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牛奶质量安全主要风险因子分析 Ⅴ.激素类药物残留

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中国畜牧兽医 2012年第5期39卷 7-13页

作者：屈雪寅王加启郑楠韩荣伟许晓敏甄云鹏赵连生中国农业科学院北京畜牧兽医研究所北京100193 农业部奶及奶制品质量监督检验测试中心(北京) 北京100193 农业部奶产品质量安全风险评估实验室(北京) 北京100193 青岛农业大学食品科学与工程学院山东青岛266109

牛奶中激素类药物残留对人体健康危害较大,各国家及国际组织制定了相关的标准和法规。作者对主要国家和国际组织牛奶中激素类药物残留的限量及禁用标准作了比较和分析,并对其所制定的检测方法和风险监测模式作了综述。

关键词：激素类药物残留限量检测方法风险监测

牛奶质量安全主要风险因子分析 Ⅱ.霉菌毒素

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中国畜牧兽医 2012年第3期39卷 1-9页

作者：郑楠王加启韩荣伟许晓敏甄云鹏屈雪寅赵连生中国农业科学院北京畜牧兽医研究所北京100193 农业部奶及奶制品质量监督检验测试中心(北京) 北京100193 农业部奶产品风险评估实验室(北京) 北京100193 青岛农业大学食品科学与工程学院山东青岛266109

霉菌毒素的污染是牛奶质量安全的重要问题。作者对牛奶中主要存在的霉菌毒素种类、各国及组织制定的限量值及风险评估等方面的研究进行了综述。以期为中国进行牛奶质量安全风险监测、风险评估,完善中国牛奶质量安全监测体系提供参考。

关键词：牛奶霉菌毒素限量风险评估

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牛奶质量安全主要风险因子分析Ⅵ.污染物

中国畜牧兽医 2012年第6期39卷 6-11页

作者：甄云鹏王加启郑楠韩荣伟许晓敏屈雪寅赵连生农业部奶及奶制品质量监督检验测试中心(北京) 北京100193 中国农业科学院北京畜牧兽医研究所反刍动物营养研究室北京100193

牛奶中污染物如重金属等对人体健康存在很大隐患,因而受到广泛关注。作者对不同国家、国际组织牛奶中污染物限量数量、限量值和种类及检测方法进行比较,针对各地区的牛奶中污染物风险监测事例与模式进行分析,以期对中国牛奶质量安全风... 详细信息

牛奶中污染物如重金属等对人体健康存在很大隐患,因而受到广泛关注。作者对不同国家、国际组织牛奶中污染物限量数量、限量值和种类及检测方法进行比较,针对各地区的牛奶中污染物风险监测事例与模式进行分析,以期对中国牛奶质量安全风险监测提供参考依据。

关键词：牛奶污染物限量

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牛奶质量安全主要风险因子分析 Ⅳ.农药残留

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中国畜牧兽医 2012年第5期39卷 1-6页

作者：许晓敏王加启郑楠韩荣伟甄云鹏屈雪寅赵连生中国农业科学院北京畜牧兽医研究所北京100193 农业部奶及奶制品质量监督检验测试中心(北京) 北京100193 农业部奶产品质量安全风险评估实验室(北京) 北京100193 青岛农业大学食品科学与工程学院山东青岛266109

牛奶在食物营养链中处于较高级所以其含有的农药的残留量相对较高,长期服用农药污染的牛奶能致畸、致癌、致突变,对人体健康危害较大,各国家及国际组织均制定了相关的标准和法规来限制本国牛奶中的农药残留。作者对国内外牛奶中农药残... 详细信息

牛奶在食物营养链中处于较高级所以其含有的农药的残留量相对较高,长期服用农药污染的牛奶能致畸、致癌、致突变,对人体健康危害较大,各国家及国际组织均制定了相关的标准和法规来限制本国牛奶中的农药残留。作者对国内外牛奶中农药残留限量情况进行了比较和分析,并且对相关检测方法和风险监测模式进行了综述。

关键词：农药残留生乳检测方法风险监测

牛奶质量安全主要风险因子分析 Ⅲ.兽药残留

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中国畜牧兽医 2012年第4期39卷 1-10页

作者：韩荣伟王加启郑楠许晓敏甄云鹏屈雪寅赵连生中国农业科学院北京畜牧兽医研究所动物营养国家重点实验室北京100193 农业部奶及奶制品质量监督检验测试中心(北京) 北京100193 青岛农业大学食品科学与工程学院山东青岛266109

作者对主要乳品贸易国家和国际组织所规定的牛奶中兽药最大残留限量、检测方法、风险评估模式进行了综述,分析了中国与其他国家和组织在兽药限量规定上的异同及原因,并就完善中国牛奶中兽药残留限量规定和风险控制提出了建议。

关键词：牛奶兽药残留最大残留限量风险评估

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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou Ying Mo Biao Zheng Miaomiao han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

Cytochrome P450 2E1 RsaI/PstI and DraI Polymorphisms Are Risk Factors for Lung Cancer in Mongolian and han Population in Inner Mongolia

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Chinese Journal of Cancer Research 2011年第2期23卷 107-111页

作者： Xiu-lan Su Ba Bin Hong-wei Cui Mei-rong Ran Clinical Medical Center Affiliated Hospital Inner Mongolian Medical College Hohhot 010050 China Department of Internal Medicine Medical Emergency Center of Kangbashi New Direct Erdos City Inner Mongolia China

Objective： To explore the relationship between cytochrome P450 2E1 （CYP2E1） RsaI/PstI and DraI polymorphism and lung cancer susceptibility in Mongolian and han population in Inner Mongolia of China. Methods： CYP2E1 RsaI/PstI and DraI polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism in 64 lung cancer patients, 150 healthy Mongolian and 150 healthy han individuals. The distribution of genotype and allele frequencies of CYP2E1 RsaI/PstI and DraI polymorphisms were studied. Results： The risk of lung cancer was increased in individuals with CYP2E1 （cl/cl） and CYP2E1 （DD） with OR values of 2.431 （95%CI=1.082-5.460） and 2.778 （95%CI=1.358-5.683） respectively （P0.05）. When CYP2E1 RsaI/PstI and DraI polymorphisms were combined, the risk of lung cancer was reduced in individuals with CYP2E1 （cl/c2＋c2/c2 and DD＋CC） with OR values of 0.233 （95%CI=0.088-0.615, P0.05）. In smokers, the susceptibility to lung cancer was higher in the individuals with CYP2E1 （c1/c1） and CYP2E1 （DD） than in the individuals with c2 and C allele （P0.05, OR=2.643 and 4.308 respectively）. There was no significant difference in distribution of CYP2E1 genotype frequency between healthy Mongolian, han population and lung cancer patients, healthy controls in Inner Mongolia. Conclusion： CYP2E1 （c1/c1） and CYP2E1 （DD） are predisposing factors of lung cancer in population in Inner Mongolia. CYP2E1 （c2﹢C） co-mutation may decrease the risk of lung cancer. Smoking exerts synergetic effect with CYP2E1 （c1/c1） and CYP2E1 （DD） on the occurrence of lung cancer.

关键词： Cytochrome p450 2E1 Gene polymorphism Lung cancer Susceptivity

Application of ultrasonic vibration to shape-casting based on resonance vibration analysis

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China Foundry 2023年第4期20卷 339-346页

作者： Zong-hang han Zhi-ming Wang Zhi-ping Sun Bing-rong Zhang wei-feng Rao School of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Jinan Shengquan Group Jinan 250204China

The application of ultrasonic vibration during the casting process has been proven to refine the microstructure and enhance the properties of the *** using the direct inserting method,wherein the ultrasonic horn is inserted directly into the melt,ultrasonic treatment can be utilized in the semi-continuous casting process to produce aluminum ingots with simple ***,due to the attenuation of ultrasound,it is challenging to apply the direct inserting method in the die casting process to produce complex ***,in this study,the impact of ultrasonic vibration on the microstructure of a gravity die-cast AlSi9Cu3end cap was investigated by applying ultrasonic vibration on the core(indirect method).It is found that the effect of ultrasonic vibration relies greatly on the resonance mode of the *** of ultrasonic vibration schemes mainly depends on the core structure,and only a strong vibration can significantly refine the microstructure of the *** castings with complex structures,an elaborated ultrasonic vibration design is necessary to refine the microstructure of the specified *** addition,strong vibration applied on the feeding channel can promote the feeding ability of casting by breaking the dendrites during solidification,and consequently reduce the shrinkage porosity.

关键词： resonance mode ultrasonic vibration feeding channel aluminum alloy casting