检索结果-南通市图书馆

Modulation of Isoflavones on Bone-nodule Formation in Rat Calvaria Osteoblasts in vitro

Biomedical and Environmental Sciences 2003年第1期16卷 83-89页

作者： haochang YAI-YIJIN WEI-FANGJIN SHU-ZHUGU YUAN-FENZHOU DepartmentofToxicology SchoolofPublicHealthFudanUniversityShanghai200032China DivisionofBoneMetaboilismResearch InstituteofRadiationMedicineFudanUniversityShanghai200032China

Objective To observe the effects of two main isoflavones, daidzein and genistein on the bone-nodule formation in rat calvaria osteoblasts in vitro. Methods Osteoblasts obtained from newborn Sprague-dawley rat calvarias were cultured for several generations. The second generation cells were cultured in Minimum Essential Medium supplemented with ascorbic acid and Na-beta-glycerophosphate for several days, in the presence of daidzein and genistein, with or without the estrogen receptor antagonist ICI 182780. Number of nodules was counted at the end of the incubation period (day 20) by staining with Alizarin Red S calcium stain. The release of osteocalcin, as a marker of osteoblast activity, was also determined on day 7 and day 12 during the incubation period. Results Compared with the control, the numbers of nodules were both increased by incubation with daidzein and genistein. 17β-estradiol was used as a positive control and proved to be a more effective inducer of the increase in bone-nodules formation than daidzein and genistein. The release of osteocalcin into culture media was also increased in the presence of daidzein and genistein, as well as 17β-estradiol on day 7 and day 12 (day 12 were higher). The estrogen receptor antagonist ICI 182780 completely blocked the genistein- and 17β-estradiol-induced increase of nodule numbers and osteocalcin release in osteoblasts. However, the effects induced by daidzein could not be inhibited by ICI 182780. Conclusion These findings suggest that geinistein can stimulate bone-nodule formation and increase the release of osteocalcin in rat osteoblasts. The effects, like those induced by 17β-estradiol, are mediated by the estrogen receptor dependent pathway. Daidzein also can stimulate bone-nodule formation and increase the release of osteocalcin in rat osteoblasts, but it is not, at least not merely, mediated by the estrogen receptor dependent pathway.

关键词： Daidzein Genistein ICI 182780 Osteocalcin Bone-nodules Osteoblast

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Li-richening strategy in Li_(2)ZrCl_(6) lattice towards enhanced ionic conductivity

引用

Journal of Energy Chemistry 2023年第4期79卷 348-356页

作者： haochang Zhang Zhaozhe Yu Hannan Chen Yongjian Zhou Xiao Huang Bingbing Tian Guangxi Key Laboratory of Manufacturing Systems and Advanced Manufacturing Technology Guilin University of Electronic TechnologyGuilin 541004GuangxiChina International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060GuangdongChina

All-solid-state Li batteries(ASSLBs) with solid-state electrolytes(SSEs) are exciting candidates for nextgeneration energy storage and receive considerable attention owing to their reliability. Halide SSEs are promising candidates due to their excellent stability against 4 V-class layered cathodes. Compared with Li3InCl6or Li_(3)ScCl_(6), the low ionic conductivity of Li_(2)ZrCl_(6)(LZC) is a challenge despite its low raw-material cost. Herein, we report a family of Li-Richened chloride, Li_(2+2x)Zr_(1–x)MxCl_(6), which can be used in highperformance ASSLBs owing to its high ionic conductivity(up to 0.62 mS cm^(-1)). The theoretical(ab initio molecular dynamics simulations) and experimental results prove that the strategy of aliovalent substitution with divalent metals to obtain Li-Richened LZC is effective in improving Li^(+)conductivity in SSEs. By combining Li_(2.1)Zr_(0.95)Mg_(0.05)Cl_(6)(Mg5-LZC) with a Li–In anode and a LiCoO_(2)cathode, a room-temperature ASSLBs with excellent long-term cycling stability(88% capacity retention at 0.3C for 100 cycles) and highrate capability(121 m A h g^(-1)at 1C) is reported. This exploratory work sheds light on improving the Li^(+)conductivity of low-cost LZC-family SSEs for constructing high performance ASSLBs.

关键词： Li-richening Li_(2)ZrCl_(6) Halide solid electrolyte All-solid-state battery Solid electrochemistry Li^(+)conductivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Halide/sulfide composite solid-state electrolyte for Li-anode based all-solid-state batteries

引用

Chinese Chemical Letters 2023年第11期34卷 326-331页

作者： haochang Zhang Zhaozhe Yu Jinyin Cheng Hannan Chen Xiao Huang Bingbing Tian International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China Guangxi Key Laboratory of Manufacturing Systems and Advanced Manufacturing Technology Guilin University of Electronic TechnologyGuilin 541004China

Li_(2)ZrCl_(6)(LZC) solid-state electrolytes(SSEs) have been recognized as a candidate halide SSEs for allsolid-state Li batteries(ASSLBs) with high energy density and safety due to its great compatibility with4V-class cathodes and low bill-of-material(BOM) ***,despite the benefits,the poor chemical/electrochemical stability of LZC against Li metal causes the deterioration of Li/LZC interface,which has a detrimental inhibition on Li^(+) transport in ***,we report a composite SSE combining by LZC and argyrodite buffer layer(Li_(6)PS_(5)Cl,LPSC) that prevent the unfavorable interaction between LZC and Li *** Li/LPSC-LZC-LPSC/Li symmetric cell stably cycles for over 1000 h at 0.3 mA/cm^(2)(0.15mAh/cm^(2)) and has a high critical current density(CCD) value of 2.1 mA/cm^(2)at 25 ℃,Under high temperature(60℃) which promotes the reaction between Li and LZC,symmetric cell fabricated with composite SSE also display stable cycling performance over 1200h at 0.3 mAh/cm^(2).Especially,the Li/NCM ASSLBs fabricated with composite SSE exhibit a high initial coulombic efficiency,as well as superior cycling and rate *** simple and efficient strategy will be instrumental in the development of halidebased high-performance ASSLBs.

关键词： Li_(2)ZrCl_(6) Li_(6)PS_(5)Cl Composite solid-state electrolyte Interface stability Li anode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beam Induced Degradation Effect in Ion Beam Analysis of Polymer

引用

Chinese Physics Letters 1991年第9期8卷 472-475页

作者： YANG Guohua ZHU Dezhang PAN haochang XU Hongjie CHEN Shoumian Shanghai Institute of Nuclear Research Academia SinicaShanghai 201800

The question of whether ion beam analysis technique can be applied to the study of polymers has been *** of mylar foil under MeV ion beam irradiation was *** order to describe the degradation process of mylar foil under ion beam irradiation quantitatively,only one dose-independent degradation cross section for each of hydrogen and oxygen was *** results suggest that proton or He^(+) ion combined with rotation of the target(scanning area of 20mm^(2))can be used to study the mylar foil without substantially changing the compositions of the target up to ion fluence 5 × 10^(15)/cm^(2).

关键词： rotation beam degradation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineered M2 macrophage-derived extracellular vesicles with platelet membrane fusion for targeted therapy of atherosclerosis

引用

Bioactive Materials 2024年第5期35卷 447-460页

作者： Lan Xie Jinyong Chen haochang Hu Yuan Zhu Xiying Wang Siyu Zhou Feifan Wang Meixiang Xiang Department of Cardiology The Second Affiliated HospitalZhejiang University School of Medicine88 Jiefang RoadHangzhou310009China State Key Laboratory of Transvascular Implantation Devices Hangzhou310009China Cardiovascular Key Laboratory of Zhejiang Province Hangzhou310009China Department of Rheumatology The Second Affiliated HospitalZhejiang University School of Medicine88 Jiefang RoadHangzhou310009China Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of Medicine88 Jiefang RoadHangzhou310009China

Atherosclerosis is featured as chronic low-grade inflammation in the arteries,which leads to the formation of plaques rich in lipids.M_(2)macrophage-derived extracellular vesicles(M_(2)EV)have significant potential for anti-atherosclerotic ***,their therapeutic effectiveness has been hindered by their limited targeting capability in *** objective of this study was to create the P-M_(2)EV(platelet membrane-modified M_(2)EV)using the membrane fusion technique in order to imitate the interaction between platelets and macrophages.P-M_(2)EV exhibited excellent physicochemical properties,and microRNA(miRNA)-sequencing revealed that the extrusion process had no detrimental effects on miRNAs carried by the ***,miR-99a-5p was identified as the miRNA with the highest expression level,which targeted the mRNA of Homeobox A1(HOXA1)and effectively suppressed the formation of foam cells in *** an atherosclerotic low-density lipoprotein receptor-deficient(Ldlr􀀀^(-/-)􀀀)mouse model,the intravenous injection of P-M_(2)EV showed enhanced targeting and greater infiltration into atherosclerotic plaques compared to regular extracellular ***,P-M_(2)EV successfully suppressed the progression of atherosclerosis without causing systemic *** findings demonstrated a biomimetic platelet-mimic system that holds great promise for the treatment of atherosclerosis in clinical settings.

关键词： Atherosclerosis Extracellular vesicles M2 macrophage MiR-99a-5p Platelet-mimetic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antiferromagnetic element Mn modified PtCo truncated octahedral nanoparticles with enhanced activity and durability for direct methanol fuel cells

引用

Nano Research 2019年第10期12卷 2520-2527页

作者： Qiqi Zhang Jialong Liu Tianyu Xia Jie Qi haochang Lyu Baoyuan Luo Rongming Wang Yizhong Guo Lihua Wang and Shouguo Wang Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China Key Laboratory of Material Physics of Ministry of Education School of Physics and EngineeringZhengzhou UniversityZhengzhou 450052China Institute far multidisciplinary Innovation University of Science and Technology BeijingBeijing 100083China Beijng Key Lab cf Microstructure and Property of Advanced Materials Beijing University of TechnologyBeijing 100124China

Pt-based magnetic nano catalysts are one of the most suitable cand idates for electrocatalytic materials due to their high electrochemistry activity and ***,the inferior durability prevents them from being scaled-up,limiting their commercial ***,an antiferromagnetic element Mn was introduced into PtCo nanostructured alloy to synthesize uniform Mn-PtCo truncated octahedral nanoparticles(TONPs)by one-pot *** results show that Mn can tune the blocking temperature of Mn-PtCo TONPs due to its an tiferromag *** low temperatures,Mn-PtCo TONPs are ferromag netic,and the coercivity in creases gradually with in creasi ng Mn *** room temperature,the Mn-PtCo TONPs display superparamag netic behavior,which is greatly helpful for in dustrial *** doping can not only modify the electronic structure of PtCo TONPs but also enhanee electrocatalytic performance for methanol oxidation *** maximum specific activity of Mn-PtCo-3 reaches 8.1 A`m^-2,3.6 times of commercial Pt/C(2.2 A·m^-2)and 1.4 times of PtCo TONPs(5.6 A`m^-2),*** mass activity decreases by only 30%after 2,000 cycles,while it is 45%and 99%(nearly inactive)for PtCo TONPs and commercial Pt/C catalysts,respectively.

关键词： Mn-PtCo trun cated octahedral nano particles an tiferromag netic eleme nt magnetic properties electrocatalytic performa nee

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A CONDITIONAL RANDOM FIELDS APPROACH TO BIOMEDICAL NAMED ENTITY RECOGNITION

引用

Journal of Electronics(China) 2007年第6期24卷 838-844页

作者： Wang haochang Zhao Tiejun Li Sheng Yu Hao School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China

Named entity recognition is a fundamental task in biomedical data mining. In this letter, a named entity recognition system based on CRFs （Conditional Random Fields） for biomedical texts is presented. The system makes extensive use of a diverse set of features, including local features, full text features and external resource features. All features incorporated in this system are described in detail, and the impacts of different feature sets on the performance of the system are evaluated. In order to improve the performance of system, post-processing modules are exploited to deal with the abbreviation phenomena, cascaded named entity and boundary errors identification. Evaluation on this system proved that the feature selection has important impact on the system performance, and the post-processing explored has an important contribution on system performance to achieve better resuits.

关键词： Conditional Random Fields (CRFs) Named entity recognition Feature selection Post-processing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laccase/caffeic acid-catalyzed crosslinking coupled with galactomannan alters the conformational structure of ovalbumin and alleviates Th2-mediated allergic asthma

引用

Food Science and Human Wellness 2024年第4期13卷 1962-1973页

作者： Ishfaq Ahmed Suidong Ouyang Shengquan Wu haochang Song Miaoyuan Zhang Renxing Luo Peishan Lu Jiaqi Deng Tingting Zheng Yanyan Wang Xinguang Liu Gonghua Huang Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguan 523808China Haide College Ocean University of ChinaLaoshan CampusQingdao 266100China School of Medical Technology Guangdong Medical UniversityDongguan 523808China

Ovalbumin(OVA)is the major allergenic protein that can induce T helper 2(Th2)-allergic reactions,for which current treatment options are *** this study,we developed a polymerized hypoallergenic OVA product via laccase/caffeic acid(Lac/CA)-catalyzed crosslinking in conjunction with galactomannan(Man).The formation of high molecular weight crosslinked polymers and the Ig G-binding were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE)and Western *** study indicated that Lac/CA-catalyzed crosslinking plus Man conjugation substantially altered secondary and tertiary structures of OVA along with the variation in surface *** digestion stability assay indicated that crosslinked OVA exhibited less resistance in simulated gastric fluid(SGF)and simulated intestinal fluid(SIF).Mouse model study indicated that Lac-Man/OVA ameliorated eosinophilic airway inflammatory response and efficiently downregulated the expression of Th2-related cytokines(interleukin(IL)-4,IL-5,and IL-13),and upregulated IFN-γand IL-10 *** of bone marrow-derived dendritic cells with Lac-Man/OVA suppressed the expression of phenotypic maturation markers(CD80 and CD86)and MHC class II molecules,and suppressed the expression levels of proinflammatory *** knowledge obtained in the present study offers an effective way to acquire a hypoallergenic OVA product that can have a therapeutic effect in alleviating OVA-induced allergic asthma.

关键词： Ovalbumin Laccase Galactomannan Conformational structure Asthma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

GONE DARK A Concrete Jungle-inspired Cafe in Guangzhou

引用

城市漫步（上海版、英文） 2018年第10期 22-23页

作者： Doninic Ngai Cao haochang 不详

Project name:.JPG Cafe Location:Tianhe district,Guangzhou Area:24 square meters Design company:Infinity Mind The brief:Located in Guangzhoifs Zhukong International Center;the design *** Cafe is inspired by the fast-paced and pressurized lifestyle of the city Inside the small 24-square-meter space,charred reclaimed wood pieces of various lengths jut out from the ceiling and walls to create an almost claustrophobic atmosphere around the shop while bringing visual focus on its centerpiece-the coffee bar.

关键词： bringing walls Cafe

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

GONE DARK A Concrete Jungle-inspired Cafe in Guangzhou

引用

城市漫步（GBA版） 2018年第10期 26-27页

作者： Dominic Ngai Cao haochang(Photos) 不详

Project name:JPG Cafe Location:Tianhe District,Guangzhou Area:24 square meters Design company:Infinity Mind The brief:Located in Guangzhou's Zhukong International Center;the design of JPG Cafe is in・spired by the fast-paced and pressurized lifestyle of the city Inside the small 24-square-meter space,charred reclaimed wood pieces of various lengths jut out from the ceiling and walls to create an almost claustrophobic atmosphere around the shop while bringing visual focus on its centerpiece-the coffee ban.

关键词： bringing Guangzhou walls

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：