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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

The neuro-glial coagulonome: the thrombin receptor and coagulation pathways as major players in neurological diseases

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Neural Regeneration Research 2019年第12期14卷 2043-2053页

作者： shany G.Gofrit Efrat Shavit-Stein Department of Neurology and Joseph Sagol Neuroscience Center Sheba Medical Center Tel Hashomer Sackler Faculty of Medicine Tel Aviv University

The neuro-glial interface extends far beyond mechanical support alone and includes interactions through coagulation cascade proteins. here, we systematically review the evidence indicating that synaptic and node of Ranvier glia cell components modulate synaptic transmission and axonal conduction by a coagulation cascade protein system, leading us to propose the concept of the neuro-glial coagulonome. In the peripheral nervous system, the main thrombin receptor protease activated receptor 1 (PAR1) is located on the Schwann microvilli at the node of Ranvier and at the neuromuscular junction. PAR1 activation effects can be both neuroprotective or harmful, depending on thrombin activity levels. Low physiological levels of thrombin induce neuroprotective effects in the Schwann cells which are mediated by the endothelial protein C receptor. High levels of thrombin induce conduction deficits, as found in experimental autoimmune neuritis, the animal model for Guillaine-Barre syndrome. In the central nervous system, PAR1 is located on the peri-synaptic astrocyte end-feet. Its activation by high thrombin levels is involved in the pathology of primary inflammatory brain diseases such as multiple sclerosis, as well as in other central nervous system insults, including trauma, neoplasms, epilepsy and vascular injury. Following activation of PAR1 by high thrombin levels the seizure threshold is lowered. On the other hand, PAR1 activation by lower levels of thrombin in the central nervous system protects against a future ischemic insult. This review presents the known structure and function of the neuro-glial coagulonome, focusing on coagulation, thrombin and PAR1 in a pathway which may be either physiological (neuroprotective) or detrimental in peripheral nervous system and central nervous system diseases. Understanding the neuro-glial coagulonome may open opportunities for novel pharmacological interventions in neurological diseases.

关键词： thrombin protease activated receptor 1 protease nexin 1 glia node of Ranvier synapse epilepsy glioblastoma Guillaine-Barre syndrome

Interaction of oblique waves with an array of long horizontal circular cylinders

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Science China(Technological Sciences) 2007年第4期50卷 490-509页

作者： ng Chiu-On Department of Mechanical Engineering the University of Hong Kong Pokfulam Road Hong Kong China

The scattering and radiations of linear oblique waves by multiple long horizontal circular cylinders submerged in water of finite depth are investigated using the multipole expansion method. Analytical expressions for the diffracted and radiated potentials are given as a linear combination of infinite multipoles. The unknown coefficients in the expressions are determined by using the addition theorem of the Bessel function and the cylinder boundary conditions. Also analytical expressions for wave forces, hydrodynamic coefficients and reflection and transmission coeffi-cients are derived. The present analytical solution is verified through the boundary element method and applied to investigate three different cases of the interaction of oblique waves with multiple submerged horizontal circular cylinders. The results show that the number of cylinders, the arrangement and spacing between cylinders play an important role in wave forces, hydrodynamic coefficients and reflection and transmission coefficients. Some interesting and important phenomena are ob-served in numerical experiments.

关键词： scattering and radiation water waves analytical technique hydrodynamic characteristics

Nonlinear dynamical characteristics of bed load motion

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Science China(Technological Sciences) 2006年第3期49卷 365-384页

作者： Chiu-On ng Department of Mechanical Engineering the University of Hong Kong Hong Kong China

Bed forms of various kinds that evolve naturally on the bottom of sandy coasts and rivers are a result of the kinematics of bed load transport. Based on the group motion of particles in the bed load within the bottom layer, a study on the nonlinear dy- namics of bed load transport is presented in this paper. It is found that some development stages, such as the initiation, the equilibrium sediment transport, and the transition from a smooth bed to sand dunes, can be accounted for by different states in the nonlinear sys- tem of the bed load transport. It is verified by comparison with experimental data reported by Laboratoire Nationae D’Hydraulique, Chatou, France, that the evolution from a smooth bed to sand dunes is determined by mutation in the bed load transport. This paper pre- sents results that may offer theoretical explanations to the experimental observations. It is also an attempt to apply the state-of-the-art nonlinear science to the classical sediment transport mechanics.

关键词： bed load, bed form, nonlinear dynamics.

Effects of Risk Perception on Disaster Preparedness Toward Typhoons:An Application of the Extended Theory of Planned Behavior

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International Journal of Disaster Risk Science 2022年第1期13卷 100-113页

作者： Sai Leung ng Graduate Institute of Earth Science Chinese Culture UniversityTaipei 11114TaiwanChina

This study adopted an extended theory of planned behavior to understand how risk perception affected disaster preparedness *** intercept survey(N=286)was conducted at a typhoon-prone district of Hong Kong,China in 2019,then the data were analyzed using structural equation *** results indicated that risk perception and intention of preparedness were predictors of disaster preparedness *** perception significantly affected intention of preparedness and the effect was partially mediated by subjective *** perception also significantly affected attitude and perceived behavioral control,but attitude and perceived behavioral control were not significantly correlated with intention of *** only may this study supplement the existing literature of disaster preparedness toward typhoons,but also it provides insights for the planning and management of natural hazards and disaster risk reduction in Hong Kong,China.

关键词： Disaster preparedness behaviour Hong Kong,China Risk perception Structural equation modelling Theory of planned behaviour Typhoon preparedness

The role of AVDR in linear cascade testing

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航空动力学报 2007年第6期22卷 933-944页

作者： Wing F.ng Department of Mechanical Engineering Virginia Polytechnic Instituteand State University

Linear cascade testing plays an important role in the research and development of turbomachinery and is widely used over the *** ideal cascade model of a turbomachinery blade row is *** actual linear cascade testing,the flow through the test section converges due to the development of the boundary layer and secondary flow along the sidewall surfaces of the test *** velocity density ratio(AVDR) is adopted to account for the deviation of the tested cascade flow from the ideal 2D *** numerous published cascade works,the influence of AVDR on cascade performance is seen to be complicated with many affecting factors,such as those related to cascade/blade geometry and flow ***,controlling AVDR is limited by the facility ***,real blade-to-blade flow in turbomachines is usually associated with AVDR greater than unity due to limited span of blades between the hub and shroud such that cascade testing without reducing AVDR could be favored *** these facets add complexity and diversification to the *** current paper reviews previous studies and results on *** understanding on the role of AVDR and recommendations on how to deal with it in linear cascade testing are provided.

关键词：线性叶栅试验轴向速度密度比空气流动叶栅特性

Rotating electroosmotic flow of an Eyring fluid

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Acta Mechanica Sinica 2017年第2期33卷 295-315页

作者： Cheng Qi Chiu-On ng Department of Mechanical Engineering The University of Hong Kong Hong Kong China

A perturbation analysis is presented in this paper for the electroosmotic (EO) flow of an Eyring fluid through a wide rectangular microchannel that rotates about an axis perpendicular to its own. Mildly shear-thinning rheology is assumed such that at the leading order the problem reduces to that of Newtonian EO flow in a rotating channel, while the shear thinning effect shows up in a higher-order problem. Using the relaxation time as the small ordering parameter, analytical solutions are deduced for the leading- as well as first-order problems in terms of the dimensionless Debye and rotation parameters. The velocity profiles of the Ekman-electric double layer (EDL) layer, which is the boundary layer that arises when the Ekman layer and the EDL are comparably thin, are also deduced for an Eyring fluid. It is shown that the present perturbation model can yield results that are close to the exact solutions even when the ordering parameter is as large as order unity. By this order of the relaxation time parameter, the enhancing effect on the rotating EO flow due to shear-thinning Eyring rheology can be significant.

关键词： Electroosmotic flow Eyring fluid Rotating channel

On the time development of dispersion in electroosmotic flow througha rectangular channel

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Acta Mechanica Sinica 2012年第3期28卷 631-643页

作者： Suvadip Paul Chiu-On ng Department of Mechanical Engineering The University of Hong Kong

This is an analytical study on the time develop- ment of hydrodynamic dispersion of an inert species in elec- troosmotic flow through a rectangular channel. The objec- tive is to determine how the channel side walls may affect the dispersion coefficient at different instants of time. To this end, the generalized dispersion model, which is valid for short and long times, is employed in the present study. An- alytical expressions are derived for the convection and dis- persion coefficients as functions of time, the aspect ratio of the channel, and the Debye-Htickel parameter representing the thickness of the electric double layer. For transport in a channel of large aspect ratio, the dispersion may undergo several stages of transience. The initial, fast time develop- ment is controlled by molecular diffusion across the narrow channel height, while the later, slower time development is governed by diffusion across the wider channel breadth. For a sufficiently large aspect ratio, there can be an interlude between these two periods during which the coefficient is nearly steady, signifying the resemblance of the transport to that in a parallel-plate channel. Given a sufficiently long time, the dispersion coefficient will reach a fully-developed steady value that may be several times higher than that with- out the side wall effects. The time scales for these periods of transience are identified in this paper.

关键词： Taylor dispersion. Electroosmotic flow. Gener-alized dispersion model

Remodeling of astrocyte secretome in amyotrophic lateral sclerosis:uncovering novel targets to combat astrocyte-mediated toxicity

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Translational Neurodegeneration 2022年第1期11卷 84-97页

作者： Winanto ng Shi-Yan ng Institute of Molecular and Cell Biology A*STAR Research EntitiesSingapore 138673Singapore

Amyotrophic lateral sclerosis(ALS)is an adult-onset paralytic disease characterized by progressive degeneration of upper and lower motor neurons in the motor cortex,brainstem and spinal *** neuron degeneration is typically caused by a combination of intrinsic neuronal(cell autonomous)defects as well as extrinsic(non-cell autonomous)factors such as astrocyte-mediated *** are highly plastic cells that react to their microenvironment to mediate relevant *** neurodegeneration,astrocytes often turn reactive and in turn secrete a slew of factors to exert pro-inflammatory and neurotoxic *** efforts have been carried out to characterize the diseased astrocyte secretome over the years,revealing that pro-inflammatory chemokines,cytokines and microRNAs are the main players in mediating neuronal *** metabolomic technologies mature,these studies begin to shed light on neurotoxic metabolites such as secreted *** this focused review,we will discuss changes in the astrocyte secretome during *** particular,we will discuss the components of the reactive astrocyte secretome that contribute to neuronal death in ALS.

关键词： Motor neuron disease Astrocyte Astrocyte-mediated toxicity Secretome