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Journal of Oceanology and limnology 2024年第3期42卷 709-714页

作者： xudong ZHANG Xiaofeng li Key Laboratory of Ocean Observation and Forecasting Key Laboratory of Ocean Circulation and WavesInstitute of OceanologyChinese Academy of SciencesQingdao 266071China

Internal solitary waves(ISW),characterized by large amplitude and long propagation distance,are widespread in global *** remote sensing images have played an essential role in studying ISWs,they mainly exploit two-dimensional image ***,with the launch of the surface water ocean topography(SWOT)satellite on December 16,2022,a unique opportunity has emerged to capture wide-swath three-dimensional ISW-induced sea surface *** this study,we examine ISWs in the Andaman Sea using data from the Ka-band Radar Interferometer(KaRIN),a crucial sensor onboard *** not only provides backscattering satellite images but also employs synthetic aperture interferometry techniques to retrieve wide-swath two-dimensional sea surface height *** observations in the Andaman Sea revealed the presence of ISWs characterized by dark-bright strips and surface elevation *** surface soliton has an amplitude of 0.32 m,resulting in an estimation of ISW amplitude of approximately 60 *** contrast to traditional two-dimensional satellite images or nadir-looking altimetry data,the SWOT mission’s capability to capture threedimensional sea surface information represents a significant *** breakthrough holds substantial promise for ISW studies,particularly in the context of ISW amplitude inversion.

关键词： internal solitary wave(ISW) surface water ocean topography(SWOT) altimeter

Twenty-nine million intrinsic Q-factor monolithic microresonators on thin-film lithium niobate

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Photonics Research 2024年第8期12卷 I0001-I0006页

作者： XINRUI ZHU YAOWEN HU SHENGYUAN LU hana kwar.er.xudong li YUNXIANG SONG LETÍCIA MAGALHÃES AMIRHASSAN SHAMS-ANSARI ANDREA CORDARO NEIL SINCLAIR MARKO LONČAR John A.Paulson School for Engineering and Applied Sciences Harvard UniversityCambridgeMassachusetts 02138USA State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China DRS Daylight Solutions San DiegoCalifornia 92127USA

The recent emergence of thin-film lithium niobate(TFLN)has extended the landscape of integrated *** has been enabled by the commercialization of TFLN wafers and advanced nanofabrication of TFLN such as high-quality dry ***,fabrication imperfections still limit the propagation loss to a few dB/m,restricting the impact of this ***,we demonstrate TFLN microresonators with a record-high intrinsic quality(Q)factor of twenty-nine million,corresponding to an ultra-low propagation loss of 1.3 dB/*** present spectral analysis and the statistical distribution of Q factors across different resonator *** work pushes the fabrication limits of TFLN photonics to achieve a Q factor within 1 order of magnitude of the material limit.

关键词： resonator lithium film

Effect of nitrile butadiene rubber hardness on the sealing characteristics of hydraulic O-ring rod seals

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第1期25卷 63-78页

作者： Xiaoxuan li Bingqing WANG xudong PENG Yuntang li Xiaolu li Yuan CHEN Jie JIN College of Quality and Safety Engineering China Jiliang UniversityHangzhou310018China College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou310018China College of Mechanical Engineering Zhejiang University of TechnologyHangzhou310023China

The nitrile butadiene rubber(NBR)hardness effect on the sealing characteristics of hydraulic O-ring rod seals is analyzed based on a mixed lubrication elastohydrodynamic *** studies are conducted to reveal the mechanism of the influence of rubber hardness on the static and dynamic behavior of *** optimized selections of rubber hardness are then investigated under different *** show that the low hardness seal is prone to stress concentration due to the extrusion effect under high pressure conditions;it is also more prone to leaking.A high hardness seal can better prevent leakage by reducing film thickness but it will cause large frictional power loss and increase the probability of wear *** choice of low hardness is recommended to reduce friction with the premise that leakage requirements are met.

关键词： Nitrile butadiene rubber(NBR)hardness Sealing characteristics Optimized selection O-ring seal

Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia

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Genes & Diseases 2024年第5期11卷 140-162页

作者： xudong li Wei li Yanli Zhang linping Xu Yongping Song Department of Hematology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhouHenan 450008China Academy of Medical Sciences Zhengzhou UniversityZhengzhouHenan 450052China Department of Hematology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China

The advent of tyrosine kinase inhibitors(TKI)targeting BCR-ABL has drastically changed the treatment approach of chronic myeloid leukemia(CML),greatly prolonged the life of CML patients,and improved their ***,TKI resistance is still a major problem with CML patients,reducing the efficacy of treatment and their quality of *** resistance is mainly divided into BCR-ABL-dependent and BCR-ABL-independent ***,the main clinical strategy addressing TKI resistance is to switch to newly developed ***,data have shown that these new drugs may cause serious adverse reactions and intolerance and cannot address all resistance ***,finding new therapeutic targets to overcome TKI resistance is crucial and the ubiquitin-proteasome system(UPS)has emerged as a *** UPS mediates the degradation of most proteins in organisms and controls a wide range of physiological *** recent years,the study of UPS in hematological malignant tumors has resulted in effective treatments,such as bortezomib in the treatment of multiple myeloma and mantle cell *** CML,the components of UPS cooperate or antagonize the efficacy of TKI by directly or indirectly affecting the ubiquitination of BCR-ABL,interfering with CML-related signaling pathways,and negatively or positively affecting leukemia stem *** of these molecules may help overcome TKI resistance and treat *** this review,the mechanism of TKI resistance is briefly described,the components of UPS are introduced,existing studies on UPS participating in TKI resistance are listed,and UPS as the therapeutic target and strategies are discussed.

关键词： Chronic myeloid leukemia Deubiquitinases E3 ligase PROTAC TKI resistance Ubiquitin-proteasome system

Pore Formation Mechanism in W-C Hard Coatings Using Directed Energy Deposition on Tungsten Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 89-101页

作者： Xinrui Zhang Weijie Fu Chen Wang Zhenglong Lei Haoran Sun xudong li State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China

Porosity is a common phenomenon and can significantly hinder the quality of the ***,the pore formation mechanism and the characteristics of the single tracks of the W-C coating using directed energy deposition(DED)are systematically *** forming quality of the tracks,the distribution of the pores,and the elemental distribution near the pores are analyzed by the observations of the cross-sections of the *** temperature field of the melt pool is discussed comprehensively to reveal the pore formation *** results confirm that Ni and Co evaporated during the DED process due to the high temperature of the melt *** were continuously produced adjacent to the fusion line when the melt pool was about to solidify since the temperature at the solidification front was higher than the boiling point of *** vaporization area at the fusion line was proposed,where Ni could also evaporate at the time the melt pool started to *** relationship between the solidification rate,the size of the vaporization area and the DED parameters(laser power and scanning speed)was established to discuss the causes of severe pores above the fusion *** work contains a practical guide to reduce or eliminate the porosity in the coating preparation process on the surface of the tungsten alloy.

关键词： Directed energy deposition(DED)process Tungsten alloy W-C coating Pores Binder phase

The Imbalanced Pattern of Population and Economy and Its Influencing Factors in the Wumeng Mountain Area

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Journal of Resources and Ecology 2024年第4期15卷 937-950页

作者： CHEN Xuan li xudong School of Geography and Environmental Science Guizhou Normal UniversityGuiyang 550025China

Based on the population and economic data of the Wumeng Mountain Area from 2000 to 2020,this study explored the imbalanced spatiotemporal patterns of population and economy in the area using methods such as the geographic concentration,gravity model,imbalance index,and inconsistency *** study also analyzed the influencing factors using geodetectors and spatiotemporal geographically weighted regression *** results show four key aspects of this phenomenon.(1)The spatial distributions of the population and economic geographic concentrations deviate from their ideal *** population distribution shows a spatial pattern of being higher in the northeast and lower in the southwest,while the economic distribution shows a spatial pattern of being higher in the south and lower in the north.(2)The population and economic gravity centers have shifted toward the northeast and south relative to the geometric center of the mountain area,respectively,and the economic center has shifted more than the population center.(3)The degree of imbalance between the population and economic distributions is decreasing,but regional development disparities still *** region with inconsistent spatial distributions between population and economy remains stable,showing a"north high,south low"pattern,with an increase in the number of counties dominated by the economy and reductions in the numbers of counties in other categories.(4)Economic power,social consumption level,industrial structure,urban development level,government regulation capacity,and health care infrastructure are the main factors affecting the inconsistent distributions of population and economy in Wumeng Mountain Area,and the effects of these factors are reflected in the promotion of economic development.

关键词： population economy imbalance pattern Wumeng Mountain Area

A self-centering and stiffness-controlled MEMS accelerometer

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Microsystems & Nanoengineering 2024年第1期10卷 27-40页

作者： Yiming Jin Zhipeng Ma Ziyi Ye Mingkang li xudong Zheng Zhonghe Jin School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310013China Key Laboratory of Micro/Nano-Satellite Research of Zhejiang Province Hangzhou 310007PR China

This paper presents a high-performance MEMS accelerometer with a DC/AC electrostatic stiffness tuning capability based on double-sided parallel plates(DSPPs).DC and AC electrostatic tuning enable the adjustment of the effective stiffness and the calibration of the geometric offset of the proof mass,respectively.A dynamical model of the proposed accelerometer was developed considering both DC/AC electrostatic tuning and the temperature *** on the dynamical model,a self-centering closed loop is proposed for pulling the reference position of the forceto-rebalance(FTR)to the geometric center of *** self-centering accelerometer operates at the optimal reference position by eliminating the temperature drift of the readout circuit and nulling the net electrostatic tuning *** stiffness closed-loop is also incorporated to prevent the pull-in instability of the tuned low-stiffness accelerometer under a dramatic temperature ***-time adjustments of the reference position and the DC tuning voltage are utilized to compensate for the residue temperature drift of the proposed *** a result,a novel controlling approach composed of a self-centering closed loop,stiffness-closed loop,and temperature drift compensation is achieved for the accelerometer,realizing a temperature drift coefficient(TDC)of approximately 7μg/℃ and an Allan bias instability of less than 1μg.

关键词： stiffness electrostatic centering

Data-driven surrogate model for aerodynamic design using separable shape tensor method

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CHINESE JOURNAL OF AerONAUTICS 2024年第9期37卷 41-58页

作者： Pang, Bo Zhang, Yang li, Junlin Wang, xudong Chang, Min Bai, Junqiang Xi An Jiao Tong Univ State Key Lab Strength & Vibrat Mech Struct Xian 710049 Peoples R China Northwestern Polytech Univ Unmanned Syst Res Inst Xian 710072 Peoples R China

In the context of increasing dimensionality of design variables and the complexity of constraints, the efficacy of Surrogate-Based Optimization (SBO) is limited. The traditional linear and nonlinear dimensionality reduction algorithms are mainly to decompose the mathematical matrix composed of design variables or objective functions in various forms, the smoothness of the design space cannot be guaranteed in the process, and additional constraint functions need to be added in the optimization, which increases the calculation cost. This study presents a new parameterization method to improve both problems of SBO. The new parameterization is addressed by decoupling affine transformations (dilation, rotation, shearing, and translation) within the Grassmannian submanifold, which enables a separate representation of the physical information of the airfoil in a highdimensional space. Building upon this, Principal Geodesic Analysis (PGA) is employed to achieve geometric control, compress the design space, reduce the number of design variables, reduce the dimensions of design variables and enhance predictive performance during the surrogate optimization process. For comparison, a dimensionality reduction space is defined using 95% of the energy, and RAE 2822 for transonic conditions are used as demonstrations. This method significantly enhances the optimization efficiency of the surrogate model while effectively enabling geometric constraints. In three-dimensional problems, it enables simultaneous design of planar shapes for various components of the aircraft and high-order perturbation deformations. Optimization was applied to the ONerA M6 wing, achieving a lift-drag ratio of 18.09, representing a 27.25% improvement compared to the baseline configuration. In comparison to conventional surrogate model optimization methods, which only achieved a 17.97% improvement, this approach demonstrates its superiority. (c) 2024 Production and hosting by Elsevier Ltd. on behalf of Chine

关键词： Aerodynamic design Grassmannian manifold Shape parameterization Surrogate-based optimization Data dimensionality reduction WING DESIGN OPTIMIZATION

BrrTCP4b interacts with BrrTTG1 to suppress the development of trichomes in Brassica rapa var. rapa

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Plant Diversity 2024年第3期46卷 416-420页

作者： Cheng li li Zhang Hefan li Yuanwen Duan Xuemei Wen Yongping Yang xudong Sun The Germplasm Bank of Wild Species Yunnan Key Laboratory of Crop Wild Relatives OmicsInstitute of Tibetan Plateau Research at KunmingKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences BeijingChina Tibet Plateau Institute of Biology Lhasa 850001TibetChina

The number of trichomes significantly increased in CRISPR/Cas9-edited BrrTCP4b turnip(Brassica rapa ***)***,the underlying molecular mechanism remains to be *** this study,we performed the Y2H screen using BrrTCP4b as the bait,which unveiled an interaction between BrrTCP4b and BrrTTG1,a pivotal WD40-repeat protein transcription factor in the MYB-bHLH-WD40(MBW)*** physical interaction was further validated through bimolecular luciferase complementation and ***,it was found that the interaction between BrrTCP4b and BrrTTG1 could inhibit the activity of MBW complex,resulting in decreased expression of BrrGL2,a positive regulator of trichomes *** contrast,AtTCP4 is known to regulate trichomes development by interacting with AtGL3 in Arabidopsis ***,this study revealed that BrrTCP4b is involved in trichome development by interacting with BrrTTG1 in turnip,indicating a divergence from the mechanisms observed in model plant *** findings contribute to our understanding of the regulatory mechanisms governing trichome development in the non-model plants turnip.

关键词： TCP transcription factor MBW complex Trichome development Turnip

Enhanced Redox Electrocatalysis in High‑Entropy Perovskite Fluorides by Tailoring d–p Hybridization

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Nano-Micro Letters 2024年第3期16卷 333-350页

作者： xudong li Zhuomin Qiang Guokang Han Shuyun Guan Yang Zhao Shuaifeng Lou Yongming Zhu Department of Applied Chemistry Harbin Institute of Technology at WeihaiWeihai 264209People’s Republic of China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China

High-entropy catalysts featuring exceptional properties are,in no doubt,playing an increasingly significant role in aprotic lithium-oxygen *** extensive effort devoted to tracing the origin of their unparalleled performance,the relationships between multiple active sites and reaction intermediates are still ***,enlightened by theoretical screening,we tailor a high-entropy perovskite fluoride(KCoMnNiMgZnF_(3)-HEC)with various active sites to overcome the limitations of conventional catalysts in redox *** entropy effect modulates the d-band center and d orbital occupancy of active centers,which optimizes the d–p hybridization between catalytic sites and key intermediates,enabling a moderate adsorption of liO_(2)and thus reinforcing the reaction *** a result,the li–O2 battery with KCoMnNiMgZnF_(3)-HEC catalyst delivers a minimal discharge/charge polarization and long-term cycle stability,preceding majority of traditional catalysts *** encouraging results provide inspiring insights into the electron manipulation and d orbital structure optimization for advanced electrocatalyst.

关键词： lithium-oxygen batteries KCoMnNiMgZnF_(3)-HEC perovskite fluoride Entropy effect Catalytic kinetics d-p orbital hybridization