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Genetic variation in LBL1 contributes to depth of leaf blades lobes between cotton subspecies, Gossypium barbadense and Gossypium hirsutum

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Journal of Integrative Agriculture 2018年第11期17卷 2394-2404页

作者： he dao-fang ZHAO Xiang LIANG Cheng-zhen ZHU Tao Muhammad Ali Abid CAI Yong-ping he Jin-ling ZHANG Rui School of Life Science Anhui Agricultural University Biotechnology Research Institute Chinese Academy of Agricultural Sciences

Leaf is a essential part of the plants for photosynthetic activities which mainly economize the resources for boll heath. Significant variations of leaf shapes across the Gossypium sp. considerably influence the infiltration of sunlight for photosynthesis. To understand the genetic variants and molecular processes underlying for cotton leaf shape, we used F2 population derived from upland cotton genotype P30A （shallow-lobed leaf） and sea-island cotton genotype ISR （deep-lobed leaf） to map leaf deep lobed phenotype controlling genes LBL1 and LBL2. Genetic analysis and localization results have unmasked the position and interaction between both loci of LBL1 and LBL2, and revealed the co-dominance impact of the genes in regulating depth of leaf blades lobes in cotton. LBL1 had been described as a main gene and member of transcription factor family leucine zipper （HD-ZIPI） from a class I homologous domain factor ***2G244000. The qRT-PCR results elaborated the continuous change in expression level of LBL1 at different growth stages and leaf parts of cotton. Higher expression level was observed in mature large leaves followed by medium and young leaves respectively. For further confirmation, plants were tested from hormonal induction treatments, which explained that LBL 1 expression was influenced by hormonal signaling. Moreover, the highest expression level was detected in brassinolides （BR） treatment as compared to other hormones, and this hormone plays an important role in the process of leaf blade lobed formation.

关键词： leaf blades lobes HD-ZIPI LBL1 cotton Gossypium barbadense Gossypium hirsutum

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U-Pb dating of monazite in the Bainiuchang silver polymetallic deposit,Yunnan Province,and its limitation on Mesozoic mineralization

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China Geology 2024年第3期7卷 592-595页

作者： Bo-de Lu Wen-chang Li Xue-long Liu Guang-zhi Meng Qi-he Long Hong Zhang Jun-shan dao fang-lan Li Jie-hu Zhou Mao-huang Fan Xue Mi Nan Shi Zhen-liang Cao College of Land Resources and Engineering Kunming University of Science and TechnologyKunming 650093China Geological Team 306 of Yunnan Non-ferrous Metals Geological Bureau Kunming 650217China Mengzi Mining and Metallurgy Co. Ltd.Mengzi 661199China

*** The Gejiu-Bozhushan-Laojunshan tin-tungsten polymetallic metallogenic belt is located in southeastern *** is bounded by the Mile-Shizong Fault and the Yangzi Plate to the north and west,respectively,while the Honghe Fault represents its southwestern *** is adjacent to the Ailaoshan Fault,and extends to Guangxi and Vietnam to the southeast(Fig.1a;Liu JP et al.,2021).

关键词： silver dating southeast

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江苏省工业碳排放强度时空分异研究

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云南地理环境研究 2017年第3期29卷 41-48页

作者：袁荷仇方道金娜江苏师范大学地理测绘与城乡规划学院江苏徐州221116

采用空间自相关和Tobit等方法,以县域为研究单元,探讨了2002~2014年江苏省工业碳排放强度差异的时空格局演化特征及影响因素。结果表明:江苏省工业碳排放强度总体差异呈缩小趋势,苏南、苏中和苏北3地区差异程度低,各区域内部差异是江苏... 详细信息

采用空间自相关和Tobit等方法,以县域为研究单元,探讨了2002~2014年江苏省工业碳排放强度差异的时空格局演化特征及影响因素。结果表明:江苏省工业碳排放强度总体差异呈缩小趋势,苏南、苏中和苏北3地区差异程度低,各区域内部差异是江苏省工业碳排放强度整体差异的主因;H-H型县域集中分布于苏中、苏北地区,L-L型县域分布于苏南地区。经济水平、能源利用率、产业结构、政府调控、人口规模和技术创新是江苏省工业碳排放强度空间差异的主要影响因素,其中经济水平和人口规模对工业碳排放强度表现为正向驱动作用,而能源利用率、产业结构和政府调控的驱动作用则相反。

关键词：工业碳排放强度时空格局江苏省

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A novel mouse model of calcific aortic valve stenosis

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Animal Models and Experimental Medicine 2024年第4期7卷 523-532页

作者： Ningjing Qian Yaping Wang Wangxing Hu Naifang Cao Yi Qian Jinyong Chen Juan fang Dilin Xu Haochang Hu Shuangshuang Yang dao Zhou Hanyi Dai Dongdong Wei Jian'an Wang Xianbao Liu Department of Cardiology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina State Key Laboratory of Transvascular Implantation Devices China Cardiovascular Key Laboratory of Zhejiang Province HangzhouChina Department of Cardiovascular Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Endocrinology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Binjiang Institute of Zhejiang University HangzhouChina

Background:Calcific aortic valve stenosis(CAVS)is one of the most challenging heart diseases in clinical with rapidly increasing ***,study of the mecha-nism and treatment of CAVS is hampered by the lack of suitable,robust and efficient models that develop hemodynamically significant stenosis and typical calcium ***,we aim to establish a mouse model to mimic the development and features of ***:The model was established via aortic valve wire injury(AVWI)combined with vitamin D subcutaneous injected in wild type C57/BL6 *** transthoracic echocardiography was applied to evaluate aortic jet peak velocity and mean *** specimens were collected and examined in respect of valve thickening,calcium deposition,collagen accumulation,osteogenic differentiation and ***:Serial transthoracic echocardiography revealed that aortic jet peak velocity and mean gradient increased from 7 days post model establishment in a time depend-ent manner and tended to be stable at 28 *** with the sham group,sim-ple AVWI or the vitamin D group,the hybrid model group showed typical pathological features of CAVS,including hemodynamic alterations,increased aortic valve thicken-ing,calcium deposition,collagen accumulation at 28 *** addition,osteogenic dif-ferentiation,fibrosis and inflammation,which play critical roles in the development of CAVS,were observed in the hybrid ***:We established a novel mouse model of CAVS that could be induced efficiently,robustly and economically,and without genetic *** provides a fast track to explore the underlying mechanisms of CAVS and to identify more effec-tive pharmacological targets.

关键词： animal model calcific aortic valve stenosis valve calcification

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Exploring the mechanism of active ingredients of Smilacis Glabrae Rhizoma in treating migraine headache through network pharmacology and animal experiments

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Integrative Medicine Discovery 2024年第18期8卷 1-10页

作者： dao-Xian Shu Yan-Yan Chen Jiao-Rong Wang Ying Wang Yong-fang Gu Yan-Xin Wang Department of Brain DiseaseⅡ The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031China

Background:To explore the potential mechanism of action of the active ingredients of Smilacis Glabrae Rhizoma(SGR)in the treatment of migraine using network pharmacology and in vivo ***:Through the search of Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform,Genecards,Drugbank and other databases,we obtained active ingredients,targets of SGR and related disease targets of migraine,and took the intersection for protein-protein interactions *** constructing the network diagram,network topology analysis was performed to derive the core targets and key active ingredients,and Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were ***,molecular docking was performed and validated by in vivo *** vivo experiments,18 male BALB/c mice were selected,and the SGR group was fed with SGR drinking tablet concentrate,and nitroglycerin injection was used to construct a mouse model of ***-linked immunosorbent assay test was used to detect the levels of TNF-α,IL-1β,IL-6,and AKT1 in ***:The results showed that the core targets of SGR for the treatment of migraine were TNF-α,IL-1β,IL-6,and *** core targets and key active ingredients had better binding *** with the blank group,the number of head scratching in the model group *** with the model group,there was a significant reduction of the number of head scratching in the SGR *** comparison with the blank group,the protein level in the plasma in the model group was markedly *** with the model group,the protein level in the SGR group was significantly ***:SGR has the characteristics of improving migraine based on multi-targets,multi-components and multi-pathways,and the mechanism of action may be related to the inhibition of the release of inflammatory factors,neuron protection,and interference with apoptosis and other processes.

关键词： migraine Smilacis Glabrae Rhizoma network pharmacology molecular docking mechanism of effect

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基于序列注意力和局部相位引导的骨超声图像分割网络

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自动化学报 2024年第5期50卷 970-979页

作者：陈芳张道强廖洪恩赵喆南京航空航天大学计算机科学与技术学院南京211106 清华大学医学院北京100084 清华大学附属北京清华长庚医院骨科与运动医学中心北京102218

在超声辅助的骨科手术导航中,需要从采集的超声图像序列中精确分割出骨结构,并展示给医生,来辅助医生进行术中决策.但是,图像噪声、成像伪影以及模糊的骨边界导致从超声图像序列中精确分割提取骨结构十分困难.为解决该问题,提出一种新... 详细信息

在超声辅助的骨科手术导航中,需要从采集的超声图像序列中精确分割出骨结构,并展示给医生,来辅助医生进行术中决策.但是,图像噪声、成像伪影以及模糊的骨边界导致从超声图像序列中精确分割提取骨结构十分困难.为解决该问题,提出一种新的基于序列注意力与局部相位引导的骨超声图像分割网络.该网络一方面自适应地利用超声序列帧之间的关系即序列注意力来辅助骨结构的语义分割.另一方面,该网络通过引入局部相位引导模块,突出骨边缘信息,进一步提高分割精度.利用包含19050幅图像的骨超声数据集,进行交叉实验、消融实验并与最新的超声骨分割方法进行比较.实验结果表明所提方法对骨结构分割精度高,优于现有的超声骨分割方法.

关键词：骨科导航超声图像分割局部相位序列注意力

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试论经典说明文的教育策略

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韩山师范学院学报 2024年第2期45卷 87-94页

作者：杨道麟方芳华中师范大学湖北武汉430079 班颂德皇家师范大学曼谷10600

经典说明文,指的是以解说实物、知悉风景、讲明事理等为特定对象来了解客观实情、分析因果关系、揭示内在规律的一种文体。这种文体不但具有阐释的客观性,而且具有探寻的精准性和行文的平实性。因而要求施教者必须以文章学为统领,引导... 详细信息

经典说明文,指的是以解说实物、知悉风景、讲明事理等为特定对象来了解客观实情、分析因果关系、揭示内在规律的一种文体。这种文体不但具有阐释的客观性,而且具有探寻的精准性和行文的平实性。因而要求施教者必须以文章学为统领,引导受教者既要把握经典说明文的实物性、景观性、事理性等基本类型,又要把握其纵向式、横向式、交错式等大体结构,还要把握说明、叙述、描写等表达技巧,更要把握其周到严密、简明扼要、通俗易懂等出色语言。只有这样,才能促使他们成为“求真”“向善”“崇美”的创造性的人才和具有“健全的人格”,并进入“人的发展和完整性建构”的全新境域。

关键词：经典说明文教育策略基本类型大体结构表达技巧出色语言

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国产SW26010-Pro处理器上3级BLAS函数众核并行优化

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软件学报 2024年第3期35卷 1569-1584页

作者：胡怡陈道琨杨超马文静刘芳芳宋超博孙强史俊达中国科学院软件研究所并行软件与计算科学实验室北京100190 中国科学院大学北京100049 北京大学数学科学学院北京100871 国家并行计算机工程技术研究中心北京100190

BLAS(basic linear algebra subprograms)是最基本、最重要的底层数学库之一.在一个标准的BLAS库中,BLAS 3级函数涵盖的矩阵-矩阵运算尤为重要,在许多大规模科学与工程计算应用中被广泛调用.另外,BLAS 3级属于计算密集型函数,对充分发... 详细信息

BLAS(basic linear algebra subprograms)是最基本、最重要的底层数学库之一.在一个标准的BLAS库中,BLAS 3级函数涵盖的矩阵-矩阵运算尤为重要,在许多大规模科学与工程计算应用中被广泛调用.另外,BLAS 3级属于计算密集型函数,对充分发挥处理器的计算性能有至关重要的作用.针对国产SW26010-Pro处理器研究BLAS 3级函数的众核并行优化技术.具体而言,根据SW26010-Pro的存储层次结构,设计多级分块算法,挖掘矩阵运算的并行性.在此基础上,基于远程内存访问(remote memory access,RMA)机制设计数据共享策略,提高从核间的数据传输效率.进一步地,采用三缓冲、参数调优等方法对算法进行全面优化,隐藏直接内存访问(direct memory access,DMA)访存开销和RMA通信开销.此外,利用SW26010-Pro的两条硬件流水线和若干向量化计算/访存指令,还对BLAS 3级函数的矩阵-矩阵乘法、矩阵方程组求解、矩阵转置操作等若干运算进行手工汇编优化,提高了函数的浮点计算效率.实验结果显示,所提出的并行优化技术在SW26010-Pro处理器上为BLAS 3级函数带来了明显的性能提升,单核组BLAS 3级函数的浮点计算性能最高可达峰值性能的92%,多核组BLAS 3级函数的浮点计算性能最高可达峰值性能的88%.

关键词： BLAS 3级 SW26010-Pro众核处理器直接内存访问远程内存访问浮点计算效率

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Yield and Quality Response of Cucumber to Irrigation and Nitrogen Fertilization Under Subsurface Drip Irrigation in Solar Greenhouse

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Agricultural Sciences in China 2011年第6期10卷 921-930页

作者： ZHANG he-xi CHI dao-cai WANG Qun fang Jun fang Xiao-yu College of Water Resources Shenyang Agricultural University Shenyang 110161 P.R. China Guizhou Academy of Hydraulic Sciences Guiyang 550002 P.R.China

The aims of this research were to compare subsurface drip irrigation scheduling and nitrogen fertilization rates in cucumber, and evaluate yield and quality of cucumber fruit, water （WUE）, irrigation water （IWUE）, and nitrogen use （NUE） efficiencies in the solar greenhouse in Southwest China. The irrigation water amounts were determined based on the 20 cm diameter pan （Ep） placed over the crop canopy, and cucumber plant was subjected to three irrigation water levels （I1, 0.6 Ep; I2, 0.8 Ep; and I3, 1.0 Ep） in interaction with three nitrogen fertilization levels （N1, 300 kg ha-1; N2, 450 kg ha-1; and N3, 600 kg ha-1）. The results showed that the cucumber fruit yield increased with the improvement of irrigation water. Irrigation water increased yields by increasing the mean weight of the fruits, and also by increasing fruit number. But the highest values of IWUE and WUE were obtained from I2 treatment. NUE significantly decreased with the improvement of N application, but increased by irrigating more water. The quality of cucumber fruit decreased with the improvement irrigation water and nitrogen fertilization. In conclusion, the optimum irrigation level and nitrogen fertilizer application level for cucunber under subsurface drip irrigation in the solar greenhouse in Southwest China were 0.8 Ep and 450 and 600 kg ha-1, respectively.

关键词： subsurface drip irrigation cucumber water use efficiency nitrogen use efficiency fruit quality

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数字化、创新创业与无差别城乡:湖州案例

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科学学研究 2024年第5期42卷 1064-1075页

作者：刘道学王家芳周咏琪刘峰秀浙江省新型重点专业智库浙江工业大学中国中小企业研究院浙江杭州310023 浙江工业大学管理学院浙江杭州310023 南京师范大学商学院江苏南京210023

实现全体人民共同富裕是中国式现代化的本质要求,其难点之一在于缩小城乡差距。浙江湖州在建设共同富裕示范区的实践中首提打造“无差别城乡”的概念引发广泛关注。作为实践案例,其通过数字化赋能乡村创新创业打造无差别城乡的实现路径... 详细信息

实现全体人民共同富裕是中国式现代化的本质要求,其难点之一在于缩小城乡差距。浙江湖州在建设共同富裕示范区的实践中首提打造“无差别城乡”的概念引发广泛关注。作为实践案例,其通过数字化赋能乡村创新创业打造无差别城乡的实现路径值得深入研究。引入数字化背景下的创新创业为中介变量,选取湖州2005-2020年经济社会发展统计数据和相关可得数据,实证研究了数字化对打造无差别城乡的影响机制。结果表明:数字化对区域创新创业有显著正向影响;区域创新创业对无差别城乡建设有显著正向影响;只有数字化创新而无相应创业活动支撑则对无差别城乡建设的影响并不显著,“数字鸿沟”对无差别城乡建设有负向影响。有基于此,提出了实现全体人民共同富裕的现代化新征程中推进“数字新基建”下沉乡村、壮大乡村数字化创新创业主体、提升乡村居民数字素养及数智化赋能城乡多元共治等对策建议。

关键词：数字化共同富裕无差别城乡创新创业中国式现代化

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