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Malnutrition in Relation with Dietary, Geographical, and Socioeconomic Factors among Older Chinese

Biomedical and Environmental Sciences 2021年第5期34卷 337-347页

作者： ZHANG Jian SONG Peng Kun ZHAO Li Yun SUN Ye YU Kai YIN Jing PANG Shao Jie LIU Zhen MAN Qing Qing he Li LI Cheng ARIGONI Fabrizio BOSCO Nabil DING gang Qiang ZHAO Wen Hua National Institute of Nutrition and health Chinese Center for Disease Control and PreventionBeijing 100050China Nestlw Research Singapore Hub 138567Singapore Nestle Research Center China Beijing 100102China Nestle Research Center Lausanne 1000LausanneSwitzerland

Objective Nutrition is closely related to the health of the elderly population. This study aimed to provide a comprehensive picture of the nutrition status of elderly Chinese and its related dietary,geographical, and socioeconomic *** A total of 13,987 ≥ 60-year-old persons from the 2010–2013 Chinese National Nutrition and health Survey were included to evaluate various aspects of malnutrition, including underweight,overweight or obesity, and micronutrient *** Overall, the prevalence of obesity, overweight, and underweight was 12.4%, 34.8%, and 5.7%,respectively, with disparities both geographically and socioeconomically. The prevalence of underweight was higher among the older old(≥ 75 years), rural residents and those with low income, with low education status, and residing in undeveloped West areas. More than 75% of the elderly do not meet the Dietary Reference Intakes for vitamins A, B1, B2, and E, folate, calcium, selenium, potassium, biotin,and choline, with the prevalence of inadequate intake increasing with age for most nutrients. At the population level, the mean intakes of numerous food groups did not meet the recommendations by the Chinese Dietary *** Obesity epidemic, inadequacy of micronutrient intake, and high prevalence of underweight and anemia in susceptible older people are the major nutrition challenges for the rapidly aging population in China.

关键词： Malnutrition Older Chinese Food intake Nutrients National survey

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Relationship between lipidslevelsand right ventricular volume overload in congestive heart failure

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Journal of Geriatric Cardiology 2014年第3期11卷 192-199页

作者： Ying CheN Xiao-Mei he Hong MENG Qing-Zhen ZHAO Yu-Zhi ZheN Li TIAN Le WANG Li-Shuang JI Guo-Ping MA Yu TIAN gang LIU Zhen-Guo JI Kun-Shen LIU Chao LIU Emergency Department First Hospital of Hebei Medical University Hebei Medical University No. 89 Donggang Road Shijiazhuang050032HebeiProv-ince China heart Center First Hospital of Hebei Medical University Hebei Medical University No. 89 Donggang Road Shijiazhuang050032 HebeiProvince China

在类脂化合物和冠的动脉疾病之间的 BackgroundThe 关系很好被建立了。然而，这在类脂化合物和心失败之间不是事实。讽刺地，高类脂化合物层次充分在心失败与更好的结果被联系，但是位于现象下面的机制不是理解。这研究被执行到由于静... 详细信息

在类脂化合物和冠的动脉疾病之间的 BackgroundThe 关系很好被建立了。然而，这在类脂化合物和心失败之间不是事实。讽刺地，高类脂化合物层次充分在心失败与更好的结果被联系，但是位于现象下面的机制不是理解。这研究被执行到由于静脉的拥挤减少了肠的类脂化合物吸收的假设可以导致的测试低类脂化合物 *** 与充血的心失败在 442 个 unselected 病人收集了临床的特征， echocardiograph，和类脂化合物侧面的数据。在类脂化合物层次之间的关联[包括的全部的胆固醇( TCL )，高密度的脂蛋白胆固醇(高级数据链路控制)，低密度的脂蛋白胆固醇( LDL-C )，和 triglycerides ( TG )]并且正确的室结束心脏舒张的直径( RVEDD )，左室结束心脏舒张的直径( LVEDD )，正确中庭直径( RA )，左中庭直径( LA )，或左室喷射部分( LVEF )用皮尔森关联和部分关联被分析。RVEDD， LVEDD， RA，和 LA 被索引到身体表面 *** 是在 TCL 层次和 RVEDD 之间的显著地反的关联(r =−； 0.34， P <；0.001 ) 并且 RA (r =−； 0.36， P <；0.001 ) 。象 LDL-C，高级数据链路控制，和 TG 那样的另外的类脂化合物与 RVEDD 和 RA 有类似的反的关联。在好久调整以后未改变的仍然是的所有这些关联，性，吸烟地位，物理活动层次， comorbidities，和药 *** 层次相反地与充血的心失败在病人被相关到 RVEDD；然而，因为这是观察研究，进一步的调查被需要验证我们的结果以及如果有的话识别一种原因的关系。

关键词：充血性右心室衰竭心脏超负荷高密度脂蛋白胆固醇低密度脂蛋白胆固醇血脂水平

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Combinatorial cell surface display system in Escherichia coli for noninvasive colorectal cancer detection

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Journal of Bio-X Research 2019年第4期2卷 185-196页

作者： Hsiao Chiayi Fang Qingwei Zheng Shuyu he Peixiang Zhang Kairan Hong Yirui Ran Yuncong Sun Shiyu Liu Zhixiang Liang Zhihan Zhong Bozitao Wu Weiwen Xia Ruoyu Bai Shihao Yao Kuan Wang Yushu he Lin Ma gang Bio-X-Renji Hospital Research Center Renji HospitalSchool of MedicineShanghaiChina Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)ShanghaiChina 2018 SJTU-BioX-Shanghai Team for The International Genetically Engineered Machine Competition(iGEM) Shanghai Jiao Tong UniversityShanghaiChina Shanghai Jiao Tong University School of MedicineShanghaiChina

Navigation and recognition of disease lesions remain challenging during colorectal cancer diagnosis and treatment,given that the precision and capacity of using specific surface antigens as recognition sites are relatively ***,the low penetration rate of noninvasive detection methods has delayed disease diagnosis in developing *** developed a bacterial device targeting the Thomsen-Friedenreich antigen,which is abundant on lesion tissue,and produced vesicles that serve as markers for ultrasonic *** device uses a bacterial cell surface display system and acoustic reporter gene to function as a screening device for colorectal cancer *** diagnostic efficiency of this device was determined by flow cytometry,immunohistochemistry,microfluidic chip-based assay,and ultrasonic examinations on both cellular and tissue *** all scales and experiments,our device showed great feasibility upon differentiating disease lesion and normal tissue,while foundation of the usage of vesicle reporter system as noninvasive method has also been *** application of this device provides insight into the practicability and prospect of bacterial detecting agents in the field of *** animal studies were approved by the Institutional Animal Care and Use Committee of Shanghai Jiao Tong University,China(approval No.201801015)on February 23,2018.

关键词： colorectal cancer cell-surface display ice nucleation protein ultrasonic detection

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PPCPs in a drinking water treatment plant in the Yangtze River Delta of China: Occurrence,removal and risk assessment

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Frontiers of Environmental Science & Engineering 2019年第2期13卷 133-145页

作者： Xinshu Jiang Yingxi Qu Liquan Liu Yuan he Wenchao Li Jun Huang Hongwei Yang gang Yu School of Environment Beijing Key Laboratory for Emerging Organic Contaminants ControlTsinghua UniversityBeijing 100084China Research Institute for Environmental Innovation (Suzhou) TsinghuaSuzhou 215163China

The occurrence and removal of 39 targeted pharmaceuticals and personal care products(PPCPs)from source water,through a drinking water treatment plant(DWTP)to the water supply station,were investigated around the central part of Yangtze River Delta in China using both grab sampling and continuous *** 24 of the 39 targeted PPCPs were detected in raw water,and 12 PPCPs were detected in the finished *** highest observed concentration was enrofloxacin(85.623 ng/L)in raw *** efficiencies were remarkably negative correlated with log Kow(r =– 0.777,p he combined process(prechlorination and flocculation/precipitation),the concentration level also had a great impact on the removal *** normal process in the pilot DWTP seems to be ineffective for PPCPs control,with the limited removal efficiency of less than 30% for each step: pre-chlorination,flocculation and precipitation,post-chlorination and *** were notable differences between the data from continuous sampling and grab sampling,which should be considered for different monitoring *** chlorination and the hydrolytic decomposition of PPCPs in the water supply pipe may attenuate PPCPs concentration in the pipeline *** PPCPs examined in the effluent of DWTP do not impose a potential health risk to the local consumers due to their RQ value lower than 0.00067.

关键词： PPCPs DWTP Human health risk assessment

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Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson’s disease

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Signal Transduction and Targeted Therapy 2021年第3期6卷 596-598页

作者： An-Guo Wu Rong Pan Betty Yuen-Kwan Law Wen-Qiao Qiu Jian-Ming Wu Chang-Long he Vincent Kam-Wai Wong Chong-Lin Yu Xiao-gang Zhou Da-Lian Qin Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSchool of PharmacyDepartment of Human AnatomySchool of Preclinical MedicineEducation Ministry Key Laboratory of Medical ElectrophysiologySouthwest Medical UniversityLuzhou 646000China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina

Dear Editor,PD is characterized by the loss of dopaminergic neurons in substantia nigra,and the loss of dopamine resulting in motor deficit.1 Its main pathological hallmarks include the genetic mutations of gene such as a-synudein.2 Increasing study showed that the dopaminergic neurons in midbrain are sensitive and damaged by the PD toxins.

关键词： nude dopamine therapeutic

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爆燃火灾全程下多梁式PCT型梁桥剪力滞效应

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长安大学学报（自然科学版） 2014年第6期34卷 79-84页

作者：张岗贺拴海刘扬赵煜长安大学公路学院陕西西安710064 贵州省交通运输厅贵州贵阳550000

针对火灾下预应力混凝土T(PCT)型梁桥顶板的开裂,利用热力耦合方法分析了爆燃火灾下4片预应力混凝土T梁桥的温度场和剪力滞时程演变规律。研究结果表明:火温全程T型梁翼缘板连接部位温度值高于翼缘板根部,呈现出以腹板与顶板交合部位为... 详细信息

针对火灾下预应力混凝土T(PCT)型梁桥顶板的开裂,利用热力耦合方法分析了爆燃火灾下4片预应力混凝土T梁桥的温度场和剪力滞时程演变规律。研究结果表明:火温全程T型梁翼缘板连接部位温度值高于翼缘板根部,呈现出以腹板与顶板交合部位为中心逐渐向翼缘板边缘部位呈稀疏温度带间隔梯度过渡的'V'状分布云;火温初时,恒载作用下顶板最大压应力位于两边肋顶部,最小压应力位于两边梁外侧悬臂板端部,单片梁体顶板呈负剪力滞状态,4片梁体顶板剪力滞呈'W'状,其峰值之比接近1.0;随火温时间延增,两中肋的应力峰值点出现在半悬臂板宽度处,应力变化幅值大于两边肋与四肋同时受火的顶板应力变化幅值,顶板部分出现拉应力;随火温时间延增,各片T梁顶板处于负剪力滞状态;研究可为预应力桥梁实用抗火设计提供依据。

关键词：桥梁工程多梁式T梁桥预应力混凝土火灾剪力滞

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The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells

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Cell Research 2002年第2期12卷 151-156页

作者： MENG SEN LI, PING FENG LI, FBI YI YANG, SHI PENG he, Guo GUANG DU, gang LI1 Department of Biochemistry and Molecular Biology, 2 Department of Biophysics, health Science Center, Peking University, Beijing 100083, China Department of Biochemistry and Molecular Biology Health Science Center Peking University Beijing China Department of Biophysics Health Science Center Peking University Beijing China

AIM The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated. METHODS The effect of AFP on the proliferation of NIH 3T3 cells was measured by incorporation of 3H-TdR. Receptor-binding assay of 125I-AFP was performed to detect the properties of AFP receptor in NIH 3T3 cells. The influences of AFP on the [cAMP]i and the activities of protein kinase A (PKA) were determined. Western blot was used to detect the change of K-ras P21 protein expression. RESULTS The proliferation of NIH 3T3 cells treated with 0-80 mg/L of AFP was significantly enhanced. The Scatchard analysis indicated that there were two classes of binding sites with KD of 2.722×10-9M (Bmax=12810 sites per cell) and 8.931× 10-8M (Bmax=119700 sites per cell) respectively. In the presence of AFP (20 mg/L), the content of cAMP and activities of PKA were significantly elevated . The level of K-ras P21 protein was upregulated by

关键词： Alpha-fetoprotein receptor signal transduction monoclonal antibody gene expression.

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风洞中未知声源漂移误差的逼近修正

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吉林大学学报（工学版） 2020年第5期50卷 1584-1589页

作者：沈哲王毅刚杨志刚贺银芝同济大学机械工程博士后流动站上海201804 同济大学上海地面交通工具风洞中心上海201804 上海市地面交通工具空气动力与热环境模拟重点实验室上海201804 北京民用飞机技术研究中心北京102211

风洞试验中外场声源定位因射流结构产生声源漂移,未知声源因位置不确定造成的定位焦距不准确将增大测量声漂移误差。本文基于几何声学理论推导,确定声漂移量误差与定位焦距误差成正比关系,基于此关系,针对固体表面目标声源空间分布情况... 详细信息

风洞试验中外场声源定位因射流结构产生声源漂移,未知声源因位置不确定造成的定位焦距不准确将增大测量声漂移误差。本文基于几何声学理论推导,确定声漂移量误差与定位焦距误差成正比关系,基于此关系,针对固体表面目标声源空间分布情况,通过试验件外形几何关系建立声源位置函数,用逼近法获取更精准的定位焦距进而降低声漂移误差,其结果通过风洞试验验证。研究表明,此逼近法能快速降低定位焦距误差,消除由位置不确定带来的声漂移量误差。

关键词：车辆工程风洞声漂移逼近法几何声学

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环件热辗扩成形有限元建模仿真研究进展

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中国有色金属学报 2011年第7期21卷 1647-1655页

作者：王敏杨合郭良刚湖北汽车工业学院材料工程系十堰442002 西北工业大学材料科学与工程学院凝固技术国家重点实验室西安710072

环件热辗扩成形问题是多场、多因素耦合作用下集三维连续渐变、非稳态及非对称等特点于一体的高度非线性问题,采用有限元建模仿真方法研究与发展该技术对实现无缝环形构件的高质量、低成本及短周期制造具有重要意义。分别从宏观和微观... 详细信息

环件热辗扩成形问题是多场、多因素耦合作用下集三维连续渐变、非稳态及非对称等特点于一体的高度非线性问题,采用有限元建模仿真方法研究与发展该技术对实现无缝环形构件的高质量、低成本及短周期制造具有重要意义。分别从宏观和微观尺度评述环件热辗扩成形有限元建模仿真的国内外研究现状、存在的问题与发展趋势,进而指明其发展方向如下:大型、复杂环件径、轴双向热辗扩成形全过程自适应建模的仿真方法与关键技术;环件热辗扩成形过程宏观与微观有限元建模仿真无缝集成技术;适用于以环件热辗扩为代表的连续局部塑性成形过程的材料本构模型和组织演变模型以及相应稳健而高效的有限元算法、本构积分算法与组织演变仿真方法;考虑模具的变形、传热及主要失效形式的环件热辗扩成形过程建模仿真技术。

关键词：环件热辗扩微观组织建模仿真有限元

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防火涂层对高温后混凝土抗压强度的影响

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西安建筑科技大学学报（自然科学版） 2014年第2期46卷 241-246页

作者：侯炜贺拴海张岗长安大学公路学院陕西西安710064

对126个涂有防火层的C50混凝土试件进行高温作用,自然冷却后对其进行抗压强度试验.通过对有、无防火涂层试件的损伤形态对比分析及对高温后损伤试件的抗压强度试验,探讨了防火涂层对混凝土高温作用后抗压性能的影响程度,得到了高温作用... 详细信息

对126个涂有防火层的C50混凝土试件进行高温作用,自然冷却后对其进行抗压强度试验.通过对有、无防火涂层试件的损伤形态对比分析及对高温后损伤试件的抗压强度试验,探讨了防火涂层对混凝土高温作用后抗压性能的影响程度,得到了高温作用后试件抗压强度与防火涂层厚度、强度折减系数与防火涂层厚度的回归计算公式.试验研究表明,防火涂层对混凝土构件遭受高温作用有较好的保护作用.因此对于特殊区域采用防火涂层的混凝土结构,在遭受高温作用后的灾损性能进行研究是很有必要的,对混凝土结构抗火设计及规范制定提供一定参考.

关键词：防火涂层混凝土高温抗压强度

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