检索结果-南通市图书馆

The role of axon guidance molecules in the pathogenesis of epilepsy

Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua Pan hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

引用

Nano-Micro Letters 2025年第2期17卷 447-462页

作者： haonan Zhang Cheng hao Tongtong Fu Dian Yu Jane Howe Kaiwen Chen Ning Yan hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laser‑Induced Highly Stable Conductive Hydrogels for Robust Bioelectronics

引用

Nano-Micro Letters 2025年第3期17卷 117-120页

作者： Yibo Li hao Zhou Huayong Yang Kaichen Xu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058People’s Republic of China

Despite the promising progress in conductive hydrogels made with pure conducting polymer,great challenges remain in the interface adhesion and robustness in longterm *** address these challenges,*** Hwan Ko and Taek-Soo Kim’s team introduced a laserinduced phase separation and adhesion method for fabricating conductive hydrogels consisting of pure poly(3,4-ethylenedioxythiophene):polystyrene sulfonate on polymer *** laser-induced phase separation and adhesion treated conducting polymers can be selectively transformed into conductive hydrogels that exhibit wet conductivities of 101.4 S cm^(−1)with a spatial resolution down to 5μ***,they maintain impedance and charge-storage capacity even after 1 h of *** micropatterned electrode arrays demonstrate their potential in long-term in vivo signal recordings,highlighting their promising role in the field of bioelectronics.

关键词： Laser processing Conductive hydrogels Stable interface Bio-interfacing electrodes Bioelectronic application

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extremely low thermal conductivity from bismuth selenohalides with 1D soft crystal structure

引用

Science China Materials 2020年第9期63卷 1759-1768页

作者： Dongyang Wang Zhiwei Huang Yang Zhang lijie hao Guangtao Wang Sihao Deng Hongliang Wang Jie Chen Lunhua He Bao Xiao Yadong Xu Stephen J.Pennycook Haijun Wu Li-Dong Zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Instrumental Analysis Center of Xi’an Jiaotong University Xi’an Jiaotong UniversityXi’an 710049China Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore Department of Nuclear Physics Neutron Scattering LaboratoryChina Institute of Atomic EnergyBeijing 102413China School of Physics Henan Normal UniversityXinxiang 453007China Spallation Neutron Source Science Center Dongguan 523803China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China

Materials with intrinsically low thermal conductivity are of fundamental *** we report a new sort of simple one-dimensional(1 D)crystal structured bismuth selenohalides(Bi Se X,X=Br,I)with extremely low thermal conductivity of^0.27 W m^-1K^-1 at 573 *** mechanism of the extremely low thermal conductivity in 1 D Bi Se X is elucidated systematically using the first-principles calculations,neutron powder-diffraction measurements and temperature tunable aberration-corrected scanning transmission electron microscopy(STEM).Results reveal that the1 D structure of Bi Se X possesses unique soft bonding character,low phonon velocity,strong anharmonicity of both acoustic and optical phonon modes,and large off-center displacement of Bi and halogen ***,all these features contribute to the minimal phonon *** findings provide a novel selection rule to search low thermal conductivity materials with potential applications in thermoelectrics and thermal barrier coatings.

关键词： low thermal conductivity 1D bulk material bismuth selenohalides first-principles calculations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于中子衍射的六方相Er_(1-x)Y_(x)MnO_(3)结构和磁学性能研究

引用

原子能科学技术 2022年第3期56卷 410-418页

作者：王洪亮刘新智孙凯刘蕴韬郝丽杰马小柏郭浩李正耀田庚方陈东风中国原子能科学研究院北京102413 中山大学物理学院广东广州510275

为研究六方钙钛矿氧化物中磁结构和稀土离子对磁性能的影响,以六方相ErMnO_(3)为母体,通过非磁性Y^(3+)离子对磁性稀土Er^(3+)离子的替代,利用X射线衍射、中子粉末衍射和磁性测量等表征手段,对六方化合物Er_(1-x)Y_(x)MnO_(3)的晶体结... 详细信息

为研究六方钙钛矿氧化物中磁结构和稀土离子对磁性能的影响,以六方相ErMnO_(3)为母体,通过非磁性Y^(3+)离子对磁性稀土Er^(3+)离子的替代,利用X射线衍射、中子粉末衍射和磁性测量等表征手段,对六方化合物Er_(1-x)Y_(x)MnO_(3)的晶体结构和磁性进行系统研究。研究结果表明,Y^(3+)离子的掺杂并未引起晶体结构和磁结构的明显改变,同时发现六方晶体结构随温度的增加呈各向异性热膨胀,在ab面内膨胀而沿着c轴收缩。中子衍射实验结果表明,Er_(0.4)Y_(0.6)MnO_(3)样品的有序温度约为79 K,低温下系统的基态为反铁磁性,结构为Γ_(2)(P63c′m′)或Γ_(4)(P63′c′m)组态,与Er_(0.8)Y_(0.2)MnO_(3)相同。磁化测试结果表明,非磁性Y^(3+)离子掺杂量的增加削弱了磁化强度,2 K时磁性稀土离子Er^(3+)的自旋有序在外磁场下表现出铁磁信号。该研究阐明了Er_(1-x)Y_(x)MnO_(3)的磁性本质和稀土磁性调控特性,为其潜在应用提供了有力指导。

关键词：中子衍射磁结构磁弹耦合六方钙钛矿

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

引用

Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng hao Hongmei Duan Fei hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

重组人血管内皮抑制素在晚期非小细胞肺癌化疗患者中的应用效果

引用

癌症进展 2021年第6期19卷 603-606,637页

作者：马怡郑爽赫丽杰辽宁省人民医院肿瘤科沈阳1100160

目的探讨重组人血管内皮抑制素在晚期非小细胞肺癌(NSCLC)化疗患者中的应用效果。方法依据随机数字表法将120例晚期NSCLC患者分为观察组和对照组,每组60例。对照组患者予以顺铂注射液治疗,观察组患者在对照组的基础上联合重组人血管内... 详细信息

目的探讨重组人血管内皮抑制素在晚期非小细胞肺癌(NSCLC)化疗患者中的应用效果。方法依据随机数字表法将120例晚期NSCLC患者分为观察组和对照组,每组60例。对照组患者予以顺铂注射液治疗,观察组患者在对照组的基础上联合重组人血管内皮抑制素注射液治疗。比较治疗前后两组患者的肿瘤标志物[细胞角质蛋白19片段抗原21-1(CYFRA21-1)、癌胚抗原(CEA)、糖类抗原50(CA50)]水平、肺功能指标[用力肺活量占预计值百分比(FVC%)、第一秒用力呼气量(FEV1)以及最大通气量(MVV)]、外周血血管内皮生长因子(VEGF)和低氧诱导因子-1α(HIF-1α)水平、生活质量及免疫功能指标(CD3^(^(+))、CD4^(+)、CD8^(+)水平及CD4^(+)/CD8^(+))。结果治疗后,观察组患者的CYFRA21-1、CEA、CA50水平均低于对照组,FVC%、FEV1、MVV均高于对照组,外周血VEGF和HIF-1α水平均低于对照组,功能情况、情感情况、社会/家庭情况、生理状态评分均低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者的不良反应总发生率为5.00%,低于对照组的16.67%,差异有统计学意义(P﹤0.05)。结论重组人血管内皮抑制素有利于降低晚期NSCLC化疗患者的肿瘤标志物及外周血VEGF和HIF-1α水平,改善肺功能,提高生活质量,增强免疫功能,降低不良反应发生率。

关键词：重组人血管内皮抑制素非小细胞肺癌肿瘤标志物血管内皮生长因子低氧诱导因子-1α

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

具有脉冲出生及垂直传染的SIS传染病模型的分岔分析

引用

桂林电子科技大学学报 2013年第1期33卷 56-60页

作者：鹿鹏蒋贵荣郝丽杰桂林电子科技大学数学与计算科学学院广西桂林541004

研究了一类具有脉冲出生及垂直传染的SIS传染病模型的动力学行为,利用离散映射、中心流形定理和分岔定理,得到了超临界分岔和flip分岔发生的条件。数值模拟结果表明,地方病周期解通过超临界分岔从无病周期解中分岔出来,2-周期解通过fli... 详细信息

研究了一类具有脉冲出生及垂直传染的SIS传染病模型的动力学行为,利用离散映射、中心流形定理和分岔定理,得到了超临界分岔和flip分岔发生的条件。数值模拟结果表明,地方病周期解通过超临界分岔从无病周期解中分岔出来,2-周期解通过flip分岔从周期解中分岔出来,验证了理论分析。

关键词： SIS传染病模型出生脉冲周期解垂直传染 flip分岔

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

具有饱和接触率的SIRS传染病模型的周期解

引用

桂林电子科技大学学报 2013年第1期33卷 61-65页

作者：郝丽杰蒋贵荣鹿鹏桂林电子科技大学数学与计算科学学院广西桂林541004

基于离散映射和分岔理论,研究了具有脉冲生育、脉冲接种和饱和接触率的SIRS传染病模型的动力学性质,通过分析模型平凡解和无病周期解的存在性和稳定性以及超临界分岔发生的条件,得到决定疾病流行与否的阈值,给出验证理论分析的数值结果。

关键词： SIRS传染病模型饱和接触率脉冲接种周期解超临界分岔

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于金属磁量热技术的拾波线圈电磁性能仿真模拟

引用

原子能科学技术 2023年第9期57卷 1835-1840页

作者：李睿孟思勤郝丽杰王洪亮徐利军孙凯刘蕴韬陈东风中国原子能科学研究院中子散射实验室北京102413

金属磁量热技术是利用稀土金属的磁化在低温随温度变化明显的特性,对低能射线能谱进行高分辨的探测。拾波线圈作为拾取磁信号变化的重要部分,在金属磁量热技术中担任重要的角色,其设计构型及电磁参数直接影响到传感器的能量分辨能力。... 详细信息

金属磁量热技术是利用稀土金属的磁化在低温随温度变化明显的特性,对低能射线能谱进行高分辨的探测。拾波线圈作为拾取磁信号变化的重要部分,在金属磁量热技术中担任重要的角色,其设计构型及电磁参数直接影响到传感器的能量分辨能力。本文利用有限元模拟仿真技术对线圈的匝数、占空比等参数对电磁性能的影响进行了详细计算,并通过与实测结果的对比,验证了仿真模型与参数的正确性,为拾波线圈的设计提供了可靠依据。

关键词：金属磁量热技术低能γ射线拾波线圈电磁仿真

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：