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Simulation of the distribution,growth,and survival rate of chub mackerel larvae and juveniles in the East China Sea

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Journal of Oceanology and Limnology 2023年第4期41卷 1602-1619页

作者： Wenjiang GUAN Xuelian MA weiwei he Ruixing CAO College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China Key Laboratory of Sustainable Exploitation of Oceanic Fisheries Resources Ministry of EducationShanghai Ocean UniversityShanghai 201306China

In the East China Sea(ECS),chub mackerel Scomber japonicus constitutes an important coastal-pelagic fishery resource that is mainly exploited by Chinese,Japanese,and Korean light-purse seine *** the early life history of chub mackerel plays a significant role in its recruitment,we developed an individual-based model to study the distribution,growth,and survival rate of chub mackerel larvae and juveniles in the ECS to improve our understanding of the chub mackerel population structure and *** results show that as body length rapidly increases,the swimming capacity of chub mackerel larvae and juveniles improves quickly,and their spatial distribution depends more on their habitat conditions than the ocean ***,the juveniles from the central and southern ECS spawning ground are scarcely recruited into the Japan/East Sea(JES)or the western Pacific Ocean,but a significant proportion of juveniles from the northern ECS spawning ground still enter the JES and there are exchanges between the stocks in the ECS and ***,it seems more reasonable to assess and manage the chub mackerels in the ECS and JES as a *** water temperature and ocean primary production in the ECS are two important factors influencing the chub mackerel habitat conditions and their spatial and temporal distribution are significantly different as the spawning time ***,the spawning time and location play an important role in the growth and survival rate of the larvae and ***,when chub mackerel spawns at the southern ECS spawning ground in March,the larva and juvenile growth and survival rate is relatively high;as spawning time moves forward,higher growth and survival rates would be expected for the chub mackerel spawned coastward or *** specific spawning sites,early or delayed spawning will reduce the survival rate.

关键词： East China Sea(ECS) Scomber japonicus individual-based model early life history

Theoretical study on magnetocaloric effect and its electric-field regulation in CrI_(3)/metal heterostructure

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 134-141页

作者： weiwei he Ziming Tang Qihua Gong Min Yi Wanlin Guo State Key Laboratory of Mechanics and Control for Aerospace Structures Key Laboratory for Intelligent Nano Materials and Devices of Ministry of EducationInstitute for Frontier ScienceNanjing University of Aeronautics and AstronauticsNanjing 210016China MIIT Key Laboratory of Aerospace Information Materials and Physics College of PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China

The extraordinary properties of a heterostructure by stacking atom-thick van der Waals(vdW)magnets have been extensively ***,the magnetocaloric effect(MCE)of heterostructures that are based on monolayer magnets remains to be ***,we deliberate MCE of vd W heterostructure composed of a monolayer CrI_(3)and metal atomic layers(Ag,Hf,Au,and Pb).It is revealed that heterostructure engineering by introducing metal substrate can improve MCE of CrI_(3),particularly boosting relative cooling power to 471.72μJ m^(-2)and adiabatic temperature change to 2.1 K at 5 T for CrI_(3)/*** improved MCE is ascribed to the enhancement of magnetic moment and intralayer exchange coupling in CrI_(3)due to the CrI_(3)/metal heterointerface induced charge *** field is further found to tune MCE of CrI_(3)in heterostructures and could shift the peak temperature by around 10 K in CrI_(3)/Hf,thus manipulating the working temperature window of *** theoretical results could enrich the research on low-dimensional magnetocaloric materials.

关键词： magnetocaloric effect heterostructure metal substrate

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Nuclear Envelope Protein MAN1 Regulates the Drosophila Circadian Clock via Period

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Neuroscience Bulletin 2019年第6期35卷 969-978页

作者： Bei Bu weiwei he Li Song Luoying Zhang Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Institute of Brain Research Huazhong University of Science and TechnologyWuhan 430074China

Almost all organisms exhibit ~24-h rhythms, or circadian rhythms, in a plentitude of biological *** rhythms are driven by endogenous molecular clocks consisting of a series of transcriptional and translational feedback loops. Previously, we have shown that the inner nuclear membrane protein MAN1 regulates this clock and thus the locomotor rhythm in flies, but the mechanism remains unclear. here, we further confirmed the previous findings and found that knocking down MAN1 in the pacemaker neurons of adult flies is sufficient to lengthen the period of the locomotor rhythm. Molecular analysis revealed that knocking down MAN1 led to reduced m RNA and protein levels of the core clock gene period(per),likely by reducing its transcription. Over-expressing per rescued the long period phenotype caused by MAN1 deficiency whereas per mutation had an epistatic effect on MAN1, indicating that MAN1 sets the pace of the clock by targeting per.

关键词： Circadian clock Drosophila Nuclear envelope MAN1 Period

Persistent radical anion of perylene dianhydride:an emerging metal-free photocatalyst for near-infrared photocontrolled RAFT polymerization

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Science China Chemistry 2024年第2期67卷 677-686页

作者： Haitao Zhao Guoqing Bian Xiang Xu weiwei he Lifen Zhang Zhenping Cheng State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China

Developing a new type of photocatalyst(PC) and catalytic mechanism for near-infrared(NIR) photocontrolled reversibledeactivation radical polymerization(RDRP) system is charming but ***,a novel PC of the persistent radical anion(PRA)(possessing the properties of both radical and anion) was developed for NIR photocontrolled reversible additionfragmentation chain transfer(RAFT) polymerization,enabling successful polymerization while gaining a deep insight into the mechanism of photo-induced electron transfer RAFT(PET-RAFT) *** from the conventional and wellaccepted reductive quenching(RQ) pathway,in which the radical anion intermediates of PCs(PCs^(·-)) must be generated in an excited state(ES),here,the PRA(3,4,9,10-perylenetetracarboxylic dianhydride radical anion(PTCDA^(·-))) could generate conveniently in situ in the ground state(GS) and subsequently serve as highly efficient PC in the NIR region(740–850 nm).The successful implementation of this strategy elucidates the peculiar role played by light and the real way of electron transfer *** fact,the transfer of a single electron from PRA to chain transfer agent(CTA) and cleavage of the C–S bonds is a process from ES to GS,rather than always from GS(PCs^(·-)) to GS(CTA) in the RQ pathway as is well known to *** addition,the excellent spatial-temporal control and powerful penetration ability of the NIR light were also confirmed by this PRAcatalyzed polymerization system.

关键词： photocatalyst persistent radical anion(PRA) near-infrared(NIR)light reversible-deactivation radical polymerization(RDRP) photo-induced electron transfer RAFT(PET-RAFT)polymerization

A cationic metal-organic framework based on {Zn4} cluster for rapid and selective adsorption of dyes

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Chinese Chemical Letters 2018年第6期29卷 857-860页

作者： weiwei he Na Li Xi Wang Tongliang Hu Xianhe Bu Department of Chemistry Nankai University School of Materials Science and Engineering National Institute for Advanced Materials Nankai University Tianjin Key Laboratory of Metal and Molecule-Based Material Chemistry Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education)and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University

Until now, to remove the harmful organic dyes from effluents is an outstanding challenge. The design and synthesis of new porous materials capable of selectively adsorbing dyes are critical to the environment and human health. here, a unique cluster-based cationic metal-organic framework, named{[Zn8（BTA）6（L）5Cl2]·（NO3）3}·5 DMF（NUM-4） was synthesized, which displays one-dimensional（1 D）open channels along a axis in its 3 D supramolecular stacking structure. Benefiting from the nature of cationic framework and high surface area/pore volume, NUM-4 shows rapid and selective adsorption of anionic dyes（MO, AO, CR and MB） based on the charge-exclusive effect. Besides, the adsorbed dyes can be easily released in NH4Cl saturated solution of ethanol.

关键词： Metal-organic framework Supermolecule Anionic dyes Adsorption and separation Charge-exclusive effect

Synthesis of a glucose conjugate of pristimerin and evaluation of its anticancer activity

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Chinese Chemical Letters 2023年第1期34卷 310-312页

作者： Fan Yang Jie Zhang Jiacheng Li Wenbo Ye Ang Li weiwei he Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioorganic and Natural Product Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China The Research Center of Chiral Drugs Innovation Research Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

Taking advantage of the Warburg effect in cancer cells, glucose conjugation has emerged as a useful strategy for targeted delivery of anticancer agents. Pristimerin is a naturally occurring triterpenoid that displays potent but non-selective cytotoxicity. We developed a convergent and modular approach to construction of glucose-payload conjugates featuring copper-mediated azide-alkyne cycloaddition and prepared a glucose conjugate of pristimerin through this approach. The anticancer activity of this conjugate was evaluated in cancer cells and normal cells;however, the selectivity toward cancer cells was not significantly improved. We then examined the extracellular stability of the conjugate and found that its ester linkage was cleaved rapidly in Dulbecco’s Modified Eagle’s Medium at 37 °C, which resulted in the release of pristimerin. In fact, the inorganic components in this medium were sufficient to induce the *** that the subtle difference between intrinsic stability and extracellular stability of the conjugate linker is often underappreciated, this work highlights the importance of the latter in the development of target-selective conjugates.

关键词： Glucose conjugation Warburg effect Pristimerin Extracellular stability

Celastrol as a tool for the study of the biological events of metabolic diseases

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Science China Chemistry 2019年第4期62卷 409-416页

作者： Gongcai Lan Jie Zhang Wenbo Ye Fan Yang Ang Li weiwei he Wei-Dong Zhang Guangdong Pharmaceutical University Shanghai Key Laboratory of New Drug Design School of Pharmacy East China University of Science and Technology State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Department of Phytochemistry School of Pharmacy Second Military Medical University State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections Jiangxi Qingfeng Pharmaceutical Co.Ltd.

Celastrol is a pentacyclic triterpenoid isolated from Tripterygium wilfordii that has long been used in traditional Chinese medicine for treating rheumatoid arthritis. Previous studies showed that celastrol possessed diverse biological activities, including anti-inflammatory and anticancer properties. Interestingly, most recent literatures revealed the important role of celastrol against metabolic disorders. herein, we provide an overview of the modes of action of celastrol for combating metabolic diseases such as obesity and type 2 diabetes. The anti-obesity effect of celastrol results from relieving endoplasmic reticulum stress in hypothalamus, regulating HSF1-PGC1α axis in the adipose tissue and muscle, and alleviating inflammation via Nur77 mediated autophagy. Celastrol also reverses insulin resistance via NF-κB signaling pathway to protect against type 2 diabetes.

关键词： celastrol obesity type 2 diabetes endoplasmic reticulum stress inflammation

Characteristics of Ni-based ohmic contacts on n-type 4H-SiC using different annealing methods

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Nanotechnology and Precision Engineering 2021年第1期4卷 44-47页

作者： Ziwei Zhou weiwei he Zhenzhong Zhang Jun Sun Adolf Schöner Zedong Zheng Research and Development Department BASiC Semiconductor Ltd.Shenzhen 518000China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China

Nickel is an excellent ohmic-contact metal on *** paper discusses the formation mechanism of nickel ohmic contact on 4HSiC by assessing the electrical properties and microstructural *** high-temperature annealing,the phase of nickel-silicon compound can be observed with X-ray diffraction,and the contact resistance also changes.A comparative experiment was designed to use X-ray diffraction and energy-dispersive spectroscopy to clarify the difference of ohmic-contact material composition and elemental analysis between samples prepared using pulsed laser annealing and rapid thermal *** is found that more Ni2Si and carbon vacancies formed at the interface in the sample prepared using pulsed laser annealing,resulting in a better ohmic-contact characteristic.

关键词： Laser annealing Rapid thermal annealing Ohmic contact Ni 4H-SiC Carbon vacancy

Determination of failure degree of 1.2 kV SiC MOSFETs after short-circuit test using an improved test setup

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Nanotechnology and Precision Engineering 2020年第4期3卷 235-240页

作者： Shen Diao Jun Sun Ziwei Zhou Zhenzhong Zhang Adolf Schöner Zedong Zheng weiwei he Research and Development Department Shenzhen BASiC Semiconductor Ltd.Shenzhen 518000China Dept.Electrical Engineering Tsinghua UniversityBeijing 100084China

Analysis of the short-circuit characteristics of SiC metal-oxide-semiconductor field-effect transistors(MOSFETs)is very important for their practical *** paper studies the SiC MOSFET short-circuit characteristics with an improved test setup under different conditions.A high-current Si insulated gate bipolar transistor is used as a circuit breaker in the test circuit rather than the usual short-circuit test conducted without a circuit *** test platform with a circuit breaker does not influence the calculation results regarding the shortcircuitwithstand time and energy,but the SiCMOSFETwill switch off after failure in a very short *** addition,the degree of failure will be limited and confined to a small area,such that the damage to the chip will be clearly observable,which is significant for short-circuit failure analysis.

关键词： SiC MOSFET Short-circuit test Failure analysis