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Puerarin antagonizes peroxyntrite-induced injury in retinal pigment epithelial cells

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Neural Regeneration Research 2012年第9期7卷 669-674页

作者： lina hao Xudong Zhang Tao Yang Junling Ma Ophthalmology Department Hebei Province People＇s Hospital Shijiazhuang 050051 Hebei Province China Pharmaceutical Department Hebei Province People＇s Hospital Shijiazhuang 050051 Hebei Province China Internal Department the First Hospital Hebei Medical University Shijiazhuang 050031 Hebei Province China

A rat model of diabetes mellitus was established by intraperitoneal injection of streptozotocin. Three days later, the rats were intraperitoneally administered 140 mg puerarin/kg daily, for a total of 60 successive days. DNA ladder results showed increased apoptosis over time in retinal pigment epithelial cells from rats with streptozotocin-induced diabetes mellitus. Western blot analysis, Reverse transcription-PCR, immunohistochemistry, and flow cytometry results showed increased expression of 3-nitrotyrosine, a peroxyntrite marker, as well as inducible nitric synthase and Fas/FasL, in retinal pigment epithelial cells. Puerarin reversed these changes, and results demonstrated that puerarin inhibited Fas/FasL expression and alleviated peroxyntrite injury to retinal pigment epithelial cells. These results suggested that puerarin inhibited production of inducible nitric oxide synthase and directly antagonized peroxyntrite injury in retinal pigment epithelial cells.

关键词： apoptosis Fas/FasL inducible nitric oxide synthase oxidative stress puerarin retinal pigment epithelial cells

Simulation and Experiment Based on FSMLC Method with EUPI Hysteresis Compensation for a Piezo-Driven Micro Position Stage

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Journal of Systems Science & Complexity 2019年第5期32卷 1340-1357页

作者： GAO Jinhai hao lina CHENG Hongtai CAO Ruimin SUN Zhiyong School of Mechanical Engineering&Automation Northeastern UniversityShenyang 110819China Department of Industrial and Manufacturing Systems Engineering The University of Hong KongHong KongChina.

Micro/nano positioning technologies have been attractive for decades in industrial and scientific applications fields. The actuators have inherent hysteresis that can cause system unexpected behave in some extend. In this research, the authors used extented unparallel Prandtl-Ishlinshii(EUPI)models to represent the input-output relationship of a piezo-driven micro position stage. Integral inverse(I-I) compensator is used for compensating the hysteresis characteristics of the micro positioning stage and compared with direct inverse(D-I) compensator and inverse model(I-M) compensator. However,the accuracy and the robustness of the I-I compensator are worse when there is noisy in the system,a novel sliding-mode-like-control with EUPI(SMLC-EUPI) method was proposed and analyzed by different trajectory tracking experiments in Matlab environment. Though the above strategies can alleviate most deviation, the adjustment of the SMLC’s parameters is very complex. So the fuzzy method is used to adjust these parameters and be verified by trajectory tracking experiments. Finally,for validating the proposed control method, the paper did the corresponding experiment in microscope with CMOS and obtained convincing results.

关键词： EUPI fuzzy hysteresis compensation micro position stage sliding-mode-like-control

基于IV-MLP耦合模型的龙陵县滑坡易发性评价

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物探化探计算技术 2024年第5期46卷 618-626页

作者：张宇简季郝利娜杨鑫云南省地质矿产勘查开发局第一水文地质工程地质大队昆明650041 成都理工大学地球科学学院成都610059

滑坡易发性评价模型会直接影响到研究结果准确性,为探究不同耦合模型对滑坡易发性分析的影响,以云南省龙陵县为研究区,共选取高程、坡度、工程岩组等8个因子构建滑坡易发性评价体系,引入多层感知器方法(MLP)与信息量模型(IV)耦合以开展... 详细信息

滑坡易发性评价模型会直接影响到研究结果准确性,为探究不同耦合模型对滑坡易发性分析的影响,以云南省龙陵县为研究区,共选取高程、坡度、工程岩组等8个因子构建滑坡易发性评价体系,引入多层感知器方法(MLP)与信息量模型(IV)耦合以开展滑坡易发性评价,与传统信息量-逻辑回归模型(IV-LR)进行分析比较,并通过AUC值进行精度验证。结果表明:IV-MLP模型、IV-LR模型及IV模型的AUC值分别为0.862、0.813与0.799。IV-MLP耦合模型AUC值高于IV-LR耦合模型,MLP模型在与IV模型进行滑坡易发性耦合分析中表现更优秀;IV-MLP、IV-LR耦合模型的AUC值分别高于单一IV模型0.063、0.014,对滑坡进行易发性分区时耦合模型较单一模型效果更佳。研究结果能够为龙陵县滑坡易发性评价提供科学的理论依据,并为该地区的防灾工作提供参考。

关键词：滑坡易发性信息量法逻辑回归多层感知器龙陵县

受甲虫影响的木材与非木材产品的联合收获策略

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长春工业大学学报 2024年第1期45卷 44-51页

作者：张雅宁郝丽娜张珊长春工业大学数学与统计学院吉林长春130012

基于森林中木材和非木材产品的开发现状,考虑甲虫与森林木材的相互作用关系建立生态数学模型。首先,分析该模型的动力学行为,运用常微分方程的定性理论分析系统平衡点的存在性以及稳定性条件;其次,研究该模型下的最优收获问题,选取收获... 详细信息

基于森林中木材和非木材产品的开发现状,考虑甲虫与森林木材的相互作用关系建立生态数学模型。首先,分析该模型的动力学行为,运用常微分方程的定性理论分析系统平衡点的存在性以及稳定性条件;其次,研究该模型下的最优收获问题,选取收获努力量和对甲虫的人为消杀率为最优控制变量,求出最优解的表达式;最后,结合数值模拟给出具有实际意义的最优收获策略,为林业生态经济的可持续发展提供一定的理论依据。

关键词：非线性收获最优控制可持续木材收获森林甲虫非木材产品

Cropping pattern optimization considering uncertainty of water availability and water saving potential

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International Journal of Agricultural and Biological Engineering 2018年第1期11卷 178-186页

作者： lina hao Xiaoling Su Vijay P.Singh College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100ShaanxiChina Department of Biological&Agricultural Engineering and Zachry Department of Civil Engineering Texas A&M UniversityCollege StationTX 77843-2117USA

In arid and semi-arid areas,the profitability of irrigated agriculture mainly depends on the availability of water resources and optimal cropping patterns of irrigation *** this study,an integrated agricultural cropping pattern optimization model was developed with considering the uncertainty of water availability and water saving potential in the future,aiming to maximize agricultural net benefit per unit of irrigation *** available water which was based on the uncertainty of runoff was divided into five *** irrigation water-saving potential in the future was quantified by assuming an increase in the rate irrigation water-saving of 10% and 20%.The model was applied to the middle reaches of Heihe River basin,in Gansu Province,*** showed that if the irrigation water-saving rate was assumed to increase by 10%,then the net water-saving quantity would increase by 21.5-22.5 million m3 and the gross water-saving quantity would increase by 275.7-303.0 million ***,if the irrigation water-saving rate increased by 20%,then the net water-saving quantity would increase by 43.0-45.1 million m3 and the gross water-saving quantity would increase by 331.7-383.2 million *** the agricultural cropping pattern was optimized,the optimal water and cultivated area allocation for maize would be greater than those for other *** the premise that similar volume of irrigation water quantity was available in different scenarios,results showed differences in system benefit and net benefit per unit of irrigation water,for the distribution of available irrigation water was diverse in different irrigation districts.

关键词： cropping pattern optimization irrigation water-saving potential different scenarios water availability water use efficiency particle swarm optimization(PSO)

Modelling and analysis of hybrid stochastic timed Petri net

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Journal of Control and Decision 2019年第2期6卷 90-110页

作者： Ruimin Cao lina hao Fengli Wang Qiang Gao School of Mechanical Engineering&Automation Northeastern UniversityShenyangChina Key Laboratory of Manufacturing Industrial Integrated Automation Shenyang UniversityShenyangChina

In this paper,an interesting Hybrid Stochastic Timed Petri Net(HSTPN)is proposed for a class of hybrid *** proposed HSTPN can be adopted to represent hybrid systems with discrete,continuous,conflicting,time-delay and stochastic characteristics *** proposed HSTPN outperforms conventional hybrid Petri net models in terms of describing the scalability and immediacy of hybrid *** of the HSTPN on describing hybrid system are verified by establishing some equivalent models of HPN and its derived models.

关键词： Hybrid stochastic timed Petri net hybrid dynamic system structural equivalence equivalence rules scalability

新工科背景下低碳智能交叉融合的土木工程专业教学体系构建

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林业科技情报 2024年第04期56卷 220-222页

作者：徐喜辉徐明郝丽娜齐齐哈尔工程学院

在全球范围内推进低碳发展已成为时代的必然选择，这对土木工程领域提出了新的要求。新工科背景下，土木工程专业的教学体系构建需紧密围绕智能化技术和低碳理念展开，以培养适应未来社会需求的高素质工程技术人才。这种跨学科的交叉融... 详细信息

在全球范围内推进低碳发展已成为时代的必然选择，这对土木工程领域提出了新的要求。新工科背景下，土木工程专业的教学体系构建需紧密围绕智能化技术和低碳理念展开，以培养适应未来社会需求的高素质工程技术人才。这种跨学科的交叉融合要求学生掌握传统土木工程的核心知识，同时具备利用新兴技术解决环境和能源问题的能力。该文主要分析了土木工程学科发展中存在的问题，并基于新工科背景提出了低碳智能交叉融合的士木工程专业教学体系构建策略。

关键词：新工科低碳智能融合土木工程教学体系

基于MODIS-NDVI数据的延河流域植被覆盖时空变化及其对极端降水的响应

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湖南城市学院学报（自然科学版） 2024年第1期33卷 62-67页

作者：张明颖郝利娜钟佳悦李佳琴成都理工大学地球科学学院成都610059

基于2010-2020年MODIS-NDVI数据,分析延河流域归一化植被指数(normalizeddifference vegetation index,NDVI)和极端降水指数,辅以利用Sen趋势分析、M-K趋势检验法、Pearson相关分析等方法,研究植被覆盖时空变化及其对极端降水的响应。... 详细信息

基于2010-2020年MODIS-NDVI数据,分析延河流域归一化植被指数(normalizeddifference vegetation index,NDVI)和极端降水指数,辅以利用Sen趋势分析、M-K趋势检验法、Pearson相关分析等方法,研究植被覆盖时空变化及其对极端降水的响应。结果表明:1)2010-2020年,延河流域NDVI呈显著增加趋势,植被覆盖状况逐年改善,其增加速率为0.073/(10 a)(P<0.001);2)空间上,延河流域NDVI呈现从东南到西北减小的布局;3)趋势上,NDVI呈上升和减小趋势的面积占比分别为98.02%和1.98%,整体呈上升趋势,植被覆盖显著改善;4)近11年极端降水指数总体趋势变化平缓,R20(number of very heavy precipitation days)、RX_(5day)(max5-day precipitation amount)、CDD(consecutive dry Days)和CWD(consecutive wet days)呈上升趋势,R_(95P)(very wet day precipitation)和SDII(simple daily intensity index)呈下降趋势;5)NDVI与极端降水指数的相关性整体上偏低,除SDII外,其余指数都与NDVI正相关,且NDVI与RX_(5day)相关性最强,与R20相关性最弱。

关键词： NDVI 极端降水指数趋势分析相关分析延河流域

Apoptosis-linked antifungal effect of ambroxol hydrochloride by cystolic calcium concentration disturbance in resistant Candida albicans

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Science China(Life Sciences) 2019年第12期62卷 1601-1604页

作者： Xiuyun Li Xuexin Wu Yan Gao lina hao Shujuan Sun Pharmaceutical Department Qilu Childrens Hospital of Shandong UniversityJinan 250022China Pharmaceutical Department Shandong Provincial Qianfoshan Hospitalthe First Hospital Affiliated with Shandong First Medical UniversityJinan 250014China

Dear Editor,Since the early 1980s,the incidence of fungal infections has significantly increased in immunocompromised individuals(WisplinghofF et al.,2004;Pfaller and Diekema,2007).However,due to the extensive and indiscriminate use of available antifungal agents,an increasing number of antifungal-resistant pathogens have been isolated over the past few decades(Sanglard and Odds,2002).***,an important opportunistic fxingal pathogen,is becoming increasingly resistant to several antifungal agents,particularly triazole *** resistance in *** has emerged as an important public health concern(Sanglard and Odds,2002).Although ambroxol hydrochloride(ABH)has recently been found to display antifungal activity against susceptible ***,its antifungal effect and mechanism against resistant *** have not yet been thoroughly *** aim of this study was to elucidate the antifungal effects(in vitro and in vivo)and mechanisms of ABH against resistant ***.

关键词： antifungal effect thoroughly