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A polymeric co-assembly of subunit vaccine with polyoxometalates induces enhanced immune responses

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Nano Research 2022年第5期15卷 4175-4180页

作者： Xinpei Li xiaofeng he Dongrong he Yuan Liu Kun Chen Panchao Yin South China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510640China

Long-lasting protective immune responses are expected following ***,most vaccines alone are inability to evoke an efficient *** combinatory administration of adjuvants with vaccines is critical for generating the enhanced immune ***,with biocompatible poly(4-vinylpyridine)(P4VP)as template,2.5 nm iron/molybdenum oxide cluster,{Mo_(72)Fe_(30)},is applied as an adjuvant to co-assemble with antigens of Mycobacterium bovis via hydrogen bonding at molecular *** scale integration of the antigens and{Mo_(72)Fe_(30)}and their full exposure to body fluid media contribute to the augmentation of both humoral and cellular immune responses of the vaccines after inoculation in ***-inflammatory factor IL-10 gradually increases after 2 weeks followed by a final back to normal level by the 5th *** balance between proinflammatory cytokines and anti-inflammatory factors suggests that immune system can be activated in the early stage of infection by the antigens carried by the supra-particles and secrete acute inflammatory factors for host defense and anti-inflammatory factors for immune protection.

关键词： co-assembly immune response metal oxide cluster supramolecular interaction vaccine adjuvant

Product-oriented review summarization and scoring

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Frontiers of Computer Science 2015年第2期9卷 210-223页

作者： Rong ZHANG Wenzhe YU Chaofeng SHA xiaofeng he Aoying ZHOU Institute of Data Science and Engineering Shanghai Key Laboratory of Trustworthy Computing East China Normal University Shanghai 200062 China School of Computer Science Fudan University Shanghai 200433 China

Currently, mere are many onune review weo sites where consumers can freely write comments about different kinds of products and services. These comments are quite useful for other potential consumers. However, the number of online comments is often large and the number continues to grow as more and more consumers contribute. In addition, one comment may mention more than one product and con- tain opinions about different products, mentioning something good and something bad. However, they share only a single overall score, Therefore, it is not easy to know the quality of an individual product from these comments. This paper presents a novel approach to generate review summaries including scores and description snippets with re- spect to each individual product. From the large number of comments, we first extract the context （snippet） that includes a description of the products and choose those snippets that express consumer opinions on them. We then propose several methods to predict the rating （from 1 to 5 stars） of the snip- pets. Finally, we derive a generic framework for generating summaries from the snippets. We design a new snippet selec- tion algorithm to ensure that the returned results preserve the opinion-aspect statistical properties and attribute-aspect cov- erage based on a standard seat allocation algorithm. Through experiments we demonstrate empirically that our methods are effective. We also quantitatively evaluate each step of our ap- proach.

关键词： online transaction diversification review sum-marization review scoring

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pH-responsive metal nanoparticles as high contrast theranostic agents for selective imaging and synergistic cancer therapy

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Science China Chemistry 2024年第9期67卷 3063-3070页

作者： Sichao Tian xiaofeng he Xiao Wu Dongxue Hu Qing-Hua Xu Department of Chemistry National University of SingaporeSingapore 117543Singapore National University of Singapore(Suzhou)Research Institute Suzhou 215123China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore

The low signal-to-noise ratio(S/N)and single functionality of fluorescence imaging agents have limited their practical *** two-photon excitation(2PE)imaging probes are highly desirable in vivo with larger imaging depth,minor autofluorescence background,and less ***,we developed responsive aggregated gold nanoparticles(Au NPs)as high contrast 2PE imaging agents,capable of emitting red fluorescence upon excitation of near-infrared(NIR)laser and possessing a high signal-to-noise ratio(S/N of 2,475).By forming aggregates in situ inside tumor tissue,doxorubicin hydrochloride(DOX)-loaded mix-charged gold nanoparticles(DOX-MC-Au NPs)were utilized to act as selective fluorescence imaging probes and precise therapy *** high-contrast theranostic agents offer a promising potential for precise cancer imaging and therapy,which might open a new venue to multifunctional and noninvasive theranostics.

关键词： metal nanoparticles two-photon excitation high contrast imaging agents fluorescence imaging cancer therapy

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A double-filter-structure based COMPASS/INS deep integrated navigation system implementation and tracking performance evaluation

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Science China(Information Sciences) 2014年第1期57卷 232-245页

作者： LUO Yong WU WenQi BABU Ravindra TANG KangHua he xiaofeng College of Mechatronics and Automation National University of Defense Technology

Beidou or COMPASS is a Chinese GNSS(global navigation satellite system).Like the GPS receiver,the COMPASS receiver also faces the challenge of choosing an optimal bandwidth to satisfy both anti-jamming capability and dynamics adaptation ***/INS(inertial navigation system)deep integrated navigation system has solved this problem by fusing GPS baseband signal and INS information in a deeply coupled *** this study,a COMPASS B3 frequency is considered and a traditional federated GPS/INS deep integration model is used to derive a single-filter-structure based COMPASS/INS deep integration ***,a double-filter-structure based COMPASS/INS deep integration model is *** simulation results show a better carrier tracking performance,especially a better dynamics *** impact of IMU errors and vehicle’s dynamics on carrier tracking performance of the double-filter-structure based COMPASS/INS deep integrated navigation system are evaluated in simulated and field *** and field test results are in accordance with the theory analysis.

关键词： B3 frequency COMPASS COMPASS/INS deep integrated navigation system double-filter-structure

Towards modeling popularity of microblogs

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Frontiers of Computer Science 2013年第2期7卷 171-184页

作者： Haixin MA Weining QIAN Fan XIA xiaofeng he Jun XU Aoying ZHOU Institute of Massive Computing East China Normal UniversityChina Shanghai 200062 School of Computer Science Georgia Institute of Technology USA Atlanta 30332

As one kind of social media, microblogs are widely used for sensing the real-world. The popularity of mi- croblogs is an important measurement for evaluation of the influencial of pieces of information. The models and mod- eling techniques for popularity of microblogs are studied in this paper. A huge data set based on Sina Weibo, one of the most popular microblogging services, is used in the study. First, two different types of popularity, namely number of retweets and number of possible views are defined, while their relationships are discussed. Then, the temporal dynamics, in- cluding lifecycles and tipping-points, of tweets＇ popularity are studied. For modeling the temporal dynamics, a piece- wise sigmoid model is used. Empirical studies show the ef- fectiveness of our modeling methods.

关键词： modeling popularity effectiveness

A characteristic-featured shock wave indicator for simulating high-speed inviscid flows on 3D unstructured meshes

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Advances in Aerodynamics 2021年第1期3卷 477-497页

作者： Yiwei Feng Tiegang Liu xiaofeng he Bin Zhang Kun Wang School of Mathematical Sciences Beihang UniversityBeijingChina ShenYuan Honors College Beihang UniversityBeijingChina School of Aeronautic Science and Engineering Beihang UniversityBeijingChina.

In this work,we extend the characteristic-featured shock wave indicator based on artificial neuron training to 3D high-speed flow simulation on unstructured *** extension is achieved through dimension *** leads to that the proposed indicator is capable of identifying regions of flow compression in any *** this capability,the indicator is further developed to combine with h-adaptivity of mesh refinement to improve resolution with less computational *** present indicator provides an attractive alternative for constructing high-resolution,high-efficiency shock-processing methods to simulate high-speed inviscid flows.

关键词： High-order high-resolution method Shock wave detector H-adaptive method Transonic supersonic flow

A DDG Method with a Residual-Based Artificial Viscosity for the Transonic/Supersonic Compressible Flow

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Communications in Computational Physics 2022年第4期31卷 1134-1161页

作者： xiaofeng he Kun Wang Yiwei Feng Tiegang Liu Xiaojun Wang LMIB and School of Mathematical Sciences Beihang UniversityP.R.China School of Aeronautic Science and Engineering Beihang UniversityP.R.China Shen Yuan Honors College of Beihang University P.R.China

In this work,a direct discontinuous Galerkin(DDG)method with artificial viscosity is developed to solve the compressible Navier-Stokes equations for simulating the transonic or supersonic flow,where the DDG approach is used to discretize viscous and heat fluxes.A strong residual-based artificial viscosity(AV)technique is proposed to be applied in the DDG framework to handle shock waves and layer structures appearing in transonic or supersonic flow,which promotes convergence and ***,the AV term is added to classical BR2 methods for comparison.A number of 2-D and 3-D benchmarks such as airfoils,wings,and a full aircraft are presented to assess the performance of the DDG framework with the strong residualbased AV term for solving the two dimensional and three dimensional Navier-Stokes *** proposed framework provides an alternative robust and efficient approach for numerically simulating the multi-dimensional compressible Navier-Stokes equations for transonic or supersonic flow.

关键词： Direct discontinuous Galerkin transonic/supersonic flow residual-based artificial viscosity

An output amplitude configurable wideband automatic gain control with high gain step accuracy

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Journal of Semiconductors 2012年第2期33卷 111-116页

作者： he xiaofeng Mo Taishan Ma Chengyan Ye Tianchun Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Hangzhou Zhongke Microelectronics Co LtdHangzhou 310053China

An output amplitude configurable wideband automatic gain control（AGC） with high gain step accuracy for the GNSS receiver is *** amplitude of an AGC is configurable in order to cooperate with baseband chips to achieve interference suppression and be compatible with different full range *** what’s more,the gain-boosting technology is introduced and the circuit is improved to increase the step accuracy.A zero,which is composed by the source feedback resistance and the source capacity,is introduced to compensate for the *** AGC is fabricated in a 0.18μm CMOS *** AGC shows a 62 dB gain control range by 1 dB each step with a gain error of less than 0.2 *** AGC provides 3 dB bandwidth larger than 80 MHz and the overall power consumption is less than 1.8 mA,and the die area is 800 x 300μm^2.

关键词： automatic gain control output amplitude configurable high gain step accuracy

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A promising solution for highly reversible zinc metal anode chemistry:Functional gradient interphase

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Nano Research Energy 2024年第2期3卷 3-6页

作者： xiaofeng he Xiang-Yu Kong Liping Wen CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Rechargeable zinc(Zn)metal batteries have long been plagued by dendrite growth and parasitic reactions due to the absence of a stable Zn-ion conductive solid-electrolyte interphase(SEI).Although the current strategies assist in suppressing dendritic Zn growth,it is still a challenge to obtain the operation-stability of Zn anode with high Coulombic efficiency(CE)required to implement a sustainable and long-cycling life of Zn metal *** this perspective,we summarize the advantages of the functional gradient interphase(FGI)and try to fundamentally understand the transport behaviors of Zn ions,based on recently an article understanding Zn *** correlation between the function-orientated design of gradient interphase and key challenges of Zn metal anodes in accelerating Zn2+transport kinetics,improving electrode reversibility,and inhibiting Zn dendrite growth and side reactions was particularly ***,the rational design and innovative directions are provided for the development and application of functional gradient interphase in rechargeable Zn metal battery systems.

关键词： zinc metal battery dendrite gradient solid-electrolyte interphase energy storage