Remodeling of astrocyte secretome in amyotrophic lateral sclerosis:uncovering novel targets to combat astrocyte-mediated toxicity

作     者：Winanto Ng Shi-Yan Ng 

作者机构：Institute of Molecular and Cell BiologyA*STAR Research EntitiesSingapore 138673Singapore 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2022年第11卷第1期

页      面：84-97页

核心收录：

学科分类：0710[理学-生物学] 0402[教育学-心理学(可授教育学、理学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 100204[医学-神经病学] 1009[医学-特种医学] 10[医学] 

基　　金：the National Research Foundation Fellowship(NRF-NRFF-2018-003)and the Intra-CREATE Thematic Grant(THE-002-0001) 

主　　题：Motor neuron disease Astrocyte Astrocyte-mediated toxicity Secretome 

摘      要：Amyotrophic lateral sclerosis(ALS)is an adult-onset paralytic disease characterized by progressive degeneration of upper and lower motor neurons in the motor cortex,brainstem and spinal *** neuron degeneration is typically caused by a combination of intrinsic neuronal(cell autonomous)defects as well as extrinsic(non-cell autonomous)factors such as astrocyte-mediated *** are highly plastic cells that react to their microenvironment to mediate relevant *** neurodegeneration,astrocytes often turn reactive and in turn secrete a slew of factors to exert pro-inflammatory and neurotoxic *** efforts have been carried out to characterize the diseased astrocyte secretome over the years,revealing that pro-inflammatory chemokines,cytokines and microRNAs are the main players in mediating neuronal *** metabolomic technologies mature,these studies begin to shed light on neurotoxic metabolites such as secreted *** this focused review,we will discuss changes in the astrocyte secretome during *** particular,we will discuss the components of the reactive astrocyte secretome that contribute to neuronal death in ALS.