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Journal of Integrative Agriculture 2023年第2期22卷 514-525页

作者： WANG Ke he yan-yan ZHANG You-jun GUO Zhao-jiang XIE Wen WU Qing-jun WANG Shao-li Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing 100081P.R.China

Chemosensory proteins(CSPs) perform several functions in *** study performed the gene expression,ligand-binding,and molecular docking assays on the EforCSP3 identified in the parasitoid wasp Encarsia formosa,to determine whether EforCSP3 functions in olfaction,especially in host location and host *** results showed that EforCSP3 was highly expressed in the female head,and its relative expression was much higher in adults than in other developmental *** fluorescence binding assays suggested that the EforCSP3 exhibited high binding affinities to a wide range of host-related volatiles,among which dibutyl phthalate,1-octene,β-elemene,and tridecane had the strongest binding affinity with EforCSP3,besides α-humulene and β-myrcene,and should be assessed as potential *** structure modeling and molecular docking predicted the amino acid residues of EforCSP3possibly involved in volatile binding.α-Humulene and β-myrcene attracted *** in a previous study and exhibited strong binding affinities with EforCSP3 in the current *** conclusion,EforCSP3 may be involved in semiochemical reception by ***.

关键词： Encarsia formosa chemosensory protein expression profiles fluorescence binding assay molecular docking

On the Ethics of Cultural heritage Protection

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Journal of Literature and Art Studies 2015年第12期5卷 1137-1145页

作者： ZHANG Yun-yan he yan-mei Shanghai Jiaotong University Shanghai China

This paper tries to address the problem of a lack of ethics about intangible cultural heritage protection in current China from the perspective of the history of ideas. Though this is a not a new angle and many papers have given a more or less comprehensive discussion about this, this paper will endeavor to give a more systematic account. Seen from the perspective of ethics, the protection of cultural heritage in China is mainly challenged by imbalance or deviation from four aspects： Firstly, from the aspect of political justice; secondly, from the aspect of a lack of civic awareness; thirdly, from the aspect of excessive nationalism; fourthly, from the aspect of silent intellectuals.

关键词： cultural heritage protection ethics political justice civic awareness excessive nationalism publicintellectuals

GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells

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Chinese Medical Journal 2010年第6期123卷 739-744页

作者： YAO Xin yanG yan he Hai-yan WANG Min YIN Kai-sheng HUANG Mao Department of Respiratory Disease First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Background Intedeukin-13 （IL-13） is recognized to be a key modulator in the pathogenesis of Th2-induced allergic inflammation. Transcription factors GATA3 and NFAT1 have been both implicated in the regulation of Th2 cytokines. We previously demonstrated the GATA3-NFAT1 association during human T cell activation. However, the function of the GATA3-NFAT1 complex in Th2 cytokines regulation is still unknown. Small interference RNA （siRNA） was constructed to knock down GATA3 expression in Hut-78 cells to investigate the possible role of GATA3-NFAT1 complex in IL-13 *** Cells were stimulated with anti-CD3 plus anti-CD28 antibodies to mimic in vivo antigen-mediated co-stimulation; the expression of IL-13 mRNA was determined by real-time PCR; chromation immunoprecipitation （CHIP） assay was employed to investigate the NFAT1 binding to IL-13 promoter. Results GATA3 siRNA suppressed the expression of GATA3 both in mRNA and protein levels in Hut-78 cells. The binding of NFAT1 to IL-13 promoter was inhibited by GATA3 siRNA in activated T cells, which was followed by the reduction of IL-13 *** GATA3-NFAT1 complex may play an important role in the regulation of IL-13 transcription in human T cells.

关键词： interleukin-13 asthma GATA3 NFAT1

Inhibition of interleukin-13 gene expression in T cells through GATA-3 pathway by arsenic trioxide

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Chinese Medical Journal 2008年第22期121卷 2346-2349页

作者： YAO Xin he Hai-yan yanG yan DAI Shan-lin SUN Pei-li YIN Kai-sheng HUANG Mao Department of Respiratory Diseases the First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China

Aarsenic trioxide （AT） has a long history of use in both traditional Chinese medicine and in modem medicine in asthma therapy. Recently, Yin et al＇ found that AT even at small doses reduced the airway inflammation of sensitized guinea pigs. However the mechanism underlying this is still largely unknown. Interleukin 13 （IL-13）, as one of the important TH2 cytokines, plays an important role in asthma pathogenesis through promoting eosinophilic inflammation,

关键词： interleukin-13 asthma GATA-3 arsenic trioxide

Comparative analysis of early and middle outcomes of the arterial switch operation in children with complete transposition of the great arteries with ventricular septal defect and severe pulmonary artery hypertension

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Chinese Medical Journal 2013年第11期126卷 2074-2078页

作者： LIU Cheng-hu SU Jun-wu LI Zhi-qiang FAN Xiang-ming CheN yan he yan LIUYing-long Department of Pediatric Cardiology Beijing An Zhen HospitalAffiliated to Capital Medical University Beijing Institute of HeartLung and Blood Vessel Diseases Beijing 100029 China

Background The best age for the arterial switch operation （ASO） in complete transposition of great arteries with ventricular septal defect is usually considered to be within six months. This is because of severe pulmonary arterial hypertension and pulmonary arterial obstructive pathological changes. There are few reports on ASO surgery in children older than three years old. Methods We studied 41 children, including 24 males and 17 females, from January 2010 to December 2011. They were divided into three groups by operation age; 15 patients were 〈1 year old, 13 were 1-3 years old, and 13 were 〉3 years old. Associated cardiac abnormalities included patent ductus arteriosus in six cases, atrial septal defect in five cases, and mitral regurgitation in two cases. All the patients had echocardiography before the operation. Seventeen patients underwent a coronary computed tomography examination and five patients underwent right heart catheterization. All ASO surgeries were performed under inhalation anesthesia and hypothermic cardiopulmonary bypass. Results Three operative deaths occurred. Two were in the 〈1 year old group, who died from severe postoperative low cardiac output. The other was two years old and died of postoperative multiple organ failure. There was no significant difference in postoperative mortality and the recent mid-term survival rate among the three groups. Thirty-eight cases were followed up for an average of 11.2 months, ranging 6-20 months. One seven years old patient died of acute diarrhea and electrolyte disturbance arrhythmia caused by food poisoning. Three patients more than three years old still had residual pulmonary arterial hypertension. Conclusion Children older than three years old can still undergo the ASO procedure, but residual pulmonary hypertension is present.

关键词： transposition of the great arteries arterial switch operation pulmonary arterial hypertension congenital heart disease

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三维人脸的非均匀重采样对齐算法

北京工业大学学报 2007年第2期33卷 213-218页

作者：尹宝才何晏晏孙艳丰梁永涛张壮北京工业大学计算机学院多媒体与智能软件技术北京市重点实验室北京100022

为了用尽量少的网格点和面片数表示对齐后的三维人脸,基于分片的网格重采样思想,通过分析每片的曲率高低自动确定各片的网格稠密度,得到非均匀的网格结构,实现了不同三维人脸数据间点到点的一一对齐．实验结果表明:与以往的对齐算法相比... 详细信息

为了用尽量少的网格点和面片数表示对齐后的三维人脸,基于分片的网格重采样思想,通过分析每片的曲率高低自动确定各片的网格稠密度,得到非均匀的网格结构,实现了不同三维人脸数据间点到点的一一对齐．实验结果表明:与以往的对齐算法相比,此方法不仅可以大大减少表示人脸的网格点数目,还可以较好地保持人脸的形状和外观特征;使用非均匀重采样做对齐后的三维人脸库建立的人脸模型进行人脸重建,比使用均匀重采样得到的人脸模型在重建速度上有了很大提高．

关键词：重采样人脸分片稠密对齐主曲率平均曲率

混沌蝙蝠算法UAV网络控制系统故障诊断策略

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火力与指挥控制 2020年第8期45卷 44-50,56页

作者：何燕燕江苏商贸职业学院电子信息学院江苏南通226011

针对总线条件下具有双通道多包传输的短时变时延无人机(Unmanned Aerial Vehicle,UAV)发动机控制系统,提出一种基于改进蝙蝠优化算法(Bat Algorithm,BA)的发动机故障检测算法,快速变化的延迟被认为是系统不确定性的一种。残差信号的传... 详细信息

针对总线条件下具有双通道多包传输的短时变时延无人机(Unmanned Aerial Vehicle,UAV)发动机控制系统,提出一种基于改进蝙蝠优化算法(Bat Algorithm,BA)的发动机故障检测算法,快速变化的延迟被认为是系统不确定性的一种。残差信号的传递函数与噪声和故障信号的传递函数之比用作目标函数。通过改进的Bat算法对其进行优化,以获得最佳的观察增益矩阵,使得该故障观测器系统不仅能够抑制噪声,而且对提升对故障敏感程度。最后将该方法在网络控制系统半物理平台上进行仿真,仿真结果说明所提出的方法能够同时抑制噪声信号和放大故障信号,从而提高了故障诊断的正确率,降低了虚警率。

关键词：无人机网络控制系统蝙蝠算法故障诊断

不同浓度血清对大鼠骨髓间充质干细胞生长的影响

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武汉理工大学学报 2016年第11期38卷 52-56页

作者：何燕燕邱彤武汉理工大学材料复合新技术国家重点实验室武汉430070

血清缺乏是在细胞治疗中对供体BMSCs活性影响的重要因素之一。作者探讨了不同浓度血清对MSCs细胞凋亡的影响。体外培养大鼠MSCs,用不同浓度血清(FBS)处理MSCs,MTT法检测MSCs细胞生长曲线,用Hoechst33342/PI染色检查MSCs的细胞凋亡,并使... 详细信息

血清缺乏是在细胞治疗中对供体BMSCs活性影响的重要因素之一。作者探讨了不同浓度血清对MSCs细胞凋亡的影响。体外培养大鼠MSCs,用不同浓度血清(FBS)处理MSCs,MTT法检测MSCs细胞生长曲线,用Hoechst33342/PI染色检查MSCs的细胞凋亡,并使用Western blot法分析细胞凋亡相关生物信号分子的表达。结果表明,血清缺乏培养条件下,MSCs在培养72h内出现细胞凋亡。并且,无血清培养直接引起了Casepase-3,Casepase-8和Casepase-9蛋白质表达量的增加,导致细胞凋亡的发生,从而致使细胞生长曲线的下降。此外,高浓度的血清对细胞凋亡具有保护作用。

关键词：骨髓间充质干细胞血清缺乏细胞凋亡

习近平关于坚定共产主义理想重要论述的逻辑理路

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湖南大学学报（社会科学版） 2023年第1期37卷 6-12页

作者：秦书生何彦彦东北大学马克思主义学院辽宁沈阳110169

习近平关于坚定共产主义理想的重要论述是一个结构严谨的思想体系,呈现出条理清晰的逻辑理路。这一思想体系的逻辑起点是它始终立足于党的初心使命和精神特质;这一思想体系以马克思恩格斯共产主义学说为理论基石,在百年奋斗中始终坚持... 详细信息

习近平关于坚定共产主义理想的重要论述是一个结构严谨的思想体系,呈现出条理清晰的逻辑理路。这一思想体系的逻辑起点是它始终立足于党的初心使命和精神特质;这一思想体系以马克思恩格斯共产主义学说为理论基石,在百年奋斗中始终坚持共产主义理想,体现了它的逻辑传承;这一思想体系从本质要求、坚守立场、现实路径三个方面展开其逻辑架构,深刻回答了新时代中国共产党人为什么以及怎样坚定共产主义理想的问题。

关键词：习近平共产党共产主义理想初心使命

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Cournot-Bertrand双寡头动态博弈模型的复杂性分析

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天津工业大学学报 2014年第3期33卷 80-83页

作者：何岩岩张芳天津工业大学理学院天津300387

提出了一个主从的Cournot-Bertrand双寡头混合博弈模型援寡头都是在有限理性期望下进行的博弈,并且上级寡头考虑产量,下级寡头考虑价格援分析了该模型的纳什均衡点和它的局部稳定性援通过数值模拟,利用稳定域图、分岔图、最大Lyapunov... 详细信息

提出了一个主从的Cournot-Bertrand双寡头混合博弈模型援寡头都是在有限理性期望下进行的博弈,并且上级寡头考虑产量,下级寡头考虑价格援分析了该模型的纳什均衡点和它的局部稳定性援通过数值模拟,利用稳定域图、分岔图、最大Lyapunov指数图以及奇异吸引子图研究了该模型的复杂动力学性质,且通过分析两寡头的利润分岔图。

关键词：主从 Cournot-Bertrand 有限理性复杂动力学动态博弈模型