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Antifungal activity of various essential oils against Saccharomyces cerevisiae depends on disruption of cell membrane integrity

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bIOceLL 2017年第1期41卷 13-18页

作者： hatice bÜŞra konuk bENGÜERGÜDEN Department of bioengineering Gebze Technical UniversityKocaeliTurkey

Antifungal activity and mode of action of nine essential oils(EOs)against *** cells were *** effects of commercial lemon peel,orange peel,tea tree,turpentine,rosemary,peppermint,thyme,oregano and clove oils were determined through Minimum Inhibitory Concentration(MIC),Minimum Fungicidal Concentration(MFC)and inhibition zone *** most effective oil was turpentine *** peel,thyme and oregano oils were also effective,according to MIC and *** zone measurements,also revealed oregano,orange peel,thyme,turpentine and clove oils as most efficient ***,membrane damage of yeast cells was studied by measuring the extracellular pH and conductivity in a concentration dependent *** peel,turpentine,thyme and oregano oils caused a clear increase in extracellular pH of glucose-induced yeast cells and induced an increase in extracellular *** results point to the deterioration of yeast cell membrane integrity upon exposure to *** these oils can be used as food preservatives and pharmaceutical agents,it is very important to understand their mode of action and their main target sites in the *** this research not only opens new perspectives to understand antifungal activity mechanisms of EOs,but also help widen their use.

关键词： Saccharomyces cerevisiae Essential oils Antifungal activity cell membrane

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The effects of season on fatty acid composition and ω3/ω6 ratios of northern pike(Esox lucius L.,1758) muscle lipids

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Chinese Journal of Oceanology and Limnology 2015年第1期33卷 70-76页

作者： MERT ramazan bULUT Sait konuk Muhsin Neveshir Haci bektas Veli University Department of BiologyNevsehir 50300Turkey Akdeniz University Department of Science EducationAntalya 07058Turkey Uskiidar University Department of Molecular Biology and GeneticsIstanbul 34662Turkey

In the present study, the effects of season on fatty acid composition, total lipids, and ω3/ω6 ratios of northern pike muscle lipids in Klzlhrmak River （Klrlkkale, Turkey） were investigated. A total of 35 different fatty acids were determined in gas chromatography. Among these, palmitic, oleic, and palmitoleic acids had the highest proportion. The main polyunsaturated fatty acids （PUFAs） were found to be docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid. There were more PUFAs than monounsaturated fatty acids （MUFA） in all seasons. Similarly, the percentages of ω3 fatty acids were higher than those of total ω6 fatty acids in the fatty acid composition. ω3/ω6 ratios were calculated as 1.53, 1.32, 1.97, and 1.71 in spring, summer, autumn and winter, respectively. Overall, we found that the fatty acid composition and ω3/ω6 fatty acid ratio in the muscle of northern pike were significantly influenced by season.

关键词： freshwater fish fatty acid composition omega-3 PUFA lipid content season

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Orbital decompression surgery for the treatment of Graves＇ ophthalmopathy：comparison of different techniques and long-term results

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1363-1370页

作者： Mehmet Ozgur Cubuk Onur konuk Mehmet Unal Istanbul Education and Research Hospital Istanbul 34098Turkey Department of Ophthalmology Gazi University School of Medicine Besevler Ankara 06500 Turkey Dunya Goz Hospital Ankara 06500 Turkey

AIM： To evaluate the long-term results of different orbital decompression techniques performed in patients with Graves＇ ophthalmopathy（GO）.METHODS： Totally 170 cases with GO underwent orbital decompression between 1994 and 2014. Patients were divided into 4 groups as medial-inferior, mediallateral（balanced）, medial-lateral-inferior, and lateral only according to the applied surgical technique. Surgical indications, regression degrees on Hertel exophthalmometer, new-onset diplopia in the primary gaze and new-onset gaze-evoked diplopia after surgery and visual acuity in cases with dysthyroid optic neuropathy（DON） were compared between different surgical ***： The study included 248 eyes of 149 patients. The mean age for surgery was 42.3±13.2 y. DON was the surgical indication in 36.6% of cases, and three-wall decompression was the most preferred technique in these cases. All types of surgery significantly decrease the Hertel values（P〈0.005）. balanced medial-lateral, and only lateral wall decompression caused the lowest rate of postoperative new-onset diplopia in primary gaze. The improvement of visual acuity in patients with DON did not significantly differ between the groups（P=0.181）. CONCLUSION： The study show that orbital decompression surgery has safe and effective long term results for functional and cosmetic rehabilitation of GO. It significantly reduces Hertel measurements in disfiguring proptosis and improves visual functions especially in DON cases.

关键词： orbital decompression Graves' ophthalmopathy dysthyroid optic neuropathy

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HALLENGES IN MODELLING Ice GOUGE AND PIPELINE RESPONSE

HALLENGES IN MODELLING ICE GOUGE AND PIPELINE RESPONSE

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第19届极区港口与海洋工程国际会议

作者： Ibrahim konuk Pavel Liferov Sveinung LΦset Norwegian University of Science and Technology Trondheim Norway Statoil ASA Trondheim Norway Norwegian University of Science and Technology Trondheim Norway

This paper presents an overview of the challenges in modelling ice gouge process and pipeline response to it. It discusses possible ice gouge scenarios observed in various parts of the world. It presents guidelines for the formulation of a well posed mathematical problem that can accurately represent these processes and it describes issues that are critical in the development of a correct numerical solution algorithm. The requirements for designing scale model experiments to understand the ice gouge process and to validate the numerical models are also discussed.

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