (autonomous regions or municipalities) in China between 2011 and 2020. Seventeen diarrhea-related pathogens, including seven viruses and ten bacteria, were investigated and their association with occurrence of fever symptoms was assessed using multivariate logistic *** A total of 146,296 patients with acute diarrhea (18.6% with fever) were tested. Th diarrheal children below 5 years had the highest frequency of fever (24.2%), and related to significantly higher prevalence of viral enteropathogens (40.2%) as compared with other age groups (P he febrile-diarrheal patients were associated with a significantly higher prevalence of bacterial pathogens than afebrile-diarrheal patients (allP here was discrepancy when each pathogen was compared, i.e., nontyphoidalSalmonella (NTS) was over-represented in febrile vs non-febrile patients of all age groups, while the febrile vs non-febrile difference for diarrheagenicEscherichia coli (DEC) was only significant for adult groups. The multivariate analysis revealed significant association between fever and infection with rotavirus A among children [odds ratio (OR) = 1.60], for DEC in adult groups (OR = 1.64), for NTS in both children (OR = 2.95) and adults (OR = 3.59).Conclusions There are significant discrepancy of the infected enteric pathogens in patients with acute diarrhea with fever between age groups, and it is valuable for priority detection of NTS and rotavirus A in patients with children < 5 years

关键词： Acute diarrhea Epidemiology Enteropathogens Fever China

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Expert consensus on prevention and cardiopulmonary resuscitation for cardiac arrest in COVID-19

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Asian Pacific Journal of Tropical Medicine 2021年第6期14卷 241-253页

作者： wei Song jie wei xiangdong Jian Deren Wang Yanhong Ouyang yuanshui Liu xianjin Du ying chen yingqi Zhang heping Xu Shuming xianyu Qiong Ning xiang Li xiaotong Han Feng Zhan Tao yu Wenteng chen Jun Zhang Wenwei Cai sheng’ang Zhou shengyang yi yu Cao xiaobei chen Shunjiang Xu Zong’an Liang Duohu Wu Fen Ai Zhong Wang Qingyi Meng yuhong Mi Sisen Zhang Rongjia yang Shouchun Yan Wenbin Han Yong Lin Chuanyun Qian Wenwu Zhang Yan xiong Jun Lv Baochi Liu Yan Cao xiaojun he Xuelian Sun yufang Cao Tian’en Zhou Department of Emergency Medicine Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China Emergency Department&Intensive Care Unit Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Poisoning and Occupational Diseases EmergencyQilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012China Center of Cerebrovascular Diseases Department of NeurologyWest China Hospital of Sichuan UniversityChengdu 610041China Department of Emergency People's Hospital of Wuhan UniversityWuhan 430060China Department of Emergency Medicine the First Hospital of Hebei Medical UniversityShijiazhuang 050030China Hospital Infection Control Office Hainan General HospitalHaikou 570311China Department of Occupational Diseases Jinan HospitalJinan 250013China Department of Emergency Medicine Hunan Provincial People's HospitalChangsha 410005China Department of Emergency Medicine Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Emergency Medicine Zhejiang Provincial People's HospitalHangzhou 310014China Department of Emergency Department West China Hospital of Sichuan UniversityChengdu 610041China Department of Infectious Diseases People's Hospital of Wuhan UniversityWuhan 430060China Department of Teaching Affairs The First Hospital of Hebei Medical UniversityShijiazhuang 050031China Department of Pulmonary and Critical Care Medicine West China Hospital of Sichuan UniversityChengdu 610041China Medical Service Department Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China Department of Emergency Medicine the Central Hospital of WuhanWuhan 430015China Tsinghua Changgung Hospital School of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Emergency Medicine the First Medical CenterChinese PLA General HospitalBeijing 100853China Emergency&Critical Care Center Beijing Anzhen HospitalCapital Medical University.Beijing 100029China Peopl

Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac *** CPR,both healthcare and non-healthcare workers who provide resuscitation are at risk of *** Working Group for Expert Consensus on Prevention and Cardiopulmonary Resuscitation for Cardiac Arrest in COVID-19 has developed this Chinese Expert Consensus to guide clinical practice of CPR in COVID-19 *** recommendations:1)A medical team should be assigned to evaluate severe and critical COVID-19 for early monitoring of cardiac-arrest warning signs.2)Psychological counseling and treatment are highly recommended,since sympathetic and vagal abnormalities induced by psychological stress from the COVID-19 pandemic can induce cardiac arrest.3)healthcare workers should wear personal protective equipment(PPE).4)Mouth-to-mouth ventilation should be avoided on patients suspected of having or diagnosed with COVID-19.5)Hands-only chest compression and mechanical chest compression are recommended.6)Tracheal-intubation procedures should be optimized and tracheal-intubation strategies should be implemented early.7)CPR should be provided for 20-30 min.8)Various factors should be taken into consideration such as the interests of patients and family members,ethics,transmission risks,and laws and regulations governing infectious disease *** in management:The following changes or modifications to CPR strategy in COVID-19 patients are proposed:1)healthcare workers should wear PPE.2)Hands-only chest compression and mechanical chest compression can be implemented to reduce or avoid the spread of viruses by aerosols.3)Both the benefits to patients and the risk of infection should be considered.4)Hhealthcare workers should be fully aware of and trained in CPR strategies and procedures specifically for patients with COVID-19.

关键词： SARS-CoV-2 COVID-19 Cardiac arrest CPR Nosocomial infection Personal protective equipment

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Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： jie Wu Shu-wei Duan Hong-tao yang yue-yi Deng wei Li Ya-ni he Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang xiao-hong cheng Li-qun he Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping yin Geng-ru Jiang Hong-yu chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming chen Li-qun Song Jian chen Qing Zhu Chang-ying xing yun Li Ji-ning Gao Rong-shan Li ying Li Hao Zhang ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang he Guang-yan Cai xiang-mei chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Phe losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine *** a superiority threshold of 15%,neither was statistically ***,serum creatinine and serum albumin from the baseline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

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Lijiang 2.4-meter Telescope and its instruments

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Research in Astronomy and Astrophysics 2019年第10期19卷 95-108页

作者： Chuan-Jun Wang jin-Ming Bai yu-Feng Fan Ji-Rong Mao Liang Chang yu-xin xin Ju-Jia Zhang Bao-Li Lun Jian-Guo Wang xi-Liang Zhang Mei ying Kai-xing Lu xiao-Li Wang Kai-Fan Ji Ding-Rong xiong xiao-Guang yu Xu Ding Kai Ye Li-Feng xing wei-Min yi Liang Xu xiang-Ming Zheng yuan-jie Feng Shou-sheng he Xue-Li Wang Zhong Liu Dong chen Jun Xu Song-Nian Qin Rui-Long Zhang Hui-Song Tan Zhi Li Ke Lou Jian Li wei-wei Liu yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650216 China Center for Astronomical Mega-Science Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Astrophysics Center of Guangzhou University Guangzhou 510006China

The Lijiang 2.4-meter Telescope(LJT), the largest common-purpose optical telescope in China,has been available to the worldwide astronomical community since 2008. It is located at the Gaomeigu site,Lijiang Observatory(LJO), in the southwest of China. The site has very good observational *** its 10-year operation, several instruments have been equipped on the LJT. Astronomers can perform both photometric and spectral observations. The main scientific goals of LJT include recording photometric and spectral evolution of supernovae, reverberation mapping of active galactic nuclei, investigating the physical properties of binary stars and near-earth objects(comets and asteroids), and identification of exoplanets and all kinds of transients. Until now, the masses of 41 high accretion rate black holes have been measured, and more than 168 supernovae have been identified by the LJT. More than 190 papers related to the LJT have been published. In this paper, the general observation conditions of the Gaomeigu site is introduced at first. Then, the structure of the LJT is described in detail, including the optical, mechanical, motion and control system. The specification of all the instruments and some detailed parameters of the YFOSC is also presented. Finally, some important scientific results and future expectations are summarized.

关键词： telescopes Lijiang 2.4-m Telescope-instrumentation photometers-instrumentation spectrographs

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The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST

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Research in Astronomy and Astrophysics 2019年第11期19卷 33-48页

作者： Bo chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-jie Zhang Ling-Ping he Shuang Dai xiao-Dong Wang Hai-Feng Wang chun-Long Liu Hong-Ji Zhang Guang Zhang yunqi Wang Shi-jie Liu Hong-xin Zhang Lei Liu Shi-Lei Mao yang Liu Jia-Hao Peng Peng Wang Liang Sun yang Liu Zhen-wei Han Yan-Long Wang Kun Wu Guang-xing Ding Peng Zhou xin Zheng Ming-yi xia Qing-Wen Wu jin-Jiang xie Ya chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang yang Li Feng yu Huang wei-Qun Gan ying Li jing-wei Li Lei Lu Jian-Chao Xue Bei-Li ying Ming-Zhe Sun cheng Zhu wei-Min Bao Lei Deng Zeng-Shan yin Changchun Institute of Optics FineMechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun 130033China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Shandong University Weihai 264209China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China

As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,*** maximum exposure time can be up to20 s due to precise pointing and image stabilization *** the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attainhe mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal *** present the up-to-date design for the LST payload.

关键词： telescopes—instrumentation high angular resolution—Sun flares—Sun coronal mass ejections(CMEs)—Sun UV radiation

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Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units： a prospective cohort study

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Chinese Medical Journal 2013年第23期126卷 4409-4416页

作者： WEN ying JIANG Li XU yuan QIAN Chuan-yun LI Shu-sheng QIN Tie-he chen Er-zhen LIN Jian-dong AI yu- hang WU Da-wei WANG yu-shan SUN Ren-hua HU Zhen-jie CAO xiang-yuan ZHOU Fa-chun he Zhen-yang ZHOU Li-hua AN You-zhong KANG Yan MA xiao-chun yu xiang-you ZHAO Ming-yan xi xiu-ming DU Bin Department of Critical Care Medicine Fuxing Hospital Capital Medical University Beijing 100038 China Department of Critical Care Medicine Beijing Tongren HospitalCapital Medical University Beijing 100730 China Department of Emergency Medicine First Affiliated Hospital of Kunming Medical College Kunming Yunnan 650032 China Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of Science & TechnologyWuhan Hubei 430030 China Department of Critical Care Medicine Guangdong General HospitalGuangzhou Guangdong 510080 China Department of Emergency Medicine Ruijin Hospital Shanghai Jiao Tong University Shanghai 200025 China Department of Critical Care Medicine First Affiliated Hospital ofFuiian Medical University Fuzhou Fujian 350005 China Department of Critical Care Medicine Xiangya Hospital CentralSouth University Changsha Hunan 410008 China Department of Critical Care Medicine Qilu Hospital Shandong University Jinan Shandong 250012 China Department of Emergency and Critical Care Medicine The Second Hospital of Jilin University Changchun Jilin 130041 China Department of Critical Care Medicine Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 China Department of Critical Care Medicine Hebei Medical University Fourth Hospital Shijiazhuang Hebei 050011 China Department of Critical Care Medicine Affiliated Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Critical Care Medicine First Affiliated Hospital Chongqing Medical University Chongqing 400016 China Department of Critical Care Medicine Hainan Provincial People's Hospital Haikou Hainan 570311 China Department of Critical Care Medicine Affiliated Hospital of Inner Mongolia Medical College Huhhot Inner Mongolia 010050 China Department of Critical Care Medicine Peking University People's Hospital Beijing 100044 China Department of Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 61004

Background Acute kidney injury （AKI） has been recognized as a major healthcare problem affecting millions of patients ***,epidemiologic data concerning AKI in China are still *** objectives of this study were to characterize AKI defined by RIFLE criteria,assess the association with hospital mortality,and evaluate the impact of AKI in the context of other risk *** This prospective multicenter observational study enrolled 3,063 consecutive patients from 1 July 2009 to 31 August 2009 in 22 ICUs across China's *** excluded patients who were admitted for less than 24 hours （n=1623）,younger than 18 years （n=127）,receiving chronic hemodialysis （n=29）,receiving renal transplantation （n=1） and unknown reasons （n=28）.There were 1255 patients in the final *** was diagnosed and classified according to RIFLE *** There were 396 patients （31.6％） who had AKI,with RIFLE maximum class R,I,and F in 126 （10.0％）,91 （7.3％）,and 179 （14.3％） patients,*** function deteriorated in 206 patients （16.4％）.In comparison with non AKI patients,patients in the risk class on ICU admission were more likely to progress to the injury class （odds ratio （OR） 3.564,95％ confidence interval （CI） 1.706-7.443,P =0.001],while patients in the risk class （OR 5.215,95％ CI 2.798-9.719,P ＜0.001） and injury class （OR 13.316,95％ CI 7.507-23.622,P ＜0.001） had a significantly higher probability of deteriorating into failure *** adjusted hazard ratios for 90-day mortality were 1.884 for the risk group,3.401 for the injury group,and 5.306 for the failure *** The prevalence of AKI was high among critically ill patients in Chinese *** comparison with non-AKI patients,patients with RIFLE class R or class I on ICU admission were more susceptibility to progression to class I or class *** RIFLE criteria were robust and correlated well with clinical deterioration and mortality.

关键词： acute kidney injury intensive care units mortality prevalence risk factors

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU Dong Shan chen Ren Bo SHI Nan Nan LIU Si Hong FAN yi Pin WU Gui Hui yang Pu Ye BAI Jiang Feng chen Hong chen Li ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU xiao Mei HU yun Hong HUANG jin HUANG Qiu Hua HUANG Shao Zhen JI Liang jin Hai Hao LEI xiao LI chun Yan LI Min Qing LI Qun Tang LI xian Yong LIU Hong De LIU jin Ping LIU Zhang MA yu Ting MAO Ya MO Liu Fen NA Hui WANG jing wei SONG Fang Li SUN sheng WANG Dong Ting WANG Ming Xuan WANG xiao Yan WANG yin Zhen WANG yu Dong WU wei WU Lan Ping xiAO Yan Hua xiE Hai Jun XU Hong Ming XU Shou Fang XUE Rui xia yang chun yang Kai Jun yuAN sheng Li ZHANG Gong Qi ZHANG jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan ying ZheNG Kai ZHOU ying chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

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Reciprocating Magnetic Fields in the Pulsar Wind Observed from the Black Widow Pulsar J1720-0534

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Research in Astronomy and Astrophysics 2023年第10期23卷 255-266页

作者： chen-chen Miao Victoria Blackmon wei-wei Zhu Dong-Zi Li Ming-yu Ge xiao-Peng You Maura McLaughlin Di Li Na Wang Pei Wang Jia-Rui Niu M.Cruces Jian-Ping yuan Jun-Tao Bai D.J.Champion yu-Tong chen Ming-Min Chi P.C.C.Freire yi Feng Zhen-Ye Gan M.Kramer Fei-Fei Kou yu-xi Li Xue-Li Miao Ling-Qi Meng chen-Hui Niu sheng-Nan Sun Zhong-yi Sun H.M.Tedila Shuang-Qiang Wang Qing-Dong Wu jing-Bo Wang Zhi-Gang Wen Shen Wang Ya-Biao Wang cheng-jie Wang Meng-Yao Xue You-Ling yue Mao yuan Ju-Mei Yao Wen-Ming Yan Ru-Shuang Zhao Lei Zhang De Zhao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China West Virginia University 1500 University AveMorgantownWV 26506USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Cahill Center for Astronomy and Astrophysics California Institute of Technology1216 E California BoulevardPasadenaCA 91125USA Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Science and Technology Southwest UniversityChongqing 400715China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Max-Planck Institut für Radioastronomie Auf dem Hügel 69D-53121 BonnGermany School of Computer Science Fudan UniversityShanghai 200433China Tencent Youtu Lab Shanghai 200233China College of Physical Science and Technology Central China Normal UniversityWuhan 430079China Institute of Optoelectronic Technology Lishui UniversityLishui 323000China Guizhou Normal University Guiyang 550001China

We report the radio observations of the eclipsing black widow pulsar J1720-0534, a 3.26 ms pulsar in orbit with a low mass companion of mass 0.029 to 0.034 M⊙. We obtain the phase-connected timing ephemeris and polarization profile of this millisecond pulsar(MSP) using the Five-hundred-meter Aperture Spherical radio Telescope(FAST), the Green Bank Telescope(GBT), and the Parkes Telescope. For the first time from such a system, an oscillatory polarization angle change was observed from a particular eclipse egress with partial depolarization, indicating 10-milliGauss-level reciprocating magnetic fields oscillating in a length scale of 5 ×10^(3)km(assuming an orbital inclination angle of 90°) outside the companion's magnetosphere. The dispersion measure variation observed during the ingresses and egresses shows the rapid raising of the electron density in the shock boundary between the companion's magnetosphere and the surrounding pulsar wind. We suggest that the observed oscillatory magnetic fields originate from the pulsar wind outside the companion's magnetosphere.

关键词： (stars:)pulsars:general (stars:)pulsars:individual(J1720-0534) (stars:)binaries:eclipsing

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-yi Su Sun-Bin Ling Qiao-Nan Shan Xu-Yong wei Rui Wang Chang-Ku Jia Li Zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo Sun Guang-Ming Li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-jie Su Zhi-Hai Peng Ren Lang Tao Jiang Qiang he Lin-Sen Ye yang yang yu-Ting he Wen-Zhi Guo Liu-Gen Lan Xu-Yong Sun Dong chen Zhi-Shui chen Da-wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo Wang Jiang Liu Qian Lu wei Rao jin-Zhen Cai Tao Lv Jia-yin yang Pu-Sen Wang Lin Zhong jing-sheng Ma Qi-Gen Li sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua Zhang Xuan Wang Zi-Qiang Li Mu-Jian Teng Jun-jie Li Wen-Tao Jiang Jian-Hua Li Quan-Bao Zhang Ning-Qi Zhu Zheng-xin Wang Kang he Qiang xia Shao-Hua Song Zhi-Ren Fu wei Qiu Guo-yue Lv Rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou Gang chen ying-Peng Zhao Li Li Ze-Min Hu Qi-jie Luo Zhong-Zhou Si Bin xie xiao-Shun he Zhi-Yong Guo Shu-Sen Zheng xiao Xu Department of hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents hepatocellular carcinoma Liver transplantation Conversion

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Searching for ^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao yang Qian yue Ke-Jun Kang yuan-jing Li Hai-Peng An C.Greeshma Jian-Ping Chang yun-Huan chen Jian-Ping cheng Wen-Han Dai Zhi Deng Chang-Hao Fang xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-yuan Guo Li he sheng-Ming he jin-wei Hu Han-xiong Huang Tu-chen Huang Hai-Tao Jia xi Jiang S.Karmakar Hao-Bin Li Jian-Min Li jin Li Qian-yun Li Ren-Ming-jie Li Xue-Qian Li yu-Lan Li yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan Liu Shu-Kui Liu Yan-Dong Liu yu Liu yuan-yuan Liu Zhong-Zhi Liu Hao Ma yu-Cai Mao Qi-yuan Nie jin-Hua Ning Hui Pan Ning-chun Qi jie Ren xi-Chao Ruan Ze She Manoj Kumar Singh Tian-xi Sun Chang-Jian Tang wei-You Tang yang Tian Guang-Fu Wang Li Wang Qing Wang yu-Feng Wang yun-xiang Wang henry-Tsz-King Wong Shi-Yong Wu yu-cheng Wu Hao-yang xing Rui Xu yin Xu Tao Xue yu-Lu Yan Nan yi chun-Xu yu Hai-Jun yu Jian-Feng yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-ying Zhou jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of ^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

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