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Transcranial photobiomodulation with near-infrared light:a promising therapeutic modality for Alzheimer's disease

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Neural Regeneration Research 2023年第9期18卷 1944-1945页

作者： hanli liu Damir Nizamutdinov Jason H.Huang Bioengineering Department the University of Texas at ArlingtonArlingtonTXUSA Neurosurgery Neuroscience InstituteBaylor Scott and White HealthTempleTXUSA Neurosurgery College of MedicineTexas A&M UniversityTempleTXUSA

Transcranial photobiomodulation(tPBM) is a noninvasive neuromodulation technique that delivers near-infrared(NIR) light with low irradiance(i.e.,power density in mW/cm2) in the wavelength range of 800-1070 *** recently published books or collected literature(Hamblin,2019;GonzalezLima,2021) and papers(Nizamutdinov et al. 2022)offer comprehensive reviews of the mechanism of action and potential clinical translations of tPBM for the treatment of a variety of diseases,including neurodegenerative diseases(Alzheimer’s disease(AD),and Parkinson’s disease),traumatic brain injury.

关键词： Alzheimer diseases

A DUAL-MODALITY OPTICAL BIOPSY APPROACH FOR IN VIVO DETECTION OF PROSTATE CANCER IN RAT MODEL

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 269-277页

作者： VIKRANT SHARMA NIMIT PATEL JINHUI SHEN LIPING TANG GEORGE ALEXANDRAKIS hanli liu Department of Bioengineering Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center University of Texas at Arlington TX 76019USA

Ultrasound-guided biopsy procedure for prostate cancer diagnosis,which is the current gold standard,involves quasi-random sampling of prostate tissue without any functional *** this study,we discuss the possibility to augment the detection of prostate cancer using a dual-modality optical approach,which can be coupled with the current needle biopsy *** techniques are light reflectance spectroscopy(LRS)that uses a broadband light source and a CCD array spectrometer,and auto-fluorescence lifetime measurement(AFLM)that uses a custom-designed,time-correlated single photon counting(TCSPC)*** LRS and AFLM were employed sequentially in this study to measure cancer tissue along with control tissue on a rat prostate tumor *** an excitation wavelength of 447 nm,we investigated auto-fluorescence decay curves at the emission wavelengths of 532,562,632 and 684 nm for in vivo and ex vivo *** results show that auto-fluorescence lifetimes at all measured emission wavelengths differ between control and cancerous tissues with 100% specificity and ***,absolute values of hemoglobin derivatives and scattering coe±cient were quantified using in vivo *** part of study also demonstrates that light scattering and absorption are significantly different between the control and cancerous ***,the study demonstrates that both LRS and AFLM may provide several intrinsic biomarkers for in vivo detection of prostate cancer.

关键词： Prostate cancer light reflectance spectroscopy auto-fluorescence lifetime

Reconstructions for Continuous-Wave Diffuse Optical Tomography by a Globally Convergent Method

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Journal of Applied Mathematics and Physics 2014年第5期2卷 204-213页

作者： Jianzhong Su Yueming liu Zi-Jing Lin Steven Teng Aubrey Rhoden Natee Pantong hanli liu Department of Mathematics University of Texas at Arlington Arlington Texas USA Department of Bioengineering University of Texas at Arlington Arlington Texas USA

In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.

关键词： Inverse Problems Diffuse Optical Tomography Medical and Biological Imaging Globally Convergence Method

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农村社会风险防控比较研究

经济问题探索 2007年第2期 60-64页

作者：刘汉利中国人民武装警察部队学院河北廊坊065000

本文首先说明了中国农村社会风险的区域差别及共有的问题,然后阐述了中国各地防控农村社会风险的不同特点,接着探讨了国外防控农村社会风险的独特经验,最后根据比较提出了中国各地共同适用的防控农村社会风险的对策。

关键词：农村社会风险防控比较研究中国

党组性质党委的初次尝试与历史经验——早期军政委员会考略

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武警学院学报 2021年第11期37卷 44-50页

作者：刘汉利中国人民警察大学公安政治学院河北廊坊065000

军政委员会是在特定历史条件下产生的,它孕育于军事政治苏维埃构想,产生于长征前夕,建立于红军改编时期,发展于全面抗战时期。军政委员会制度在诞生早期与党组性质党委制度在本质上具有一致性。在早期军政委员会制度下,党的绝对领导取... 详细信息

军政委员会是在特定历史条件下产生的,它孕育于军事政治苏维埃构想,产生于长征前夕,建立于红军改编时期,发展于全面抗战时期。军政委员会制度在诞生早期与党组性质党委制度在本质上具有一致性。在早期军政委员会制度下,党的绝对领导取得了一些珍贵的历史经验,这些经验对于党组性质党委的建设具有重要的启示意义。

关键词：党组性质党委早期军政委员会历史经验

用于时间序列聚类分析的小波变换和特征量提取方法

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测绘科学技术学报 2014年第4期31卷 372-376,382页

作者：刘汉丽裴韬周成虎武汉科技大学汽车与交通工程学院湖北武汉430081 中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101

利用小波变换的多尺度分辨功能,对时间序列数据进行多次Haar小波变换,将时间序列分解为尺度分量和细节分量;通过保留尺度分量,提取时间序列的趋势信息,并结合统计特征量计算,将时间序列的趋势信息与几种统计特征量组合在一起,构成SOM神... 详细信息

利用小波变换的多尺度分辨功能,对时间序列数据进行多次Haar小波变换,将时间序列分解为尺度分量和细节分量;通过保留尺度分量,提取时间序列的趋势信息,并结合统计特征量计算,将时间序列的趋势信息与几种统计特征量组合在一起,构成SOM神经网络的输入向量,对时间序列进行聚类分析。通过在几类模拟时间序列数据上进行实验分析,取得了较好的实验效果。并将此方法应用到基于MODIS遥感影像的林地植被提取中,获得了较高的提取精度。

关键词：时间序列 Haar小波变换统计特征量提取 MODIS遥感影像 NDVI数据 SOM神经网络