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Advancing large-scale thin-film PPLN nonlinear photonics with segmented tunable micro-heaters

Photonics Research 2024年第8期12卷 1703-1708页

作者： XIAOTING LI HAOCHUAN LI ZheNZheNG WANG ZHAOXI CheN FEI MA KE ZHANG WENZHAO sun CheNG WANG Department of Electrical Engineering City University of Hong KongHong KongChina school of Physics Sun Yat-sen UniversityGuangzhou 510275China City University of Hong Kong(Dongguan) Dongguan 523808China Center of information and Communication technology City University of Hong Kong Shenzhen Research InstituteShenzhen 518057China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongHong KongChina

Thin-film periodically poled lithium niobate(TF-PPLN)devices have recently gained prominence for efficient wavelength conversion processes in both classical and quantum ***,the patterning and poling of TF-PPLN devices today are mostly performed at chip scales,presenting a significant bottleneck for future largescale nonlinear photonic systems that require the integration of multiple nonlinear components with consistent performance and low ***,we take a pivotal step towards this goal by developing a wafer-scale TF-PPLN nonlinear photonic platform,leveraging ultraviolet stepper lithography and an automated poling *** address the inhomogeneous broadening of the quasi-phase matching(QPM)spectrum induced by film thickness variations across the wafer,we propose and demonstrate segmented thermal optic tuning modules that can precisely adjust and align the QPM peak wavelengths in each *** the segmented micro-heaters,we show the successful realignment of inhomogeneously broadened multi-peak QPM spectra with up to 57%enhancement of conversion *** achieve a high normalized conversion efficiency of 3802.W-1cm-2.n a 6 mm long PPLN waveguide,recovering 84%of the theoretically predicted efficiency in this *** advanced fabrication techniques and segmented tuning architectures presented herein pave the way for wafer-scale integration of complex functional nonlinear photonic circuits with applications in quantum information processing,precision sensing and metrology,and low-noise-figure optical signal amplification.

关键词： tuning tunable waveguide

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Discriminating between photorealistic computer graphics and natural images using fractal geometry

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science in china(Series F) 2009年第2期52卷 329-337页

作者： PAN Feng CheN JiongBin huang {2. Guangdong Key Lab of information Security technology School of Information Science and Technology Sun Yat-Sen UniversityGuangzhou 510275 China

Rendering technology in computer graphics （CG） is now capable of producing highly photorealistic images, giving rise to the problem of how to identify CG images from natural images. Some methods were proposed to solve this problem. In this paper, we give a novel method from a new point of view of image perception. Although the photorealistic CG images are very similar to natural images, they are surrealistic and smoother than natural images, thus leading to the difference in perception. A pert of features are derived from fractal dimension to capture the difference in color perception between CG images and natural images, and several generalized dimensions are used as the rest features to capture difference in coarseness. The effect of these features is verified by experiments. The average accuracy is over 91.2..

关键词： image forensics computer graphics natural image fractal image authentication

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鱼类粘膜免疫研究进展

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水产学报 2005年第3期29卷 411-416页

作者：罗晓春谢明权黄玮李安兴中山大学生命科学学院水生生物研究所广东省水产学校中山大学生命科学学院水生生物研究所广东广州5102.5 广东广州51032.

Fish immunology has achieved great progress in recent years. While before 1990s, most researches focused on the fish systematic immunity, and the mucosal immunity of fish had not been given enough attention. Indeed, it has been shown that fish mucosal immunity plays an important role in disease defense. Fish mucosal immunity research has made some exciting progress in this decade. This review will focus on such progress: Constitution of mucosal-associated tissues and distribution of different immune cells, including T/B lymphocytes, granules, monocytes, macrophages, goblet cells, etc, in these sites have been well described with the development of some monoclonal antibody to these cells and associated techniques. Non-specific immune response mechanism of mucosal tissues reported these years, such as secretion of non-specific anti-bacteria and anti-fungi substances in mucus, the respiratory burst, enzyme activity of immune cells and so on, is believed important for fish disease defense. The specific immunity of mucosal tissues also attracts much interest and makes great achievement in antigen presenting, MHC genes, antibody producing and antibody secreting cells, comparison of serum and mucus immunoglobulin, relationships of immune response between different mucosal immune tissues. Whether mucosal immune system is independent of systematic immune system is another interesting question and causes great concern. In recent years, some evidences from phyletic evolution and ontogenesis show that mucosal immunity is prior to systematic immunity in evolution. Dynamics of antibody producing of mucosal tissues and serum in immersion or oral vaccines immunized fish also shows immune response can be elicited in mucosal tissues independent of systematic immune system. Some researchers also begin to pay attention to factors involved in mucosal immune regulations, for instance, neuromodulators and cytokines. The level of these factors changes in fish immune response process but th

关键词：鱼类粘膜组织特异性免疫非特异性免疫免疫调节

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Cellular Communication-Induced Dynamics in a Multicellular System

Cellular Communication-Induced Dynamics in a Multicellular S...

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第三十届中国控制会议

作者： YI Qizhi~(1,3),DU Yan~2.1.school of Mat{2.matics and information science,Jiangxi Normal University,Nanchang 33002.,P.R.china 2.school of C{2.mistry and C{2.mical Engineering,Jiangxi Normal University,Nanchang 33002.,P.R.china 3.school of Mat{2.matics and Computational science,sun yat-sen University,guangzhou 5102.5,P.R.china

＜正＞Traditionally,the main role of cell-cell communication was thought of as synchronizing a population of cells,thereby coordinating cellular ***,we show that cell density,which quantifies cellular communication,can induce multi-stability and multirhythmicity in a synthetic multicellular system,where individual oscillators are a merge of repressilator and hysteresis-based oscillator and are coupled through a quorum-sensing ***,for moderately small cell densities, the coupled system can exhibit multistability including stable homogenous and inhomogeneous steady *** moderately large cell densities,it has potentials to generate multirhythmicity including multi-mode oscillations such as in-phase period-1 oscillation,antiphase period-2.oscillation,asymmetric period-2.oscillation,and oscillations with mixed modes,coexistence of periodic orbits of several different modes,and bursting oscillations such as periodic bursting,torus quasi-periodic bursting,and *** versatility of cell-cell communication would be beneficial for cells or organisms to live in diversely changeable environments.

关键词： Multistability Multirhythmicity Quorum sensing Synthetic genetic oscillator

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Image processing operations identification via convolutional neural network

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science china({2. sciences) 2020年第3期63卷 275-281页

作者： Bolin CheN Haodong LI Weiqi LUO jiwu {2. Guangdong Key Laboratory of information Security technology School of Data and Computer Science Sun Yat-sen University College of information Engineering Shenzhen University

Dear editor,In recent years, image forensics has attracted increasing attention, and many forensic methods have been proposed for identifying image processing operations. Until now, most existing methods have been based on hand-crafted features, and only one specific operation is considered in these methods. In many forensic scenarios, however,

关键词： image Image processing operations identification via convolutional neural network

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Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer

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Chinese Chemical Letters 2024年第8期35卷 443-448页

作者： Yiran Tao Chunlei Dai Zhaoxiang Xie Xinru You Kaiwen Li Jun Wu Hai huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China school of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life science The Hong Kong University of Science and TechnologyHong KongChina Guangdong Provincial Clinical Research Center for Urological Diseases Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Traditional therapies such as surgery and endocrine therapy no longer meet the clinical needs in prostate cancer treatment,and more effective treatments are urgently *** studies have reported that targeted inhibition of the transcription factor cyclin dependent kinase 7(CDK7)could effectively suppress prostate cancer ***,the toxicity of CDK7 inhibitors such as THZ1 is the main limitation of the clinical *** this work,we synthesized Cys8E(C8E)nanoparticles(NPs)loaded with THZ1(C8E@THZ1),a novel GSH-targeting and stimuli-responsive nano-delivery platform,and investigated its anti-tumor potential and biosafety *** vitro,C8E@THZ1 potently inhibited the proliferation and promoted the apoptosis of prostate cancer *** tumor-bearing mice,C8E@THZ1 inhibited tumors by up to 85%,while the damage of THZ1 to liver function was effectively *** results confirmed that inhibition of CDK7 can effectively block the progression of prostate cancer,and that Cys8E NPs is a highly prospective delivery platform to promote the clinical application of CDK7 inhibitors.

关键词： Prostate cancer Nanoparticles CDK7 THZ1 THZ1@Cys8E NPs

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Efficient Tate pairing computation using double-base chains

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science in china(Series F) 2008年第8期51卷 1096-1105页

作者： ZHAO ChangAn ZHANG FangGuo huang jiwu school of information {2. and technology Sun Yat-Sen University Guangdong Key Laboratory of Information Security Technology Guangzhou 510275 China

Pairing-based cryptosystems have developed very fast in the last few years. The efficiencies of these cryptosystems depend on the computation of the bilinear pairings, In this paper, a new efficient algorithm based on double-base chains for computing the Tate pairing is proposed for odd characteristic p 〉 3. The inherent sparseness of double-base number system reduces the computational cost for computing the Tate pairing evidently. The new algorithm is 9% faster than the previous fastest method for the embedding degree k = 6.

关键词： public key cryptography Tate pairing elliptic curves double-base chains

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低盐度养殖的凡纳滨对虾体长和体重的增长规律

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水产学报 2006年第4期30卷 489-494页

作者：查广才周昌清黄建荣何建国中山大学生命科学院中山大学生命科学院广东广州5102.5 韩山师范学院生物系广东潮州52.041

通过池塘陆基围隔实验,研究了凡纳滨对虾在最适水温、溶氧、pH及低盐度(2.6)养殖环境的生长特性及规律。实验结果,低盐度养殖健康对虾体长和体重平均生长率分别为1.398mm.d-1和0.169g.d-1,对虾前期体长呈线性生长,中后期体重呈加速增长... 详细信息

通过池塘陆基围隔实验,研究了凡纳滨对虾在最适水温、溶氧、pH及低盐度(2.6)养殖环境的生长特性及规律。实验结果,低盐度养殖健康对虾体长和体重平均生长率分别为1.398mm.d-1和0.169g.d-1,对虾前期体长呈线性生长,中后期体重呈加速增长。非线性拟合结果,对虾体长生长为二次曲线,符合Quadratic模型,体重增长为S型曲线,符合Boltzmann模型,生长观测值与模型拟合相关系数R2.达到0.99;凡纳滨对虾低盐度养殖典型体长和体重生长模型为L=7.843+2.2.7t-0.0105t2.W=16.541+(-0.62.-16.541)/(1+e(t-54.809)/15.456)。低盐度养殖,对虾体长与体重呈立方关系,符合幂指数模型W=aLb,a值范围4.9~9.0×10-6,b值范围2.9495~3.0716,相关系数R2.0.99以上,典型幂指数模型为W=4.9×10-6L3.0716。

关键词：凡纳滨对虾低盐度生长率生长模型

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Expert consensus on pediatric orthodontic therapies of malocclusions in children

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International Journal of Oral science 2024年第2期16卷 186-196页

作者： Chenchen Zhou Peipei Duan Hong he Jinlin Song Min Hu Yuehua Liu Yan Liu Jie Guo Fang Jin Yang Cao Lingyong Jiang Qingsong Ye Min Zhu Beizhan Jiang Wenhua Ruan Xiao Yuan huang Li Rui Zou Yulou Tian Li Gao Rui Shu Jianwei Chen Renkai Liu Shujuan Zou Xiaobing Li State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&Key Laboratory of Oral Biomedicine Ministry of Education&Hubei Key Laboratory of Stomatology&Department of Orthodontics&Center for Dentofacial Development and Sleep Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Chongqing Key Laboratory of Oral Diseases and Biomedical sciences&Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical UniversityChongqing Medical University&College of StomatologyChongqing Medical UniversityChongqingChina Department of Orthodontics Hospital of StomatologyJilin UniversityChangchunChina Department of Orthodontic&Oral Biomedical Engineering Laboratory Shanghai Stomatological HospitalFudan UniversityShanghaiChina Department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Department of Orthodontics School and Hospital of StomatologyCollege of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue

Malocclusion,identified by the World health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~2.0 million children in *** its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these *** intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the *** orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition *** an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social *** consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early *** elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment.

关键词： permanent stated children

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Wearable pressure sensors based on antibacterial and porous chitosan hydrogels for full-range human motion detection

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science china(Technological sciences) 2024年第8期67卷 2475-2484页

作者： ZHANG YingXin LIU HanGuang JIN ShunYu LI YaJuan ZHANG Wan ZHOU Hang NIE ZanXiang huang Yuan school of Microelectronics science and {2. Sun Yat-sen UniversityGuangzhou 510275China hefei National Research Center for Physical sciences at the Microscale University of Science and Technology of ChinaHefei 230022China Department of Clinical Laboratory the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China school of Electronic and Computer Engineering Peking University Shenzhen Graduate SchoolShenzhen 518055China Zinergy Shenzhen Ltd. Shenzhen 518109China

Wearable pressure sensors made from conductive hydrogels hold significant potential in health ***,limited pressure range(Pa to hundreds of kPa)and inadequate antibacterial properties restrict their practical applications in diagnostic and health ***,a wearable high-performance pressure sensor was assembled using a facilely prepared porous chitosan-based hydrogel,which was constructed from commercial phenolphthalein particles as a sacrificial *** relationship between the porosity of hydrogels and sensing performance of sensors was systematically ***,the wearable pressure sensor,featuring an optimized porosity of hydrogels,exhibits an ultrawide sensing capacity from 4.83 Pa to 2.0 k Pa(range-to-limit ratio of 51,760)and high sensitivity throughout high pressure ranges(0.7 kPa~(-1),12.–2.0 kPa).The presence of chitosan endows these hydrogels with outstanding antibacterial performance against *** and ***,making them ideal candidates for use in wearable *** features allow for a practical approach to monitor full-range human motion using a single device with a simple structure.

关键词： porous hydrogels antibacterial performances wearable pressure sensors full-range human motion chitosan

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